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Priapism

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81. Trends in Sickle-Cell-Disease-Related Priapism in U.S. Children's Hospitals. Full Text available with Trip Pro

Trends in Sickle-Cell-Disease-Related Priapism in U.S. Children's Hospitals. To define rates of priapism diagnosis and inpatient admission among males with sickle cell disease (SCD).We retrospectively reviewed the Pediatric Health Information System database for males aged <21 years treated 2004-2012. We identified patients with SCD and priapism based on the International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis codes. Logistic regression and generalized (...) estimating equation models were used to control for confounding and to adjust for within-hospital clustering of similar patients.We identified 17,186 males who were admitted 137,710 times during the study period. Of these, 362 (2.1%) were diagnosed with priapism on 748 admissions. There was a significant decrease in the number of priapism admissions among patients with SCD over time (0.81% in 2004 to 0.44% in 2012, P  <  .001). The number of patients diagnosed with SCD-related priapism varied over time

2015 Urology

82. Prevention of Ischemic Priapism in Sickle Cell Disease: Sildenafil. (Abstract)

Prevention of Ischemic Priapism in Sickle Cell Disease: Sildenafil. 26431892 2016 04 21 2018 12 02 1527-9995 86 6 2015 Dec Urology Urology Prevention of Ischemic Priapism in Sickle Cell Disease: Sildenafil: Commentary on: Randomized Controlled Trial of Sildenafil for Preventing Recurrent Ischemic Priapism in Sickle Cell Disease. 1055-6 10.1016/j.urology.2015.07.003 S0090-4295(15)00650-0 Shakeri Aria A Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario, Canada (...) Phosphodiesterase 5 Inhibitors therapeutic use Piperazines therapeutic use Priapism etiology prevention & control Sulfones therapeutic use 2015 07 07 2015 07 07 2015 07 10 2015 10 4 6 0 2015 10 4 6 0 2016 4 22 6 0 ppublish 26431892 S0090-4295(15)00650-0 10.1016/j.urology.2015.07.003

2015 Urology Controlled trial quality: uncertain

83. Subacute Hemolysis in Sickle Cell Mice Causes Priapism Secondary to NO Imbalance and PDE5 Dysregulation. Full Text available with Trip Pro

Subacute Hemolysis in Sickle Cell Mice Causes Priapism Secondary to NO Imbalance and PDE5 Dysregulation. Recent research suggests that priapism in sickle cell disease (SCD) is due to dysregulation of penile erection homeostasis including alteration of nitric oxide synthase (NOS) and phosphodiesterase type 5 (PDE5) activities by excessive levels of reactive oxygen species (ROS) released during hemolysis. It is unknown if subacute exposure to hemolysis is sufficient or if chronic reconditioning (...) of erectile tissues is required for perturbation of homeostatic pathways and whether PDE5 inhibitor (PDE5I) treatment can restore erectile homeostasis in the subacute setting.The aim of this study was to investigate the effects of subacute hemolysis (3-month exposure) on priapism and NO pathway regulation.Mice underwent bone marrow transplantation with either SCD (BM-SS) or wild-type (WT) bone marrow. BM-SS mice were treated with sildenafil 100 mg/kg/day. We measured intracavernous pressure (ICP

2015 Journal Of Sexual Medicine

84. Post-Traumatic High Flow Priapism: Multidetector Computed Tomography Demonstration. (Abstract)

Post-Traumatic High Flow Priapism: Multidetector Computed Tomography Demonstration. High-flow priapism due to pseudoaneurysm is a relatively rare urologic condition. Clear anatomic delineation of the number and origin of feeding vessels facilitates pre-embolization planning. Computed tomographic angiography can afford a three-dimensional display of the feeding vessels. We present a 26-year-old man with post-traumatic high-flow priapism, which is the first case studied with computed tomographic

2015 Urology

85. Does pentoxifylline enhance the recovery of erectile function after a T-shunt procedure for prolonged ischaemic priapism? A prospective randomised controlled trial. Full Text available with Trip Pro

Does pentoxifylline enhance the recovery of erectile function after a T-shunt procedure for prolonged ischaemic priapism? A prospective randomised controlled trial. To evaluate the role of oral pentoxifylline for enhancing the recovery of erectile function (EF) in patients who had a T-shunt, a technically simple procedure for treating prolonged ischaemic priapism, as the recovery of EF has been reported in many patients treated by this procedure.This prospective randomised study was conducted (...) on 40 patients with prolonged ischaemic priapism treated with a T-shunt. Patients were randomly divided into two groups; group A received oral pentoxifylline from the second day after surgery for 3 months, and group B received placebo. Patients were followed for 18 months.The pain resolved in all patients, and EF recovered in 15 patients in group A and 10 in group B within 3 months. All patients but three had recovery of EF within the 18-month follow-up. Six patients had recovery of EF by using

2015 Arab journal of urology Controlled trial quality: uncertain

86. Simultaneous urethrocutaneous and urethrocavernous fistula after proximal corporospongiosal shunt for priapism. (Abstract)

Simultaneous urethrocutaneous and urethrocavernous fistula after proximal corporospongiosal shunt for priapism. Proximal corporospongiosal shunts are used for the most refractory cases of priapism. Here, we present the case of a 58-year-old man whose priapism was only partially responsive to phenylephrine injections and distal shunting. Proximal shunting was required, and he subsequently developed fistulization of the proximal penile urethra into the skin and the corpora cavernosa

2015 Urology

87. Malleable penile prosthesis is a cost-effective treatment for refractory ischemic priapism. (Abstract)

Malleable penile prosthesis is a cost-effective treatment for refractory ischemic priapism. Refractory ischemic priapism (RIP) can be difficult to treat, consuming significant healthcare-related resources. Acute insertion of a malleable penile prosthesis (MPP) has been reported as an effective therapy that treats the priapism and restores sexual function.We report our 6-year, urban public hospital experience with acute insertion of MPP in patients with RIP.We retrospectively reviewed (...) the records of patients receiving MPPs for RIP from 2007 to 2013. Data analyzed included duration of erection, number of emergency room (ER) visits, hospital admissions, days of hospitalization, and postoperative course. Costs were estimated using standard Medicare reimbursement rates.Healthcare-related costs of treatment of RIP episodes in men presenting to our institution.During the study period, 14 men underwent MPP placement acutely for refractory priapism. Thirteen presented with RIP, and one had

2015 Journal Of Sexual Medicine

88. Erectile dysfunction after sickle cell disease-associated recurrent ischemic priapism: profile and risk factors. Full Text available with Trip Pro

Erectile dysfunction after sickle cell disease-associated recurrent ischemic priapism: profile and risk factors. Risk factors associated with erectile dysfunction (ED) that results from recurrent ischemic priapism (RIP) in sickle cell disease (SCD) are incompletely defined.This study aims to determine and compare ED risk factors associated with SCD and non-SCD-related "minor" RIP, defined as having ≥2 episodes of ischemic priapism within the past 6 months, with the majority (>75%) of episodes (...) lasting <5 hours.We performed a retrospective study of RIP in SCD and non-SCD patients presenting from June 2004 to March 2014 using the International Index of Erectile Function (IIEF), IIEF-5, and priapism-specific questionnaires.Prevalence rates and risk factor correlations for ED associated with RIP.The study was comprised of 59 patients (40 SCD [mean age 28.2 ± 8.9 years] and 19 non-SCD [15 idiopathic and four drug-related etiologies] [mean age 32.6 ± 11.7 years]). Nineteen of 40 (47.5%) SCD

2015 Journal Of Sexual Medicine

89. Penile Doppler ultrasound in men with stuttering priapism and sickle cell disease-a labile baseline diastolic velocity is a characteristic finding. (Abstract)

Penile Doppler ultrasound in men with stuttering priapism and sickle cell disease-a labile baseline diastolic velocity is a characteristic finding. Stuttering priapism (SP) is seen in sickle cell disease (SCD) and characterized by short-lived painful erections. Imbalanced vascular tone is the postulated cause and this may be reflected in changes in baseline penile blood flow as measured using penile Doppler ultrasound (PDU).The aim of this study was to investigate the baseline penile blood flow

2015 Journal Of Sexual Medicine

90. Cavernosal hematoma mimicking priapism. (Abstract)

Cavernosal hematoma mimicking priapism. We present a case of corpus cavernosum hematoma mimicking priapism. A 42-year-old man presented to the emergency room with penile pain and partial erection. Examination revealed partial erection and palpable space-occupying lesion of the corpus cavernosum without lymphadenopathy. Malignant workup was negative. Imaging assisted in diagnosis of unilateral hematoma of the corpus cavernosum. The lesion spontaneously resolved without the need for intervention

2015 Urology

91. Priapism Impact Profile Questionnaire: Development and Initial Validation. Full Text available with Trip Pro

Priapism Impact Profile Questionnaire: Development and Initial Validation. To create and evaluate a psychometric instrument that measures the impact of experiencing priapism from the patient perspective.The research protocol consisted of several phases as follows: (1) generating items, (2) composing a patient questionnaire, (3) administering the questionnaire to patients with both active and remitted (≥1 year without priapism episodes) histories of priapism, (4) performing internal consistency (...) and criterion-oriented validity analyses in correlation with clinical histories and erectile function assessment tools, and (5) ascertaining psychometric properties of the instrument.The final instrument comprised a 12-item Priapism Impact Profile (PIP) questionnaire, representing the following 3 domains adversely impacted by priapism: quality of life (QoL), sexual function (SF), and physical wellness (PW), with higher scores indicating inferior experience in respective domains. Internal consistency

2015 Urology

92. Sickle Cell Disease in Priapism: Disparity in Care? (Abstract)

Sickle Cell Disease in Priapism: Disparity in Care? To determine the effect of sickle cell disease (SCD) on hospital resource use among patients admitted for priapism.Using the Nationwide Inpatient Sample, a weighted sample of 12,547 patients was selected with a primary diagnosis of priapism from 2002 to 2011. Baseline differences for patient demographics and hospital characteristics were compared between SCD and non-SCD patients. Multivariate analysis was performed to identify the effect (...) patients did have an operation, it was performed later in the admission (mean, 0.87 vs 0.47 days; P <.001). SCD was not a significant predictor of increased cost (OR, 1.02; P = .869).SCD patients represent a demographically distinct subgroup of priapism patients with different patterns of resource use manifested by longer hospital stays and more blood transfusions. Moreover, despite evidence that immediate treatment of priapism results in improved erectile function outcomes, SCD patients had less

2015 Urology

93. Pediatric Priapism Secondary to Psychotherapeutic Medications. (Abstract)

Pediatric Priapism Secondary to Psychotherapeutic Medications. With the increased application of many different drug classes for the treatment of psychiatric conditions in children, the incidence of priapism has also increased. Priapism of pharmacotherapeutic etiology in the pediatric population is a complex and poorly understood entity that continues to present new management challenges for clinicians. We present 2 cases of pediatric priapism thought to be secondary to the use (...) of pharmacotherapeutic agents. In the first case, sertraline, an antidepressant, and in the second case, atomoxetine, a nonstimulant medication, are implicated as the most likely causative agents. Both medications have a growing association with priapism in the literature. Copyright © 2015 Elsevier Inc. All rights reserved.

2015 Urology

94. Proceedings: Surgical treatment of initial priapism and recurrent priapism. Full Text available with Trip Pro

Proceedings: Surgical treatment of initial priapism and recurrent priapism. 4519102 1974 02 01 2018 11 13 0035-9157 66 10 1973 Oct Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Proceedings: Surgical treatment of initial priapism and recurrent priapism. 1051-2 Griffiths D A DA Webb A J AJ eng Journal Article England Proc R Soc Med 7505890 0035-9157 9005-49-6 Heparin ZTI6C33Q2Q Guanethidine IM Adult Guanethidine adverse effects Hemodialysis, Home adverse effects Heparin adverse (...) effects Humans Leukemia, Myeloid complications Male Middle Aged Priapism surgery Saphenous Vein surgery 1973 10 1 1973 10 1 0 1 1973 10 1 0 0 ppublish 4519102 PMC1645605 J Urol. 1972 Jul;108(1):97-100 4556046 Invest Urol. 1964 Mar;1:509-13 14130594

1973 Proceedings of the Royal Society of Medicine

95. Management of Priapism

Management of Priapism Priapism Guideline - American Urological Association advertisement Toggle navigation About Us About the AUA Membership AUA Governance Industry Relations Education AUAUniversity Education Products & Resources Normal Histology and Important Histo-anatomic Structures Urinary Bladder Prostate Kidney Renovascular Diseases Andrenal Gland Testis Paratesticular Tumors Penis Retroperitoneum Cytology Online Learning For Medical Students Exams/LLL/Certifications Exam Prep Research (...) and Reporting Patient Education Management of Priapism (2010) Published 2003; Reviewed and Validity Confirmed 2010 Priapism, a relatively uncommon disorder, is a medical emergency. Although not all forms of priapism require immediate intervention, ischemic priapism is associated with progressive fibrosis of the cavernosal tissues and erectile dysfunction. This clinical guideline discusses evaluation, ischemic priapism, non-ischemic priapism, and stuttering priapism. [pdf] Panel Members Drogo K. Montague, MD

2010 American Urological Association

96. Malignant priapism secondary to isolated penile metastasis from a renal pelvic carcinoma Full Text available with Trip Pro

Malignant priapism secondary to isolated penile metastasis from a renal pelvic carcinoma We report a case of isolated penile metastasis from renal pelvic carcinoma in a 69-year-old man with malignant priapism. The patient had radical resection of the renal pelvic carcinoma 2 months earlier with urothelial carcinoma (UC) and sarcomatoid differentiation histology. Physical examination showed no visible skin lesions, but a palpable hard nodule was present over the penile shaft. The imaging studies (...) did not reveal other metastases. Cavernous-Glans shunt and nodule resection were performed, and histological examination showed metastasis UC with sarcomatoid differentiation. To our knowledge, we describe the first case of malignant priapism due to isolated penile metastasis of renal pelvic carcinoma.

2014 Canadian Urological Association Journal

97. Priapism in a patient with sickle cell trait using marijuana Full Text available with Trip Pro

Priapism in a patient with sickle cell trait using marijuana A 22-year-old man with a history of multiple episodes of priapism presented to the emergency room with an erection lasting more than 48 h after conservative management failed at home. He had no known family history of sickle cell disease or trait. He was haemodynamically stable. Physical examination revealed an enlarged, tender penis. Laboratory data revealed a positive sickle solubility test. Haemoglobin electrophoresis revealed (...) sickle cell trait and urine drug screen was positive for cannabinoids. Initial management was attempted with intracavernosal phenylephrine without any success. The patient underwent a limited El-Ghorab procedure on the right corpora cavernosa but the priapism did not resolve adequately. Two days later, the patient had to undergo a bilateral El-Ghorab procedure and achieved complete resolution of the priapism.

2014 BMJ case reports

98. Priapism Associated with Homozygous Hb E State: A Causal Association or an Incidental Finding? Full Text available with Trip Pro

Priapism Associated with Homozygous Hb E State: A Causal Association or an Incidental Finding? 27408418 2016 07 13 2018 11 13 0971-4502 32 Suppl 1 2016 Jun Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion Indian J Hematol Blood Transfus Priapism Associated with Homozygous Hb E State: A Causal Association or an Incidental Finding? 301-3 10.1007/s12288-014-0459-0 Venkatesan S S Department of Hematology, All India

2014 Indian Journal of Hematology & Blood Transfusion

99. A Case of Painless Pediatric Priapism and Cough. (Abstract)

A Case of Painless Pediatric Priapism and Cough. Pediatric priapism can be a medical emergency but is not a common complaint seen in pediatric emergency department. Priapism in a previously healthy child is also rare. We report a case of painless stuttering priapism associated with an acute Mycoplasma pneumoniae infection in a previously healthy boy.

2014 Pediatric Emergency Care

100. Randomized Controlled Trial of Sildenafil for Preventing Recurrent Ischemic Priapism in Sickle Cell Disease. Full Text available with Trip Pro

Randomized Controlled Trial of Sildenafil for Preventing Recurrent Ischemic Priapism in Sickle Cell Disease. Successful preventive therapy for ischemic priapism, a disorder of penile erection with major physical and psychologic consequences, is limited. We conducted a randomized, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of sildenafil by a systematic dosing protocol to prevent recurrent ischemic priapism associated with sickle cell disease.Thirteen (...) patients with sickle cell disease reporting priapism recurrences at least twice weekly were randomized to receive sildenafil 50 mg or placebo daily, unassociated with sleep or sexual activity, for 8 weeks, followed by open-label use of this sildenafil regimen for an additional 8 weeks.Priapism frequency reduction by 50% did not differ between sildenafil and placebo groups by intention-to-treat or per protocol analyses (P = 1.0). However, during open-label assessment, 5 of 8 patients (62.5

2014 The American journal of medicine Controlled trial quality: predicted high

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