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Priapism

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101. Priapism Impact Profile Questionnaire: Development and Initial Validation. Full Text available with Trip Pro

Priapism Impact Profile Questionnaire: Development and Initial Validation. To create and evaluate a psychometric instrument that measures the impact of experiencing priapism from the patient perspective.The research protocol consisted of several phases as follows: (1) generating items, (2) composing a patient questionnaire, (3) administering the questionnaire to patients with both active and remitted (≥1 year without priapism episodes) histories of priapism, (4) performing internal consistency (...) and criterion-oriented validity analyses in correlation with clinical histories and erectile function assessment tools, and (5) ascertaining psychometric properties of the instrument.The final instrument comprised a 12-item Priapism Impact Profile (PIP) questionnaire, representing the following 3 domains adversely impacted by priapism: quality of life (QoL), sexual function (SF), and physical wellness (PW), with higher scores indicating inferior experience in respective domains. Internal consistency

2015 Urology

102. Sickle Cell Disease in Priapism: Disparity in Care? (Abstract)

Sickle Cell Disease in Priapism: Disparity in Care? To determine the effect of sickle cell disease (SCD) on hospital resource use among patients admitted for priapism.Using the Nationwide Inpatient Sample, a weighted sample of 12,547 patients was selected with a primary diagnosis of priapism from 2002 to 2011. Baseline differences for patient demographics and hospital characteristics were compared between SCD and non-SCD patients. Multivariate analysis was performed to identify the effect (...) patients did have an operation, it was performed later in the admission (mean, 0.87 vs 0.47 days; P <.001). SCD was not a significant predictor of increased cost (OR, 1.02; P = .869).SCD patients represent a demographically distinct subgroup of priapism patients with different patterns of resource use manifested by longer hospital stays and more blood transfusions. Moreover, despite evidence that immediate treatment of priapism results in improved erectile function outcomes, SCD patients had less

2015 Urology

103. Pediatric Priapism Secondary to Psychotherapeutic Medications. (Abstract)

Pediatric Priapism Secondary to Psychotherapeutic Medications. With the increased application of many different drug classes for the treatment of psychiatric conditions in children, the incidence of priapism has also increased. Priapism of pharmacotherapeutic etiology in the pediatric population is a complex and poorly understood entity that continues to present new management challenges for clinicians. We present 2 cases of pediatric priapism thought to be secondary to the use (...) of pharmacotherapeutic agents. In the first case, sertraline, an antidepressant, and in the second case, atomoxetine, a nonstimulant medication, are implicated as the most likely causative agents. Both medications have a growing association with priapism in the literature. Copyright © 2015 Elsevier Inc. All rights reserved.

2015 Urology

104. Prevention of Ischemic Priapism in Sickle Cell Disease: Sildenafil. (Abstract)

Prevention of Ischemic Priapism in Sickle Cell Disease: Sildenafil. 26431892 2016 04 21 2018 12 02 1527-9995 86 6 2015 Dec Urology Urology Prevention of Ischemic Priapism in Sickle Cell Disease: Sildenafil: Commentary on: Randomized Controlled Trial of Sildenafil for Preventing Recurrent Ischemic Priapism in Sickle Cell Disease. 1055-6 10.1016/j.urology.2015.07.003 S0090-4295(15)00650-0 Shakeri Aria A Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario, Canada (...) Phosphodiesterase 5 Inhibitors therapeutic use Piperazines therapeutic use Priapism etiology prevention & control Sulfones therapeutic use 2015 07 07 2015 07 07 2015 07 10 2015 10 4 6 0 2015 10 4 6 0 2016 4 22 6 0 ppublish 26431892 S0090-4295(15)00650-0 10.1016/j.urology.2015.07.003

2015 Urology Controlled trial quality: uncertain

105. Post-Traumatic High Flow Priapism: Multidetector Computed Tomography Demonstration. (Abstract)

Post-Traumatic High Flow Priapism: Multidetector Computed Tomography Demonstration. High-flow priapism due to pseudoaneurysm is a relatively rare urologic condition. Clear anatomic delineation of the number and origin of feeding vessels facilitates pre-embolization planning. Computed tomographic angiography can afford a three-dimensional display of the feeding vessels. We present a 26-year-old man with post-traumatic high-flow priapism, which is the first case studied with computed tomographic

2015 Urology

106. Subacute Hemolysis in Sickle Cell Mice Causes Priapism Secondary to NO Imbalance and PDE5 Dysregulation. Full Text available with Trip Pro

Subacute Hemolysis in Sickle Cell Mice Causes Priapism Secondary to NO Imbalance and PDE5 Dysregulation. Recent research suggests that priapism in sickle cell disease (SCD) is due to dysregulation of penile erection homeostasis including alteration of nitric oxide synthase (NOS) and phosphodiesterase type 5 (PDE5) activities by excessive levels of reactive oxygen species (ROS) released during hemolysis. It is unknown if subacute exposure to hemolysis is sufficient or if chronic reconditioning (...) of erectile tissues is required for perturbation of homeostatic pathways and whether PDE5 inhibitor (PDE5I) treatment can restore erectile homeostasis in the subacute setting.The aim of this study was to investigate the effects of subacute hemolysis (3-month exposure) on priapism and NO pathway regulation.Mice underwent bone marrow transplantation with either SCD (BM-SS) or wild-type (WT) bone marrow. BM-SS mice were treated with sildenafil 100 mg/kg/day. We measured intracavernous pressure (ICP

2015 Journal Of Sexual Medicine

107. Proceedings: Surgical treatment of initial priapism and recurrent priapism. Full Text available with Trip Pro

Proceedings: Surgical treatment of initial priapism and recurrent priapism. 4519102 1974 02 01 2018 11 13 0035-9157 66 10 1973 Oct Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Proceedings: Surgical treatment of initial priapism and recurrent priapism. 1051-2 Griffiths D A DA Webb A J AJ eng Journal Article England Proc R Soc Med 7505890 0035-9157 9005-49-6 Heparin ZTI6C33Q2Q Guanethidine IM Adult Guanethidine adverse effects Hemodialysis, Home adverse effects Heparin adverse (...) effects Humans Leukemia, Myeloid complications Male Middle Aged Priapism surgery Saphenous Vein surgery 1973 10 1 1973 10 1 0 1 1973 10 1 0 0 ppublish 4519102 PMC1645605 J Urol. 1972 Jul;108(1):97-100 4556046 Invest Urol. 1964 Mar;1:509-13 14130594

1973 Proceedings of the Royal Society of Medicine

108. Management of Priapism

Management of Priapism Priapism Guideline - American Urological Association advertisement Toggle navigation About Us About the AUA Membership AUA Governance Industry Relations Education AUAUniversity Education Products & Resources Normal Histology and Important Histo-anatomic Structures Urinary Bladder Prostate Kidney Renovascular Diseases Andrenal Gland Testis Paratesticular Tumors Penis Retroperitoneum Cytology Online Learning For Medical Students Exams/LLL/Certifications Exam Prep Research (...) and Reporting Patient Education Management of Priapism (2010) Published 2003; Reviewed and Validity Confirmed 2010 Priapism, a relatively uncommon disorder, is a medical emergency. Although not all forms of priapism require immediate intervention, ischemic priapism is associated with progressive fibrosis of the cavernosal tissues and erectile dysfunction. This clinical guideline discusses evaluation, ischemic priapism, non-ischemic priapism, and stuttering priapism. [pdf] Panel Members Drogo K. Montague, MD

2010 American Urological Association

109. Malignant priapism secondary to isolated penile metastasis from a renal pelvic carcinoma Full Text available with Trip Pro

Malignant priapism secondary to isolated penile metastasis from a renal pelvic carcinoma We report a case of isolated penile metastasis from renal pelvic carcinoma in a 69-year-old man with malignant priapism. The patient had radical resection of the renal pelvic carcinoma 2 months earlier with urothelial carcinoma (UC) and sarcomatoid differentiation histology. Physical examination showed no visible skin lesions, but a palpable hard nodule was present over the penile shaft. The imaging studies (...) did not reveal other metastases. Cavernous-Glans shunt and nodule resection were performed, and histological examination showed metastasis UC with sarcomatoid differentiation. To our knowledge, we describe the first case of malignant priapism due to isolated penile metastasis of renal pelvic carcinoma.

2014 Canadian Urological Association Journal

110. Priapism in a patient with sickle cell trait using marijuana Full Text available with Trip Pro

Priapism in a patient with sickle cell trait using marijuana A 22-year-old man with a history of multiple episodes of priapism presented to the emergency room with an erection lasting more than 48 h after conservative management failed at home. He had no known family history of sickle cell disease or trait. He was haemodynamically stable. Physical examination revealed an enlarged, tender penis. Laboratory data revealed a positive sickle solubility test. Haemoglobin electrophoresis revealed (...) sickle cell trait and urine drug screen was positive for cannabinoids. Initial management was attempted with intracavernosal phenylephrine without any success. The patient underwent a limited El-Ghorab procedure on the right corpora cavernosa but the priapism did not resolve adequately. Two days later, the patient had to undergo a bilateral El-Ghorab procedure and achieved complete resolution of the priapism.

2014 BMJ case reports

111. Priapism Associated with Homozygous Hb E State: A Causal Association or an Incidental Finding? Full Text available with Trip Pro

Priapism Associated with Homozygous Hb E State: A Causal Association or an Incidental Finding? 27408418 2016 07 13 2018 11 13 0971-4502 32 Suppl 1 2016 Jun Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion Indian J Hematol Blood Transfus Priapism Associated with Homozygous Hb E State: A Causal Association or an Incidental Finding? 301-3 10.1007/s12288-014-0459-0 Venkatesan S S Department of Hematology, All India

2014 Indian Journal of Hematology & Blood Transfusion

112. A Case of Painless Pediatric Priapism and Cough. (Abstract)

A Case of Painless Pediatric Priapism and Cough. Pediatric priapism can be a medical emergency but is not a common complaint seen in pediatric emergency department. Priapism in a previously healthy child is also rare. We report a case of painless stuttering priapism associated with an acute Mycoplasma pneumoniae infection in a previously healthy boy.

2014 Pediatric Emergency Care

113. Randomized Controlled Trial of Sildenafil for Preventing Recurrent Ischemic Priapism in Sickle Cell Disease. Full Text available with Trip Pro

Randomized Controlled Trial of Sildenafil for Preventing Recurrent Ischemic Priapism in Sickle Cell Disease. Successful preventive therapy for ischemic priapism, a disorder of penile erection with major physical and psychologic consequences, is limited. We conducted a randomized, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of sildenafil by a systematic dosing protocol to prevent recurrent ischemic priapism associated with sickle cell disease.Thirteen (...) patients with sickle cell disease reporting priapism recurrences at least twice weekly were randomized to receive sildenafil 50 mg or placebo daily, unassociated with sleep or sexual activity, for 8 weeks, followed by open-label use of this sildenafil regimen for an additional 8 weeks.Priapism frequency reduction by 50% did not differ between sildenafil and placebo groups by intention-to-treat or per protocol analyses (P = 1.0). However, during open-label assessment, 5 of 8 patients (62.5

2014 The American journal of medicine Controlled trial quality: predicted high

114. Penile prosthesis insertion in patients with refractory ischaemic priapism: early vs delayed implantation. (Abstract)

Penile prosthesis insertion in patients with refractory ischaemic priapism: early vs delayed implantation. To compare the long-term results of early and delayed insertion of a penile prosthesis (PP) in men with refractory ischaemic priapism (IP).Early insertion of a PP was carried out in 68 men with IP within a median of 7 days from the onset of priapism, while 27 had delayed insertion after a median of 5 months. The results for sexual ability, satisfaction and subjective penile shortening were

2014 BJU international

115. Hematoma or "partial priapism" in the proximal part of the corpus cavernosum. (Abstract)

Hematoma or "partial priapism" in the proximal part of the corpus cavernosum. "Partial priapism" is a rare disorder. Therapy is controversial in literature.To show that conservative treatment leads to a full functional recovery of this condition.This report describes a case of a hematoma or "partial priapism" in the proximal part of the right corpus cavernosum.Complete functional recovery after conservative treatment with nonsteroidal anti-inflammatory drugs."Partial priapism" probably

2014 Journal Of Sexual Medicine

116. Prevention of recurrent ischemic priapism with ketoconazole: evolution of a treatment protocol and patient outcomes. (Abstract)

Prevention of recurrent ischemic priapism with ketoconazole: evolution of a treatment protocol and patient outcomes. The management of recurrent ischemic priapism (RIP) is not clearly defined. Ketoconazole (KTZ) is used to treat RIP and produces a temporary hypogonadal state to suppress sleep-related erections (SREs), which often evolve into episodes of ischemic priapism in this population.We review our experience to prevent RIP using KTZ and present our outcomes using a decreased dose (...) was the prevention of RIP using KTZ. Secondary outcomes included side effects secondary to KTZ use and patient satisfaction.All men experienced daily or almost daily episodes of prolonged, painful erections prior to starting KTZ. The mean number of emergency room (ER) visits per patient prior to starting KTZ was 6.5. No patient required an ER visit for RIP while on KTZ. Sixteen of 17 patients (94%) had complete resolution of priapism while on KTZ with effects noted immediately after starting therapy

2014 Journal Of Sexual Medicine

117. An unexpected etiology of priapism: infection-related anti-protein s antibodies. (Abstract)

An unexpected etiology of priapism: infection-related anti-protein s antibodies. In adolescents, the occurrence of priapism is commonly related to sickle cell disease and rarely to other causes. We hereby report a case of priapism due to an acquired protein S (PS) deficiency.The aim of this study was to describe a young man who developed a priapism with a thrombosis of the corpora cavernosa associated with an anti-PS antibody (anti-PS Ab).One week after the onset of an influenza-like illness (...) , a young male developed multiple extensive venous thromboses including a thrombosis of the corpora cavernosa causing painful partial priapism. These thromboses along with purpuric lesions with necrotic vesicles of the feet skin were linked to an acquired PS deficiency due to an anti-PS Ab. The optimal treatment of anti-PS Ab-associated thrombosis is debated but we chose to initiate (i) heparin; (ii) corticosteroids; and (iii) plasmapheresis.Even if priapism lasted more than 4 days, a full recovery

2014 Journal Of Sexual Medicine

118. Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression Full Text available with Trip Pro

Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression Priapism is featured with prolonged and painful penile erection and is prevalent among males with sickle cell disease (SCD). The disorder is a dangerous urological and hematological emergency since it is associated with ischemic tissue damage and erectile disability. Here we report that phosphodiesterase-5 (PDE5) gene expression and PDE activity is significantly reduced (...) in penile tissues of two independent priapic models: SCD mice and adenosine deaminase (ADA)-deficient mice. Moreover, using ADA enzyme therapy to reduce adenosine or a specific antagonist to block A(2B) adenosine receptor (ADORA2B) signaling, we successfully attenuated priapism in both ADA(-/-) and SCD mice by restoring penile PDE5 gene expression to normal levels. This finding led us to further discover that excess adenosine signaling via ADORA2B activation directly reduces PDE5 gene expression

2014 The FASEB Journal

119. Priapism (Diagnosis)

Priapism (Diagnosis) Priapism: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNDM3MjM3LW92ZXJ2aWV3 processing > Priapism Updated: Nov 28, 2016 Author: Hosam S Al (...) -Qudah, MD; Chief Editor: Edward David Kim, MD, FACS Share Email Print Feedback Close Sections Sections Priapism Overview Practice Essentials Priapism (see the image below) is an involuntary, prolonged erection unrelated to sexual stimulation and unrelieved by ejaculation. This condition is a true urologic emergency, and early intervention allows the best chance for functional recovery. Priapism. Corporeal relaxation causes external pressure on the emissary veins exiting the tunica albuginea

2014 eMedicine.com

120. Priapism (Treatment)

Priapism (Treatment) Priapism Treatment & Management: Approach Considerations, Prehospital Care, Low-Flow Priapism Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNDM3MjM3LXRyZWF0bWVudA== processing > Priapism (...) Treatment & Management Updated: Nov 28, 2016 Author: Hosam S Al-Qudah, MD; Chief Editor: Edward David Kim, MD, FACS Share Email Print Feedback Close Sections Sections Priapism Treatment Approach Considerations Appropriate treatment of priapism varies, depending on whether the patient has low-flow or high-flow priapism. Most priapism cases are the low-flow ischemic type. Treatment of low-flow priapism should progress in a stepwise fashion, starting with therapeutic aspiration, with or without irrigation

2014 eMedicine.com

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