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Promethazine

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1. Promethazine

Promethazine Top results for promethazine - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) ) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for promethazine The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you

2018 Trip Latest and Greatest

2. Haloperidol plus promethazine for psychosis-induced aggression. Full Text available with Trip Pro

Haloperidol plus promethazine for psychosis-induced aggression. Health services often manage agitated or violent people, and such behaviour is particularly prevalent in emergency psychiatric services (10%). The drugs used in such situations should ensure that the person becomes calm swiftly and safely.To examine whether haloperidol plus promethazine is an effective treatment for psychosis-induced aggression.On 6 May 2015 we searched the Cochrane Schizophrenia Group's Register of Trials, which (...) is compiled by systematic searches of major resources (including MEDLINE, EMBASE, AMED, BIOSIS, CINAHL, PsycINFO, PubMed, and registries of clinical trials) and their monthly updates, handsearches, grey literature, and conference proceedings.All randomised clinical trials with useable data focusing on haloperidol plus promethazine for psychosis-induced aggression.We independently extracted data. For binary outcomes, we calculated risk ratio (RR) and its 95% confidence interval (CI), on an intention

2016 Cochrane

3. Rapid tranquillisation in mental health settings: promethazine hydrochloride

Rapid tranquillisation in mental health settings: promethazine hydrochloride Rapid tr Rapid tranquillisation in mental health settings: anquillisation in mental health settings: promethazine h promethazine hy ydrochloride drochloride Evidence summary Published: 11 March 2014 nice.org.uk/guidance/esuom28 pathways K Ke ey points from the e y points from the evidence vidence The content of this evidence summary was up-to-date in March 2014. See summaries of product characteristics (SPCs), British (...) national formulary (BNF) or the MHRA or NICE websites for up-to-date information. Summary A Cochrane review (Huf et al. 2009; 4 randomised controlled trials [RCTs], n=1117) provides limited evidence that intramuscular haloperidol plus promethazine is effective for the rapid tranquillisation of people with agitation or aggression associated with mental illness. However, it is difficult to draw any firm conclusions because the results are heterogeneous. In addition, the results were not relevant to UK

2014 National Institute for Health and Clinical Excellence - Advice

4. Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi (Abstract)

Prevention of Opioid-Induced Nausea and Vomiting During Treatment of Moderate to Severe Acute Pain: A Randomized Placebo-Controlled Trial Comparing CL-108 (Hydrocodone 7.5 mg/Acetaminophen 325 mg/Rapid-Release, Low-Dose Promethazine 12.5 mg) with Conventi To evaluate the prevention of opioid-induced nausea and vomiting (OINV) and the relief of moderate to severe acute pain by CL-108, a novel drug combining a low-dose antiemetic (rapid-release promethazine 12.5 mg) with hydrocodone 7.5 mg

2019 EvidenceUpdates

5. Comparison of Haloperidol, Promethazine, Trifluoperazine, and Chlorpromazine in Terms of Velocity and Durability of the Sedation among Acute Aggressive Patients: A Randomized Clinical Trial. Full Text available with Trip Pro

Comparison of Haloperidol, Promethazine, Trifluoperazine, and Chlorpromazine in Terms of Velocity and Durability of the Sedation among Acute Aggressive Patients: A Randomized Clinical Trial. Knowledge and skill about sedation of aggressive patients is necessary for each psychiatrist. The purpose of this study was comparing the velocity and durability of sedation induced by the haloperidol, trifluoperazine, promethazine, and chlorpromazine in aggressive patients.This randomized clinical trial (...) was done on 76 aggressive patients referred to Psychiatry Emergency Service of Noor Hospital of Isfahan University of Medical Sciences that were randomly divided into four groups of haloperidol, promethazine, chlorpromazine, and trifluoperazine. Patients were evaluated at 30 min intervals for aggressive symptoms, and if they did not respond to intervention after the first 30 min or if they showed aggression again, a same dose of the injected drug was prescribed. The length of sedation time was recorded

2019 Advanced biomedical research Controlled trial quality: uncertain

6. Comparison of nitrous oxide/midazolam and nitrous oxide/promethazine for pediatric dental sedation: A randomized, cross-over, clinical trial. (Abstract)

Comparison of nitrous oxide/midazolam and nitrous oxide/promethazine for pediatric dental sedation: A randomized, cross-over, clinical trial. This study compared the safety and efficacy of nitrous oxide (N2O)/midazolam and N2O/promethazine for dental treatment of uncooperative children.In this randomized, cross-over, clinical trial investigation Eighteen healthy uncooperative children with a pair of similar teeth requiring the same treatment were included. Combination of N2O/midazolam was given (...) in one visit, where N2O/promethazine was administrated in the other appointment for each patient in a cross-over manner. Oxygen saturation and heart rate as well as behavior parameters according to Houpt behavior scales were recorded. Postoperatively, patients' anxiety and parents' satisfaction were assessed by visual analog score and a questionnaire, respectively. Data were analyzed using Wilcoxon' s signed rank test and Paired t-tests with a P value set at 0.05.Physiologic parameters were within

2019 Dental research journal Controlled trial quality: uncertain

7. Low dose concomitant treatment with chlorpromazine and promethazine is safe in acute ischemic stroke. (Abstract)

Low dose concomitant treatment with chlorpromazine and promethazine is safe in acute ischemic stroke. Acute ischemic stroke (AIS) is associated with significant morbidity and mortality and has a very narrow window of treatment with fibrinolytics. We investigated the safety and efficacy of combined chlorpromazine and promethazine (C+P) treatment in AIS.A total of 64 consecutive patients diagnosed with AIS were selected and were randomly (double-blind) assigned into either the control group (...) differences in those scores between the two group (P>0.05) suggesting no improved benefit with C+P. Moreover, using C+P did not lead to any serious adverse effects when compared to the treatment group.While the addition of low dose chlorpromazine and promethazine to standard of care for acute ischemic stroke did not have any significant improvement in functional outcomes, there were no serious adverse effects. Thus, the use of chlorpromazine and promethazine in the acute ischemic stroke setting and future

2019 Journal Of Neurosurgical Sciences Controlled trial quality: uncertain

8. Promethazine exhibits antiparasitic properties <i>in vitro</i> and reduces worm burden, egg production, hepato-, and splenomegaly in a schistosomiasis animal model. (Abstract)

Promethazine exhibits antiparasitic properties in vitro and reduces worm burden, egg production, hepato-, and splenomegaly in a schistosomiasis animal model. The treatment and control of schistosomiasis, a neglected disease that affects more than 200 million people worldwide, rely on the use of a single drug, praziquantel. A vaccine has yet to be developed and since new drug design and development is a lengthy and costly process, drug repurposing is a promising strategy. In this study (...) , the efficacy of promethazine, a first-generation antihistamine, was evaluated against Schistosoma mansoniex vivo and in a murine model of schistosomiasis. In vitro assays demonstrated that promethazine affected parasite motility, viability, and it induced severe tegumental damage in schistosomes. The LC50 of the drug was 5.84 μM. Similar to promethazine, schistosomes incubated with atropine, a classical anticholinergic drug, displayed reduced motor activity. In an animal model, promethazine treatment

2019 Antimicrobial Agents and Chemotherapy

9. Ondansetron or promethazine: Which one is better for the treatment of acute peripheral vertigo? (Abstract)

Ondansetron or promethazine: Which one is better for the treatment of acute peripheral vertigo? Vertigo is a common annoying complaint needing emergent treatment. There are various treatment options for this condition with different outcomes and side effects.Assessment and comparison of the effectiveness of Ondansetron and Promethazine in the treatment of acute peripheral vertigo.This clinical trial was conducted in an academic hospital in the north of Iran in 2017. A total of 170 eligible (...) patients were randomly allocated to groups A: received intramuscular (IM) promethazine; and B: received intravenous (IV) Ondansetron, using quadripartite blocks. The severity of vertigo, nausea, blood pressure, heart rate, side-effects, need for re-administration, and the time to become asymptomatic were assessed before the injections, 30 min after and 2 h after the injections.Excellent improvement in vertigo occurred in both groups (P < 0.001), with a more significant reduction in the promethazine

2018 American Journal of Otolaryngology Controlled trial quality: uncertain

10. Comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry Full Text available with Trip Pro

Comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry Background. The aim of this investigation was to compare the sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine combinations on fearful children needing dental treatment. Methods. This crossover double-blind clinical trial was conducted on 30 children aged 2‒6 years, who had at least two similar teeth needing pulp treatment. Standard vital signs were (...) recorded before and after premedication. Wilson sedation scale was used to judge the level of sedation. Cases were divided into two groups based on the sequence of medication received. This was to overcome the sequence effect. Group I received oral midazolam (0.4 mg/kg/chloral hydrate (50 mg/kg) at the first visit while they received midazolam (0.4 mg/kg)/promethazine (5 mg/kg) in their second visit. Group II received the premedication in the opposite sequence. The operator and child were blinded

2018 Journal of dental research, dental clinics, dental prospects Controlled trial quality: uncertain

11. Promethazine and Oral Midazolam Preanesthetic Children Medication. (Abstract)

Promethazine and Oral Midazolam Preanesthetic Children Medication. Several kinds of drugs have been investigated in preschool children as a preanesthetic sedation after various routes of administration for surgeries. This study aims to compare the efficacy of promethazine and oral midazolam for premedication in children aged 3 to 9 years who were scheduled for surgeries.This is a double-blind randomized controlled study conducted on 93 patients between the age of 3 and 9 years at Loresten (...) University of Medical Sciences Teaching Hospital, Khoramabad, Iran. The subjects were grouped into P (promethazine), M (midazolam), and C (control). About 0.3 mg/kg of oral promethazine was administered to patients in group P, 0.5 mg/kg of oral midazolam was administered to patients in group M, and 3 mL of normal saline as placebo was administered to patients in group C. Patient satisfaction, sedation and emotional score, systolic blood pressure (SBP), diastolic blood pressure, respiratory rate (RR

2018 Pediatric Emergency Care Controlled trial quality: uncertain

12. Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects. (Abstract)

Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects. A battery of evoked pain tasks (PainCart) was developed to investigate the pharmacodynamic properties of novel analgesics in early-phase clinical research. As part of its clinical validation, compounds with different pharmacological mechanisms of actions are investigated. The aim was to investigate the analgesic effects of classic and nonclassic analgesics compared to a sedating (...) negative control in a randomized placebo-controlled crossover study in 24 healthy volunteers using the PainCart.The PainCart consisted of pain tasks eliciting electrical, pressure, heat, cold and inflammatory pain. Subjective scales for cognitive functioning and psychotomimetic effects were included. Subjects were administered each of the following oral treatments: paracetamol (1000 mg), Δ9-THC (10 mg), promethazine (50 mg) or matching placebo. Pharmacodynamic measurements were performed at baseline

2018 European Journal of Pain Controlled trial quality: uncertain

13. A Prospective, Randomized, Double-Blinded, Double-Dummy Pilot Study to Assess the Preemptive Effect of Triple Therapy with Aprepitant, Dexamethasone, and Promethazine versus Ondansetron, Dexamethasone and Promethazine on Reducing the Incidence of Postoper Full Text available with Trip Pro

A Prospective, Randomized, Double-Blinded, Double-Dummy Pilot Study to Assess the Preemptive Effect of Triple Therapy with Aprepitant, Dexamethasone, and Promethazine versus Ondansetron, Dexamethasone and Promethazine on Reducing the Incidence of Postoper Postoperative nausea and vomiting (PONV) is among the most common distressing complications of surgery under anesthesia. Previous studies have demonstrated that patients who undergo craniotomy have incidences of nausea and vomiting as high (...) as 50-70%. The main purpose of this pilot study is to assess the incidence of PONV by using two different prophylactic regimens in subjects undergoing a craniotomy. Thus, we designed this study to assess the efficacy and safety of triple therapy with the combination of dexamethasone, promethazine, and aprepitant versus ondansetron to reduce the incidence of PONV in patients undergoing craniotomy.This is a prospective, single center, two-armed, randomized, double-dummy, double-blind, pilot study

2016 Frontiers in medicine Controlled trial quality: predicted high

14. A Comparison of the Effects and Side Effects of Oral Betahistine with Injectable Promethazine in the Treatment of Acute Peripheral Vertigo in Emergency Full Text available with Trip Pro

A Comparison of the Effects and Side Effects of Oral Betahistine with Injectable Promethazine in the Treatment of Acute Peripheral Vertigo in Emergency Vertigo is an illusion of rotation that is caused by the asymmetry of neurological function of the right and left vestibular nuclei. The aim of this study was to compare the efficacy and side effects of oral betahistine with injectable promethazine in treatment of acute peripheral vertigo.In this double-blind clinical trial study, the patients (...) with acute peripheral vertigo were assigned in the two groups: receiving promethazine intramuscularly at a dose of 25 mg (group A) and receiving 8 mg betahistine tablets (group B) and the severity of their vertigo was evaluated on the visual analog scale (VAS) scoring system. In addition, adverse events in both groups of patients were compared and evaluated.A total of 162 patients (82 subjects in group A) participated in this study. The mean age, gender distribution, intensity and symptoms of vertigo

2017 Journal of clinical medicine research Controlled trial quality: uncertain

15. Comparison Effect of Promethazine/Dexamethasone and Metoclopramide /Dexamethasone on Postoperative Nausea and Vomiting after Laparascopic Gastric Placation: A Randomized Clinical Trial Full Text available with Trip Pro

Comparison Effect of Promethazine/Dexamethasone and Metoclopramide /Dexamethasone on Postoperative Nausea and Vomiting after Laparascopic Gastric Placation: A Randomized Clinical Trial Laparoscopic gastric plication (LGP) is a technique in the restrictive category of bariatric procedures that reduces the gastric volume and increases intragastric pressure. Nausea and vomiting are the most common complications after this procedure. The goal of this research is to compare the combined effect (...) of promethazine/dexamethasone versus Metoclopramide/ dexamethasone on the prevention of nausea and vomiting after LGP.In recovery, the patients were divided into two groups, the Metoclopramide group which was given Metoclopramide 10 mg plus dexamethasone 4 mg/8 hours intravenous for 48 hours, and the promethazine group which was given promethazine 50 mg /12 hours, intramuscular for the first 24 hours and then promethazine 25 mg/12 hours for the next 24 hours plus dexamethasone 4 mg/8 hours intravenous for 48

2017 Anesthesiology and pain medicine Controlled trial quality: uncertain

16. The Impact of Oral Promethazine on Human Whole-Body Motion Perceptual Thresholds Full Text available with Trip Pro

The Impact of Oral Promethazine on Human Whole-Body Motion Perceptual Thresholds Despite the widespread treatment of motion sickness symptoms using drugs and the involvement of the vestibular system in motion sickness, little is known about the effects of anti-motion sickness drugs on vestibular perception. In particular, the impact of oral promethazine, widely used for treating motion sickness, on vestibular perceptual thresholds has not previously been quantified. We examined whether (...) promethazine (25 mg) alters vestibular perceptual thresholds in a counterbalanced, double-blind, within-subject study. Thresholds were determined using a direction recognition task (left vs. right) for whole-body yaw rotation, y-translation (interaural), and roll tilt passive, self-motions. Roll tilt thresholds were 31 % higher after ingestion of promethazine (P = 0.005). There were no statistically significant changes in yaw rotation and y-translation thresholds. This worsening of precision could have

2017 JARO: Journal of the Association for Research in Otolaryngology

17. Promethazine

Promethazine USE OF PROMETHAZINE IN PREGNANCY 0344 892 0909 USE OF PROMETHAZINE IN PREGNANCY (Date of issue: September 2015 , Version: 2 ) This is a UKTIS monograph for use by health care professionals. For case-specific advice please contact UKTIS on 0344 892 0909. To report an exposure please download and complete a . Please encourage all women to complete an . A corresponding patient information leaflet on is available at . Summary (...) patient may be eligible to enrol in a randomised control trial to investigate the best treatment for Hyperemesis Gravidarum (severe pregnancy sickness). Please visit the to find out more. ………………………………………………………………………………………………………………………………………………………… Promethazine is a first generation (sedating) phenothiazine antihistamine used in the treatment of nausea and vomiting, allergy such as hay fever and urticaria, emergency treatment of anaphylactic reactions, and for sedation. Studies (including two small

2014 UK Teratology Information Service

18. Promethazine

Promethazine Promethazine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Promethazine Promethazine Aka: Promethazine , Phenergan From (...) Children: 0.25 to 0.5 mg/kg PO/IM/PR q4-6 hours Maximum: 25 mg per dose VIII. Efficacy Less effective than ( ) in ER patients Sedation may delay Emergency Department discharge IX. References Johnson (1993) Harriet Lane, Mosby, p. 521 (2002) Tarascon Pocket Pharmacopoeia, p. 67 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Promethazine." Click on the image (or right click) to open the source website in a new browser window. Related

2018 FP Notebook

19. Comparison of Efficacy of Granisetron and Promethazine in Control of Hyperemesis Gravidarum. Full Text available with Trip Pro

Comparison of Efficacy of Granisetron and Promethazine in Control of Hyperemesis Gravidarum. Hyperemesis gravidarum is the third leading cause of hospitalization during pregnancy. 5-HT3-receptor antagonists are the most effective against chemotherapy-induced nausea and vomiting and radiation. This randomized study aimed to compare and evaluate the efficacies of granisetron and promethazine for controlling nausea and vomiting of pregnancy.The included patients were administered (oral (...) and intravenous) granisetron and promethazine randomly. The patients were evaluated for nausea and vomiting by a senior gynecology resident blinded to designated drugs.This study revealed that granisetron significantly decreased nausea and vomiting in pregnant women (p < 0.05). Greater patient satisfaction and lesser adverse drug reactions in women receiving granisetron observed in this study suggest that it can be introduced as a more effective and safer drug in comparison with promethazine.Considering

2016 Journal of obstetrics and gynaecology of India Controlled trial quality: uncertain

20. Comparison of the efficacy of adding clonidine, chlorpromazine, promethazine, and midazolam to morphine pumps in postoperative pain control of addicted patients. Full Text available with Trip Pro

Comparison of the efficacy of adding clonidine, chlorpromazine, promethazine, and midazolam to morphine pumps in postoperative pain control of addicted patients. Addicted patients present difficulties for pain management because they have another problem besides their pain. Adding adjuvants to opioid pumps to intensify quality, control other problems, lengthen analgesia, and reduce side effects has been considered in the field.The objective of this study was to evaluate the analgesic effects (...) of adding clonidine, promethazine, chlorpromazine, and midazolam to morphine in patient-controlled intravenous analgesia (PCIA) in orthopedic patients with addiction problems.90 patients with histories of substance abuse were enrolled in this randomized controlled trial. Patients were randomly divided into three groups. The first group received 20 mg of morphine sulfate +50 mg of chlorpromazine + 50 mg of promethazine +10 mg of midazolam (M20P). The second group received the first group's regimen plus

2015 Anesthesiology and pain medicine Controlled trial quality: uncertain

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