How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,179 results for

Proctitis

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1. Assessment of proctitis

Assessment of proctitis Assessment of proctitis - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of proctitis Last reviewed: February 2019 Last updated: June 2018 Summary Proctitis refers to inflammation in the rectum. It may result in rectal bleeding or discharge, urgency, painful defecation, tenesmus, and crampy lower abdominal pain. The inflammation can develop as a consequence of exposure of the rectal (...) mucosa to infectious organisms, allergens, radiation, ischaemia, and toxins, or diversion of faecal flow from the rectum (diversion proctitis). In addition, it can be the primary location of idiopathic inflammatory bowel disease, such as ulcerative colitis or Crohn's disease. As there are many possible causes for this condition, accurate assessment and identification of the underlying cause is essential for appropriate therapy. Workowski KA, Bolan GA; Centers for Disease Control and Prevention

2018 BMJ Best Practice

4. Treatment of Chronic Radiation Proctitis

Treatment of Chronic Radiation Proctitis Copyright © The American Society of Colon & Rectal Surgeons, Inc. Unauthorized reproduction of this article is prohibited. 1135 DISEASES OF THE COLON & RECTUM VOLUME 61: 10 (2018) The American Society of Colon and Rectal Surgeons (ASCRS) is dedicated to ensuring high-quality patient care by advancing the science, prevention, and management of disorders and diseases of the colon, rectum, and anus. The Clinical Practice Guidelines Committee is charged (...) be made rather than to dictate a specific form of treatment. STATEMENT OF THE PROBLEM Radiation therapy is frequently used in many types of cancer, including anal, cervical, prostate, and rectal. Al- though radiation has beneficial effects in treating tumors, collateral damage to the GI tract can occur, and although acute toxicity in the form of either proctitis or enteritis may occur, the more concerning symptom is the devel- opment of a chronic hemorrhagic radiation proctitis. Chronic hemorrhagic

2018 American Society of Colon and Rectal Surgeons

5. Can acetarsol be used to treat proctitis?

Can acetarsol be used to treat proctitis? Can acetarsol be used to treat proctitis? – SPS - Specialist Pharmacy Service – The first stop for professional medicines advice Menu · · 8th April 2019 · UKMi This updated Medicines Q&A evaluates the limited evidence available for the use of acetarsol to treat proctitis Attachments · Word · 48 KB Regional Medicines Information Manager, London Medicines Information Service · · Copyright © 2019 SPS - Specialist Pharmacy Service. All Rights Reserved.

2019 Specialist Pharmacy Services

6. Phlegmonous Proctitis: A Rare Entity of the Presentation of Proctitis Full Text available with Trip Pro

Phlegmonous Proctitis: A Rare Entity of the Presentation of Proctitis Phlegmonous proctitis is a rare condition; it was first described in 1940. We report the case of an elderly woman who presented with acute severe lower abdominal pain, tenesmus, and fever. A computed tomography of the whole abdomen revealed a long segment of circumferential wall thickening of the rectum and rectosigmoid colon. Colonoscopy was done subsequently and showed marked edematous and erythematous rectal mucosa. When (...) rectal tissue biopsy was performed, a large amount of pus came out at the biopsy site, which led to the diagnosis of phlegmonous proctitis.

2018 Case reports in gastroenterology

7. Efficacy of Tumor Necrosis Factor Antagonist Treatment in Patients With Refractory Ulcerative Proctitis. Full Text available with Trip Pro

Efficacy of Tumor Necrosis Factor Antagonist Treatment in Patients With Refractory Ulcerative Proctitis. It is a challenge to manage patients with ulcerative proctitis (UP) refractory to standard therapy. We investigated the effectiveness of tumor necrosis factor (TNF) antagonists in a large cohort of patients with refractory UP.We conducted a nationwide retrospective cohort study of 104 consecutive patients with active UP refractory to conventional therapies, treated at 1 of 15 centers

2019 Clinical Gastroenterology and Hepatology

8. Efficacy and safety of radiofrequency ablation for treatment of chronic radiation proctitis: A systematic review and meta-analysis. (Abstract)

Efficacy and safety of radiofrequency ablation for treatment of chronic radiation proctitis: A systematic review and meta-analysis. Although argon plasma coagulation is the current standard endoscopic treatment for chronic radiation proctitis (CRP), radiofrequency ablation (RFA) has emerged as an attractive alternative. The aim of this study is to evaluate the efficacy and safety of RFA for the treatment of CRP.Searches of PubMed, EMBASE, Web of Science, and Cochrane Library databases were

2019 Journal of gastroenterology and hepatology

9. Efficacy of Synbiotics to Reduce Symptoms and Rectal Inflammatory Response in Acute Radiation Proctitis: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial. (Abstract)

Efficacy of Synbiotics to Reduce Symptoms and Rectal Inflammatory Response in Acute Radiation Proctitis: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial. Purpose: Evaluate whether the daily intake of synbiotics improves symptoms and rectal/systemic inflammatory response in patients with radiation-induced acute proctitis. Methods and Materials: Twenty patients who underwent three-dimensional conformal radiotherapy for prostate cancer were randomized to intake either a synbiotic powder (...) containing Lactobacillus reuteri (108 CFU) and soluble fiber (4.3 g) or placebo. EORTC QLQ-PRT23 questionnaire was applied before the beginning of radiotherapy and after the fifth, sixth, and seventh weeks of treatment, and the sum of both the complete (proctitis symptoms plus quality of life) and partial (proctitis symptoms) scores were compared. Fecal calprotectin was measured at Day 0 and in the fourth week of treatment, and serum C-reactive protein/albumin ratio were measured in the fourth week

2019 Nutrition and cancer Controlled trial quality: predicted high

10. A Study of Niclosamide Enemas in Subjects With Active Ulcerative Proctitis or Ulcerative Proctosigmoiditis

A Study of Niclosamide Enemas in Subjects With Active Ulcerative Proctitis or Ulcerative Proctosigmoiditis A Study of Niclosamide Enemas in Subjects With Active Ulcerative Proctitis or Ulcerative Proctosigmoiditis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. A Study of Niclosamide Enemas in Subjects With Active Ulcerative Proctitis or Ulcerative Proctosigmoiditis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03521232

2018 Clinical Trials

11. Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis Full Text available with Trip Pro

Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis The aim of the present study was to investigate the safety and efficacy of mesalazine suppository in the treatment of refractory ulcerative chronic radiation proctitis (CRP). In total, 10 refractory ulcerative CRP patients who did not respond to previous medical treatments were recruited for the present study and were treated with mesalazine suppository (0.5 g) twice daily for 24 weeks. For each

2018 Experimental and therapeutic medicine

12. International validation of the EORTC QLQ-PRT20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase IV study Full Text available with Trip Pro

International validation of the EORTC QLQ-PRT20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase IV study Although patients experience radiation proctitis post radiotherapy no internationally tested instruments exist to measure these symptoms. This Phase IV study tested the scale structure, reliability and validity and cross-cultural applicability of the EORTC proctitis module (QLQ-PRT23) in patients who were receiving pelvic radiotherapy.Patients (n

2018 Radiation oncology (London, England)

13. Proctitis Caused by Mycobacterium avium-intracellulare in an HIV-Infected Patient Full Text available with Trip Pro

Proctitis Caused by Mycobacterium avium-intracellulare in an HIV-Infected Patient Infectious proctitis is usually associated with sexually transmitted diseases, especially in HIV-infected individuals. Limited information is found about the role of Mycobacterium avium-intracellulare as a causative agent for this condition. Here, we report the case of an HIV-infected patient with a CD4 count of 304 cells/uL and undetectable HIV viral load, who presented with constipation and painful defecation (...) . Endoscopic evaluation was significant for shallow rectal ulcerations. Histopathology revealed poorly formed granulomas. Stool culture grew Mycobacterium sp. that was further identified as Mycobacterium avium-intracellulare by DNA probe. He was successfully treated with a 3-drug regimen that included azithromycin, ethambutol and rifabutin. We advocate the use of AFB stool culture in cases of proctitis in which initial investigations for sexually transmitted diseases are unrevealing.

2018 Diseases

14. Acetarsol Suppositories: Effective Treatment for Refractory Proctitis in a Cohort of Patients with Inflammatory Bowel Disease Full Text available with Trip Pro

Acetarsol Suppositories: Effective Treatment for Refractory Proctitis in a Cohort of Patients with Inflammatory Bowel Disease Management of proctitis refractory to conventional therapies presents a common clinical problem. The use of acetarsol suppositories, which are derived from organic arsenic, was first described in 1965. Data concerning clinical efficacy and tolerability are very limited.To examine the efficacy of acetarsol suppositories for the treatment of refractory proctitis.A (...) was effective for two out of every three patients with refractory proctitis. This cohort had failed a broad range of topical and systemic treatments, including anti-TNFα therapy. Clinical efficacy was reflected in significant endoscopic improvement. Adverse effects of acetarsol were rare.

2018 Digestive diseases and sciences

15. Evaluation of prophylactic and therapeutic effects of ruscogenin on acute radiation proctitis: an experimental rat model Full Text available with Trip Pro

Evaluation of prophylactic and therapeutic effects of ruscogenin on acute radiation proctitis: an experimental rat model Radiation proctitis (RP) is inflammation and damage to the rectum, manifested secondary to ionizing radiation utilized for treatment. In this study, we evaluated the anti-inflammatory therapeutical and protective effects of ruscogenin in a model of acute RP.Thirty-two Sprague-Dawley rats were divided into 4 groups (n = 8) as sham, control, treatment, and prophylaxis groups

2018 Annals of surgical treatment and research

16. Budesonide Suppositories are Effective and Safe for Treating Acute Ulcerative Proctitis. Full Text available with Trip Pro

Budesonide Suppositories are Effective and Safe for Treating Acute Ulcerative Proctitis. Although proctitis is the most limited form of ulcerative colitis, it causes unpleasant symptoms. Topical mesalamine, the standard treatment, is not always effective. We conducted a randomized phase 2 trial to determine the efficacy and safety of 2 doses of a budesonide suppository vs mesalamine suppositories vs combined budesonide and mesalamine suppositories for proctitis.We performed a prospective (...) , double-blind, double-dummy, multicenter trial in 337 patients with active proctitis to compare the efficacies of 4 different suppository treatments. Patients were randomly assigned to groups given 2 mg budesonide suppositories (2 mg BUS; n = 89 patients), 4 mg BUS (n = 79), 1 g mesalamine suppositories (1 g MES; n = 81), or the combination of 2 mg BUS and 1 g MES (n = 88). The study was performed from November 2013 through July 2015 at 36 study sites in Europe and Russia. The primary end point

2018 Clinical Gastroenterology and Hepatology Controlled trial quality: predicted high

17. A case of a rectal stricture related to ischemic proctitis following rupture of an aortic aneurysm Full Text available with Trip Pro

A case of a rectal stricture related to ischemic proctitis following rupture of an aortic aneurysm Background and study aims  Ischemic proctitis is a rare disease and comprises 2 % to 5 % of cases of ischemic colitis, because the rectum has abundant blood supply and rich collaterals. Herein, we report a case of a 73-year-old male patient with a pronounced rectal stricture caused by ischemic proctitis resulting from an abdominal aortic rupture and treated by endoscopic balloon dilation therapy (...) . To date, only 3 cases of rectal stricture related to ischemic proctitis including our case have been reported, and this is the first case of rectal stricture related to ischemic proctitis, which was successfully treated by endoscopic balloon dilation.

2018 Endoscopy international open

18. Development and Preliminary Evaluation of a Murine Model of Chronic Radiation-Induced Proctitis. (Abstract)

Development and Preliminary Evaluation of a Murine Model of Chronic Radiation-Induced Proctitis. Radiotherapy (RT) is commonly used to treat most pelvic malignancies. While treatment is often effective, curative radiation doses to the rectum can result in chronic radiation-induced proctitis, which is characterized by diarrhea, tenesmus, and/or rectal bleeding, recently termed pelvic radiation disease. An animal model of chronic radiation-induced proctitis would be useful to test both (...) preventative and therapeutic strategies to limit this morbidity but has been elusive because of the high rodent mortality associated with acute bowel RT injury. The objective of this research was to develop a novel mouse model of chronic radiation-induced proctitis using advanced technology.Using an X-RAD 225-Cx (Precision X-Ray) small animal irradiator, multiple plan configurations were evaluated for planning treatment volume and organ-at-risk avoidance to deliver a 15 Gy 3D conformal treatment plan

2018 Biology and Physics

19. Reactivated cytomegalovirus proctitis in an immunocompetent patient presenting as nosocomial diarrhea: a case report and literature review. Full Text available with Trip Pro

Reactivated cytomegalovirus proctitis in an immunocompetent patient presenting as nosocomial diarrhea: a case report and literature review. Reactivated cytomegalovirus (CMV) infection has been known to cause significant morbidity and mortality in immunocompromised patients. However, CMV disease rarely develops in immunocompetent patients, and reported cases often present with a mild, self-limiting course, without severe life-threatening sequelae. While the colon is the most common (...) gastrointestinal site affected by CMV disease in immunocompetent patients, rectal involvement is rarely reported. CMV proctitis can present in two distinct forms, primary and reactivated. However, reactivated CMV proctitis is rarely reported as a causative etiology of nosocomial diarrhea, except in transplant patients. Herein we present a case of reactivated CMV proctitis in an immunocompetent patient, presenting as nosocomial diarrhea. Previously reported cases of reactivated CMV proctitis in immunocompetent

2017 BMC Infectious Diseases

20. Efficacy of Topical 5-aminosalicylate Monotherapy in Patients with Ulcerative Proctitis with Skip Inflammation. (Abstract)

Efficacy of Topical 5-aminosalicylate Monotherapy in Patients with Ulcerative Proctitis with Skip Inflammation. In some patients with ulcerative proctitis (UP), skip inflammation is noted in the right side of the colon, but little is known about its clinical course. The aim of this study was to evaluate the clinical course of UP with skip inflammation and the efficacy of topical 5-aminosalicylate (5-ASA) monotherapy.This study reviewed the data of 388 patients with an initial diagnosis of UP

2017 Journal of gastroenterology and hepatology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>