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82. Atrial Fibrillation ? Diagnosis and Management

-threatening pulmonary fibrosis, hepatic dysfunction, and aggravation of arrhythmias Monitor transaminases and thyroid function every 6 months. Reduce dose of concurrently used beta-blockers, procainamide, quinidine, and warfarin by 50%. dronedarone Multaq® (IR tablet: 400 mg) 400 mg PO BID. $139 Limited Coverage Special Authority Diarrhea, dyspepsia, nausea, and hepatic dysfunction (rare) Slight increase in plasma creatinine related to inhibition of secretion Contraindicated in patients with severe heart

2015 Clinical Practice Guidelines and Protocols in British Columbia

84. HPLC-DAD Quantification of Flucytosine (5-Fluorocytosine)

Phenobarbital X 102 µmol/L 30 µmol/L Phenytoin X X 52 µmol/L 20 µmol/L Prednisolone X X Prednisone X Primidone 42 µmol/L Procainamide X 22 µmol/L 6 µmol/L Procarbazine X Prochlorperazine X Quinidine X 11.1 µmol/L 5 µmol/L Salicylate 1.4 mmol/L 300 µmol/L 23 DRUGS TESTED BURY ET AL., 1979 DIASIO ET AL., 1978 MINERS ET AL., 1980 NG ET AL., 1996 PETERSEN ET AL., 1994* SCHWERTSCHLAG ET AL., 1984 WARNOCK AND TURNER, 1981 Theobromine X Theophylline X 83 µmol/L 20 µmol/L Thioguanine X Thyroxine 175 nmol/L

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

85. A Young Woman with Regular Narrow Complex Tachy at both 160 and 240

the AV node. For the two rates to be different, the rate of conduction would have to be different depending on the direction of the impulse. This is possible. Procainamide and amiodarone were also suggested by some as management. However, they have very limited success in refractory SVT, especially SVT that involves AV nodal conduction. This article studied their effect in pediatrics: =================================== MY Comment by K EN G RAUER, MD ( 5/30/2020

2020 Dr Smith's ECG Blog

86. Is it VT or SVT with Aberrancy?

). Choice of anti-dysrhythmic for recurrent refractory or recurrent VT is beyond the scope of this blog post, but you can start by looking at the for stable VT: procainamide was better than amiodarone. In short, the literature on pharmacologic therapy for VT is terrible, whether using it for stable VT, refractory VT, or recurrent VT. Ken Grauer on the ECG: MY THOUGHTS on ECG #1: The ECG in Figure-1 shows a regular WCT ( W ide- C omplex T achycardia ) Rhythm at ~220/minute , without clear sign of atrial

2020 Dr Smith's ECG Blog

87. Purification of human butyrylcholinesterase from frozen Cohn fraction IV-4 by ion exchange and Hupresin affinity chromatography. Full Text available with Trip Pro

Purification of human butyrylcholinesterase from frozen Cohn fraction IV-4 by ion exchange and Hupresin affinity chromatography. Human butyrylcholinesterase (HuBChE) is being developed as a therapeutic for protection from the toxicity of nerve agents. An enriched source of HuBChE is Cohn fraction IV-4 from pooled human plasma. For the past 40 years, purification of HuBChE has included affinity chromatography on procainamide-Sepharose. The present report supports a new affinity sorbent, Hupresin (...) by 90% when the paste was stored at -20°C for 1 year, and reduced 100% when stored at 4°C for 24h. No reduction in HuBChE recovery occurred when paste was stored at -80°C for 3 months or 3 years. Hupresin and procainamide-Sepharose were equally effective at purifying HuBChE from Cohn fraction. HuBChE in Cohn fraction required 1000-fold purification to attain 99% purity, but 15,000-fold purification when the starting material was plasma. HuBChE (P06276) purified from Cohn fraction was a 340 kDa

2019 PLoS ONE

89. CRACKCast E010 – Pediatric Resuscitation

) adenosine 0.1 mg/kg rapid IV push, max 6mg, second dose 0.2 mg/kg rapid IV push, max 12mg 4b) amiodarone 5mg/kg IV/IO over 20-50 minutes OR procainamide 15mg/kg IV/IO over 30-60 minutes 5) narrow complex – probable SVT 5a) consider vagal maneuvers – ice bath, carotid sinus massage, or any Valsalva (REVERT trial?) 5b) adenosine as above or synchronized DCCV if no vascular access 6) If probable sinus tachycardia: search for and treat the cause NOT the HR 3) Describe the PALS septic shock algorithm Rosen’s (...) 0.05 – 2 mcg/kg/min – for shock (septic particularly) Procainamide 15 mg/kg for stable wide complex tachycardia Sodium bicarbonate 1-2 mEq/kg – for profound metabolic acidosis or Na channel blocker overdose (e.g. TCA) Two more medications that Rosen’s lists: Alprostadil (PGE1) – Prostaglandin used for ductal dependent congenital heart disease infusion: start at 0.05 – 0.1 mcg/kg/min can cause apnea Milrinone for bad cardiogenic shock to decrease SVR and PVR 5) What are 8 risk factors for Sudden

2016 CandiEM

91. Arrhythmogenic drugs can amplify spatial heterogeneities in the electrical restitution in perfused guinea-pig heart: An evidence from assessments of monophasic action potential durations and JT intervals. Full Text available with Trip Pro

with clinically proved proarrhythmic potential (dofetilide, quinidine, procainamide, and flecainide) and, if so, whether these effects can translate to the appropriate changes of the ECG metrics of ventricular repolarization, such as JT intervals. In isolated, perfused guinea-pig heart preparations, monophasic action potentials and volume-conducted ECG were recorded at progressively increased pacing rates. The APD90 measured at distinct ventricular sites, as well as the JTpeak and JTend values were plotted (...) as a function of preceding diastolic interval, and the maximum slopes of the restitution curves were determined at baseline and upon drug administration. Dofetilide, quinidine, and procainamide reverse rate-dependently prolonged APD90 and steepened the restitution curve, with effects being greater at the endocardium than epicardium, and in the right ventricular (RV) vs. the left ventricular (LV) chamber. The restitution slope was increased to a greater extent for the JTend vs. the JTpeak interval

2018 PLoS ONE

93. Management of drug-induced immune and secondary autoimmune, haemolytic anaemia

IVIg can also cause acute haemolysis related to passive transfer of antibodies e.g. to ABO or Rh antigens. Some drugs (e.g. fludarabine, cladribine, levodopa, mefenamic acid and procainamide) cause drug-independent DIIHA that can be serologically indistinguishable from warm AIHA while others can only be detected in vitro in the presence of the drug or its metabolites (drug-dependent DIIHA). Patients can present within hours of exposure to drug with severe complement- mediated intravascular

2016 British Committee for Standards in Haematology

95. Vylaer Spiromax - budesonide / formoterol

bronchodilators, in acute severe asthma as the associated risk may be augmented by hypoxia and in other conditions when the likelihood for hypokalaemia is increased. It is recommended that serum potassium levels are monitored during these circumstances. Section 4.5, interactions with other medicinal products and other forms of interactions, SmPC: Concomitant treatment with quinidine, disopyramide, procainamide, phenothiazines, antihistamines (terfenadine), monoamine oxidase inhibitors and tricyclic

2014 European Medicines Agency - EPARs

98. Classification of Anemias

deficiency high RDW, low-normal reticulocyte , Hemolytic anemia Drug induced Aplastic anemia: allopurinol, antithyroid meds , chemo, chloramphenicol, chlorpromazine, clopidogrel, corticosteroids, furosemide, gold, indomethacin, interferon a2a&2b , isoniazid, methyldopa, NSAIDs, penicillamine, phenothiazines, procainamide, sulfonamides & ticlopidine. Drug induced Hemolysis in G6PD Deficiency: ascorbic acid, benzocaine, chloroquine, dapsone, hydroxychloroqine, nitrofurantoin, phenazopyridine, primaquine (...) , sulfacetamide, sulfamethoxazole, sulfanilamide & sulfapyridine. Drug induced Hemolytic anemia: ACEI, acetaminophen, ASA/NSAIDs, cephalosporins, chlorpromazine, chlorpropamide, diclofenac, hydrochlorothiazide, interferon a2a&2b , isoniazid, levodopa, levofloxacin, mefenamic acid, methadone, methyldopa, penicillins, probenecid, procainamide, quinine, quinidine, ribavirin, rifampin, sulfonamides, & tetracycline. (Direct antiglobulin test-DAT or Coomb’s test is used to detect cause of hemolytic anemia) Drug

2014 RxFiles

99. Do you recognize this ECG yet?

R wave component in lead aVR. T HEREFORE : As per Drs. Gordon and Meyers — ECG #1 is completely consistent with any toxicity producing Sodium-Channel Blockade ( ie, tricyclic antidepressant overdose; proarrhythmia from antiarrhythmics such as flecainide or procainamide — or other agents, as listed by Dr. Burns at the above LITFL link ) . B eyond- t he- C ore : Returning for a moment to ECG #1 — I was not at all certain in my initial assessment of this tracing that there were P waves deforming

2019 Dr Smith's ECG Blog

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