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61. ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay

• Amiodarone • Dronedarone • Flecainide • Procainamide • Propafenone • Quinidine • Sotalol • Donepezil • Lithium • Opioid analgesics • Phenothiazine antiemetics and antipsychotics • Phenytoin • Selective serotonin reuptake inhibitors • Tricyclic antidepressants • Anesthetic drugs (propofol) • Cannabis • Digoxin • Ivabradine • Muscle relaxants (e.g., succinylcholine) Table 5. Conditions Associated With Bradycardia and Conduction Disorders Intrinsic Cardiomyopathy (ischemic or nonischemic) Congenital heart

2018 American College of Cardiology

64. Management of Acute Atrial Fibrillation and Atrial Flutter in Non-Pregnant Hospitalized Adults

of the ventricular rate, hypotension, or ventricular fibrillation. Beta blockers are ineffective and may cause hypotension. When the arrhythmia is associated with hemodynamic compromise, early DCCV is indicated (see Figure 1). In hemodynamically stable patients with preexcited AF/AFL, procainamide is recommended to restore sinus rhythm. Further management should be guided by consultation with EP. Of note, any patient with preexcitation and syncope, with or without history of AF/AFL, warrants inpatient EP (...) agent in ED populations is procainamide, 1gm IV over 1 hour. Studies show that this results in an approximately 60% cardioversion rate. Procainamide should be held for SBP 24 hours post-op includes cardiology consultation for consideration of rhythm control in the majority of patients (see more below). Patients who spontaneously convert back to sinus rhythm within a 24-hour period may be treated somewhat differently. In these patients, it is unclear if the AF/AFL represents an isolated event

2017 University of Michigan Health System

65. CRACKCast E110 – Thought Disorders

ANTICONVULSANTS Ethosuximide Phenobarbital Phenytoin Primidone ANTIDEPRESSANTS Amitriptyline Doxepin Imipramine Protriptyline Trimipramine CARDIOVASCULAR DRUGS Captopril Digitalis Disopyramide Methyldopa Procainamide Propranolol Reserpine DRUGS OF ABUSE Alcohol Amphetamines Cannabis Cocaine Hallucinogens Opioids Phencyclidine Sedative-hypnotics MISCELLANEOUS DRUGS Antihistamines Antineoplastics Bromides Cimetidine Corticosteroids Disulfiram Heavy metals Acute Psychosis: Antihistamines Cocaine, cannabis

2017 CandiEM

66. CRACKCast E108 – Neuromuscular Disorders

precipitants of a myasthenic crisis and describe 3 chronic therapies and 2 acute therapies General Precipitants: Infection Aspiration Medication changes Eg. stopping anticholinergics New medication that precipitates weakness Surgery Pregnancy Medications (Box 98.2) Cardiovascular Beta Blockers CCB’s Quinidine Lidocaine Procainamide Antibiotics Aminoglycosides Tetracyclines Clindmycin Lincomycin Polymyxin B Colistin Other Phenytoin Neuromuscular Blockers Thyroid Replacement Treatment: BiPAP +/- IPPV

2017 CandiEM

67. Fingolimod (Gilenya): new contraindications in relation to cardiac risk

requiring treatment with class Ia (eg, quinidine, procainamide, disopyramide) and class III (potassium‐channel blockers—eg, amiodarone, sotalol, ibutilide, dofetilide) antiarrhythmic drugs second‐degree Mobitz type II atrioventricular (AV) block or third‐degree AV block, or sick‐sinus syndrome, if they do not have a pacemaker pre-treatment QT intervals ≥500 milliseconds report all suspected adverse drug reactions with fingolimod on a is authorised to treat relapsing-remitting multiple sclerosis

2017 MHRA Drug Safety Update

68. CRACKCast E118 – SLE and Vasculitides

levels · Direct coombs test positive Table 108.1 is very busy – Remember the only mnemonic from med school SOAP BRAIN MD Serositis Oral Ulcers Arthritis Photosensitivity & Pulmonary Fibrosis Blood cells (pancytopenia) Renal, Raynauds ANA Immunologic (anti-Sm, anti-dsDNA) Neuropsych Malar Rash Discoid Rash [3] List drugs that induce lupus See Box 108.2 from Rosens 8 th Edition – SLE and Vasculitides Drugs Definitively Implicated in Causing Drug-Induced Lupus Procainamide Hydralazine Methyldopa

2017 CandiEM

71. Management of Pregnancy in Patients With Complex Congenital Heart Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association Full Text available with Trip Pro

MetoprololPropranololCarvedilolAtenolol CCCD None reported Association with fetal growth restriction in second and third trimesters (atenolol, propranolol), neonatal bradycardia (esmolol, nadolol) Consider serial fetal sonography to assess interval fetal growth in second and third trimesters Except for atenolol, probably safe Class 1A Quinidine Procainamide CC None reported Yes Class 1C Flecainide C None reported Yes Class III SotalolAmiodarone BD None reported Thyroid dysfunction NoNo WHO)/(AAP Yes) Purine nucleosides Adenosine C

2017 American Heart Association

72. Arrhythmias in Congenital Heart Disease: A Position Paper of EHRA, AEPC, and ESC Working Group on Grown-up Congenital Heart Disease

, implantable cardioverter-de?brillator; LV, left ventricular; RV, right ventricular; SCD, sudden cardiac death; SVT, supraventricular tachycardia; VT, ventricular tachycardia. Table6 Recommendations for pharmacological therapy of ventricular tachycardia Recommendations Consensus statement References Electrical cardioversion is recommended for acute termination of haemodynamic stable/unstable VT. If not possible, intravenous amiodarone or procainamide may be considered. 155 For non-sustained ventricular

2017 Heart Rhythm Society

74. CRACKCast E091 – Pancreas

of GI bleeding Bowel obstruction correction Treatment of acute cholangitis / venous thrombosis Wisecracks Question 1) Specifically list 10 drug causes of pancreatitis. Cannabis Codeine Dapsone Enalapril Furosemide Isoniazid Metronidazole Pravastatin Procainamide Simvastatin Sulfamethoxazole Tetracycline Valproic acid These are some of the class Ia drugs – from Uptodate – where people have developed pancreatitis on a re-challenge of the drug and other causes of pancreatitis have been ruled out (e.g

2017 CandiEM

75. CRACKCast E079 – Dysrhythmias

: carbamazepine TCA neuroleptics citalopram, antihistamines cocaine pufferfish toxin shellfish toxin Class II: beta-adrenergic ANTagonists: suppress SA automaticity and slow AV node conduction Class III: prolong repolarization and refractory period (K+ channels) Other drugs: TCA’s, Antipsychotics Citalopram, Venlafaxine Antihistamines, Antimicrobials Class IV: Ca+ channel blockers (slow AV node conduction) for SVT’s Verapamil Diltiazem Other IA: >PROCAINAMIDE< 20-30 mg/min (total dose 12-20 mg) or ~1g. Risk (...) contraindicated Treatment 1st line: Procainamide, 2nd line: Amiodarone; then cardioversion if unstable. “Likewise, with a very rapid irregular tachycardia (i.e., atrial fibrillation with a ventricular rate exceeding 200) accompanied by a wide-complex QRS, the likelihood of accessory pathway conduction should be considered and nodal blocking agents again withheld. Procainamide is recommended any time an accessory pathway with wide QRS complexes or very rapid rates exists, with amiodarone as a secondary choice

2017 CandiEM

76. Certain People With Atrial Fibrillation May Have Changes on Ecg When Given Procainamide That May be Related to a Genetic Difference

Certain People With Atrial Fibrillation May Have Changes on Ecg When Given Procainamide That May be Related to a Genetic Difference ST-segment Elevation as an AF Endophenotype - Full Text View - Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) Center Collaborator: National Heart, Lung, and Blood Institute (NHLBI) Information provided by (Responsible Party): Dan Roden, Vanderbilt University Medical Center Study Details Study Description Go to Brief Summary: The purpose of this study is to look for a similarity in people's genes that may help understand which people could benefit from certain drugs for the treatment of atrial fibrillation (AF). Condition or disease Intervention/treatment Phase Atrial Fibrillation Drug: Procainamide

2010 Clinical Trials

78. Medications in Adult Advanced Life Support

), amiodarone, lidocaine (lignocaine), procainamide, bretylium, magnesium (magnesium sulfate heptahydrate), buffers, calcium, hormones or fibrinolytics) during human CPR increases survival to hospital discharge. 4 3 Specific Resuscitation Drugs 3.1 Adrenaline (Epinephrine) This is a naturally occurring catecholamine with alpha and beta effects. It is administered in cardiac arrest to cause peripheral vasoconstriction via its alpha-adrenergic action (directing available cardiac output to myocardium and brain

2016 Australian Resuscitation Council

80. Atrial Fibrillation ? Diagnosis and Management

-threatening pulmonary fibrosis, hepatic dysfunction, and aggravation of arrhythmias Monitor transaminases and thyroid function every 6 months. Reduce dose of concurrently used beta-blockers, procainamide, quinidine, and warfarin by 50%. dronedarone Multaq® (IR tablet: 400 mg) 400 mg PO BID. $139 Limited Coverage Special Authority Diarrhea, dyspepsia, nausea, and hepatic dysfunction (rare) Slight increase in plasma creatinine related to inhibition of secretion Contraindicated in patients with severe heart

2015 Clinical Practice Guidelines and Protocols in British Columbia

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