How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

477 results for

Progestin Androgenic Activity

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

82. Practice Bulletin: Endometrial Cancer

2 diabetes mellitus and hypertension are associated with an increased risk of endometrial cancer that may be related to concurrent obe- sity (19, 20), although an independent association between diabetes and endometrial cancer has been reported (21). Systemic unopposed estrogen therapy increases the risk of endometrial cancer by up to 20-fold, with the increasing risk correlating with the duration of use (22–26). Concomitant progestin administration mitigates this risk. When progestins (...) are discussed in this section. Additional risk factors for type I endometrial cancer are listed in Table 1. Unopposed Estrogen Prolonged exposure to unopposed estrogen, whether endo- genous or exogenous, is associated with most cases of type I endometrial cancer. Unopposed endogenous estro- gen exposure occurs in chronic anovulation (eg, poly- cystic ovary syndrome), with estrogen-producing tumors, and with excessive peripheral conversion of androgens to estrone in adipose tissue. Obesity is associated

2015 Society of Gynecologic Oncology

83. Menopausal Symptoms: Comparative Effectiveness of Therapies

vasomotor symptoms and were accompanied by better quality-of-life scores. SSRIs/SNRIs relieve vasomotor symptoms less effectively than estrogens but were accompanied by the largest improvement in global measures of psychological well-being. Estrogens administered vaginally diminished pain during sex and testosterone increased sexual activity. Measures of urogenital atrophy were improved with ospemifene and vaginal or oral estrogens. Estrogens also improved sleep, but the effect appeared to be modest (...) efficacy for psychological symptoms 67 Table 29. Psychological outcomes pairwise effect estimates (pooled random effect estimates or single trial effects if only data available) 70 Table 30. Trials comparing different routes of estrogen administration reporting psychological outcomes 72 Table 31. Trials comparing estrogen with estrogen plus testosterone reporting psychological outcomes 72 Table 32. Trials comparing progestin alone with placebo reporting psychological outcomes 73 Table 33. Trials

2015 Effective Health Care Program (AHRQ)

84. Anamorelin (Adlumiz) - Anorexia, Cachexia, Non-Small-Cell Lung Carcinoma

interventions largely preclude significant reversal of muscle wasting. No widely approved drug for the treatment of cancer cachexia is available. However, steroid hormones have been shown to be effective in stimulating appetite, with corticosteroids and progestins being more effective than androgens; however, corticosteroids are associated with additional side effects and their positive effects are generally short-lasting. About the product Anamorelin is an orally active, high-affinity, selective ghrelin (...) . Quality aspects 10 2.2.1. Introduction 10 2.2.2. Active Substance 10 2.2.3. Finished Medicinal Product 13 2.2.4. Discussion on chemical, pharmaceutical and biological aspects 15 2.2.5. Conclusions on the chemical, pharmaceutical and biological aspects 15 2.2.6. Recommendations for future quality development 15 2.3. Non-clinical aspects 15 2.3.1. Introduction 15 2.3.2. Pharmacology 16 2.3.3. Pharmacokinetics 21 2.3.4. Toxicology 25 2.3.5. Ecotoxicity/environmental risk assessment 33 2.3.6. Discussion

2017 European Medicines Agency - EPARs

85. Management of Osteoporosis

• Hyperparathyroidism 2. Drugs • Glucocorticoids • Heparin • Anticonvulsants (phenytoin) • Immunosuppressants • Thiazolidinediones • Oncology (e.g. Aromatase inhibitors, androgen deprivation therapy) 3. Chronic Diseases • Renal impairment • Liver cirrhosis • Malabsorption • Chronic inflammatory polyarthropathies (e.g. rheumatoid arthritis) 4. Others • Nutritional deficiency e.g. anorexia nervosa • Multiple myeloma and malignancy • Osteogenesis imperfecta • Post-gastrectomy / gastric bypass surgical procedures21 3.3 (...) per day. Elderly who are institutionalised, immobile, lack outdoor activities and have a poor diet will benefit from 800 IU vitamin D supplementation daily. 4631 Vitamin D supplements are available as ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3). With daily dosing, vitamin D2 and D3 appear to be equally potent 47 (Level 1a), but with intermittent (weekly or monthly) dosing, vitamin D3 appears to be about 3 times more potent than vitamin D2 48 (Level IIa) Vitamin D supplementation

2015 Ministry of Health, Malaysia

87. Guidelines for the prevention of stroke in women

than men. One study reported that although women were more likely than men to have heard of tissue-type plasminogen activator therapy for stroke, they were less likely to know that it must be administered within 3 hours. Population-based surveys of women conducted by the AHA have identified an overall poor level of knowledge about CVD and stroke, particularly in minority women , ; however, the studies excluded men and were therefore unable to report on sex differences. Epidemiology of Ischemic (...) vascular function and BP must take hormonal status into account. , Sex differences in sympathetic activity, vascular reactivity, water regulation (arginine vasopressin signaling), and autonomic control have been well documented, but most of these studies were performed in young women. Efforts to assess the effects of hormonal effects on the vasculature have examined specific points in the menstrual cycle or suppressed ovarian function using gonadotropin-releasing hormone agonists or antagonists

Full Text available with Trip Pro

2014 American Academy of Neurology

88. Treatment of pelvic pain associated with endometriosis: a committee opinion

). Although considered a progressive dis- ease, endometriosis also can remain static and even regress without treat- ment (6). The three most commonly suggested mechanisms for pain pro- duction in endometriosis are [1] pro- duction of substances such as growth factors and cytokines by activated macrophages and other cells asso- ciated with functioning endometriotic Received and accepted February 7, 2014; published online March 13, 2014. No reprints will be available. Correspondence: Practice Committee (...) , American Society for Reproductive Medicine, 1209 Montgomery Hwy, Birmingham, Alabama 35216 (E-mail: ASRM@asrm.org). Fertility and Sterility® Vol. 101, No. 4, April 2014 0015-0282/$36.00 Copyright ©2014 American Society for Reproductive Medicine, Published by Elsevier Inc. http://dx.doi.org/10.1016/j.fertnstert.2014.02.012 VOL. 101 NO. 4 / APRIL 2014 927 ASRM PAGESimplants (7, 8); [2] the direct and indirect effects of active bleeding from endometriotic implants; and [3] irritation of pelvic ?oor nerves

2014 Society for Assisted Reproductive Technology

89. Guidelines for the Prevention of Stroke in Women: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association

, several population-based studies have shown that knowledge and awareness of stroke warning signs and symptoms are somewhat higher in women than men. One study reported that although women were more likely than men to have heard of tissue-type plasminogen activator therapy for stroke, they were less likely to know that it must be administered within 3 hours. Population-based surveys of women conducted by the AHA have identified an overall poor level of knowledge about CVD and stroke, particularly (...) in hypertension and BP regulation are complex, because ovarian hormones influence BP considerably. Therefore, studies that examine vascular function and BP must take hormonal status into account. , Sex differences in sympathetic activity, vascular reactivity, water regulation (arginine vasopressin signaling), and autonomic control have been well documented, but most of these studies were performed in young women. Efforts to assess the effects of hormonal effects on the vasculature have examined specific

Full Text available with Trip Pro

2014 American Heart Association

90. General practice management of type 2 diabetes 2014-15

2 diabetes to approach/reach these goals Diet Normal healthy eating. If concerns regarding cardiovascular risk, advise Mediterranean diet. Body mass index (kg/m 2 ) Therapeutic goal is 5–10% loss for people overweight or obese with type 2 diabetes. With BMI >35 and comorbidities or BMI >40, greater weight loss measures should be considered. Note that BMI is a difficult parameter to standardise between different population groups. Physical activity At least 30 minutes of moderate physical (...) activity on most if not all days of the week (total =150 minutes/week). Cigarette consumption 0 (per day) Alcohol consumption =2 standard drinks (20 g) per day for men and women. BGL 6–8 mmol/L fasting and 8–10 mmol/L postprandial. Ongoing self-monitoring of blood glucose is recommended for people with diabetes using insulin, with hyperglycaemia arising from illness, with haemoglobinopathies, pregnancy or other conditions where data on glycaemic patterns is required. Routine self-monitoring of blood

2014 Clinical Practice Guidelines Portal

91. Combined transdermal testosterone gel and the progestin nestorone suppresses serum gonadotropins in men. (PubMed)

Combined transdermal testosterone gel and the progestin nestorone suppresses serum gonadotropins in men. Testosterone (T) plus progestin combinations are the most promising hormonal male contraceptives. Nestorone (NES), a progestin without estrogenic or androgenic activity, when combined with T may be an excellent candidate for male contraception.Our objective was to determine the effect of transdermal NES gel alone or with T gel on gonadotropin suppression.The randomized, unblinded clinical (...) mg.Suppression of serum LH and FSH concentrations to 0.5 IU/liter or less after treatment was the main outcome variable.A total of 119 subjects were compliant with gel applications with few study-related adverse events. NES alone reduced gonadotropins significantly but less than T gel alone. Combined T gel 10g plus NES gel 6 or 8 mg suppressed both serum gonadotropins to 0.5 IU/liter or less in significantly more men than either gel alone.Transdermal NES gel alone had gonadotropin suppression activity

Full Text available with Trip Pro

2009 The Journal of clinical endocrinology and metabolism Controlled trial quality: uncertain

92. Study of Daily Application of Nestorone® (NES) and Testosterone (T) Combination Gel for Male Contraception

will be eligible for enrollment in the trial: Good health as confirmed by medical history, physical examination, and clinical laboratory tests of blood and urine at the time of screening; 18 to 50 years of age, at the enrollment visit; BMI < 33 kg/m2; No history of androgen use in the six months prior to the first screening visit; Agreement to use an effective method of contraception with his female partner (refer to Appendix 11 for acceptable forms of contraception) during the suppression and recovery phases (...) and then only use the experimental method during the efficacy phase of the study; In the opinion of the investigator, the male subject is willing and able to comply with the protocol; The subject is legally competent, has been informed of the nature, the scope and the relevance of the study, voluntarily agrees to participation and the study's provisions and has duly signed the informed consent form (ICF); Sexually active with a female partner (as specified below) with whom he has been in a stable, mutually

2018 Clinical Trials

93. Cancer Driving Mutations in Endometriosis Lesions and Development of Progesterone Resistance

, estrogen replacement/supplemental therapy, androgens (Danazol, Cyclomen, Danocrine, testosterone) or progesterone. She may not be taking or be on Celebrex. Pregnant. Presence of pelvic infection. Mullerian anomalies with absence of a cervix. History of cancer of the reproductive tract. Presence of undiagnosed uterine bleeding. Treatment with intrauterine device (IUD) or progestin-containing intrauterine device. Contacts and Locations Go to Information from the National Library of Medicine To learn more (...) . Criteria Inclusion Criteria: Signed informed consent. Gender: female. Age: 18-45 years at the time of signing consent. Clinical or surgical diagnosis of endometriosis undergoing laparoscopy. Controls may not have clinical or surgical diagnosis of endometriosis. Regular menstrual cycles. BMI between 18-40 kg/m2. Sexually active or have had a previous vaginal exam that used a speculum. English speaking Exclusion Criteria: Use of any kind of steroidal therapy including oral contraceptives, Norplant

2018 Clinical Trials

94. Effects of Sex Steroids on Fish Leukocytes (PubMed)

and the adaptive immune system of fish by regulating the main leukocyte activities and transcriptional genes. They activate nuclear oestrogen receptors and/or G-protein coupled oestrogen receptor. Less understood is the role of androgens in the immune system, mainly due to the complexity of the transcriptional regulation of androgen receptors in fish. The aim of this manuscript is to review our present knowledge concerning the effect of sex steroid hormones and the presence of their receptors on fish (...) leukocytes, taking into consideration that the studies performed vary as regard the fish species, doses, exposure protocols and hormones used. Moreover, we also include evidence of the probable role of progestins in the regulation of the immune system of fish.

Full Text available with Trip Pro

2018 Biology

95. Would male hormonal contraceptives affect cardiovascular risk? (PubMed)

Would male hormonal contraceptives affect cardiovascular risk? The aim of hormonal male contraception is to prevent unintended pregnancies by suppressing spermatogenesis. Hormonal male contraception is based on the principle that exogenous administration of androgens and other hormones such as progestins suppress circulating gonadotropin concentrations, decreasing testicular Leydig cell and Sertoli cell activity and spermatogenesis. In order to achieve more complete suppression of circulating (...) gonadotropins and spermatogenesis, a progestin has been added testosterone to the most recent efficacy trials of hormonal male contraceptives. This review focusses on the potential effects of male hormonal contraceptives on cardiovascular risk factors, lipids and body composition, mainly in the target group of younger to middle-aged men. Present data suggest that hormonal male contraception can be reasonably regarded as safe in terms of cardiovascular risk. However, as all trials have been relatively short

Full Text available with Trip Pro

2018 Asian journal of andrology

96. A Trial of Personalized Acupuncture, Standardized Acupuncture, Letrozole and Placebo on Live Birth in Women With PCOS

will be connected to an electrical stimulator: ST25 bilaterally, ST29 bilaterally, SP6 bilaterally, LR3 bilaterally. Other: Acupuncture Women in this groups will receive acupuncture treatment three times a week. Acupuncture treatment will start on days 3-5 after a spontaneous period or after a withdrawal bleeding following progestin. Each treatment session will last for 30 min, with a maximum of 48 treatment sessions over 16 weeks. Active Comparator: Letrozole Letrozole will be started on day 3-5 after (...) and EXCA1 of both types will be connected to electrical stimulator. Moreover, the points CV6, CV12 and ST25 for yang deficiency of spleen and kidney will receive moxibustion with needles, and CV8 will only receive ginger-salt-indirect moxibustion without acupuncture. Other: Acupuncture Women in this groups will receive acupuncture treatment three times a week. Acupuncture treatment will start on days 3-5 after a spontaneous period or after a withdrawal bleeding following progestin. Each treatment

2018 Clinical Trials

97. Liraglutide 3mg (Saxenda) on Weight, Body Composition, Hormonal and Metabolic Parameters in Obese Women With PCOS

contraceptives, GnRH analogues, glucocorticoids, anabolic steroids, C-19 progestins) including herbal medicines for at least 8 weeks. Use of anti-androgens that act peripherally to reduce hirsutism such as 5-alpha reductase inhibitors (finasteride, spironolactone, flutamide) for at least 4 weeks Prior history of a malignant disease requiring chemotherapy Family or personal history of familial medullary thyroid carcinoma or multiple endocrine neoplasia type 2 Known hypersensitivity or contraindications to use (...) -obesity medication combined with lifestyle changes on body weight and composition and androgen excess in obese women diagnosed with PCOS are lacking. The investigators aim to elucidate the most efficacious weight reduction regime in obese PCOS women. The investigators further hope to determine which treatment(s) addressing the multifaceted disturbances of this disorder in patients with PCOS and obesity emerges as the preferable therapy. Condition or disease Intervention/treatment Phase Pre Diabetes

2018 Clinical Trials

98. A Study of SHR3680 in Treating Patients With Hormone Sensitive Prostate Cancer

to day 1; Previous use or are using a second-generation androgen receptor antagonist (enzalutamide, ARN-509, ODM-201), abiraterone, ketoconazole for prostate cancer, or other agents that will inhibit the production of androgens; Have participated in an interventional clinical trial or been treated with the following drugs in the past 4 weeks prior to day 1: 5-alpha reductase inhibitors, estrogen, progestin, and herbal products known to decrease PSA levels ; Evidence of brain metastasis or primary (...) Resource links provided by the National Library of Medicine related topics: related topics: available for: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: SHR3680 Participants will receive SHR3680 orally Drug: SHR3680 Tablet. Specifications of 80 mg; orally, once a day Active Comparator: bicalutamide Participants will receive bicalutamide orally Drug: Bicalutamide Tablet. Specifications of 50 mg; orally, once a day Outcome Measures Go to Primary Outcome Measures : rPFS

2018 Clinical Trials

99. Vaginal Progesterone Supplementation in Women With PCOS Undergoing Ovulation Induction With Letrozole

, 2018 Sponsor: Eastern Virginia Medical School Collaborator: Watson Pharmaceuticals Information provided by (Responsible Party): Laurel Stadtmauer, Eastern Virginia Medical School Study Details Study Description Go to Brief Summary: Aromatase inhibitors such as letrozole are hypothesized to maintain normal hypothalamic/ pituitary feedback mechanisms and in the case of OI (ovulation induction) in women with PCOS, may act to increase follicular sensitivity to FSH by increasing intrafollicular androgen (...) . In addition P has been shown to decrease LH pulse frequency which is elevated in PCOS and has been shown to down regulate endometrial androgen receptors. There have been retrospective studies showing progesterone supplementation seems to benefit both CC and letrozole treatment groups. In fact, this study showed the only pregnancies in the letrozole group were those in women who took P supplementation. However the number of cycles studied was small. There is a place for a randomized controlled trial (RCT

2018 Clinical Trials

100. Topical Treatment for Sexual Pain, Vulvar Pain, in Postmenopausal Women Not Taking Estrogens or Similiar Hormones

: Parallel Assignment Intervention Model Description: Randomized, Double Blinded, Placebo Controlled Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Masking Description: Double Blinded Primary Purpose: Treatment Official Title: 5% Sinecatechins Ointment, a Botanical Drug Derived From Green Tea, for the Treatment of Significant to Severe Secondary Provoked Vestibulodynia in Sexually Active, Post-Menopausal Women With Vulvovaginal Atrophy Actual Study Start Date : August 30 (...) with the gynecologist. In addition, 2 short questionnaires will be filled out online on a HIPAA compliant web based survey at the end of week 1,2,4 and 5. Other: Placebo Aquaphor Active Comparator: 5% Topical sinecatechins ointment 30 postmenopausal women not using estrogen will apply one 0.5cm strand of 5% sinecatechins topical ointment once daily to their vulvar vestibule for a total of 6 weeks. They will come for three office visits with the gynecologist, who will exam their vulvar vestibule and perform a Qtip

2018 Clinical Trials

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>