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Procainamide

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1. Procainamide vs. Amiodarone for Stable Ventricular Tachycardia. (PubMed)

Procainamide vs. Amiodarone for Stable Ventricular Tachycardia. Electrical cardioversion is an effective treatment for termination of ventricular tachycardia (VT)1,2 but is typically performed with procedural sedation, and thus involves associated risk. In hemodynamically stable VT, pharmacologic cardioversion is an option. Historically, lidocaine, amiodarone, procainamide, and sotalol have been used for pharmacologic cardioversion, based mostly upon expert opinion. This article is protected

2019 Academic Emergency Medicine

2. Comparison of 2-Aminobenzamide, Procainamide and RapiFluor-MS as Derivatizing Agents for High-Throughput HILIC-UPLC-FLR-MS N-glycan Analysis (Full text)

Comparison of 2-Aminobenzamide, Procainamide and RapiFluor-MS as Derivatizing Agents for High-Throughput HILIC-UPLC-FLR-MS N-glycan Analysis Rising awareness of the universal importance of protein N-glycosylation governs the development of further advances in N-glycan analysis. Nowadays it is well known that correct glycosylation is essential for proper protein function, which emanates from its important role in many physiological processes. Furthermore, glycosylation is involved (...) the performance of frequently used labeling compounds -2-aminiobenzamide (2-AB) and procainamide (ProA), and the recently introduced RapiFluor-MS (RF-MS) fluorescent tag. In all experiments N-glycans were released by PNGase F, fluorescently derivatized, purified by HILIC solid phase extraction and profiled using HILIC-UPLC-FLR-MS. We assessed sensitivity, linear range, limit of quantification (LOQ), repeatability and labeling efficiency for all three labels. For this purpose, we employed in-house prepared IgG

2018 Frontiers in chemistry PubMed

3. Simultaneous Determination of Procainamide and N-acetylprocainamide in Rat Plasma by Ultra-High-Pressure Liquid Chromatography Coupled with a Diode Array Detector and Its Application to a Pharmacokinetic Study in Rats (Full text)

Simultaneous Determination of Procainamide and N-acetylprocainamide in Rat Plasma by Ultra-High-Pressure Liquid Chromatography Coupled with a Diode Array Detector and Its Application to a Pharmacokinetic Study in Rats A simple, sensitive, and reliable reversed-phase, Ultra-High-Pressure Liquid Chromatography (UHPLC) coupled with a Diode Array Detector (DAD) method for the simultaneous determination of Procainamide (PA) and its major metabolite, N-acetylprocainamide (NAPA), in rat plasma (...) the limitations of previous methods, which use large sample volume and complex sample preparation. The devised method was successfully applied to the quantification of PA and NAPA after an intravenous bolus administration of 10 mg/kg procainamide hydrochloride to rats.

2018 Pharmaceutics PubMed

4. Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study (Full text)

Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study Intravenous procainamide and amiodarone are drugs of choice for well-tolerated ventricular tachycardia. However, the choice between them, even according to Guidelines, is unclear. We performed a multicentre randomized open-labelled study to determine the safety and efficacy of intravenous procainamide and amiodarone for the acute treatment (...) of tolerated wide QRS complex (probably ventricular) tachycardia.Patients were randomly assigned to receive intravenous procainamide (10 mg/kg/20 min) or amiodarone (5 mg/kg/20 min). The primary endpoint was the incidence of major predefined cardiac adverse events within 40 min after infusion initiation. Of 74 patients included, 62 could be analysed. The primary endpoint occurred in 3 of 33 (9%) procainamide and 12 of 29 (41%) amiodarone patients (odd ratio, OR = 0.1; 95% confidence interval, CI 0.03-0.6

2016 EvidenceUpdates PubMed

5. Procainamide Inhibits DNA Methylation and Alleviates Multiple Organ Dysfunction in Rats with Endotoxic Shock. (Full text)

Procainamide Inhibits DNA Methylation and Alleviates Multiple Organ Dysfunction in Rats with Endotoxic Shock.

2016 PLoS ONE PubMed

6. In Vivo Imaging of Experimental Melanoma Tumors using the Novel Radiotracer 68Ga-NODAGA-Procainamide (PCA) (Full text)

In Vivo Imaging of Experimental Melanoma Tumors using the Novel Radiotracer 68Ga-NODAGA-Procainamide (PCA) The most aggressive form of skin cancer is the malignant melanoma. Because of its high metastatic potential the early detection of primary melanoma tumors and metastases using non-invasive PET imaging determines the outcome of the disease. Previous studies have already shown that benzamide derivatives, such as procainamide (PCA) specifically bind to melanin pigment. The aim of this study

2017 Journal of Cancer PubMed

7. Stability of Procainamide Injection in Clear Glass Vials and Polyvinyl Chloride Bags (Full text)

Stability of Procainamide Injection in Clear Glass Vials and Polyvinyl Chloride Bags The objective of this study was to evaluate the chemical stability of procainamide hydrochloride, 100 mg/mL, when repackaged in clear glass vials or diluted to 3 mg/mL with normal saline and packaged in polyvinyl chloride (PVC) bags when stored at either 23°C and exposed to light (ETL) or 5°C and protected from light (PFL).Solutions were assayed using a stability-indicating high-performance liquid (...) when stored at 23ºC and ETL or 5ºC and PFL. When further diluted to 3 mg/mL with normal saline and packaged in PVC bags, procainamide was also stable for 193 days at either 23ºC and ETL or 5°C and PFL.The stability of procainamide, 100 mg/mL, repackaged in clear glass vials was 193 days when stored at either 23ºC and ETL or 5ºC or PFL. If diluted further to 3 mg/mL with normal saline and packaged in PVC bags, the drug was also stable for 193 days at either 23ºC and ETL or 5°C and PFL.

2017 Hospital pharmacy PubMed

8. Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study. (Full text)

Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study. Intravenous procainamide and amiodarone are drugs of choice for well-tolerated ventricular tachycardia. However, the choice between them, even according to Guidelines, is unclear. We performed a multicentre randomized open-labelled study to determine the safety and efficacy of intravenous procainamide and amiodarone for the acute treatment (...) of tolerated wide QRS complex (probably ventricular) tachycardia.Patients were randomly assigned to receive intravenous procainamide (10 mg/kg/20 min) or amiodarone (5 mg/kg/20 min). The primary endpoint was the incidence of major predefined cardiac adverse events within 40 min after infusion initiation. Of 74 patients included, 62 could be analysed. The primary endpoint occurred in 3 of 33 (9%) procainamide and 12 of 29 (41%) amiodarone patients (odd ratio, OR = 0.1; 95% confidence interval, CI 0.03-0.6

2017 European Heart Journal PubMed

9. Therapeutic Effects of Procainamide on Endotoxin-Induced Rhabdomyolysis in Rats (Full text)

Therapeutic Effects of Procainamide on Endotoxin-Induced Rhabdomyolysis in Rats Overt systemic inflammatory response is a predisposing mechanism for infection-induced skeletal muscle damage and rhabdomyolysis. Aberrant DNA methylation plays a crucial role in the pathophysiology of excessive inflammatory response. The antiarrhythmic drug procainamide is a non-nucleoside inhibitor of DNA methyltransferase 1 (DNMT1) used to alleviate DNA hypermethylation. Therefore, we evaluated the effects (...) of procainamide on the syndromes and complications of rhabdomyolysis rats induced by lipopolysaccharide (LPS). Rhabdomyolysis animal model was established by intravenous infusion of LPS (5 mg/kg) accompanied by procainamide therapy (50 mg/kg). During the experimental period, the changes of hemodynamics, muscle injury index, kidney function, blood gas, blood electrolytes, blood glucose, and plasma interleukin-6 (IL-6) levels were examined. Kidneys and lungs were exercised to analyze superoxide production

2016 PloS one PubMed

10. Procainamide

Procainamide Procainamide Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Procainamide Procainamide Aka: Procainamide , Pronestyl From (...) ) These images are a random sampling from a Bing search on the term "Procainamide." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Procainamide (C0033216) Definition (MSH) A class Ia antiarrhythmic drug that is structurally-related to PROCAINE. Definition (CSP) derivative of procaine, cardiac depressant used in treatment of cardiac arrhythmias. Concepts Pharmacologic Substance ( T121 ) , Organic Chemical ( T109 ) MSH

2018 FP Notebook

11. Investigation of binding behaviour of procainamide hydrochloride with human serum albumin using synchronous, 3D fluorescence and circular dichroism (Full text)

Investigation of binding behaviour of procainamide hydrochloride with human serum albumin using synchronous, 3D fluorescence and circular dichroism Interaction of procainamide hydrochloride (PAH) with human serum albumin (HSA) is of great significance in understanding the pharmacokinetic and pharmacodynamic mechanisms of the drug. Multi-spectroscopic techniques were used to investigate the binding mode of PAH to HSA and results revealed the presence of static type of quenching mechanism

2016 Journal of Pharmaceutical Analysis PubMed

12. Procainamide infusion in the evaluation of unexplained cardiac arrest: from the Cardiac Arrest Survivors with Preserved Ejection Fraction Registry (CASPER). (PubMed)

Procainamide infusion in the evaluation of unexplained cardiac arrest: from the Cardiac Arrest Survivors with Preserved Ejection Fraction Registry (CASPER). Provocative testing with sodium channel blockers is advocated for the evaluation of unexplained cardiac arrest (UCA) with the primary purpose of unmasking the typical ECG features of Brugada syndrome. The Cardiac Arrest Survivors with Preserved Ejection Fraction Registry (CASPER) systematically assesses subjects with UCA or a family history (...) of sudden death (FHSD).The purpose of this study was to determine the clinical yield of procainamide infusion in a national registry of subjects with either UCA or a FHSD.Subjects with either UCA or a FHSD without evidence of a Brugada pattern at baseline underwent procainamide testing (15 mg/kg to a maximum of 1 g at 50 mg/min). A test was considered positive for Brugada pattern if there was an increase in ST elevation >1 mm or if there was >1 mm of new ST elevation in leads V1 and/or V2. Genetic

2014 Heart Rhythm

13. Comparison of procainamide and mexiletine in prevention of ventricular arrhythmias after acute myocardial infarction. (PubMed)

Comparison of procainamide and mexiletine in prevention of ventricular arrhythmias after acute myocardial infarction. The incidence of ventricular arrhythmias after myocardial infarction has been compared in a controlled study of procainamide, mexiletine, and placebo. Sixty male patients who has sustained a myocardial infarction and had received lignocaine for ventricular tachycardia or ventricular ectopic beats which were R-on-T, multiform, or close-coupled took part. The efficacy of the drugs (...) was evaluated by continuous 24-hour recordings of the electrocardiogram on the 4th and 10th days after admission to the study. Procainamide was given as 500 mg. 4-hourly and mexiletine as 250 mg. 8-hourly with corresponding placebo regimens for 12 days. 77% of patients receiving placebo showed serious ventricular rhythm disorders compared with 33% receiving antiarrhythmic therapy (p smaller than 0.05). Although only 35% of patients receiving procainamide achieved accepted therapeutic plasma concentrations

1975 Lancet

14. Natural antibody to procainamide and procainamide-induced systematic lupus erythematosus. (Full text)

Natural antibody to procainamide and procainamide-induced systematic lupus erythematosus. 5305703 1969 07 09 2013 11 21 0003-4967 28 3 1969 May Annals of the rheumatic diseases Ann. Rheum. Dis. Natural antibody to procainamide and procainamide-induced systematic lupus erythematosus. 328 Russel A S AS Ziff M M eng Journal Article England Ann Rheum Dis 0372355 0003-4967 0 Antibodies, Antinuclear 0 Autoantibodies L39WTC366D Procainamide IM Animals Antibodies, Antinuclear analysis Arthritis (...) , Rheumatoid immunology Autoantibodies analysis Cricetinae Dogs Humans Infant, Newborn Lupus Erythematosus, Systemic chemically induced immunology Procainamide adverse effects Rabbits 1969 5 1 1969 5 1 0 1 1969 5 1 0 0 ppublish 5305703 PMC1031200

1969 Annals of the Rheumatic Diseases PubMed

15. Procainamide

Procainamide Procainamide Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Procainamide Procainamide Aka: Procainamide , Pronestyl From (...) ) These images are a random sampling from a Bing search on the term "Procainamide." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Procainamide (C0033216) Definition (MSH) A class Ia antiarrhythmic drug that is structurally-related to PROCAINE. Definition (CSP) derivative of procaine, cardiac depressant used in treatment of cardiac arrhythmias. Concepts Pharmacologic Substance ( T121 ) , Organic Chemical ( T109 ) MSH

2015 FP Notebook

16. Can procainamide improve the prognosis of patients with ventricular arrhythmias after myocardial infarction? (PubMed)

Can procainamide improve the prognosis of patients with ventricular arrhythmias after myocardial infarction? 348411 1978 07 15 2013 11 21 0907-8916 25 3 1978 Apr Danish medical bulletin Dan Med Bull Can procainamide improve the prognosis of patients with ventricular arrhythmias after myocardial infarction? 121-5 Nielsen B L BL Clausen J J Nielsen J S JS eng Clinical Trial Journal Article Randomized Controlled Trial Denmark Dan Med Bull 0066040 0907-8916 L39WTC366D Procainamide IM Aged (...) Arrhythmias, Cardiac drug therapy etiology Clinical Trials as Topic Drug Evaluation Female Humans Male Middle Aged Myocardial Infarction complications mortality Procainamide therapeutic use Prognosis 1978 4 1 1978 4 1 0 1 1978 4 1 0 0 ppublish 348411

1978 Danish Medical Bulletin

17. Comparative evaluation of procainamide and its main metabolite, N-acetylprocainamide, in the acute treatment of ventricular arrhythmias [proceedings]. (PubMed)

Comparative evaluation of procainamide and its main metabolite, N-acetylprocainamide, in the acute treatment of ventricular arrhythmias [proceedings]. 911617 1977 12 29 2013 11 21 0306-5251 4 5 1977 Oct British journal of clinical pharmacology Br J Clin Pharmacol Comparative evaluation of procainamide and its main metabolite, N-acetylprocainamide, in the acute treatment of ventricular arrhythmias [proceedings]. 632P Karlsson E E Sonnhag C C eng Clinical Trial Comparative Study Journal Article (...) Randomized Controlled Trial England Br J Clin Pharmacol 7503323 0306-5251 L39WTC366D Procainamide IM Acetylation Arrhythmias, Cardiac drug therapy Heart Ventricles Humans Procainamide analogs & derivatives therapeutic use 1977 10 1 1977 10 1 0 1 1977 10 1 0 0 ppublish 911617

1977 British journal of clinical pharmacology

18. Ventricular arrhythmias after acute myocardial infarction treated with procainamide or mexiletine. (PubMed)

Ventricular arrhythmias after acute myocardial infarction treated with procainamide or mexiletine. 327453 1977 08 12 2013 11 21 0032-5473 53 Suppl 1 1977 Postgraduate medical journal Postgrad Med J Ventricular arrhythmias after acute myocardial infarction treated with procainamide or mexiletine. 150-3 Campbell R W RW Dolder M A MA Prescott L F LF Talbot R G RG Murray A A Julian D G DG eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial England Postgrad Med J 0234135 (...) 0032-5473 0 Propylamines 1U511HHV4Z Mexiletine L39WTC366D Procainamide IM Aged Arrhythmias, Cardiac drug therapy etiology Clinical Trials as Topic Humans Male Mexiletine blood therapeutic use Myocardial Infarction complications Procainamide therapeutic use Propylamines therapeutic use 1977 1 1 1977 1 1 0 1 1977 1 1 0 0 ppublish 327453

1977 Postgraduate medical journal

19. Comparative anti-arrhythmic efficacy of mexiletine, procainamide and tolamolol in patients with symptomatic ventricular arrhythmias. (PubMed)

Comparative anti-arrhythmic efficacy of mexiletine, procainamide and tolamolol in patients with symptomatic ventricular arrhythmias. 327454 1977 08 12 2013 11 21 0032-5473 53 Suppl 1 1977 Postgraduate medical journal Postgrad Med J Comparative anti-arrhythmic efficacy of mexiletine, procainamide and tolamolol in patients with symptomatic ventricular arrhythmias. 158-62 Jewitt D E DE Jackson G G McComish M M eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial England (...) Postgrad Med J 0234135 0032-5473 0 Propanolamines 0 Propylamines 1U511HHV4Z Mexiletine L39WTC366D Procainamide IM Adult Aged Arrhythmias, Cardiac drug therapy Clinical Trials as Topic Female Heart Ventricles Humans Male Mexiletine therapeutic use Middle Aged Procainamide therapeutic use Propanolamines therapeutic use Propylamines therapeutic use 1977 1 1 1977 1 1 0 1 1977 1 1 0 0 ppublish 327454

1977 Postgraduate medical journal

20. Therapy of myotonia. A double-blind evaluation of diphenylhydantoin, procainamide, and placebo. (PubMed)

Therapy of myotonia. A double-blind evaluation of diphenylhydantoin, procainamide, and placebo. 5336680 1967 06 02 2013 11 21 0028-3878 17 4 1967 Apr Neurology Neurology Therapy of myotonia. A double-blind evaluation of diphenylhydantoin, procainamide, and placebo. 359-67 Munsat T L TL eng Clinical Trial Comparative Study Controlled Clinical Trial Journal Article Randomized Controlled Trial United States Neurology 0401060 0028-3878 0 Placebos 6158TKW0C5 Phenytoin L39WTC366D Procainamide IM Cell (...) Membrane Permeability drug effects Clinical Trials as Topic Electrocardiography Humans Muscular Dystrophies drug therapy Myotonia Congenita drug therapy Phenytoin therapeutic use Placebos Procainamide therapeutic use 1967 4 1 1967 4 1 0 1 1967 4 1 0 0 ppublish 5336680

1967 Neurology

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