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Promethazine

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181. Relative Efficacy of Seven Common H1 Receptor Antagonist Antihistamines in Chronic Idiopathic Urticaria. (PubMed)

, chlorpheniramine, embramine, promethazine, dimeth'mdene and dexchlorpheniramme. The differences between the first five antihistamines were not statistically significant, though these were superior to ddxchlorpheniralmine and placebo. Dexchlorpheniramine was statistically better than placebo.

2017 Indian journal of dermatology, venereology and leprology

182. Medications influencing central cholinergic pathways affect fixation stability, saccadic response time and associated eye movement dynamics during a temporally-cued visual reaction time task. (PubMed)

investigation. Eye tracking technology recorded eye movements while participants reacted to visual stimuli following temporally informative and uninformative cues. The task was performed pre-ingestion as well as 0.5 and 2 h post-ingestion of promethazine hydrochloride (strong centrally acting anticholinergic), hyoscine hydrobromide (moderate centrally acting anticholinergic), hyoscine butylbromide (anticholinergic devoid of central properties) and a placebo.Promethazine decreased fixation stability during (...) the reaction time task. In addition, promethazine was the only drug to increase saccadic response time during temporally informative and uninformative cued trials, whereby effects on response time were more pronounced following temporally informative cues. Promethazine also decreased saccadic amplitude and increased saccadic duration during the temporally-cued reaction time task.Collectively, the results of the study highlight the significant role that central cholinergic pathways play in the control

2017 Psychopharmacology

183. "THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"

Ketorolac Metoclopramide Diphenhydramine Ketamine BB 1101 Promethazine Anti-Inflammatory Agents Antiemetics Autonomic Agents Peripheral Nervous System Agents Physiological Effects of Drugs Gastrointestinal Agents Glucocorticoids Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Antineoplastic Agents, Hormonal Antineoplastic Agents

2017 Clinical Trials

184. Metoclopramide for Post-Traumatic Headache. A Pilot Study

.: No Additional relevant MeSH terms: Layout table for MeSH terms Headache Post-Traumatic Headache Pain Neurologic Manifestations Signs and Symptoms Headache Disorders, Secondary Headache Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Diphenhydramine Metoclopramide Promethazine Sleep Aids, Pharmaceutical Hypnotics and Sedatives Central Nervous System Depressants Physiological Effects of Drugs Anesthetics, Local Anesthetics Sensory System Agents Peripheral Nervous System Agents

2017 Clinical Trials

185. E-aid Sleep-focused TrEatment for Prevention of Major Depression (STEP-MD)

treatment eCBTI internet Psychotherapy Additional relevant MeSH terms: Layout table for MeSH terms Depression Depressive Disorder Sleep Initiation and Maintenance Disorders Self-Injurious Behavior Behavioral Symptoms Mood Disorders Mental Disorders Sleep Disorders, Intrinsic Dyssomnias Sleep Wake Disorders Nervous System Diseases Diphenhydramine Promethazine Sleep Aids, Pharmaceutical Hypnotics and Sedatives Central Nervous System Depressants Physiological Effects of Drugs Anesthetics, Local Anesthetics

2017 Clinical Trials

186. Motion Perception in Individuals With Type 2 Diabetes

for at least 10 years Under 250 pounds Exclusion Criteria: Medications not to be used include: Ambien (Zolpidem), Antivert, Bonine (Meclizine), Ativan (Lorazepam), Benadryl (diphenhydramine), Dalmane (Flurazepam), Dramamine, Doral (Quazepam), Fiorinal, Fiorcet (Butalbital), Halcion (Triazolam), Klonopin (Clonazepam), Librium, Librax (Chlordiazepoxide), Nembutal (Pentobarbital), Phenergan (Promethazine), Placidyl (Ethchlorvynol), Prosom (Estazolam), Restoril (Temazepam), Seconal (Secobarbital), Serax

2017 Clinical Trials

187. Single Dose of the CXCR4 Antagonist BL-8040 Induces Rapid Mobilization for the Collection of Human CD34+ Cells in Healthy Volunteers. (Full text)

site and systemic reactions were mitigated by methylprednisolone, paracetamol, and promethazine pretreatment. In the first part of the study, BL-8040 triggered rapid and substantial mobilization of WBCs and CD34+ cells in all tested doses. Four hours postdose, the count rose to a mean of 8, 37, 31, and 35 cells/μL (placebo, 0.5, 0.75, and 1 mg/kg, respectively). FACS analysis revealed substantial mobilization of immature dendritic, T, B, and NK cells. In the second part, the mean CD34+ cells/kg

2017 Clinical Cancer Research PubMed

188. Interventions for treating hyperemesis gravidarum: A Cochrane systematic review and meta-analysis. (PubMed)

1.23-4.69, and RR 2.38, 95% CI 1.10-5.11, respectively). There were no clear differences between groups for other side effects. In a single study with 146 participants comparing metoclopramide with promethazine, more women taking promethazine reported drowsiness, dizziness, and dystonia (risk ratio (RR) 0.70, 95% CI 0.56-0.87, RR 0.48, 95% CI 0.34-0.69, and RR 0.31, 95% CI 0.11-0.90, respectively). There were no clear differences between groups for other important outcomes including quality of life (...) and other side effects. In a single trial with 30 women, those receiving ondansetron had no difference in duration of hospital admission compared to those receiving promethazine (mean difference (MD) 0.00, 95% CI -1.39-1.39), although there was increased sedation with promethazine (RR 0.06, 95% CI 0.00-0.94). Regarding corticosteroids, in a study with 110 participants there was no difference in days of hospital admission compared to placebo (MD -0.30, 95% CI -0.70-0.10), but there was a decreased

2017 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

189. Pharmacologic Treatment of Cannabinoid Hyperemesis Syndrome: A Systematic Review. (PubMed)

. Evidence was graded using Oxford Center for Evidence-Based Medicine guidelines. The search resulted in 1262 articles with 63 of them eligible for inclusion (205 human subjects). There were 4 prospective level-2, 3 retrospective level-3 studies, 12 level-4 case series, and 44 level-5 case reports. Among level-2 studies (64 subjects), tricyclic antidepressants (TCAs) and lorazepam were discussed as effective long- and short-term treatments, respectively, in two studies. Ondansetron, promethazine (...) . For level-5 case reports (44 subjects), benzodiazepines, metoclopramide, haloperidol, ondansetron, morphine, and capsaicin were reported as effective. Effective treatments mentioned only once included fentanyl, diazepam, promethazine, methadone, nabilone, levomepromazine, piritramide, and pantoprazole. Hot showers and baths were cited in all level-4 and -5 articles as universally effective. High-quality evidence for pharmacologic treatment of CHS is limited. Benzodiazepines, followed by haloperidol

2017 Pharmacotherapy

190. Richard Lehman’s journal review—10 October 2016

, although more positively expressed: “For mild symptoms of nausea and emesis of pregnancy, ginger, pyridoxine, antihistamines, and metoclopramide were associated with greater benefit than placebo. For moderate symptoms, pyridoxine-doxylamine, promethazine, and metoclopramide were associated with greater benefit than placebo. Ondansetron was associated with improvement for a range of symptom severity. Corticosteroids may be associated with benefit in severe cases. Overall the quality of evidence was low

2016 The BMJ Blog

191. Primary Care Corner with Geoffrey Modest MD: 2 CDC Reports on Spread and Toxicity of Fentanyl

, with some differences in the apparent composition of the counterfeit drug: all had fentanyl (a potent synthetic opioid, 100x that of morphine, and a full m-opioid receptor agonist. fentanyl has high lipophilicity, allowing it to enter the CNS rapidly. It is not marketed as an oral pill, so its presence in pill form confirms its being illicit); some had promethazine (used for nausea/vomiting, motion sickness, and it may potentiate the opiate high), some trace amounts of cocaine and several

2016 Evidence-Based Medicine blog

192. Pearls of wisdom for future leaders

at the same institution: it is comfortable and familiar. However, by leaving your ‘safe’ zone for an elective, fellowship or exchange, you will see variation in clinical practice. I have been to countless talks from academics who cite observing variation as a trigger for a research career. Dr. Freedman, for example, completed his paediatric emergency fellowship in Chicago where children were routinely managed with promethazine unlike dimenhydrinate in Toronto: . But, such opportunities rarely fall

2016 CEBM blog

193. Metoclopramide for Post Traumatic Headache

Additional relevant MeSH terms: Layout table for MeSH terms Headache Post-Traumatic Headache Pain Neurologic Manifestations Signs and Symptoms Headache Disorders, Secondary Headache Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Diphenhydramine Metoclopramide Promethazine Sleep Aids, Pharmaceutical Hypnotics and Sedatives Central Nervous System Depressants Physiological Effects of Drugs Anesthetics, Local Anesthetics Sensory System Agents Peripheral Nervous System Agents

2017 Clinical Trials

194. Epidemiology and Pathophysiology of Post-Infectious Functional GI Disorders

, dolasetron, mirtazapine) All narcotics (e.g, codeine, morphine, and propoxyphene, either alone or in combination) Anti-cholinergic agents (e.g, dicyclomine, hyoscyamine, propantheline) Ultram GI preparations Anti-nausea agents (e.g, trimethobenzamide, promethazine, prochlorperazine, dimenhydrinate, hydroxyzine) Osmotic laxative agents (e.g, lactulose, sorbitol or polyethylene glycol (PEG) solutions as Miralax and Glycolax) Prokinetic agents (e.g, cisapride, metoclopramide, itopride, domperidone (...) , cholestyramine, alosetron Drugs with a known pharmacological activity at 5-HT4, 5-HT2b or 5-HT3 receptors (e.g, tegaserod, ondansetron, tropisetron, granisetron, dolasetron, mirtazapine) All narcotics (e.g, codeine, morphine, and propoxyphene, either alone or in combination) Anti-cholinergic agents (e.g, dicyclomine, hyoscyamine, propantheline) Ultram GI preparations Anti-nausea agents (e.g, trimethobenzamide, promethazine, prochlorperazine, dimenhydrinate, hydroxyzine) Osmotic laxative agents (e.g

2017 Clinical Trials

195. A Controlled Study to Determine the Efficacy and Safety of CL-108 5 mg as a Treatment for Acute Pain and the Prevention of OINV

5 mg Drug: Norco Drug: Placebo Phase 3 Detailed Description: Adult patients with moderate or severe pain after bunionectomy will be randomized to CL-108 5 mg (hydrocodone 5 mg/acetaminophen 325 mg/ promethazine 12.5 mg), hydrocodone 5 mg/ acetaminophen 325 mg, or placebo under double-blind conditions. Over 48 hours they will use the assigned study medication and assess pain intensity, nausea, and vomiting. Uses of supplementary analgesic and antiemetic medications will be documented. Patient (...) (Hydrocodone 5 mg/Acetaminophen 325 mg/Promethazine 12.5 mg) as a Treatment for Acute Pain and the Prevention of Opioid-Induced Nausea and Vomiting (OINV) Actual Study Start Date : August 2, 2017 Actual Primary Completion Date : April 16, 2018 Actual Study Completion Date : November 30, 2018 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: CL-108 5 mg Hydrocodone 5 mg/APAP 325 mg/promethazine

2017 Clinical Trials

196. Preventative Delirium Protocol in Elderly Patients

usage intraoperatively Intubation + GA adjunct total: 1-2 mcg/kg Sedation: 0-0.25 mcg/kg Post-op: 0.5-1 mcg/kg Avoid morphine Avoid ketamine Avoid diphenhydramine, dexamethasone, scopolamine, metoclopramide, and promethazine Avoid H2-blockers (cimetidine, ranitidine, famotidine) Avoid polypharmacy intraoperatively if possible (i.e. >5 new medications) Fluid repletion based on maintenance and losses Other: Preventative Delirium Protocol Preventative Delirium Protocol Outcome Measures Go to Primary

2017 Clinical Trials

197. Clinical Benefit of SAR650984, Bortezomib, Lenalidomide and Dexamethasone Combination in NDMM Patients Not Eligible for Transplant

: Layout table for MeSH terms Multiple Myeloma Neoplasms, Plasma Cell Neoplasms by Histologic Type Neoplasms Hemostatic Disorders Vascular Diseases Cardiovascular Diseases Paraproteinemias Blood Protein Disorders Hematologic Diseases Hemorrhagic Disorders Lymphoproliferative Disorders Immunoproliferative Disorders Immune System Diseases Dexamethasone Dexamethasone acetate Diphenhydramine Lenalidomide Bortezomib Ranitidine Acetaminophen BB 1101 Promethazine Anti-Inflammatory Agents Antiemetics Autonomic

2017 Clinical Trials

198. CSE for Labour Analgesia: A Comparison of Two Intrathecal Regimens

Comparator: BF Interventions: Intrathecal administration -Bupivacaine 2.5mg (0.5ml) + Fentanyl 25mcg (0.5ml) + 1ml sterile water in one shot Ephedrine 3-5mg in aliquots in the event of hypotension Promethazine 12.5 - 25mg in the event of vomiting or significant pruritus naloxone 2mcg/kg in the event of respiratory distress Drug: Bupivacaine-fentanyl Dosages as previously written Active Comparator: BFM Interventions: Intrathecal administration - Bupivacaine 2.5mg (0.5ml) + fentanyl 25mcg (0.5ml) + 0.25mg (...) morphine (0.25ml) + 0.75ml sterile water in one shot ephedrine 3-5mg in aliquots for hypotension Promethazine 12.5 - 25mg for vomiting or significant pruritus Naloxone 2mcg/kg in the event of respiratory distress Drug: Bupivacaine-fentanyl morphine Dosage as previously written Outcome Measures Go to Primary Outcome Measures : Time to First painless contraction (TFC) [ Time Frame: time zero to first painless contraction estimated 15 minutes ] This is the onset of action of the drugs. The time duration

2017 Clinical Trials

199. PK/PD Study of Netupitant and Palonosetron in Pediatric Patients for Prevention of Chemotherapy-induced Nausea and Vomiting

., prochlorperazine, promethazine, perphenazine, fluphenazine, chlorpromazine, thiethylperazine); Benzodiazepines initiated 48 h prior to study drug administration or expected to be received within 120 h following initiation of chemotherapy, except for single doses of midazolam, temazepam or triazolam; Butyrophenones (e.g., droperidol, haloperidol); Anticholinergics (e.g., scopolamine, with the exception of inhaled anticholinergics for respiratory disorders e.g., ipratropium bromide); Antihistamines (e.g

2017 Clinical Trials

200. Treatment Modalities of Oral Lichen Planus

calcineurin inhibitors (TCIs) retinoids, photochemotherapy; amitryptaline; thalidomide; amlexanox and traditional medicines such as curcumin, selenium-ACE combined with itraconazole, glycyrrhiza glabra and aloe vera. But the exact treatment is still unknown. Objective: To compare the efficacy of Dexamethasone, Doxycycline, Nystatin and Promethazine cocktail with Triamcinolone as topical treatment of OLP Subjects and Methods: 40 patients of symptomatic OLP will be randomly divided in to study and control (...) group. Study group will be given a cocktail containing dexamethasone, doxycycline, nystatin and promethazine and will be advised to rinse with 1 and half teaspoon of this cocktail 3 times a day for 2 minutes for the period of 8 weeks. Study group is also advised to apply an orabase containing 0.1% triamcinolone on lesions 3 times a day for the period of 8 weeks. The control group will be advised to apply only triamcinolone orabase 3 times a day for 8 weeks. Condition or disease Intervention

2017 Clinical Trials

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