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Promethazine

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1. Promethazine

Promethazine Top results for promethazine - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) ) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for promethazine The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you

2018 Trip Latest and Greatest

2. Haloperidol plus promethazine for psychosis-induced aggression. (PubMed)

Haloperidol plus promethazine for psychosis-induced aggression. Health services often manage agitated or violent people, and such behaviour is particularly prevalent in emergency psychiatric services (10%). The drugs used in such situations should ensure that the person becomes calm swiftly and safely.To examine whether haloperidol plus promethazine is an effective treatment for psychosis-induced aggression.On 6 May 2015 we searched the Cochrane Schizophrenia Group's Register of Trials, which (...) is compiled by systematic searches of major resources (including MEDLINE, EMBASE, AMED, BIOSIS, CINAHL, PsycINFO, PubMed, and registries of clinical trials) and their monthly updates, handsearches, grey literature, and conference proceedings.All randomised clinical trials with useable data focusing on haloperidol plus promethazine for psychosis-induced aggression.We independently extracted data. For binary outcomes, we calculated risk ratio (RR) and its 95% confidence interval (CI), on an intention

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2016 Cochrane

3. A Prospective, Randomized, Double-Blinded, Double-Dummy Pilot Study to Assess the Preemptive Effect of Triple Therapy with Aprepitant, Dexamethasone, and Promethazine versus Ondansetron, Dexamethasone and Promethazine on Reducing the Incidence of Postoper (PubMed)

A Prospective, Randomized, Double-Blinded, Double-Dummy Pilot Study to Assess the Preemptive Effect of Triple Therapy with Aprepitant, Dexamethasone, and Promethazine versus Ondansetron, Dexamethasone and Promethazine on Reducing the Incidence of Postoper Postoperative nausea and vomiting (PONV) is among the most common distressing complications of surgery under anesthesia. Previous studies have demonstrated that patients who undergo craniotomy have incidences of nausea and vomiting as high (...) as 50-70%. The main purpose of this pilot study is to assess the incidence of PONV by using two different prophylactic regimens in subjects undergoing a craniotomy. Thus, we designed this study to assess the efficacy and safety of triple therapy with the combination of dexamethasone, promethazine, and aprepitant versus ondansetron to reduce the incidence of PONV in patients undergoing craniotomy.This is a prospective, single center, two-armed, randomized, double-dummy, double-blind, pilot study

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2016 Frontiers in medicine

4. Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi (PubMed)

Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi To evaluate the prevention of opioid-induced nausea and vomiting (OINV) and the relief of moderate to severe acute pain by CL-108, a novel drug combining a low-dose antiemetic (rapid-release promethazine 12.5 mg) with hydrocodone 7.5 mg

2019 Pain Medicine

5. Promethazine and Oral Midazolam Preanesthetic Children Medication. (PubMed)

Promethazine and Oral Midazolam Preanesthetic Children Medication. Several kinds of drugs have been investigated in preschool children as a preanesthetic sedation after various routes of administration for surgeries. This study aims to compare the efficacy of promethazine and oral midazolam for premedication in children aged 3 to 9 years who were scheduled for surgeries.This is a double-blind randomized controlled study conducted on 93 patients between the age of 3 and 9 years at Loresten (...) University of Medical Sciences Teaching Hospital, Khoramabad, Iran. The subjects were grouped into P (promethazine), M (midazolam), and C (control). About 0.3 mg/kg of oral promethazine was administered to patients in group P, 0.5 mg/kg of oral midazolam was administered to patients in group M, and 3 mL of normal saline as placebo was administered to patients in group C. Patient satisfaction, sedation and emotional score, systolic blood pressure (SBP), diastolic blood pressure, respiratory rate (RR

2018 Pediatric Emergency Care

6. Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects. (PubMed)

Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects. A battery of evoked pain tasks (PainCart) was developed to investigate the pharmacodynamic properties of novel analgesics in early-phase clinical research. As part of its clinical validation, compounds with different pharmacological mechanisms of actions are investigated. The aim was to investigate the analgesic effects of classic and nonclassic analgesics compared to a sedating (...) negative control in a randomized placebo-controlled crossover study in 24 healthy volunteers using the PainCart.The PainCart consisted of pain tasks eliciting electrical, pressure, heat, cold and inflammatory pain. Subjective scales for cognitive functioning and psychotomimetic effects were included. Subjects were administered each of the following oral treatments: paracetamol (1000 mg), Δ9-THC (10 mg), promethazine (50 mg) or matching placebo. Pharmacodynamic measurements were performed at baseline

2018 European Journal of Pain

7. Comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry (PubMed)

Comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry Background. The aim of this investigation was to compare the sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine combinations on fearful children needing dental treatment. Methods. This crossover double-blind clinical trial was conducted on 30 children aged 2‒6 years, who had at least two similar teeth needing pulp treatment. Standard vital signs were (...) recorded before and after premedication. Wilson sedation scale was used to judge the level of sedation. Cases were divided into two groups based on the sequence of medication received. This was to overcome the sequence effect. Group I received oral midazolam (0.4 mg/kg/chloral hydrate (50 mg/kg) at the first visit while they received midazolam (0.4 mg/kg)/promethazine (5 mg/kg) in their second visit. Group II received the premedication in the opposite sequence. The operator and child were blinded

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2018 Journal of dental research, dental clinics, dental prospects

8. Ondansetron or promethazine: Which one is better for the treatment of acute peripheral vertigo? (PubMed)

Ondansetron or promethazine: Which one is better for the treatment of acute peripheral vertigo? Vertigo is a common annoying complaint needing emergent treatment. There are various treatment options for this condition with different outcomes and side effects.Assessment and comparison of the effectiveness of Ondansetron and Promethazine in the treatment of acute peripheral vertigo.This clinical trial was conducted in an academic hospital in the north of Iran in 2017. A total of 170 eligible (...) patients were randomly allocated to groups A: received intramuscular (IM) promethazine; and B: received intravenous (IV) Ondansetron, using quadripartite blocks. The severity of vertigo, nausea, blood pressure, heart rate, side-effects, need for re-administration, and the time to become asymptomatic were assessed before the injections, 30 min after and 2 h after the injections.Excellent improvement in vertigo occurred in both groups (P < 0.001), with a more significant reduction in the promethazine

2018 American Journal of Otolaryngology

9. A Comparison of the Effects and Side Effects of Oral Betahistine with Injectable Promethazine in the Treatment of Acute Peripheral Vertigo in Emergency (PubMed)

A Comparison of the Effects and Side Effects of Oral Betahistine with Injectable Promethazine in the Treatment of Acute Peripheral Vertigo in Emergency Vertigo is an illusion of rotation that is caused by the asymmetry of neurological function of the right and left vestibular nuclei. The aim of this study was to compare the efficacy and side effects of oral betahistine with injectable promethazine in treatment of acute peripheral vertigo.In this double-blind clinical trial study, the patients (...) with acute peripheral vertigo were assigned in the two groups: receiving promethazine intramuscularly at a dose of 25 mg (group A) and receiving 8 mg betahistine tablets (group B) and the severity of their vertigo was evaluated on the visual analog scale (VAS) scoring system. In addition, adverse events in both groups of patients were compared and evaluated.A total of 162 patients (82 subjects in group A) participated in this study. The mean age, gender distribution, intensity and symptoms of vertigo

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2017 Journal of clinical medicine research

10. The Impact of Oral Promethazine on Human Whole-Body Motion Perceptual Thresholds (PubMed)

The Impact of Oral Promethazine on Human Whole-Body Motion Perceptual Thresholds Despite the widespread treatment of motion sickness symptoms using drugs and the involvement of the vestibular system in motion sickness, little is known about the effects of anti-motion sickness drugs on vestibular perception. In particular, the impact of oral promethazine, widely used for treating motion sickness, on vestibular perceptual thresholds has not previously been quantified. We examined whether (...) promethazine (25 mg) alters vestibular perceptual thresholds in a counterbalanced, double-blind, within-subject study. Thresholds were determined using a direction recognition task (left vs. right) for whole-body yaw rotation, y-translation (interaural), and roll tilt passive, self-motions. Roll tilt thresholds were 31 % higher after ingestion of promethazine (P = 0.005). There were no statistically significant changes in yaw rotation and y-translation thresholds. This worsening of precision could have

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2017 JARO: Journal of the Association for Research in Otolaryngology

11. Comparison Effect of Promethazine/Dexamethasone and Metoclopramide /Dexamethasone on Postoperative Nausea and Vomiting after Laparascopic Gastric Placation: A Randomized Clinical Trial (PubMed)

Comparison Effect of Promethazine/Dexamethasone and Metoclopramide /Dexamethasone on Postoperative Nausea and Vomiting after Laparascopic Gastric Placation: A Randomized Clinical Trial Laparoscopic gastric plication (LGP) is a technique in the restrictive category of bariatric procedures that reduces the gastric volume and increases intragastric pressure. Nausea and vomiting are the most common complications after this procedure. The goal of this research is to compare the combined effect (...) of promethazine/dexamethasone versus Metoclopramide/ dexamethasone on the prevention of nausea and vomiting after LGP.In recovery, the patients were divided into two groups, the Metoclopramide group which was given Metoclopramide 10 mg plus dexamethasone 4 mg/8 hours intravenous for 48 hours, and the promethazine group which was given promethazine 50 mg /12 hours, intramuscular for the first 24 hours and then promethazine 25 mg/12 hours for the next 24 hours plus dexamethasone 4 mg/8 hours intravenous for 48

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2017 Anesthesiology and pain medicine

12. Promethazine

Promethazine USE OF PROMETHAZINE IN PREGNANCY 0344 892 0909 USE OF PROMETHAZINE IN PREGNANCY (Date of issue: September 2015 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary (...) patient may be eligible to enrol in a randomised control trial to investigate the best treatment for Hyperemesis Gravidarum (severe pregnancy sickness). Please visit the to find out more. ………………………………………………………………………………………………………………………………………………………… Promethazine is a first generation (sedating) phenothiazine antihistamine used in the treatment of nausea and vomiting, allergy such as hay fever and urticaria, emergency treatment of anaphylactic reactions, and for sedation. Studies (including two small

2014 UK Teratology Information Service

13. Rapid tranquillisation in mental health settings: promethazine hydrochloride

Rapid tranquillisation in mental health settings: promethazine hydrochloride Rapid tr Rapid tranquillisation in mental health settings: anquillisation in mental health settings: promethazine h promethazine hy ydrochloride drochloride Evidence summary Published: 11 March 2014 nice.org.uk/guidance/esuom28 pathways K Ke ey points from the e y points from the evidence vidence The content of this evidence summary was up-to-date in March 2014. See summaries of product characteristics (SPCs), British (...) national formulary (BNF) or the MHRA or NICE websites for up-to-date information. Summary A Cochrane review (Huf et al. 2009; 4 randomised controlled trials [RCTs], n=1117) provides limited evidence that intramuscular haloperidol plus promethazine is effective for the rapid tranquillisation of people with agitation or aggression associated with mental illness. However, it is difficult to draw any firm conclusions because the results are heterogeneous. In addition, the results were not relevant to UK

2014 National Institute for Health and Clinical Excellence - Advice

14. Comparison of Efficacy of Granisetron and Promethazine in Control of Hyperemesis Gravidarum. (PubMed)

Comparison of Efficacy of Granisetron and Promethazine in Control of Hyperemesis Gravidarum. Hyperemesis gravidarum is the third leading cause of hospitalization during pregnancy. 5-HT3-receptor antagonists are the most effective against chemotherapy-induced nausea and vomiting and radiation. This randomized study aimed to compare and evaluate the efficacies of granisetron and promethazine for controlling nausea and vomiting of pregnancy.The included patients were administered (oral (...) and intravenous) granisetron and promethazine randomly. The patients were evaluated for nausea and vomiting by a senior gynecology resident blinded to designated drugs.This study revealed that granisetron significantly decreased nausea and vomiting in pregnant women (p < 0.05). Greater patient satisfaction and lesser adverse drug reactions in women receiving granisetron observed in this study suggest that it can be introduced as a more effective and safer drug in comparison with promethazine.Considering

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2016 Journal of obstetrics and gynaecology of India

15. Promethazine

Promethazine Promethazine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Promethazine Promethazine Aka: Promethazine , Phenergan From (...) Children: 0.25 to 0.5 mg/kg PO/IM/PR q4-6 hours Maximum: 25 mg per dose VIII. Efficacy Less effective than ( ) in ER patients Sedation may delay Emergency Department discharge IX. References Johnson (1993) Harriet Lane, Mosby, p. 521 (2002) Tarascon Pocket Pharmacopoeia, p. 67 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Promethazine." Click on the image (or right click) to open the source website in a new browser window. Related

2018 FP Notebook

16. Cochrane review suggests adding promethazine to haloperidol to rapidly tranquillise psychotic patients with fewer side effects

Cochrane review suggests adding promethazine to haloperidol to rapidly tranquillise psychotic patients with fewer side effects Cochrane review suggests adding promethazine to haloperidol to rapidly tranquillise psychotic patients with fewer side effects Search National Elf Service Search National Elf Service » » » » Cochrane review suggests adding promethazine to haloperidol to rapidly tranquillise psychotic patients with fewer side effects Dec 4 2012 Posted by The hallucinations and delusions (...) , n = 67, RR 8.25, CI 0.46 to 147.45; required antiparkinson medication RR 2.74, CI 0.81 to 9.25) 1 more reliable RCT compared haloperidol alone with promethazine and haloperidol in combination and found: More patients on haloperidol alone were not tranquil or asleep by 20 minutes (RR 1.60, CI 1.18 to 2.16) Significantly more patients on haloperidol alone experienced one or more side effects (RR 11.28, CI 1.47 to 86.35) Acute dystonia for patients just taking haloperidol was so common

2012 The Mental Elf

17. A study of promethazine hydrochloride and pentazocine intramuscular sedation along with 2 % lidocaine hydrochloride and adrenaline and comparison to placebo along with 2 % lidocaine hydrochloride and adrenaline for surgical extraction of mandibular thir (PubMed)

A study of promethazine hydrochloride and pentazocine intramuscular sedation along with 2 % lidocaine hydrochloride and adrenaline and comparison to placebo along with 2 % lidocaine hydrochloride and adrenaline for surgical extraction of mandibular thir The main objective is to study and compare the sedative and analgesic effects of intramuscular injection fortwin-phenergan along with local anesthetic and normal saline placebo along with local anesthetics in mandibular third molar surgery. We

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2015 Journal of maxillofacial and oral surgery

18. A comparison of two differing doses of promethazine for the treatment of postoperative nausea and vomiting. (PubMed)

A comparison of two differing doses of promethazine for the treatment of postoperative nausea and vomiting. To compare the use of promethazine 6.25 mg intravenous (IV) (experimental group) with promethazine 12.5 mg IV (control group) among adult ambulatory surgery patients to control established postoperative nausea or vomiting (PONV).In a double-blind, randomized controlled trial (n = 120), 59 subjects received promethazine 6.25 mg and 61 subjects received promethazine 12.5 mg to treat PONV (...) . Study doses were administered postoperatively if the subject reported/exhibited nausea and/or vomiting. Outcomes for experimental and control groups were compared on the basis of relief of PONV and sedation levels.Ninety-seven percent of subjects reported total relief of nausea with a single administration of promethazine at either dose. Sedation levels differed between groups at 30 minutes post-medication administration and at the time of discharge to home.Promethazine 6.25 mg is as effective

2015 Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses / American Society of PeriAnesthesia Nurses

19. Comparison of the efficacy of adding clonidine, chlorpromazine, promethazine, and midazolam to morphine pumps in postoperative pain control of addicted patients. (PubMed)

Comparison of the efficacy of adding clonidine, chlorpromazine, promethazine, and midazolam to morphine pumps in postoperative pain control of addicted patients. Addicted patients present difficulties for pain management because they have another problem besides their pain. Adding adjuvants to opioid pumps to intensify quality, control other problems, lengthen analgesia, and reduce side effects has been considered in the field.The objective of this study was to evaluate the analgesic effects (...) of adding clonidine, promethazine, chlorpromazine, and midazolam to morphine in patient-controlled intravenous analgesia (PCIA) in orthopedic patients with addiction problems.90 patients with histories of substance abuse were enrolled in this randomized controlled trial. Patients were randomly divided into three groups. The first group received 20 mg of morphine sulfate +50 mg of chlorpromazine + 50 mg of promethazine +10 mg of midazolam (M20P). The second group received the first group's regimen plus

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2015 Anesthesiology and pain medicine

20. Study of Promethazine for Treatment of Diabetic Gastroparesis

Study of Promethazine for Treatment of Diabetic Gastroparesis Study of Promethazine for Treatment of Diabetic Gastroparesis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study of Promethazine (...) : American College of Gastroenterology Information provided by (Responsible Party): Dartmouth-Hitchcock Medical Center Study Details Study Description Go to Brief Summary: Adult diabetic patients (ages 18-65) with gastric emptying scintigraphy-confirmed delayed gastric emptying will be recruited to participate in the study. Using double-blinded methodology, study participants will be randomly assigned to one of two treatment arms: promethazine 12.5 mg three times daily for 28 days or placebo three times

2014 Clinical Trials

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