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1. Valproate medicines and serious harms in pregnancy: new Annual Risk Acknowledgement Form and clinical guidance from professional bodies to support compliance with the Pregnancy Prevention Programme

Valproate medicines and serious harms in pregnancy: new Annual Risk Acknowledgement Form and clinical guidance from professional bodies to support compliance with the Pregnancy Prevention Programme Valproate medicines and serious harms in pregnancy: new Annual Risk Acknowledgement Form and clinical guidance from professional bodies to support compliance with the Pregnancy Prevention Programme - GOV.UK GOV.UK uses cookies to make the site simpler. or Search Valproate medicines and serious harms (...) in pregnancy: new Annual Risk Acknowledgement Form and clinical guidance from professional bodies to support compliance with the Pregnancy Prevention Programme Ongoing patient survey data suggest that more effort is needed by clinicians to achieve full and timely compliance with the valproate Pregnancy Prevention Programme and meet the goal to rapidly reduce and eventually eliminate the harms of valproate in pregnancy in view of its serious teratogenicity. We have updated the Annual Risk Acknowledgement

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2019 MHRA Drug Safety Update

2. Simple preventive actions by parents linked to fewer child injuries

of controls not to put medicines away straight after use (OR 2.11, 95% CI 1.54 to 2.90). A number of other and child behaviours were also linked to hospital-attended injury. These included not teaching children about safety rules, storing medicines and household products within reach, and having stairs in need of repair. What does current guidance say on this issue? Public Health England and the Child Accident Prevention Trust produced guidance in 2017 for all staff who work with children under five years (...) Simple preventive actions by parents linked to fewer child injuries Simple preventive actions by parents linked to fewer child injuries Discover Portal Discover Portal Simple preventive actions by parents linked to fewer child injuries Published on 3 October 2017 doi: Education is promoted as a way to tackle the scale of avoidable injuries to young children. Children have two to five times the risk of an accident leading to injury if a parent leaves them on a raised surface, places hot drinks

2019 NIHR Dissemination Centre

3. General medicine: Prevention of exacerbations in patients with stable non-cystic fibrosis bronchiectasis: a systematic review and meta-analysis of pharmacological and non-pharmacological therapies

General medicine: Prevention of exacerbations in patients with stable non-cystic fibrosis bronchiectasis: a systematic review and meta-analysis of pharmacological and non-pharmacological therapies Prevention of exacerbations in patients with stable non-cystic fibrosis bronchiectasis: a systematic review and meta-analysis of pharmacological and non-pharmacological therapies | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You (...) of exacerbations in patients with stable non-cystic fibrosis bronchiectasis: a systematic review and meta-analysis of pharmacological and non-pharmacological therapies Article Text Evidence synthesis General medicine Prevention of exacerbations in patients with stable non-cystic fibrosis bronchiectasis: a systematic review and meta-analysis of pharmacological and non-pharmacological therapies Free Abd Moain Abu Dabrh , , Adam T Hill , Claudia C Dobler , Noor Asi , Wigdan H Farah , Qusay Haydour , Zhen Wang

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2018 Evidence-Based Medicine (Requires free registration)

4. Simple preventive actions by parents linked to fewer child injuries

of controls not to put medicines away straight after use (OR 2.11, 95% CI 1.54 to 2.90). A number of other and child behaviours were also linked to hospital-attended injury. These included not teaching children about safety rules, storing medicines and household products within reach, and having stairs in need of repair. What does current guidance say on this issue? Public Health England and the Child Accident Prevention Trust produced guidance in 2017 for all staff who work with children under five years (...) Simple preventive actions by parents linked to fewer child injuries Simple preventive actions by parents linked to fewer child injuries Discover Portal Discover Portal Simple preventive actions by parents linked to fewer child injuries Published on 3 October 2017 doi: Education is promoted as a way to tackle the scale of avoidable injuries to young children. Children have two to five times the risk of an accident leading to injury if a parent leaves them on a raised surface, places hot drinks

2018 NIHR Dissemination Centre

5. Let food be thy medicine: linking local food and health systems to address the full spectrum of malnutrition in low-income and middle-income countries (PubMed)

Let food be thy medicine: linking local food and health systems to address the full spectrum of malnutrition in low-income and middle-income countries 29225956 2018 11 13 2059-7908 2 4 2017 BMJ global health BMJ Glob Health Let food be thy medicine: linking local food and health systems to address the full spectrum of malnutrition in low-income and middle-income countries. e000564 10.1136/bmjgh-2017-000564 Jaacks Lindsay M LM 0000-0002-7791-5167 Department of Global Health and Population (...) , Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. Bellows Alexandra L AL Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. eng Editorial 2017 11 25 England BMJ Glob Health 101685275 2059-7908 child health health systems maternal health nutrition prevention strategies Competing interests: None declared. 2017 09 12 2017 10 13 2017 10 18 2017 12 12 6 0 2017 12 12 6 0 2017 12 12 6 1 epublish 29225956 10.1136/bmjgh-2017

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2017 BMJ global health

6. Preventive Medicine Links

Preventive Medicine Links Preventive Medicine Links Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Preventive Medicine Links (...) Preventive Medicine Links Aka: Preventive Medicine Links , Preventive Health Patient Education , Patient Education in Prevention II. Resources: Best Practice in Prevention Health Resources (NIDDK) National Center Chronic Disease Prevention (CDC) III. Resources: Lifestyle Shape Up America Cooper Institute for Aerobics Research Tufts University Nutrition Navigator Weight Loss Worksheet Pearls to Quit Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search

2018 FP Notebook

7. Update on the Methods of the U.S. Preventive Services Task Force: Linking Intermediate Outcomes and Health Outcomes in Prevention. (PubMed)

Update on the Methods of the U.S. Preventive Services Task Force: Linking Intermediate Outcomes and Health Outcomes in Prevention. The U.S. Preventive Services Task Force (USPSTF) is an independent body of experts who make evidence-based recommendations about clinical preventive services using a transparent and objective process. Developing recommendations on a clinical preventive service requires evidence of its effect on health outcomes. Health outcomes are symptoms, functional levels (...) , and conditions that affect a patient's quantity or quality of life and are measured by assessments of physical or psychologic well-being. Intermediate outcomes are pathologic, physiologic, psychologic, social, or behavioral measures related to a preventive service. Given the frequent lack of evidence on health outcomes, the USPSTF uses evidence on intermediate outcomes when appropriate. The ultimate goal is to determine precisely a consistent relationship between the direction and magnitude of change

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2018 American journal of preventive medicine

8. Summary of recommendations for the prevention of malaria by the Committee to Advise on Tropical Medicine and Travel (CATMAT)

Summary of recommendations for the prevention of malaria by the Committee to Advise on Tropical Medicine and Travel (CATMAT) CATMAT recommendations for prevention of malaria - Canada.ca Language selection Search Search Canada.ca Search Menu Main Menu You are here: CATMAT recommendations for prevention of malaria Published by: Issue: Date published: April 3, 2014 ISSN: 1481-8531 Submit a manuscript About CCDR Browse Volume 40-7, April 3, 2014: Malaria Summary Summary of recommendations (...) for the prevention of malaria by the Committee to Advise on Tropical Medicine and Travel (CATMAT) Boggild A 1 , Brophy J 2 , Charlebois P 3 , Crockett M 4 , Geduld J 5 , Ghesquiere W 6 , McDonald P 7 , Plourde P 8 , Teitelbaum P 9 , Tepper M 10 , Schofield S 11 , McCarthy A (Chair) 12 * Affiliations 1 University Health Network, Toronto General Hospital (Toronto, ON) 2 Division of Infectious Diseases, Children’s Hospital of Eastern Ontario (Ottawa, ON) 3 Internal Medicine, Canadian Forces Health Services Centre

2014 CPG Infobase

9. Linking HIV-Negative Youth to Prevention Services in 12 U.S. Cities: Barriers and Facilitators to Implementing the HIV Prevention Continuum. (PubMed)

Linking HIV-Negative Youth to Prevention Services in 12 U.S. Cities: Barriers and Facilitators to Implementing the HIV Prevention Continuum. Linkage of HIV-negative youth to prevention services is increasingly important with the development of effective pre-exposure prophylaxis that complements behavioral and other prevention-focused interventions. However, effective infrastructure for delivery of prevention services does not exist, leaving many programs to address HIV prevention without data (...) to guide program development/implementation. The objective of this study was to provide a qualitative description of barriers and facilitators of linkage to prevention services among high-risk, HIV-negative youth.Thematic analysis of structured interviews with staff implementing linkage to prevention services programs for youth aged 12-24 years.Twelve adolescent medicine HIV primary care programs as part of larger testing research program focused on young sexual minority men of color. The study

2017 The Journal of Adolescent Health

10. Valproate medicines: are you in acting in compliance with the pregnancy prevention measures?

Valproate medicines: are you in acting in compliance with the pregnancy prevention measures? Valproate medicines: are you acting in compliance with the pregnancy prevention measures? - GOV.UK GOV.UK uses cookies to make the site simpler. Search Valproate medicines: are you acting in compliance with the pregnancy prevention measures? Although use of valproate medicines in female patients continues to slowly decline, there is wide variation in prescribing between Clinical Commissioning Groups (...) December 2018 From: Therapeutic area: , , , , , Contents New information Compliance by healthcare professionals with the new valproate measures for pregnancy prevention appears currently patchy Women are not always receiving Patient Information Leaflets with their medicines, as is required Some women using valproate for off-label indications are not being reviewed in line with the new pregnancy prevention measures is available for psychiatrists on the withdrawal of, and alternatives to, valproate

2019 MHRA Drug Safety Update

11. Exercise in the Prevention and Management of Oxidative Stress-Linked Diseases (PubMed)

Exercise in the Prevention and Management of Oxidative Stress-Linked Diseases 29854095 2018 12 11 2018 12 11 1942-0994 2018 2018 Oxidative medicine and cellular longevity Oxid Med Cell Longev Exercise in the Prevention and Management of Oxidative Stress-Linked Diseases. 7643721 10.1155/2018/7643721 Venditti Paola P 0000-0003-0522-1788 Department of Biology, University Federico II of Naples, Naples, Italy. Zhang Yong Y 0000-0001-7747-1562 Tianjin Key Laboratory of Exercise Physiology and Sports (...) Medicine, Tianjin University of Sport, Tianjin, China. Radák Zsolt Z Faculty of Physical Education and Sport Science Research Institute of Sport Science, Semmelweis University, Budapest, Hungary. Magalhães José J Department of Sport Biology Faculty of Sport, University of Porto, Porto, Portugal. eng Editorial Introductory Journal Article 2018 04 26 United States Oxid Med Cell Longev 101479826 1942-0994 IM Aging Animals Cardiovascular Diseases metabolism pathology prevention & control Exercise Humans

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2018 Oxidative medicine and cellular longevity

12. Novel Intervention Linking Public Housing With Primary Care to Prevent Diabetes

Novel Intervention Linking Public Housing With Primary Care to Prevent Diabetes Novel Intervention Linking Public Housing With Primary Care to Prevent Diabetes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Novel Intervention Linking Public Housing With Primary Care to Prevent Diabetes (SHAPE-Up) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03526237 Recruitment Status : Completed First Posted : May 16, 2018 Last Update Posted : May 16, 2018 Sponsor: Medical University of South Carolina Collaborator

2018 Clinical Trials

13. Lack of Evidence Linking Calcium With or Without Vitamin D Supplementation to Cardiovascular Disease in Generally Healthy Adults: A Clinical Guideline From the National Osteoporosis Foundation and the American Society for Preventive Cardiology. (PubMed)

Lack of Evidence Linking Calcium With or Without Vitamin D Supplementation to Cardiovascular Disease in Generally Healthy Adults: A Clinical Guideline From the National Osteoporosis Foundation and the American Society for Preventive Cardiology. Calcium is the dominant mineral present in bone and a shortfall nutrient in the American diet. Supplements have been recommended for persons who do not consume adequate calcium from their diet as a standard strategy for the prevention of osteoporosis (...) and related fractures. Whether calcium with or without vitamin D supplementation is beneficial or detrimental to vascular health is not known.The National Osteoporosis Foundation and American Society for Preventive Cardiology convened an expert panel to evaluate the effects of dietary and supplemental calcium on cardiovascular disease based on the existing peer-reviewed scientific literature. The panel considered the findings of the accompanying updated evidence report provided by an independent evidence

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2016 Annals of Internal Medicine

14. Direct-to-Consumer Genetic Testing: Impact on Patients and Preventive Medicine

Direct-to-Consumer Genetic Testing: Impact on Patients and Preventive Medicine Direct-to-Consumer Genetic Testing: Impact on Patients and Preventive Medicine – Clinical Correlations Search Direct-to-Consumer Genetic Testing: Impact on Patients and Preventive Medicine April 25, 2014 6 min read By Neelesh Rastogi Peer Reviewed In reference to the $100,000 he spent to research the genetic basis of the pancreatic cancer that ultimately killed him, Steve Jobs famously said, “I’m either going (...) to many Americans and could have significant implications for preventive medicine in the near future. 23andMe is just one of several companies offering direct-to-consumer genetic testing. iGENEA, DNA Tribes, FamilyBuilder, deCODEme, Navigenics and others are also in the business [4]. When Angelina Jolie learned that she tested positive for the BRCA1 and BRCA2 gene mutations, putting her at increased risk of breast and ovarian cancers, she underwent prophylactic bilateral mastectomy, [2

2014 Clinical Correlations

15. An Open Study of the Safety and Pharmacokinetics of a Medicinal Product for Emergency Prevention of Ebola

for Ebola Fever Emergency Prevention Based on Monoclonal Recombinant Antibodies With a Single Application in 3 Groups of Healthy Volunteers Actual Study Start Date : March 12, 2018 Actual Primary Completion Date : December 29, 2018 Actual Study Completion Date : December 29, 2018 Resource links provided by the National Library of Medicine related topics: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: Group 1 1.4 mg/kg body weight Biological: GamEMab drug for emergency (...) An Open Study of the Safety and Pharmacokinetics of a Medicinal Product for Emergency Prevention of Ebola An Open Study of the Safety and Pharmacokinetics of a Medicinal Product for Emergency Prevention of Ebola - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2018 Clinical Trials

16. Valproate medicines (Epilim, Depakote): Pregnancy Prevention Programme materials online

requirements for all valproate medicines (see ). The Marketing Authorisation Holder for Epilim has produced new materials to support the Pregnancy Prevention Programme – branded as Prevent. These are linked to above and will be sent by post to healthcare professionals in the coming weeks. Once received, please dispose of any old materials which you have remaining. Stickers with warning symbols to attach to the pack for supply to the patient will be included in materials to pharmacists. This is pending (...) Valproate medicines (Epilim, Depakote): Pregnancy Prevention Programme materials online Valproate medicines (Epilim▼, Depakote▼): Pregnancy Prevention Programme materials online - GOV.UK GOV.UK uses cookies to make the site simpler. Search Valproate medicines (Epilim▼, Depakote▼): Pregnancy Prevention Programme materials online Use materials online now and hardcopies arriving over the coming weeks by post to ensure women and girls of childbearing potential on valproate medicines meet

2018 MHRA Drug Safety Update

17. Gualou Xiebai Decoction, a Traditional Chinese Medicine, Prevents Cardiac Reperfusion Injury of Hyperlipidemia Rat via Energy Modulation (PubMed)

Gualou Xiebai Decoction, a Traditional Chinese Medicine, Prevents Cardiac Reperfusion Injury of Hyperlipidemia Rat via Energy Modulation Background: Gualou Xiebai Decoction (GLXB) is a classic prescription of Chinese medicine used for the treatment of cardiac problems. The present study was designed to explore the effect and mechanism of GLXB on ischemia/reperfusion (I/R) induced disorders in myocardial structure and function, focusing on the regulation of energy metabolism and the RhoA/ROCK (...) pathway. Methods: After hyperlipidemic rat model was established by oral administration of high fat diet, the rats were treated with GLXB for 6 weeks and subjected to 30 min occlusion of the left anterior descending coronary artery (LADCA) followed by 90 min reperfusion to elicit I/R challenge. Myocardial infarct size was assessed by Evans blue-TTC staining. Myocardial blood flow (MBF) and cardiac function were evaluated. Enzyme-linked immunosorbent assay was performed to examine the content of ATP

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2018 Frontiers in physiology

18. Unravelling Immunoglobulin G Fc N-Glycosylation: A Dynamic Marker Potentiating Predictive, Preventive and Personalised Medicine (PubMed)

Unravelling Immunoglobulin G Fc N-Glycosylation: A Dynamic Marker Potentiating Predictive, Preventive and Personalised Medicine Multiple factors influence immunoglobulin G glycosylation, which in turn affect the glycoproteins' function on eliciting an anti-inflammatory or pro-inflammatory response. It is prudent to underscore these processes when considering the use of immunoglobulin G N-glycan moieties as an indication of disease presence, progress, or response to therapeutics. It has been (...) biomarker from the perspective of predictive, preventive, and personalised medicine. Undoubtedly, a deeper understanding of how the multiple factors interact with each other to alter immunoglobulin G glycosylation is crucial. Herein we review the current literature on immunoglobulin G glycoprotein structure, immunoglobulin G Fc glycosylation, associated receptors, and complement factors, the downstream effector functions, and the factors associated with the heterogeneity of immunoglobulin G

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2018 International journal of molecular sciences

19. Anti-platelet Precision Medicine to Prevent Stroke Early Progression and Recurrence (PRECISE)

Anti-platelet Precision Medicine to Prevent Stroke Early Progression and Recurrence (PRECISE) Anti-platelet Precision Medicine to Prevent Stroke Early Progression and Recurrence (PRECISE) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Anti-platelet Precision Medicine to Prevent Stroke Early Progression and Recurrence (PRECISE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03701360 Recruitment Status : Recruiting

2018 Clinical Trials

20. Individualised patient profile: clinical utility of Flammer syndrome phenotype and general lessons for predictive, preventive and personalised medicine (PubMed)

Individualised patient profile: clinical utility of Flammer syndrome phenotype and general lessons for predictive, preventive and personalised medicine This case report introduces a female patient, who since her teenager age evidently suffers from Flammer syndrome (FS) as the clearly defined sub-optimal health condition. Further, the patient has experienced collateral pathological conditions which primarily might be linked to the family (genetic) predisposition, but the development of which (...) could be synergistically promoted by the FS-phenotype. The facts are thoroughly analysed and consequent hypotheses are presented, which are indicative for highly desirable predictive diagnostics and targeted preventive measures to be created based on the accurate interpretation of the individualised patient profile. The authors emphasise the great clinical relevance of the FS and field-related research.

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2018 The EPMA journal

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