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121. Effect of Baseline Antiarrhythmic Drug on Outcomes With Ablation in Ischemic Ventricular Tachycardia: A VANISH Substudy (Ventricular Tachycardia Ablation Versus Escalated Antiarrhythmic Drug Therapy in Ischemic Heart Disease). Full Text available with Trip Pro

patient on procainamide rather than sotalol). Amio-refractory patients had more renal insufficiency (23.7% versus 10%; P=0.0008), worse New York Heart Association class (82.3% II/III versus 65.5%; P=0.0003), and lower ejection fraction (29±9.7% versus 35.2±11%; P<0.0001). Within the amio-refractory group, ablation resulted in reduction of any ventricular arrhythmia compared with escalated drug therapy (hazard ratio, 0.53; 95% confidence interval, 0.31-0.9), P=0.020). Sotalol-refractory patients had

2018 Circulation. Arrhythmia and electrophysiology Controlled trial quality: uncertain

122. Amiodarone for sustained stable ventricular tachycardia in the prehospital setting. (Abstract)

for cardioversion occurring very infrequently. Amiodarone was relatively safe and moderately effective for the treatment of sustained stable VT. However, given recent evidence of increased efficacy of procainamide for stable VT, further studies are required in the prehospital setting to compare these two drugs.© 2018 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

2018 Emergency medicine Australasia

123. Drug-induced lupus: Traditional and new concepts. (Abstract)

Drug-induced lupus: Traditional and new concepts. Drug-induced lupus (DIL) includes a spectrum of drug-induced reactions often characterised by a clinical phenotype similar to that of idiopathic systemic lupus eruthematosus (SLE) but usually lacking major SLE complications. Different drugs may be associated with distinct clinical and serological profiles, and early recognition is crucial. Drugs traditionally associated with DIL include procainamide, hydralazine, quinidine and others, but strong

2018 Autoimmunity reviews

124. Pilot Randomized Trial With Flecainide in ARVC Patients

contraindication to beta-blockers exists. Persons prescribed quinidine, procainamide, propafenone, disopyramide, dronedarone phenytoin, mexilitene, flecainide, may be included after 5 day washout period with subsequent 24 Hour Holter obtained after washout period. Persons prescribed sotalol must be included after 5 day washout period during which another beta-blocker may be administered with subsequent 24 Hour Holter obtained. Subject and personal physician and or cardiologist must agree not to use any

2018 Clinical Trials

125. Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study

to study entry Treatment or planned treatment involving diuretics No current or planned treatment with cationic drugs excreted by the kidneys (e.g. amiloride, cimetidine, digoxin, morphine, nifedipine, procainamide, quinidine, quinine, ranitidine, triamterence, trimethoprim and vancomycin). No treatment or planned treatment with concomitant medications with potential unacceptable interaction with metformin including topirimate, lamotrigine, levetiracetam, beta blockers, ACE inhibitors, glycopyrrolate

2018 Clinical Trials

126. A 66-Year-Old Female with Apical Hypertrophic Cardiomyopathy Presenting with Hypertensive Crises and Type 2 Myocardial Infarction and a Normal Coronary Angiogram Full Text available with Trip Pro

) in which the hypertrophy predominantly involves the apex of the left ventricle resulting in midventricular obstruction, as opposed to the left ventricular outflow tract obstruction seen in HCM. Patients with apical HCM may present with angina, heart failure, myocardial infarction, syncope, or arrhythmias and are typically managed with medications like verapamil and beta-blockers for those who have symptoms and antiarrhythmic agents like amiodarone and procainamide for treatment of atrial fibrillation

2018 Case reports in cardiology

127. Panitumumab-IRDye800 in Diagnosing Participants With Malignant Glioma Undergoing Surgery

values that in the opinion of the primary surgeon would prevent surgical resection Subjects receiving class IA (quinidine, procainamide) or class III (dofetilide, amiodarone, sotalol) antiarrhythmic agents Subjects with a history or evidence of interstitial pneumonitis or pulmonary fibrosis Subjects not deemed to be appropriate candidates for optimal resection of tumor based on location, involvement of eloquent brain, satellite lesions, or other factors not specifically listed here Contacts

2018 Clinical Trials

128. Efficacy of Lidocaine Patch in Acute Musculoskeletal Pain in the Emergency Department

, Fosphenytoin, Halothane, Nadolol, Oxprenolol, Pentazocine, Propafenone Subject is on class I antiarrhythmics therapy (including lidocaine, procainamide, disopyramide etc) Subject has injuries requiring splint/casting where patient may not be able to reach the area of greatest pain to apply and reapply the patch Subject has prior history of chronic pain in the affected area (defined as greater than or equal to 6 weeks of pain) Subject has received opioid medication in triage area or within 4 hours

2018 Clinical Trials

129. Effects of Metformin During Nicotine Withdrawal

otherwise by the Study PI or Study Physician, upon review. Medication: Current use or recent discontinuation (within the past 14 days) of any of the following medications: Anti-anxiety or panic disorder medications (e.g., clonazepam, alprazolam). Anti-psychotic medications as assessed on a case-by-case basis Glucophage/metformin Glyburide Furosemide or digoxin Nifedipine Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim

2018 Clinical Trials

130. Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis

treatment with monoamine oxidase inhibitors or in the preceding 14 days Current treatment with linezolid (self-report or by chart review) Current treatment with other drugs that are inhibitors of CYP3A4 (e.g., itraconazole, clarithromycin, voriconazole), or known to prolong QT interval including Class 1A antiarrhythmics (e.g., quinidine, procainamide) or Class 3 antiarrhythmics (e.g., amiodarone, sotalol), antipsychotic medications (ziprasidone, chlorpromazine, thioridazine), and quinolone antibiotics

2018 Clinical Trials

131. Anamorelin Hydrochloride in Reducing Anorexia in Participants With Advanced Non-small Cell Lung Cancer

or diaphragm) with spermicide Uncontrolled diabetes mellitus (fasting blood sugar > 200 mg/dl) at screening Patients on drugs with strong CYP 3A4 inhibitors within the previous two weeks (ketoconazole, clarithromycin, itraconazole, nefazodone, telithromycin) Patients on drugs that may prolong the PR or QRS interval durations, such as any of the class I/sodium (Na+) channel blocking antiarrhythmic medications should be avoided (e.g. flecainide, procainamide, propafenone, quinidine) Patients currently

2018 Clinical Trials

132. Placebo-Controlled, Randomized, SAD Study to Evaluate the Safety, Tolerability, and PK of TBI-223 in Healthy Adults

, sertraline, etc.), bupropion, agents known to prolong the QTc interval (erythromycin, clarithromycin, astemizole, type Ia [quinidine, procainamide, disopyramide] and III [amiodarone, sotalol] anti-arrhythmics, carbamazepine, sulfonylureas, and meperidine). Use of any over-the-counter (OTC) medication, including herbal products and vitamins, within 7 days prior to dosing, except acetaminophen. Up to 3 grams per day of acetaminophen is allowed at the discretion of the Investigator prior to dosing. Use

2018 Clinical Trials

133. Contraindicated drug-drug interactions associated with oral antimicrobial agents prescribed in the ambulatory care setting in the United States. Full Text available with Trip Pro

combination was use of fluoroquinolones with antiarrhythmic agents (amiodarone, sotalol, quinidine or procainamide) (365 622 visits, proportion = 0.19%; 95% CI, 0.06-0.32).Providers should be aware of potential contraindicated DDIs when prescribing antibiotics, especially macrolides and fluoroquinolones.Copyright © 2018 European Society of Clinical Microbiology and Infectious Diseases. All rights reserved.

2018 Clinical Microbiology and Infection

134. Drug-induced lupus erythematosus: an update on drugs and mechanisms. (Abstract)

%) involved in subacute cutaneous lupus erythematosus, with an observed higher incidence in female patients. Enhanced neutrophil extracellular trap (NET) formation induced by procainamide and hydralazine could be a new mechanism contributing to the pathogenesis of DILE.The list of drugs implicated in triggering DILE is expanding as new drugs with novel mechanisms of action are being developed. It is important to recognize culprit drugs that may induce lupus erythematosus, as discontinuation usually

2018 Current Opinion in Rheumatology

135. A Clinical Study to Evaluate the Bioavailability Between Two Products Containing Paliperidone 100 mg in the Form of a Prolonged Release Suspension for Injection in Patients With Schizophrenia Who Are Already Stabilized in This Treatment

Antiarrhythmics (e.g., quinidine, disopyramide, procainamide) and class III antiarrhythmics (e.g. amiodarone, sotalol), antihistamines, antipsychotics known to prolong QT interval, and antimalarials (e.g. mefloquine, quinine), tricyclic antidepressants (eg amitriptyline), tetracyclic antidepressants (eg maprotiline). The patient is receiving centrally acting medicinal products e.g. anxiolytics, risperidone, opiates, etc. or alcohol The patient is receiving drugs that induce orthostatic hypotension (e,g other

2018 Clinical Trials

136. Panitumumab-IRDye800 Compared to Sentinel Node Biopsy and (Selective) Neck Dissection in Identifying Metastatic Lymph Nodes in Patients With Head and Neck Cancer

within 6 months prior to enrollment History of infusion reactions monoclonal antibody therapies Pregnant or breastfeeding Magnesium or potassium lower than the normal institutional values Patients receiving class IA (quinidine, procainamide) or class III (dofetilide, amiodarone, sotalol) antiarrhythmic agents Patients with a history or evidence of interstitial pneumonitis or pulmonary fibrosis Hypersensitivity to dextran and/or modified form thereof Contacts and Locations Go to Information from

2018 Clinical Trials

137. Pembrolizumab and Vorinostat Combined With Temozolomide for Newly Diagnosed Glioblastoma

informed consent/assent for the trial. Life expectancy ≥ 12 weeks Willingness to discontinue medications known to be associated with risk of Torsades de Pointes such as quinidine, procainamide, disopyramide, amiodarone, erythromycin, clarithromycin, chlorpromazine and haloperidol Single measureable lesion < 4 cm in longest diameter Patient shouldn't have received any anti-cancer therapy for glioblastoma in past Females of childbearing potential (FOCBP) should have a negative urine or serum pregnancy

2018 Clinical Trials

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