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Priapism

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81. Penile Doppler ultrasound in men with stuttering priapism and sickle cell disease-a labile baseline diastolic velocity is a characteristic finding. (PubMed)

Penile Doppler ultrasound in men with stuttering priapism and sickle cell disease-a labile baseline diastolic velocity is a characteristic finding. Stuttering priapism (SP) is seen in sickle cell disease (SCD) and characterized by short-lived painful erections. Imbalanced vascular tone is the postulated cause and this may be reflected in changes in baseline penile blood flow as measured using penile Doppler ultrasound (PDU).The aim of this study was to investigate the baseline penile blood flow

2015 Journal Of Sexual Medicine

82. Malleable penile prosthesis is a cost-effective treatment for refractory ischemic priapism. (PubMed)

Malleable penile prosthesis is a cost-effective treatment for refractory ischemic priapism. Refractory ischemic priapism (RIP) can be difficult to treat, consuming significant healthcare-related resources. Acute insertion of a malleable penile prosthesis (MPP) has been reported as an effective therapy that treats the priapism and restores sexual function.We report our 6-year, urban public hospital experience with acute insertion of MPP in patients with RIP.We retrospectively reviewed (...) the records of patients receiving MPPs for RIP from 2007 to 2013. Data analyzed included duration of erection, number of emergency room (ER) visits, hospital admissions, days of hospitalization, and postoperative course. Costs were estimated using standard Medicare reimbursement rates.Healthcare-related costs of treatment of RIP episodes in men presenting to our institution.During the study period, 14 men underwent MPP placement acutely for refractory priapism. Thirteen presented with RIP, and one had

2015 Journal Of Sexual Medicine

83. Erectile dysfunction after sickle cell disease-associated recurrent ischemic priapism: profile and risk factors. (PubMed)

Erectile dysfunction after sickle cell disease-associated recurrent ischemic priapism: profile and risk factors. Risk factors associated with erectile dysfunction (ED) that results from recurrent ischemic priapism (RIP) in sickle cell disease (SCD) are incompletely defined.This study aims to determine and compare ED risk factors associated with SCD and non-SCD-related "minor" RIP, defined as having ≥2 episodes of ischemic priapism within the past 6 months, with the majority (>75%) of episodes (...) lasting <5 hours.We performed a retrospective study of RIP in SCD and non-SCD patients presenting from June 2004 to March 2014 using the International Index of Erectile Function (IIEF), IIEF-5, and priapism-specific questionnaires.Prevalence rates and risk factor correlations for ED associated with RIP.The study was comprised of 59 patients (40 SCD [mean age 28.2 ± 8.9 years] and 19 non-SCD [15 idiopathic and four drug-related etiologies] [mean age 32.6 ± 11.7 years]). Nineteen of 40 (47.5%) SCD

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2015 Journal Of Sexual Medicine

84. Pediatric Priapism Secondary to Psychotherapeutic Medications. (PubMed)

Pediatric Priapism Secondary to Psychotherapeutic Medications. With the increased application of many different drug classes for the treatment of psychiatric conditions in children, the incidence of priapism has also increased. Priapism of pharmacotherapeutic etiology in the pediatric population is a complex and poorly understood entity that continues to present new management challenges for clinicians. We present 2 cases of pediatric priapism thought to be secondary to the use (...) of pharmacotherapeutic agents. In the first case, sertraline, an antidepressant, and in the second case, atomoxetine, a nonstimulant medication, are implicated as the most likely causative agents. Both medications have a growing association with priapism in the literature. Copyright © 2015 Elsevier Inc. All rights reserved.

2015 Urology

85. Sickle Cell Disease in Priapism: Disparity in Care? (PubMed)

Sickle Cell Disease in Priapism: Disparity in Care? To determine the effect of sickle cell disease (SCD) on hospital resource use among patients admitted for priapism.Using the Nationwide Inpatient Sample, a weighted sample of 12,547 patients was selected with a primary diagnosis of priapism from 2002 to 2011. Baseline differences for patient demographics and hospital characteristics were compared between SCD and non-SCD patients. Multivariate analysis was performed to identify the effect (...) patients did have an operation, it was performed later in the admission (mean, 0.87 vs 0.47 days; P <.001). SCD was not a significant predictor of increased cost (OR, 1.02; P = .869).SCD patients represent a demographically distinct subgroup of priapism patients with different patterns of resource use manifested by longer hospital stays and more blood transfusions. Moreover, despite evidence that immediate treatment of priapism results in improved erectile function outcomes, SCD patients had less

2015 Urology

86. Cavernosal hematoma mimicking priapism. (PubMed)

Cavernosal hematoma mimicking priapism. We present a case of corpus cavernosum hematoma mimicking priapism. A 42-year-old man presented to the emergency room with penile pain and partial erection. Examination revealed partial erection and palpable space-occupying lesion of the corpus cavernosum without lymphadenopathy. Malignant workup was negative. Imaging assisted in diagnosis of unilateral hematoma of the corpus cavernosum. The lesion spontaneously resolved without the need for intervention

2015 Urology

87. Priapism Impact Profile Questionnaire: Development and Initial Validation. (PubMed)

Priapism Impact Profile Questionnaire: Development and Initial Validation. To create and evaluate a psychometric instrument that measures the impact of experiencing priapism from the patient perspective.The research protocol consisted of several phases as follows: (1) generating items, (2) composing a patient questionnaire, (3) administering the questionnaire to patients with both active and remitted (≥1 year without priapism episodes) histories of priapism, (4) performing internal consistency (...) and criterion-oriented validity analyses in correlation with clinical histories and erectile function assessment tools, and (5) ascertaining psychometric properties of the instrument.The final instrument comprised a 12-item Priapism Impact Profile (PIP) questionnaire, representing the following 3 domains adversely impacted by priapism: quality of life (QoL), sexual function (SF), and physical wellness (PW), with higher scores indicating inferior experience in respective domains. Internal consistency

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2015 Urology

88. Simultaneous urethrocutaneous and urethrocavernous fistula after proximal corporospongiosal shunt for priapism. (PubMed)

Simultaneous urethrocutaneous and urethrocavernous fistula after proximal corporospongiosal shunt for priapism. Proximal corporospongiosal shunts are used for the most refractory cases of priapism. Here, we present the case of a 58-year-old man whose priapism was only partially responsive to phenylephrine injections and distal shunting. Proximal shunting was required, and he subsequently developed fistulization of the proximal penile urethra into the skin and the corpora cavernosa

2015 Urology

89. Priapism in a patient with sickle cell trait using marijuana (PubMed)

Priapism in a patient with sickle cell trait using marijuana A 22-year-old man with a history of multiple episodes of priapism presented to the emergency room with an erection lasting more than 48 h after conservative management failed at home. He had no known family history of sickle cell disease or trait. He was haemodynamically stable. Physical examination revealed an enlarged, tender penis. Laboratory data revealed a positive sickle solubility test. Haemoglobin electrophoresis revealed (...) sickle cell trait and urine drug screen was positive for cannabinoids. Initial management was attempted with intracavernosal phenylephrine without any success. The patient underwent a limited El-Ghorab procedure on the right corpora cavernosa but the priapism did not resolve adequately. Two days later, the patient had to undergo a bilateral El-Ghorab procedure and achieved complete resolution of the priapism.

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2014 BMJ case reports

90. Priapism Associated with Homozygous Hb E State: A Causal Association or an Incidental Finding? (PubMed)

Priapism Associated with Homozygous Hb E State: A Causal Association or an Incidental Finding? 27408418 2016 07 13 2018 11 13 0971-4502 32 Suppl 1 2016 Jun Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion Indian J Hematol Blood Transfus Priapism Associated with Homozygous Hb E State: A Causal Association or an Incidental Finding? 301-3 10.1007/s12288-014-0459-0 Venkatesan S S Department of Hematology, All India

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2014 Indian Journal of Hematology & Blood Transfusion

91. Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression (PubMed)

Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression Priapism is featured with prolonged and painful penile erection and is prevalent among males with sickle cell disease (SCD). The disorder is a dangerous urological and hematological emergency since it is associated with ischemic tissue damage and erectile disability. Here we report that phosphodiesterase-5 (PDE5) gene expression and PDE activity is significantly reduced (...) in penile tissues of two independent priapic models: SCD mice and adenosine deaminase (ADA)-deficient mice. Moreover, using ADA enzyme therapy to reduce adenosine or a specific antagonist to block A(2B) adenosine receptor (ADORA2B) signaling, we successfully attenuated priapism in both ADA(-/-) and SCD mice by restoring penile PDE5 gene expression to normal levels. This finding led us to further discover that excess adenosine signaling via ADORA2B activation directly reduces PDE5 gene expression

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2014 The FASEB Journal

92. An unexpected etiology of priapism: infection-related anti-protein s antibodies. (PubMed)

An unexpected etiology of priapism: infection-related anti-protein s antibodies. In adolescents, the occurrence of priapism is commonly related to sickle cell disease and rarely to other causes. We hereby report a case of priapism due to an acquired protein S (PS) deficiency.The aim of this study was to describe a young man who developed a priapism with a thrombosis of the corpora cavernosa associated with an anti-PS antibody (anti-PS Ab).One week after the onset of an influenza-like illness (...) , a young male developed multiple extensive venous thromboses including a thrombosis of the corpora cavernosa causing painful partial priapism. These thromboses along with purpuric lesions with necrotic vesicles of the feet skin were linked to an acquired PS deficiency due to an anti-PS Ab. The optimal treatment of anti-PS Ab-associated thrombosis is debated but we chose to initiate (i) heparin; (ii) corticosteroids; and (iii) plasmapheresis.Even if priapism lasted more than 4 days, a full recovery

2014 Journal Of Sexual Medicine

93. Hematoma or "partial priapism" in the proximal part of the corpus cavernosum. (PubMed)

Hematoma or "partial priapism" in the proximal part of the corpus cavernosum. "Partial priapism" is a rare disorder. Therapy is controversial in literature.To show that conservative treatment leads to a full functional recovery of this condition.This report describes a case of a hematoma or "partial priapism" in the proximal part of the right corpus cavernosum.Complete functional recovery after conservative treatment with nonsteroidal anti-inflammatory drugs."Partial priapism" probably

2014 Journal Of Sexual Medicine

94. Prevention of recurrent ischemic priapism with ketoconazole: evolution of a treatment protocol and patient outcomes. (PubMed)

Prevention of recurrent ischemic priapism with ketoconazole: evolution of a treatment protocol and patient outcomes. The management of recurrent ischemic priapism (RIP) is not clearly defined. Ketoconazole (KTZ) is used to treat RIP and produces a temporary hypogonadal state to suppress sleep-related erections (SREs), which often evolve into episodes of ischemic priapism in this population.We review our experience to prevent RIP using KTZ and present our outcomes using a decreased dose (...) was the prevention of RIP using KTZ. Secondary outcomes included side effects secondary to KTZ use and patient satisfaction.All men experienced daily or almost daily episodes of prolonged, painful erections prior to starting KTZ. The mean number of emergency room (ER) visits per patient prior to starting KTZ was 6.5. No patient required an ER visit for RIP while on KTZ. Sixteen of 17 patients (94%) had complete resolution of priapism while on KTZ with effects noted immediately after starting therapy

2014 Journal Of Sexual Medicine

95. Penile prosthesis insertion in patients with refractory ischaemic priapism: early vs delayed implantation. (PubMed)

Penile prosthesis insertion in patients with refractory ischaemic priapism: early vs delayed implantation. To compare the long-term results of early and delayed insertion of a penile prosthesis (PP) in men with refractory ischaemic priapism (IP).Early insertion of a PP was carried out in 68 men with IP within a median of 7 days from the onset of priapism, while 27 had delayed insertion after a median of 5 months. The results for sexual ability, satisfaction and subjective penile shortening were

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2014 BJU international

96. Malignant priapism secondary to isolated penile metastasis from a renal pelvic carcinoma (PubMed)

Malignant priapism secondary to isolated penile metastasis from a renal pelvic carcinoma We report a case of isolated penile metastasis from renal pelvic carcinoma in a 69-year-old man with malignant priapism. The patient had radical resection of the renal pelvic carcinoma 2 months earlier with urothelial carcinoma (UC) and sarcomatoid differentiation histology. Physical examination showed no visible skin lesions, but a palpable hard nodule was present over the penile shaft. The imaging studies (...) did not reveal other metastases. Cavernous-Glans shunt and nodule resection were performed, and histological examination showed metastasis UC with sarcomatoid differentiation. To our knowledge, we describe the first case of malignant priapism due to isolated penile metastasis of renal pelvic carcinoma.

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2014 Canadian Urological Association Journal

97. A Case of Painless Pediatric Priapism and Cough. (PubMed)

A Case of Painless Pediatric Priapism and Cough. Pediatric priapism can be a medical emergency but is not a common complaint seen in pediatric emergency department. Priapism in a previously healthy child is also rare. We report a case of painless stuttering priapism associated with an acute Mycoplasma pneumoniae infection in a previously healthy boy.

2014 Pediatric Emergency Care

98. Randomized Controlled Trial of Sildenafil for Preventing Recurrent Ischemic Priapism in Sickle Cell Disease. (PubMed)

Randomized Controlled Trial of Sildenafil for Preventing Recurrent Ischemic Priapism in Sickle Cell Disease. Successful preventive therapy for ischemic priapism, a disorder of penile erection with major physical and psychologic consequences, is limited. We conducted a randomized, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of sildenafil by a systematic dosing protocol to prevent recurrent ischemic priapism associated with sickle cell disease.Thirteen (...) patients with sickle cell disease reporting priapism recurrences at least twice weekly were randomized to receive sildenafil 50 mg or placebo daily, unassociated with sleep or sexual activity, for 8 weeks, followed by open-label use of this sildenafil regimen for an additional 8 weeks.Priapism frequency reduction by 50% did not differ between sildenafil and placebo groups by intention-to-treat or per protocol analyses (P = 1.0). However, during open-label assessment, 5 of 8 patients (62.5

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2014 The American journal of medicine

99. Priapism (Treatment)

Priapism (Treatment) Priapism Treatment & Management: Approach Considerations, Prehospital Care, Low-Flow Priapism Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNDM3MjM3LXRyZWF0bWVudA== processing > Priapism (...) Treatment & Management Updated: Nov 28, 2016 Author: Hosam S Al-Qudah, MD; Chief Editor: Edward David Kim, MD, FACS Share Email Print Feedback Close Sections Sections Priapism Treatment Approach Considerations Appropriate treatment of priapism varies, depending on whether the patient has low-flow or high-flow priapism. Most priapism cases are the low-flow ischemic type. Treatment of low-flow priapism should progress in a stepwise fashion, starting with therapeutic aspiration, with or without irrigation

2014 eMedicine.com

100. Priapism (Overview)

Priapism (Overview) Priapism: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvNDM3MjM3LW92ZXJ2aWV3 processing > Priapism Updated: Nov 28, 2016 Author: Hosam S Al (...) -Qudah, MD; Chief Editor: Edward David Kim, MD, FACS Share Email Print Feedback Close Sections Sections Priapism Overview Practice Essentials Priapism (see the image below) is an involuntary, prolonged erection unrelated to sexual stimulation and unrelieved by ejaculation. This condition is a true urologic emergency, and early intervention allows the best chance for functional recovery. Priapism. Corporeal relaxation causes external pressure on the emissary veins exiting the tunica albuginea

2014 eMedicine.com

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