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Promethazine

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181. Validation of Pupillary Response to Nociceptive Stimulation in Cardiac Surgery During Extracorporeal Circulation Period

, dicyclomine, diphenhydramine, doxepin, flavoxate, hydroxyzine, hyoscyamine, imipramine, meclizine, nortriptyline, orphenadrine, oxybutynin, paroxetine, perphenazine, procyclidine, promazine, promethazine, propentheline, pyrilamine, scopolamine, thioridazine, tolterodine, trifluoperazine, trihexyphenidyl, trimipramine pregnant or lactating women Patient having objected to the processing of his data Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study

2018 Clinical Trials

182. A Pharmacokinetic Trial of Naproxen Sodium and Diphenhydramine Hydrochloride Soft Capsules Versus Naproxen Sodium and Diphenhydramine Hydrochloride Tablets in Healthy Adult Subjects

Promethazine Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Gout Suppressants Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Sleep Aids, Pharmaceutical Hypnotics and Sedatives Central Nervous System Depressants Anesthetics, Local Anesthetics Antiemetics Autonomic Agents Gastrointestinal Agents Histamine

2018 Clinical Trials

183. Delirium Prevention Protocol in Elderly Patients

fentanyl usage intraoperatively Intubation + general anesthesia adjunct total: 1-2 mcg/kg fentanyl Sedation: 0-0.24 mcg/kg fentanyl Post-operative: 0.5 - 1 mcg/kg fentanyl Avoid morphine Avoid ketamine Avoid diphenhydramine, dexamethasone, scopolamine, metoclopramide, and promethazine Avoid H2-blockers (cimetidine, ranitidine, famotidine) Avoid polypharmacy intraoperatively if possible (i.e. > 5 new medications) Fluid repletion based on maintenance and losses Other: Preventative Delirium Protocol

2018 Clinical Trials

184. NK Cells Infusion for Advanced Malignancies

: NK cells infusion Pretreatment:patients enrolled in this study will receive 20 mg/kg of cyclophosphamide for solid tumor or 20-60 mg/kg of cyclophosphamide for hematological tumor once daily for 3 times. NK cells infusion is allowed within 2-14 days after treatment. NK cells infusion:30-60 minutes before infusion,ant-allergic agents are applied (promethazine 25mg,i.m. ; Cimetidine 0.4g i.v. ; diphenhydramine 50mg po.). NK cells are intravenously infused into patients with 15-30 minutes every

2018 Clinical Trials

185. Therapeutic Rest in Early Labor, A Study on Morphine Sleep.

examine the potential benefits of therapeutic rest from the perspective of either patient satisfaction or cost-effectiveness. The investigators aim to determine whether therapeutic rest using morphine and promethazine is associated with variations in obstetric or neonatal outcomes, patient satisfaction, or costs of labor admission. Methods: This will be a prospective cohort study. Women who are eligible for therapeutic rest (reactive non-stress test, normal amniotic fluid, in prodromal or early labor (...) Sulfate Patients accepted morphine and promethazine as a method for pain management in early or prodromal labor. Drug: Morphine Sulfate Morphine sulfate and promethazine Other Name: Morphine Sleep Declined Morphine Sulfate Patients declined morphine and promethazine as a method for pain management in early or prodromal labor. Outcome Measures Go to Primary Outcome Measures : Time from hospital admission to delivery of baby [ Time Frame: 1-2 weeks after admission to hospital ] Mean hours from time

2018 Clinical Trials

186. Imaging 5HT7 Antagonist Effects in Bipolar Disorder

, perhexiline, phenacetin, phenformin, promethazine, propafenone, propranolol, sparteine, tamoxifen, tramadol, venlafaxine. Participants planning to use these medications after their participation in the study must commit to a two-week washout period at the end of the study before commencing these medications. As JNJ-18038683 is a moderate inhibitor of cytochrome P450 2C19, use of the following CYP2C19 substrates will be an exclusion: Proton pump inhibitors, phenytoin, phenobarbitone, diazepam, Norphenytoin

2018 Clinical Trials

187. TREC-Lebanon: A Trial for Rapid Tranquilisation for Agitated Patients in the Emergency Setting

: Recruiting First Posted : August 21, 2018 Last Update Posted : October 25, 2018 See Sponsor: Joseph Dib Collaborators: University of Nottingham Hopital Psychiatrique De La Croix Information provided by (Responsible Party): Joseph Dib, Hopital Psychiatrique De La Croix Study Details Study Description Go to Brief Summary: This is a randomised controlled trial comparing haloperidol + promethazine versus haloperidol + promethazine + chlorpromazine for agitated patients in the emergency department. Condition (...) or disease Intervention/treatment Phase Psychiatric Emergency Aggression Agitation Drug: Haloperidol + Promethazine + Chlorpromazine Drug: Haloperidol + Promethazine Phase 4 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 100 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment Official Title: TREC-Lebanon Trial: A Randomised Controlled

2018 Clinical Trials

188. A Pharmacokinetic Trial of Naproxen Sodium and Diphenhydramine Hydrochloride Soft Capsules Versus Naproxen Sodium and Diphenhydramine Hydrochloride Tablets in Healthy Adult Subjects Under Fed Conditions

terms Naproxen Diphenhydramine Promethazine Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Gout Suppressants Cyclooxygenase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Sleep Aids, Pharmaceutical Hypnotics and Sedatives Central Nervous System Depressants Anesthetics, Local Anesthetics Antiemetics Autonomic

2018 Clinical Trials

189. Post Operative Pain Control After Pediatric Hip Surgery

to Share IPD: No Additional relevant MeSH terms: Layout table for MeSH terms Pain, Postoperative Postoperative Complications Pathologic Processes Pain Neurologic Manifestations Signs and Symptoms Morphine Fentanyl Oxycodone Acetaminophen Ropivacaine Ondansetron Diphenhydramine Lorazepam Promethazine Analgesics, Opioid Narcotics Central Nervous System Depressants Physiological Effects of Drugs Analgesics Sensory System Agents Peripheral Nervous System Agents Adjuvants, Anesthesia Anesthetics

2018 Clinical Trials

190. Evaluation of the effects of anti-motion sickness drugs on subjective sleepiness and cognitive performance of healthy males. (Abstract)

Evaluation of the effects of anti-motion sickness drugs on subjective sleepiness and cognitive performance of healthy males. This study aimed to investigate the clinical and cognitive side effects of baclofen (10 mg), meclizine (25 mg), dimenhydrinate (40 mg) plus cinnarizine (25 mg) and promethazine (25 mg) plus d-amphetamine (10 mg). The study had a double-blind, placebo controlled, repeated measures design and was conducted on healthy male volunteers. The psychomotor vigilance test (...) an influence of these drugs on the working memory. Significant side effects for baclofen were: sleepiness, tiredness, blurred vision, concentration problems and dizziness whereas for dimenhydrinate-cinnarizine only sleepiness and blurred vision were reported. Meclizine decreased the accuracy on the Sternberg working memory task and thus seemed to affect short-term memory. A reported side effect was increased sleepiness. Promethazine plus d-amphetamine did not affect any of the tested cognitive functions

2018 Journal of psychopharmacology (Oxford, England) Controlled trial quality: uncertain

191. Treatment of Dyspnoea in Advanced Cancer Patients

DE. Effects of chronic administration of codeine and promethazine on breathlessness and exercise tolerance in patients with chronic air?ow obstruction. Br J Dis Chest 1987; 81: 287–292. 68. Stark RD, Gambles SA, Lewis JA. Methods to assess breathlessness in healthy subjects: a critical evaluation and application to analyse the acute effects of diazepam and promethazine on breathlessness induced by exercise or by exposure to raised levels of carbon dioxide. Clin Sci 1981; 61: 429–439. 69

2015 European Society for Medical Oncology

194. Controversies in Migraine Management

, antiemetics (chlorpromazine, droperidol, metoclopramide, prochlorperazine, promethazine), dexamethasone, and opioids (meperidine, tramadol, nalbuphine). 32-35 Ketorolac is the preferred first-line agent because of its minimal side effects and at least eight randomized trials demonstrating equivalence or superiority to parenteral sumatriptan and the antiemetics. The evidence about opioids will be discussed in detail in the evidence review. Antiemetic therapy, such as metoclopramide, can facilitate the use

2014 California Technology Assessment Forum

195. Management of Gastroparesis

en associated with tachyphylaxis due to downregulation of the motilin receptor. Clinical responsiveness drops aft er 4 weeks of oral erythromycin The American Journal of GASTROENTEROLOGY VOLUME 108 | JANUARY 2013 www.amjgastro.com 26 Camilleri et al . agents (including promethazine). Several US medical centers have recently placed several additional restrictions on promethazine, related to concerns about sedation, possible cardiac toxicity (corrected QT prolongation ( 110 )), damage to peripheral (...) veins, and lack of availability of the drug ( 111 ). Th ere are no studies that compare effi cacy of phenothiazines with newer antiemetics (such as serotonin 5-HT 3 -receptor antagonists) for gastroparesis. Th ere is no evidence that ondansetron is superior to metoclopramide and promethazine in reducing nausea in adults attending an emer gency depa r tmen t ( 112 ). 5-HT 3 -receptor antagonists are reasonable second-line medications; the neurokinin receptor-1 antagonist, aprepitant, was eff ective

2013 American College of Gastroenterology

196. Geriatric Trauma Management

Recommendation Quality of Evidence Strength of Recom- mendation Anticholinergics (excludes TCAs) First-generation antihistamines (as single agent or as part of combination products) z Brompheniramine z Carbinoxamine z Chlorpheniramine z Clemastine z Cyproheptadine z Dexbrompheniramine z Dexchlorpheniramine z Diphenhydramine (oral) z Doxylamine z Hydroxyzine z Promethazine z Triprolidine Highly anticholinergic; clearance reduced with advanced age, and tolerance develops when used as hypnotic; increased risk (...) of confusion, dry mouth, constipation, and other anticholinergic effects/toxicity Use of diphenhydramine in special situations such as acute treatment of severe allergic reaction may be appropriate Avoid Hydroxyzine and promethazine: High All others: Moderate Strong Anti-Parkinson agents z Benztropine (oral) z Trihexyphenidyl Not recommended for prevention of extrapyramidal symptoms with antipsychotics; more effective agents available for treatment of Parkinson disease Avoid Moderate Strong Antispasmodics

2013 American College of Surgeons

197. Practice Guidelines for Postanesthetic Care

promethazine with placebo corroborates findings of reduced nausea and vomiting reported in the original Guidelines ( Category A3-B evidence ). 5-HT3 Antiemetics. Meta-analysis of new double-blind RCTs corroborate findings reported in the original Guidelines indicating that 5-HT3 antiemetics compared with placebo are effective in the prophylaxis of postoperative nausea and vomiting, and reduced use of rescue antiemetics ( Category A1-B evidence ). Findings for specific 5-HT3 antiemetics are: dolasetron

2013 American Society of Anesthesiologists

198. Pathogenesis, consequences, and control of peritoneal adhesions in gynecologic surgery: a committee opinion

and adhesion-reducing substances, including dexamethasone and promethazine, have been evaluated, but none has been found effective for reducing postoperative adhesions (37–39). Peritoneal instillates. Antibiotic solutions for peritoneal la- vageandpreventionofpostoperativeinfectiondonotreduce adhesions, and some may promote adhesion formation (40). Thirty-two percent dextran 70 and crystalloid solution instillates, such as normal saline and Ringer's lactate with or without heparin or corticosteroids, have

2013 Society for Assisted Reproductive Technology

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