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Prevention of Vector-borne Infection

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161. IVM Alone vs ALB + IVM Against Onchocerciasis

L. King, MD, PhD, Case Western Reserve University Study Details Study Description Go to Brief Summary: Onchocerciasis is a vector-borne nematode parasitic disease that causes severe disability. Onchocerciasis affects approximately 33 million people, mostly in 30 countries in sub-Saharan Africa (with small foci in Latin America and Yemen) 1This disease causes blindness and severe skin disease and it is spread by black flies. O. volvulus adult worms live in subcutaneous nodules. O. volvulus adult (...) table for MeSH terms Onchocerciasis Filariasis Spirurida Infections Secernentea Infections Nematode Infections Helminthiasis Parasitic Diseases Skin Diseases, Parasitic Skin Diseases, Infectious Skin Diseases Ivermectin Albendazole Antiparasitic Agents Anti-Infective Agents Anthelmintics Anticestodal Agents Antiplatyhelmintic Agents Antiprotozoal Agents Tubulin Modulators Antimitotic Agents Mitosis Modulators Molecular Mechanisms of Pharmacological Action Antineoplastic Agents

2017 Clinical Trials

162. Zika Virus. Full Text available with Trip Pro

Zika Virus. 27028561 2016 04 25 2018 04 11 1533-4406 374 16 2016 Apr 21 The New England journal of medicine N. Engl. J. Med. Zika Virus. 1552-63 10.1056/NEJMra1602113 Petersen Lyle R LR From the Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO (L.R.P., A.M.P.); and the Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion (D.J.J (...) ), and the Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities (M.A.H), Centers for Disease Control and Prevention, Atlanta. Jamieson Denise J DJ From the Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO (L.R.P., A.M.P.); and the Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion (D.J.J

2016 NEJM

163. Zika Virus and Birth Defects - Reviewing the Evidence for Causality. Full Text available with Trip Pro

and Developmental Disabilities (M.A.H.), Centers for Disease Control and Prevention, Atlanta; and the Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO (L.R.P.). eng Journal Article 2016 04 13 United States N Engl J Med 0255562 0028-4793 AIM IM Brazil epidemiology Causality Humans Microcephaly epidemiology virology Zika Virus Zika Virus Infection complications 2016 4 14 6 0 2016 4 14 6 0 2016 6 4 6 0 (...) Disease Prevention and Health Promotion (D.J.J.), and Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities (M.A.H.), Centers for Disease Control and Prevention, Atlanta; and the Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO (L.R.P.). Jamieson Denise J DJ From the Division of Public Health Information Dissemination, Center

2016 NEJM

164. Lyme Disease Serology Full Text available with Trip Pro

Infect Dis. 2015 Nov 1;61(9):1374-80 26195017 Vector Borne Zoonotic Dis. 2013 Dec;13(12):877-83 24107201 J Clin Microbiol. 2014 Oct;52(10):3755-62 25122862 Clin Infect Dis. 2014 Dec 15;59(12):1711-3 25182243 (...) Lyme Disease Serology 27115380 2016 05 09 2018 11 13 1538-3598 315 16 2016 Apr 26 JAMA JAMA Lyme Disease Serology. 1780-1 10.1001/jama.2016.4882 Lantos Paul M PM Divisions of Pediatric Infectious Diseases & General Internal Medicine, Duke University School of Medicine, Durham, North Carolina. Auwaerter Paul G PG The Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland. Nelson Christina A CA Division of Vector

2016 JAMA

165. Zika and the Risk of Microcephaly. Full Text available with Trip Pro

Zika and the Risk of Microcephaly. 27222919 2016 07 26 2018 11 13 1533-4406 375 1 2016 Jul 07 The New England journal of medicine N. Engl. J. Med. Zika and the Risk of Microcephaly. 1-4 10.1056/NEJMp1605367 Johansson Michael A MA From the Division of Vector-Borne Diseases (M.A.J., L.M.-T.-R., S.L.H.) and the Division of Congenital and Developmental Disorders (J.R., S.M.G.), Centers for Disease Control and Prevention, Atlanta; and the Department of Epidemiology, Harvard T.H. Chan School (...) of Public Health, Boston (M.A.J.). Mier-y-Teran-Romero Luis L From the Division of Vector-Borne Diseases (M.A.J., L.M.-T.-R., S.L.H.) and the Division of Congenital and Developmental Disorders (J.R., S.M.G.), Centers for Disease Control and Prevention, Atlanta; and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (M.A.J.). Reefhuis Jennita J From the Division of Vector-Borne Diseases (M.A.J., L.M.-T.-R., S.L.H.) and the Division of Congenital and Developmental Disorders

2016 NEJM

166. Development of temporal modelling for forecasting and prediction of malaria infections using time-series and ARIMAX analyses: A case study in endemic districts of Bhutan. Full Text available with Trip Pro

Development of temporal modelling for forecasting and prediction of malaria infections using time-series and ARIMAX analyses: A case study in endemic districts of Bhutan. Malaria still remains a public health problem in some districts of Bhutan despite marked reduction of cases in last few years. To strengthen the country's prevention and control measures, this study was carried out to develop forecasting and prediction models of malaria incidence in the endemic districts of Bhutan using time (...) series and ARIMAX.This study was carried out retrospectively using the monthly reported malaria cases from the health centres to Vector-borne Disease Control Programme (VDCP) and the meteorological data from Meteorological Unit, Department of Energy, Ministry of Economic Affairs. Time series analysis was performed on monthly malaria cases, from 1994 to 2008, in seven malaria endemic districts. The time series models derived from a multiplicative seasonal autoregressive integrated moving average

2010 Malaria journal

167. The global burden of bacterial and viral zoonotic infections. Full Text available with Trip Pro

The global burden of bacterial and viral zoonotic infections. Bacterial and viral zoonotic infections comprise a practically endless, ever-expanding list of pathogens that have the potential to induce human disease of varying severity, with varying means of transmission to humans (including vector-borne and foodborne agents) and of varying epidemiology. Not all theoretically zoonotic pathogens are truly zoonotic in practice, the prime example being influenza viruses; aviann H5N1 influenza (...) . Understanding their burden may allow for improved surveillance and prevention measures.© 2011 The Author. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.

2010 Clinical Microbiology and Infection

168. Searching for Persistence of Infection in Lyme Disease

: Xenodiagnosis Procedure: Blood Drawing Early Phase 1 Detailed Description: Lyme disease is the most common vector borne disease in the United States. Although antibiotic therapy is clinically effective in treating the symptoms of Lyme disease for most patients early in the course of disease, a significant number of patients who receive therapy report persistent symptoms. The cause of persistent symptoms after antibiotic therapy for Lyme disease is an area of great controversy. Recent studies have shown (...) Eligible for Study: All Accepts Healthy Volunteers: No Criteria INCLUSION CRITERIA: Criteria for the diagnosis of Lyme disease can be found at The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America (4). Patients With EM (N=35), Post Treatment Age 18 or older EM diagnosed by the study physician or, with a diagnosis of EM that is thought to be highly likely by the study

2010 Clinical Trials

169. Family Practice Notebook Updates 2017

patients) s have the potential for life threatening complications; prevention for , , vector-borne disease (hemeonc, ) Methemoglobin levels >20-30% or significant cardiopulmonary symptoms indicate antidote (methylene blue) s (cv, prevent, cad) Some additional lesser known CAD risk factors ( , , ) (lung, procedure, airway) Nonrebreather face mask can deliver >90% FIO2 for preoxygenation if combined with at 15 L/min (lung, procedure, airway) In , in-line stabilization offers little protection yet (...) Family Practice Notebook Updates 2017 Family Practice Notebook Updates 2017 Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Family

2018 FP Notebook

170. Chagas Disease

, American Trypanosomiasis , Trypanosoma cruzi , Rowana's Sign From Related Chapters II. Epidemiology Endemic Regions (tropical Americas) Mexico Central America South America (estimated) Endemic regions: 8-11 Million infected United States: 300,000 infected Most cases are via immigration and travel However vector-borne transmission has occurred in U.S. III. Pathophysiology Organism : Trypanosoma cruzi Transmission: Vector borne (primary source) Triatomine bug (reduviid bug, assassin bug or kissing bug (...) Chagas Disease Chagas Disease Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Chagas Disease Chagas Disease Aka: Chagas Disease

2018 FP Notebook

171. Typhus

, Murine Typhus , Endemic Typhus , Flea-Borne Typhus , Scrub Typhus , Brill-Zinsser Disease From Related Chapters II. Epidemiology Typhus is rare worldwide III. Pathophysiology Vector-borne illnesses caused by l or Oriential infection IV. Types Typhus or Epidemic Typhus Louse-borne transmission of prowazekii Typically occurs during war or over-crowded conditions, transmitted by May recur years after initial infection (Brill-Zinsser Disease) Murine Typhus or Endemic Typhus -borne transmission from rats (...) Typhus Typhus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Typhus Typhus Aka: Typhus , Epidemic Typhus , Louse-Borne Typhus

2018 FP Notebook

172. Family Practice Notebook Updates 2017

patients) s have the potential for life threatening complications; prevention for , , vector-borne disease (hemeonc, ) Methemoglobin levels >20-30% or significant cardiopulmonary symptoms indicate antidote (methylene blue) s (cv, prevent, cad) Some additional lesser known CAD risk factors ( , , ) (lung, procedure, airway) Nonrebreather face mask can deliver >90% FIO2 for preoxygenation if combined with at 15 L/min (lung, procedure, airway) In , in-line stabilization offers little protection yet (...) Family Practice Notebook Updates 2017 Family Practice Notebook Updates 2017 Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Family

2018 FP Notebook

173. Tooth Discoloration

Tooth Discoloration Tooth Discoloration Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tooth Discoloration Tooth Discoloration Aka (...) under age 8 (age 12 in Canada) Incorporated into developing enamel Even a single dose can stain teeth Yellow, brown or gray staining, that is much less common with than with Avoid in age <8 years, except in certain vector borne illness where alternative options are lacking Green, blue or gray staining Typically seen with prolonged use over 100 mg/day Staining risk may be reduced with supplementation (Chronic excessive fluoride intake) See Results in mottled dental enamel IV. Management See

2018 FP Notebook

174. West Nile Virus Encephalitis

West Nile Virus Encephalitis Aka: West Nile Virus Encephalitis , West Nile Encephalitis , West Nile Fever , West Nile Virus From Related Chapters II. Epidemiology Most common vector-borne virus in United States (as of 2016) Most severe illness occurs in older patients Over age 50: Twenty fold risk of severe illness Timing Temperate climate: Late summer and early fall Range of infections: Mid-July to early December Peaks in late August to early September Southern climate: Year round transmission (...) West Nile Virus Encephalitis West Nile Virus Encephalitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 West Nile Virus Encephalitis

2018 FP Notebook

175. Dengue

Limit contact ( , protective clothing, bed nets) See Vector borne infection New Dengue is available in Mexico (but not in U.S.) as of 2016 XII. References Anderson (2014) Crit Dec Emerg Med 28(7): 11-9 Black, Martin, DeVos (2018) Crit Dec Emerg Med 32(8): 3-12 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Dengue." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip (...) Dengue Dengue Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Dengue Dengue Aka: Dengue , Break-bone Fever , Dandy Fever , Duengero

2018 FP Notebook

176. Jay Lemery et al: We need climate doctors

), dyspnea (from degraded air quality and aeroallergens), fever (from vector-borne diseases or heat stroke), vomiting and diarrhea (from diminished water quality) and trauma (from extreme weather events) . All this begs the question: why hasn’t the physician community been more engaged in explaining these risks to the public? A simple explanation is because there is not one clinical specialty that owns the topic. A nephrologist understands kidney failure from an extreme heat event; an infectious disease (...) and climatologists at the University of Colorado launched a graduate medical education fellowship in climate and health policy. Working with partners at the Centers for Disease Control and Prevention and the National Institutes of Health, the fellowship will train young physicians to be thought leaders on this health threat, and to bring invaluable proficiencies to the forefront of policy conversations and decisions. Yet all these actions, taken alone, will ultimately be inadequate to serve the massive

2017 The BMJ Blog

177. Manuj C Weerasinghe and Sinha De Silva: It’s time to review strategies for dengue in Sri Lanka

of patients with dengue due to a lack of facilities and space [3,4]. The country has not experienced an epidemic of this magnitude in many recent years. At a time when Sri Lanka has been able to reduce the burden of many infectious diseases, including the elimination of malaria, and has achieved high vaccine coverage across the country for preventable communicable diseases, the emergence of yet another vector borne disease poses a major threat to the health of the population. The present situation raises (...) ]. However, at present fogging is initiated even if a single serologically confirmed or clinically diagnosed patient is found in an area. This has resulted in a false assurance in the minds of the general public that fogging can prevent dengue, which makes them less likely to become involved in prevention activities. A reduced awareness of the inherent limitations of using chemical methods to control vector born disease, along with a false image created in the minds of the public on fogging, further

2017 The BMJ Blog

178. Tracking Network Data Spotlight: Drought

users to track the duration and severity of drought over time throughout the country. This information can inform a wide variety of environmental and public health efforts related to drought. Drought and Health Drought can lead to other environmental health problems like reduced quantity and quality of drinking water and poorer air quality. These conditions can affect health by increasing the risks of infectious, chronic, and vector-borne diseases. Lower water levels can also result in diminished (...) and SPEI, available for . You can access county-level SPEI data from 1895-2016, while county level USDM, Palmer Drought Severity Index, and Standard Precipitation Index data are available from 2000-2016. Although many factors influence how drought will affect a community, drought trend data and other related information can be used to prepare for and prevent potential negative health effects. The Tracking Network provides several ways for health professionals, policy makers, researchers, and community

2018 CDC Your Health - Your Environment Blog

179. #WorldMalariaDay: can nets and sprays keep the bugs away? | Your Say

net out altogether as I crawled underneath it each evening, ready for another bout of tumbling and turning in the claustrophobic, heat-catching device. This same device has saved millions of people worldwide from vector-borne diseases such as malaria, Zika, dengue, and more. On World Malaria Day 2017, I can’t help but recall the many global health voyages I have taken to India, Sub-Saharan Africa, Southeast Asia, and Latin America, the regions of the world in which malaria is a daily plague (...) residual insecticide, outdoor aerial spraying, and the use of coils, mats and other repellents that remain in the house. However, given many villagers in these regions are subsistence farmers, they are in dire need of adequate malaria prevention while working outside, often near stagnant water and mosquito breeding grounds. Traditional mosquito repellents are expensive, wash off with sweat from the skin, and are undermined further because of mosquito resistance. Additionally, people have poor adherence

2017 PLOS Blogs Network

180. The Driving Force for 2014 Dengue Outbreak in Guangdong, China. Full Text available with Trip Pro

The Driving Force for 2014 Dengue Outbreak in Guangdong, China. Dengue fever has rapidly spread in recent decades to become the most globally expansive viral vector-borne disease. In mainland China, a number of dengue outbreaks have been reported since 1978, but the worst epidemic in decades, involving 45230 cases and 76 imported cases, resulting in six deaths in Guangdong province, emerged in 2014. Reasons for this ongoing surge in dengue, both imported and autochthonous, are currently unclear (...) and demand urgent investigation. Here, a seasonally-driven dynamic epidemiological model was used to simulate dengue transmission data recorded from the unprecedented outbreak. Sensitivity analysis demonstrate that delayed mosquito control, the continuous importations between the end of April to the early of July, the transmission of asymptomatic dengue infections, and the abnormally high precipitation from May to August might be the causal factors for the unprecedented outbreak. Our results suggested

2016 PLoS ONE

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