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Priapism

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81. Beneficial Effect of the Nitric Oxide Donor Compound 3-(1,3-Dioxoisoindolin-2-yl)Benzyl Nitrate on Dysregulated Phosphodiesterase 5, NADPH Oxidase, and Nitrosative Stress in the Sickle Cell Mouse Penis: Implication for Priapism Treatment Full Text available with Trip Pro

Beneficial Effect of the Nitric Oxide Donor Compound 3-(1,3-Dioxoisoindolin-2-yl)Benzyl Nitrate on Dysregulated Phosphodiesterase 5, NADPH Oxidase, and Nitrosative Stress in the Sickle Cell Mouse Penis: Implication for Priapism Treatment Patients with sickle cell disease (SCD) display priapism, and dysregulated nitric oxide (NO) pathway may contribute to this condition. However, current therapies offered for the prevention of priapism in SCD are few. The 3-(1,3-dioxoisoindolin-2-yl)benzyl (...) and oxidative stress in erectile tissue. Wild-type, SCD, and dNOS-/- mice were treated with compound 4C (100 μmol/kg/d, 3 weeks). Intracavernosal pressure in anesthetized mice was evaluated. Corpus cavernosum tissue was dissected free and mounted in organ baths. SCD and dNOS-/- mice displayed a priapism phenotype, which was reversed by compound 4C treatment. Increased corpus cavernosum relaxant responses to acetylcholine and electrical-field stimulation were reduced by 4C in SCD mice. Likewise, increased

2016 The Journal of pharmacology and experimental therapeutics

82. Priapism as the Presenting Manifestation of Multiple Myeloma Full Text available with Trip Pro

Priapism as the Presenting Manifestation of Multiple Myeloma 28194073 2018 11 13 0971-4502 33 1 2017 Mar Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion Indian J Hematol Blood Transfus Priapism as the Presenting Manifestation of Multiple Myeloma. 133-136 10.1007/s12288-016-0722-7 Sahu Kamal Kant KK Department of Internal Medicine, P.G.I.M.E.R, Union Territory of Chandigarh, 160012 India. Mishra Kundan K Department

2016 Indian Journal of Hematology & Blood Transfusion

83. Embolization Treatment of High-Flow Priapism Full Text available with Trip Pro

Embolization Treatment of High-Flow Priapism Priapism is prolonged erection that persists beyond or is unrelated to sexual stimulation. There are two main types of priapism: high flow and low flow. The treatment of priapism will differ depending on the diagnosis of these two different types. In particular, interventional radiology plays a key role in treating patients with high-flow priapism. This article will review the diagnosis and treatment of the high-flow priapism.

2016 Seminars in interventional radiology

84. Correction: Emergency Department Visits and Inpatient Admissions Associated with Priapism among Males with Sickle Cell Disease in the United States, 2006–2010 Full Text available with Trip Pro

Correction: Emergency Department Visits and Inpatient Admissions Associated with Priapism among Males with Sickle Cell Disease in the United States, 2006–2010 [This corrects the article DOI: 10.1371/journal.pone.0153257.].

2016 PloS one

85. Priapism and renal colic in a patient treated with duloxetine Full Text available with Trip Pro

Priapism and renal colic in a patient treated with duloxetine Antidepressant medications are associated with a variety of genitourinary and adverse sexual effects, such as urinary hesitation, priapism, and delayed ejaculation. Here, we report a case of priapism and renal colic following initiation of duloxetine in a patient with history of tolerated selective serotonin reuptake inhibitor treatment. To our knowledge, this represents the first report of priapism and renal colic associated

2016 The Mental Health Clinician

86. Effect of phenylephrine and terbutaline on ischemic priapism: a retrospective review. (Abstract)

Effect of phenylephrine and terbutaline on ischemic priapism: a retrospective review. Ischemic priapism is the most common cause of priapism due to low blood flow. Current guidelines recommend penile aspiration and the use of intracavernous injection of vasoactive agents. The data to support these recommendations are limited and rely on expert consensus.The objective was to determine the effectiveness of terbutaline and phenylephrine on detumescence of ischemic priapism.This was a retrospective (...) review of patients presenting to the emergency department with a chief concern of priapism who received oral or subcutaneous terbutaline or intracavernous phenylephrine. The primary outcome is successful detumescence. The secondary outcome is drug-related adverse drug events.A total of 31 cases of ischemic priapism were included, with 8 patients receiving terbutaline and 23 receiving phenylephrine. Of the cases treated with terbutaline, 25% had successful detumescence compared with phenylephrine

2016 American Journal of Emergency Medicine

87. al-Ghorab Shunt for Priapism. (Abstract)

al-Ghorab Shunt for Priapism. The Surgical Techniques Section is sponsored in part by Coloplast.Copyright © 2016. Published by Elsevier Inc.

2016 Journal Of Sexual Medicine

88. Priapism as a new symptom of anaphylaxis in a prepubescent child. (Abstract)

Priapism as a new symptom of anaphylaxis in a prepubescent child. 27496320 2018 03 16 2018 12 02 1399-3038 27 8 2016 12 Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Pediatr Allergy Immunol Priapism as a new symptom of anaphylaxis in a prepubescent child. 871-872 10.1111/pai.12618 Castilla-Hernández Eva E Pediatric Allergy Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Garriga-Baraut Teresa T Pediatric (...) Allergy Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain. eng Case Reports Letter 2016 09 16 England Pediatr Allergy Immunol 9106718 0905-6157 IM Anaphylaxis Child Humans Male Penis Priapism 2016 8 9 6 0 2018 3 17 6 0 2016 8 7 6 0 ppublish 27496320 10.1111/pai.12618

2016 Pediatric Allergy and Immunology

89. Risk Factors for Priapism Readmission. (Abstract)

Risk Factors for Priapism Readmission. Priapism is a urologic emergency with a tendency to recur in some patients. The frequency of, time to, and risk factors for priapism recurrence have not been well characterized.To identify predictors of priapism readmission.We used the New York Statewide Planning and Research Cooperative System database to identify patients presenting to emergency departments with priapism from 2005 through 2014. Patients were tracked up to 12 months after initial (...) presentation. Proportional hazards regression was used to identify risk factors for priapism readmission.Readmissions for priapism.The analytic cohort included 3,372 men with a diagnosis of priapism. The average age at first presentation was 39 ± 18 years and 40% were black. Within 1 year, 24% of patients were readmitted for recurrent priapism, 68% of whom were readmitted within 60 days. On multivariate analysis, sickle cell disease (hazard ratio [HR] = 2.5, 95% CI = 2.0-3.0), drug abuse or psychiatric

2016 Journal Of Sexual Medicine

90. Guideline of Guidelines Priapism. (Abstract)

Guideline of Guidelines Priapism. 27860090 2018 03 14 2018 03 14 1464-410X 119 2 2017 02 BJU international BJU Int. Guideline of guidelines: priapism. 204-208 10.1111/bju.13717 Muneer Asif A Departments of Urology, University College London Hospitals, London, UK. National Institute for Health Research (NIHR) Biomedical Research Centre, University College London Hospitals, London, UK. Ralph David D Departments of Andrology, University College London Hospitals, London, UK. St Peters Andrology (...) Centre, London, UK. eng Letter Research Support, Non-U.S. Gov't Review 2016 12 29 England BJU Int 100886721 1464-4096 0 Sympathomimetics N8ONU3L3PG Terbutaline YKH834O4BH Epinephrine IM Epinephrine therapeutic use Evidence-Based Medicine Humans Injections, Intralesional Male Practice Guidelines as Topic Priapism drug therapy physiopathology surgery therapy Prognosis Risk Assessment Severity of Illness Index Societies, Medical standards Sympathomimetics therapeutic use Terbutaline therapeutic use

2016 BJU international

91. Use of High-Dose Phenylephrine in the Treatment of Ischemic Priapism: Five-Year Experience at a Single Institution. (Abstract)

Use of High-Dose Phenylephrine in the Treatment of Ischemic Priapism: Five-Year Experience at a Single Institution. Ischemic priapism is an uncommon urologic emergency characterized by a compartment syndrome-like ischemic insult to the corpora cavernosa of the penis. The goal of treatment in ischemic priapism is rapid detumescence to prevent long-term erectile dysfunction. Non-surgical treatment options include aspiration, irrigation, and intracavernous injections of sympathomimetic agents (...) . At our institution, phenylephrine is used in the treatment of ischemic priapism at concentrations and doses that are higher than those recommended in established guidelines.To characterize our experience with high-concentration intracavernous phenylephrine in the treatment of ischemic priapism at an urban tertiary care center.A retrospective chart review identified 58 unique patients presenting to the emergency department on 136 occasions and receiving the diagnosis of ischemic priapism by urologic

2016 Journal Of Sexual Medicine

92. T-Shaped Shunt with Intracavernosal Tunneling, for a Pediatric Case of Refractory Ischemic Priapism. (Abstract)

T-Shaped Shunt with Intracavernosal Tunneling, for a Pediatric Case of Refractory Ischemic Priapism. We present the first reported case of refractory pediatric priapism treated by intracavernosal tunneling T shunt. A 12-year-old male, with sickle cell disease, presented with 72 hours of painful erection. The patient failed conservative measures including aspiration, injection of phenylephrine, as well as distal shunt procedure. A T-T shunt was performed, as previously described in the adult (...) literature. There was immediate resolution of the erection with no complications. At 1-year follow-up, he reports no subsequent episodes of priapism and normal erections. T shunt with tunneling can be performed in select cases of severe pediatric refractory ischemic priapism.Copyright © 2016 Elsevier Inc. All rights reserved.

2016 Urology

93. Proceedings: Surgical treatment of initial priapism and recurrent priapism. Full Text available with Trip Pro

Proceedings: Surgical treatment of initial priapism and recurrent priapism. 4519102 1974 02 01 2018 11 13 0035-9157 66 10 1973 Oct Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Proceedings: Surgical treatment of initial priapism and recurrent priapism. 1051-2 Griffiths D A DA Webb A J AJ eng Journal Article England Proc R Soc Med 7505890 0035-9157 9005-49-6 Heparin ZTI6C33Q2Q Guanethidine IM Adult Guanethidine adverse effects Hemodialysis, Home adverse effects Heparin adverse (...) effects Humans Leukemia, Myeloid complications Male Middle Aged Priapism surgery Saphenous Vein surgery 1973 10 1 1973 10 1 0 1 1973 10 1 0 0 ppublish 4519102 PMC1645605 J Urol. 1972 Jul;108(1):97-100 4556046 Invest Urol. 1964 Mar;1:509-13 14130594

1973 Proceedings of the Royal Society of Medicine

94. The Effectiveness of Oral Terbutaline in Treatment of Priapism

The Effectiveness of Oral Terbutaline in Treatment of Priapism BestBets: The Effectiveness of Oral Terbutaline in Treatment of Priapism The Effectiveness of Oral Terbutaline in Treatment of Priapism Report By: Dr. James Enderle - Emergency Medicine Resident Search checked by Dr. Jeff Jones - Research Director, EM Residency Program Institution: Grand Rapids Medical Education and Research Center for Health Professions/Michigan State University Date Submitted: 14th March 2010 Date Completed: 3rd (...) June 2011 Last Modified: 7th June 2011 Status: Green (complete) Three Part Question In [patients presenting to the emergency department with priapism], does the [use of oral terbutaline] result in [detumescence] Clinical Scenario A 46 year old man presents with a painful erection lasting approximately 4 hours. Your attending physician recommends giving oral terbutaline to the patient, but cannot recall the effectiveness of this drug in the treatment of acute priapism. Search Strategy Medline 1948

2011 BestBETS

95. Priapism – A Rare Presentation in Chronic Myeloid Leukemia: Case Report Full Text available with Trip Pro

Priapism – A Rare Presentation in Chronic Myeloid Leukemia: Case Report Priapism is a complication rarely seen in leukemia. We report a 19-year-old man presented with persistent painful erection of penis for over 24 hours at home. The patient had underwent immediate irrigation and decompression of priapism by urologist at emergency services of the hospital. This approach resulted in a flaccid penis later. During hospitalization, peripheral blood smear and bone marrow aspiration confirmed

2015 Urology case reports

96. Does pentoxifylline enhance the recovery of erectile function after a T-shunt procedure for prolonged ischaemic priapism? A prospective randomised controlled trial. Full Text available with Trip Pro

Does pentoxifylline enhance the recovery of erectile function after a T-shunt procedure for prolonged ischaemic priapism? A prospective randomised controlled trial. To evaluate the role of oral pentoxifylline for enhancing the recovery of erectile function (EF) in patients who had a T-shunt, a technically simple procedure for treating prolonged ischaemic priapism, as the recovery of EF has been reported in many patients treated by this procedure.This prospective randomised study was conducted (...) on 40 patients with prolonged ischaemic priapism treated with a T-shunt. Patients were randomly divided into two groups; group A received oral pentoxifylline from the second day after surgery for 3 months, and group B received placebo. Patients were followed for 18 months.The pain resolved in all patients, and EF recovered in 15 patients in group A and 10 in group B within 3 months. All patients but three had recovery of EF within the 18-month follow-up. Six patients had recovery of EF by using

2015 Arab journal of urology Controlled trial quality: uncertain

97. Pediatric Priapism Secondary to Psychotherapeutic Medications. (Abstract)

Pediatric Priapism Secondary to Psychotherapeutic Medications. With the increased application of many different drug classes for the treatment of psychiatric conditions in children, the incidence of priapism has also increased. Priapism of pharmacotherapeutic etiology in the pediatric population is a complex and poorly understood entity that continues to present new management challenges for clinicians. We present 2 cases of pediatric priapism thought to be secondary to the use (...) of pharmacotherapeutic agents. In the first case, sertraline, an antidepressant, and in the second case, atomoxetine, a nonstimulant medication, are implicated as the most likely causative agents. Both medications have a growing association with priapism in the literature. Copyright © 2015 Elsevier Inc. All rights reserved.

2015 Urology

98. Sickle Cell Disease in Priapism: Disparity in Care? (Abstract)

Sickle Cell Disease in Priapism: Disparity in Care? To determine the effect of sickle cell disease (SCD) on hospital resource use among patients admitted for priapism.Using the Nationwide Inpatient Sample, a weighted sample of 12,547 patients was selected with a primary diagnosis of priapism from 2002 to 2011. Baseline differences for patient demographics and hospital characteristics were compared between SCD and non-SCD patients. Multivariate analysis was performed to identify the effect (...) patients did have an operation, it was performed later in the admission (mean, 0.87 vs 0.47 days; P <.001). SCD was not a significant predictor of increased cost (OR, 1.02; P = .869).SCD patients represent a demographically distinct subgroup of priapism patients with different patterns of resource use manifested by longer hospital stays and more blood transfusions. Moreover, despite evidence that immediate treatment of priapism results in improved erectile function outcomes, SCD patients had less

2015 Urology

99. Penile Doppler ultrasound in men with stuttering priapism and sickle cell disease-a labile baseline diastolic velocity is a characteristic finding. (Abstract)

Penile Doppler ultrasound in men with stuttering priapism and sickle cell disease-a labile baseline diastolic velocity is a characteristic finding. Stuttering priapism (SP) is seen in sickle cell disease (SCD) and characterized by short-lived painful erections. Imbalanced vascular tone is the postulated cause and this may be reflected in changes in baseline penile blood flow as measured using penile Doppler ultrasound (PDU).The aim of this study was to investigate the baseline penile blood flow

2015 Journal Of Sexual Medicine

100. Malleable penile prosthesis is a cost-effective treatment for refractory ischemic priapism. (Abstract)

Malleable penile prosthesis is a cost-effective treatment for refractory ischemic priapism. Refractory ischemic priapism (RIP) can be difficult to treat, consuming significant healthcare-related resources. Acute insertion of a malleable penile prosthesis (MPP) has been reported as an effective therapy that treats the priapism and restores sexual function.We report our 6-year, urban public hospital experience with acute insertion of MPP in patients with RIP.We retrospectively reviewed (...) the records of patients receiving MPPs for RIP from 2007 to 2013. Data analyzed included duration of erection, number of emergency room (ER) visits, hospital admissions, days of hospitalization, and postoperative course. Costs were estimated using standard Medicare reimbursement rates.Healthcare-related costs of treatment of RIP episodes in men presenting to our institution.During the study period, 14 men underwent MPP placement acutely for refractory priapism. Thirteen presented with RIP, and one had

2015 Journal Of Sexual Medicine

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