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161. Research and Reviews in the Fastlane 144

the world tell us what they think is worth reading from the published literature. This edition contains 6 recommended reads . The R&R Editorial Team includes Jeremy Fried, Nudrat Rashid, Soren Rudolph, Justin Morgenstern, Anand Swaminathan and, of course, Chris Nickson. Find more R&R in the Fastlane reviews in the , read more or check out the This Edition’s R&R Hall of Famer Cardiology Ortiz M, et al. Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment (...) of tolerated wide QRS tachycardia: the PROCAMIO study. European heart journal. 2016. PMID: The evidence for amiodarone has always been on the weak side. This is a good paper that should be practice changing for some people. It is a multicenter, randomized trial comparing amiodarone (5mg/kg over 20 minutes) to procainamide (10mg/kg over 20 min) in 74 adult patients with hemodynamically stable ventricular tachycardia. Procainamide was better. The primary outcome of cardiac adverse events (mostly hypotension

2016 Life in the Fast Lane Blog

162. J K Aronson – The Hitchhiker’s Guide to Clinical Pharmacology Part 2

-glucuronide Procainamide Acecainide Spironolactone Canrenone Sulfasalazine Mesalazine Terfenadine Fexofenadine Other drugs that were discovered independently and that are metabolized to active compounds include codeine, diamorphine, and tramadol (all metabolized to morphine), tamoxifen (metabolized to 4-hydroxytamoxifen), and aspirin (metabolized to salicylate). In some cases active metabolites cause adverse effects; these include the metabolites of lidocaine (the glycine xylidides) and pethidine

2016 CEBM blog

163. Antimicrobial activity and acetylcholinesterase inhibition by extracts from chromatin modulated fungi (PubMed)

to promote the expression of genes commonly silenced. For such finality, five filamentous fungal species (Talaromyces funiculosus, Talaromyces islandicus, Talaromyces minioluteus, Talaromyces pinophilus, Penicillium janthinellum) were grown or not with DNA methyltransferases inhibitors (procainamide or hydralazine) and/or a histone deacetylase inhibitor (suberohydroxamic acid). Extracts from T. islandicus cultured or not with hydralazine inhibited Listeria monocytogenes growth in 57.66±5.98% and 15.38 (...) ±1.99%, respectively. Increment in inhibition of acetylcholinesterase activity was observed for the extract from P. janthinellum grown with procainamide (100%), when compared to the control extract (39.62±3.76%). Similarly, inhibition of acetylcholinesterase activity increased from 20.91±3.90% (control) to 92.20±3.72% when the tested extract was obtained from T. pinophilus under a combination of suberohydroxamic acid and procainamide. Concluding, increases in antimicrobial activity

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2017 Brazilian Journal of Microbiology

164. Sweet 16 (papers of the year for NYGH EMU 2017)

in the ICU with no hope of recovery. This is one of the worst things we can do to people with modern medicine, and we need to be more cognizant of it as a harm. My bottom line: I will not use amiodarone or lidocaine routinely as part of ACLS Other FOAMed commentaries: Procainamide is better than amiodarone for stable ventricular tachycardia Ortiz M, Martín A, Arribas F. Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia (...) : the PROCAMIO study. European heart journal. 2016. PMID: Methods: A multicenter, randomized, open-label trial. They included 74 patients with stable ventricular tachycardia (SBP >/= 90 mm Hg, absence of dyspnea at rest, absence of peripheral hypoperfusion and no severe anginal symptoms). Were randomized to either procainamide 10 mg/kg IV over 20 minutes or amiodarone 5 mg/kg over 20 minutes. Results: The primary outcome (major cardiac events within 40 minutes) favoured procainamide: procainamide = 9% vs

2017 First10EM

165. Torsades de Pointes

patient, deliver an unsynchronized shock.) 1 What do you do if the patient is stable? I think it is reasonable to electrically cardiovert stable ventricular tachycardia, but you can also attempt to treat it medically. Torsades de pointes is caused by a prolonged QT. Almost all of the antiarrhythmics that we normally use to treat ventricular tachycardia, such as amiodarone and procainamide, will prolong the QT further, and therefore can make your patient worse. Do not give amiodarone or procainamide

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2017 First10EM

166. A High-Performance Liquid Chromatography Assay Method for the Determination of Lidocaine in Human Serum (PubMed)

A High-Performance Liquid Chromatography Assay Method for the Determination of Lidocaine in Human Serum Here we report on the development of a selective and sensitive high-performance liquid chromatographic method for the determination of lidocaine in human serum. The extraction of lidocaine and procainamide (internal standard) from serum (0.25 mL) was achieved using diethyl ether under alkaline conditions. After liquid-liquid extraction, the separation of analytes was accomplished using

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2017 Pharmaceutics

167. Direct Comparison of Derivatization Strategies for LC-MS/MS Analysis of N-Glycans (PubMed)

different properties that affect both glycan retention on LC columns and MS analyses. To provide guidance for the proper selection of derivatizing reagents and LC columns, herein, we describe a comprehensive assessment of 2-aminobenzamide, procainamide, aminoxyTMT, RapiFluor-MS (RFMS) labeling, reduction and reduction with permethylation for N-glycan analysis. Of the derivatization strategies examined, RFMS provided the highest MS signal enhancement for neutral glycans, while permethylation

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2017 The Analyst

168. LITFL Review 243

the Core EM post on with some great tables for clinical reference. [AS] Steve Mathieu discusses the recently published : Early Vasopressin vs Norepinephrine on Kidney Failure in Patients with Septic Shock. [SR] Phillipe Rola and Thomas Woodcock discuss the in this excellent podcast. After listening, you might want to rethink using any colloid. [SO] The Best of Resuscitation Last week: Amiodarone is the best anti-arrhythmic. Or is it? Rory Spiegel discusses the data on amiodarone vs procainamide

2016 Life in the Fast Lane Blog

169. Diagnosis and classification of drug-induced autoimmunity (DIA). (PubMed)

Diagnosis and classification of drug-induced autoimmunity (DIA). Since sulfadiazine associated lupus-like symptoms were first described in 1945, certain drugs have been reported to interfere with the immune system and induce a series of autoimmune diseases (named drug-induced autoimmunity, DIA), exemplified by systemic lupus erythematosus (SLE). Among the drugs, procainamide and hydralazine are considered to be associated with the highest risk for developing lupus, while quinidine has

2017 Journal of Autoimmunity

170. Geriatric Trauma Management

, Ic, III) z Amiodarone z Dofetilide z Dronedarone z Flecainide z Ibutilide z Procainamide z Propafenone z Quinidine z Sotalol Data suggest that rate control yields better balance of benefits and harms than rhythm control for most older adults Amiodarone is associated with multiple toxicities, including thyroid disease, pulmonary disorders, and QT interval prolongation Avoid antiarrhythmic drugs as first- line treatment of atrial fibrillation High Strong Disopyramide* Disopyramide is a potent

2013 American College of Surgeons

171. Guidelines for Responsible Opioid Prescribing in Chronic Non-Cancer Pain

) Pseudoephedrine Methamphetamine d-Methamphetamine d-Amphetamine Chloroquine (Aralen) Desoxyephedrine MDMA (Ecstasy) Methamphetamine (Desoxyn) Bupropion (Wellbutrin & Zyban) Chloroquine (Aralen) Chlorpromazine (Thorazine, Largactil) Desipramine (Norpramin) Dextroamphetamine (Dexedrine) Ephedrine (Ephedra and Ma Huang) Fenfluramine (Fen Phen) Labetalol (Labetalol) Mexiletine (Mexitil) n-acetyl procainamide (Procainamide) Phenylephrine (Neo-synephrine) Propranolol (Inderal) Pseudoephedrine (Claritin-D

2012 American Society of Interventional Pain Physicians

173. The Society of Thoracic Surgeons Practice Guideline on the Prophylaxis and Management of Atrial Fibrillation Associated With General Thoracic Surgery

history of structural cardiac disease including ventricular hypertrophy, systolic dysfunction, or any valve or coronary disease. (Level of evidence A) Antiarrhythmic drugs with the ability to convert AF to sinus rhythm include amiodarone, disopyramide, dofeti- lide, ?ecainide, ibutilide, procainamide, propafenone, quinidine, and sotalol. A series of comparative studies of medical AF patients has established broadly that ?ecain- ide, ibutilide, dofetilide, propafenone, and amiodarone are the most

2011 Society of Thoracic Surgeons

176. Study of APD421 as PONV Treatment (Prior Prophylaxis)

, procainamide; Class III antiarrhythmic agents such as amiodarone and sotalol; and other medications such as bepridil, cisapride, thioridazine, methadone, IV erythromycin, IV vincamine, halofantrine, pentamidine, sparfloxacin, etc. Patients who have a documented, clinically significant cardiac arrhythmia or congenital long QT syndrome. Patients who are pregnant or breast feeding. Patients being treated with levodopa. Patients diagnosed with Parkinson's disease. Patients who have received emetogenic anti

2016 Clinical Trials

177. Cetuximab-IRDye 800CW in Detecting Tumors in Patients With Malignant Glioma Undergoing Surgery

of cetuximab IRDye800 Within 6 months prior to enrollment, myocardial infarction (MI); cerebrovascular accident (CVA); uncontrolled congestive heart failure (CHF); significant liver disease; or unstable angina History of infusion reactions to cetuximab or other monoclonal antibody therapies Evidence of QT prolongation on pretreatment electrocardiogram (ECG) (greater than 440 ms in males or greater than 450 ms in females) Receiving class IA (quinidine, procainamide) or class III (dofetilide, amiodarone

2016 Clinical Trials

178. 18F-AV-1451 PET Imaging in Participants Enrolled in the LEARN Study

a condition that could, in the opinion of the investigator, affect his or her response to the radiopharmaceutical and related testing procedures; Is deemed likely to be unable to perform all of the imaging procedures for any reason; Has a history of risk factors for torsades de pointes, including clinically significant findings on ECG, or is taking medications known to prolong QT interval such as citalopram ≥ 40 mg/day, disopyramide, dofetilide, ibutilide, procainamide, quinidine, sotalol, or bepridil

2016 Clinical Trials

179. Trimebutine Maleate Combined With Rabeprazole in Patients With Grade A or B Reflux Esophagitis Whose Symptoms Refractory to Rabeprazole

or rabeprazole. Use of drugs have interaction with the study drugs (e.g. cisapride ,procainamide, clopidogrel or ciclosporin),or drugs which may affect the results of the study(e.g. antisecretory drugs(PPIs or H2RA),prokinetics,mucosal protective drugs or anticholinergics),or drugs absorbed depending on the acidity of the gastric fluid(e.g.ketoconazole or digoxin),or CYP3A4,CYP2C19 inhibitors during the study. Patients inability or refuse to consent, unable to complete the questionnaire,and have poor

2016 Clinical Trials

180. Cetuximab-IRDye 800CW and Intraoperative Imaging in Finding Pancreatic Cancer in Patients Undergoing Surgery

on pretreatment electrocardiography (ECG) (greater than 440 ms in males or greater than 450 ms in females) Lab values that in the opinion of the primary surgeon would prevent surgical resection Patients receiving class IA (quinidine, procainamide) or class III (dofetilide, amiodarone, sotalol) antiarrhythmic agents Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information

2016 Clinical Trials

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