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Prevention of Vector-borne Infection

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141. Investments in Research and Surveillance Are Needed to Go Beyond Elimination and Stop Transmission of Leishmania in the Indian Subcontinent Full Text available with Trip Pro

for Research & Training in Tropical Diseases (TDR), Geneva, Switzerland. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom. Shamsuzzaman Tushar A K M TA Directorate General of Health Services (DGHS), Ministry of Health, Dhaka, Bangladesh. Marasini Baburam B Epidemiology and Disease Control Division, Department of Health Services, Ministry of Health, Kathmandu, Nepal. Dhariwal A C AC National Vector Borne Disease Control Programme (...) (NVBDCP), Directorate General of Health Services, Ministry of Health, New Delhi, India. Be-Nazir Ahmed A National Institute of Preventive and Social Medicine (NIPSOM), Ministry of Health, Dhaka, Bangladesh. Mondal Dinesh D International Centre for Diarrhoeal Diseases Research, Bangladesh (ICDDRB), Dhaka, Bangladesh. Banjara Megha Raj MR Central Department of Microbiology, Tribhuvan University, Kathmandu, Nepal. Das Pradeep P Rajendra Memorial Research Institute (RMRI)-ICMR, Patna, India. Sundar Shyam

2017 PLoS neglected tropical diseases

142. Lack of evidence for Zika virus transmission by Culex mosquitoes Full Text available with Trip Pro

Institute for Human Infections and Immunity, Institute for Translational Research, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA. Brault Aaron C AC Division of Vector-Borne Infectious Disease, Centers for Disease Control and Prevention, Fort Collins, CO, USA. Ebel Gregory D GD Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Ft. Collins, CO, USA. Failloux Anna-Bella (...) Lack of evidence for Zika virus transmission by Culex mosquitoes 29044195 2018 04 17 2018 12 02 2222-1751 6 10 2017 10 18 Emerging microbes & infections Emerg Microbes Infect Lack of evidence for Zika virus transmission by Culex mosquitoes. e90 10.1038/emi.2017.85 Roundy Christopher M CM Institute for Human Infections and Immunity, Institute for Translational Research, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA. Azar Sasha R SR

2017 Emerging Microbes & Infections

143. A tiny tick can cause a big health problem Full Text available with Trip Pro

that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination. The ticks were firmly latched on to the skin and careful removal prevented incarceration of the mouth parts. Rickettsial diseases that were believed to have disappeared from India are reemerging and their presence has recently been documented in at least 11 states in the country. Among vector borne (...) A tiny tick can cause a big health problem Ticks are tiny crawling bugs in the spider family that feed by sucking blood from animals. They are second only to mosquitoes as vectors of human disease, both infectious and toxic. Infected ticks spread over a hundred diseases, some of which are fatal if undetected. They spread the spirochete (which multiplies in the insect's gut) with a subsequent bite to the next host. We describe the only reported cases of peri ocular tick bite from India

2017 Indian journal of ophthalmology

144. Borrelia burgdorferi glycosaminoglycan-binding proteins: a potential target for new therapeutics against Lyme disease Full Text available with Trip Pro

Borrelia burgdorferi glycosaminoglycan-binding proteins: a potential target for new therapeutics against Lyme disease The spirochete bacterium Borrelia burgdorferi sensu lato is the causative agent of Lyme disease, the most common vector-borne disease in Europe and the United States. The spirochetes can be transmitted to humans via ticks, and then spread to different tissues, leading to arthritis, carditis and neuroborreliosis. Although antibiotics have commonly been used to treat infected (...) individuals, some treated patients do not respond to antibiotics and experience persistent, long-term arthritis. Thus, there is a need to investigate alternative therapeutics against Lyme disease. The spirochete bacterium colonization is partly attributed to the binding of the bacterial outer-surface proteins to the glycosaminoglycan (GAG) chains of host proteoglycans. Blocking the binding of these proteins to GAGs is a potential strategy to prevent infection. In this review, we have summarized the recent

2017 Microbiology

145. Liver Fluke-Associated Biliary Tract Cancer Full Text available with Trip Pro

fluke-induced changes in the biliary tract microbiome and the effects of repeated treatment for liver fluke. A vaccine and novel biomarkers are needed for the primary and secondary prevention of CCA in endemic areas. Importantly, climate change exerts an effect on vector-borne parasitic diseases, and awareness of liver fluke should be enhanced in potentially migrated habitat areas. (...) Liver Fluke-Associated Biliary Tract Cancer Cholangiocarcinoma (CCA) is an aggressive cancer arising from epithelial cells of the bile duct. Most patients with CCA have an unresectable tumor at the time of diagnosis. In Western countries, the risk of CCA increases in patients with primary sclerosing cholangitis, whereas liver fluke infection appears to be the major risk factor for CCA in Asian countries. A diagnosis of liver fluke infection often relies on stool samples, including microscopic

2017 Gut and liver

146. First molecular detection and characterization of zoonotic Bartonella species in fleas infesting domestic animals in Tunisia Full Text available with Trip Pro

First molecular detection and characterization of zoonotic Bartonella species in fleas infesting domestic animals in Tunisia Bartonellosis is an emerging vector-borne disease caused by different intracellular bacteria of the genus Bartonella (Rhizobiales: Bartonellaceae) that is transmitted primarily by blood-sucking arthropods such as sandflies, ticks and fleas. In Tunisia, there are no data available identifying the vectors of Bartonella spp. In our research, we used molecular methods (...) for the presence of Bartonella spp., targeting the citrate synthase gene (gltA). Bartonella DNA was detected in 14% (121/866) of the tested flea pools [estimated infection rate (EIR) per 2 specimens: 0.072, 95% confidence interval (CI): 0.060-0.086]. The Bartonella infection rate per pool was broken down as follows: 55% (65/118; EIR per 2 specimens: 0.329, 95% CI: 0.262-0.402) in C. canis; 23.5% (8/34; EIR per 2 specimens: 0.125, 95% CI: 0.055-0.233) in P. irritans and 6.7% (48/714; EIR per 2 specimens: 0.032

2017 Parasites & vectors

147. Infravec2: expanding researcher access to insect vector tools and resources Full Text available with Trip Pro

Unit of Hosts, Vectors and Pathogens (URA3012) , Paris , France. eng Editorial 2017 07 03 England Pathog Glob Health 101583421 2047-7724 IM Animals Biomedical Research methods organization & administration Disease Transmission, Infectious prevention & control Entomology methods Europe Humans Insect Vectors physiology virology 2017 7 5 6 0 2018 4 12 6 0 2017 7 5 6 0 ppublish 28673120 10.1080/20477724.2017.1347079 PMC5560197 Curr Trop Med Rep. 2017;4(1):27-39 28386524 Nature. 2016 Jan 21;529(7586 (...) ):256 26791685 Pathog Glob Health. 2013 Dec;107(8):458-62 24428829 Science. 2017 Jan 20;355(6322):234-235 28104846 Pathog Glob Health. 2016 Jun-Jul;110(4-5):164-72 27677378 Vector Borne Zoonotic Dis. 2012 Jun;12(6):435-47 22448724

2017 Pathogens and global health

148. Imaging of viral neuroinvasion in the zebrafish reveals that Sindbis and chikungunya viruses favour different entry routes Full Text available with Trip Pro

Imaging of viral neuroinvasion in the zebrafish reveals that Sindbis and chikungunya viruses favour different entry routes Alphaviruses, such as chikungunya virus (CHIKV) and Sindbis virus (SINV), are vector-borne pathogens that cause acute illnesses in humans and are sometimes associated with neuropathies, especially in infants and elderly patients. Little is known about their mechanism of entry into the central nervous system (CNS), even for SINV, which has been used extensively as a model (...) for viral encephalopathies. We previously established a CHIKV infection model in the optically transparent zebrafish larva; here we describe a new SINV infection model in this host. We imaged in vivo the onset and progression of the infection caused by intravenous SINV inoculation. Similar to that described for CHIKV, infection in the periphery was detected early and was transient, whereas CNS infection started at later time points and was persistent or progressive. We then tested the possible

2017 Disease models & mechanisms

149. Transmission dynamics and control of Rickettsia rickettsii in populations of Hydrochoerus hydrochaeris and Amblyomma sculptum Full Text available with Trip Pro

strategies for the control and prevention of vector-borne infectious diseases can be focused on amplifier hosts management practices. This work provides a basis for future prevention strategies for other neglected vector-borne diseases. (...) , vector of the R. rickettsii in this area.We proposed a semi-discrete-time stochastic model to evaluate the role of capybaras in the transmission dynamics of R. rickettsii. Through a sensitivity analysis, we identified the parameters with significant influence on the R. rickettsii establishment. Afterward, we implemented the Gillespie's algorithm to simulate the impact of potential public health interventions to prevent BSF human cases.The introduction of a single infected capybara with at least one

2017 PLoS neglected tropical diseases

150. Viral polymerase inhibitors T-705 and T-1105 are potential inhibitors of Zika virus replication Full Text available with Trip Pro

Viral polymerase inhibitors T-705 and T-1105 are potential inhibitors of Zika virus replication Since 2015, 69 countries and territories have reported evidence of vector-borne Zika virus (ZIKV) transmission. Currently, there are no effective licensed vaccines or drugs available for the treatment or prevention of ZIKV infection. We tested a series of compounds for their ability to inhibit ZIKV replication in cell culture. The compounds in T-705 (favipiravir) and T-1105 were found to have

2017 Archives of Virology

151. Tick Bioactive Molecules as Novel Therapeutics: Beyond Vaccine Targets Full Text available with Trip Pro

Animals Antigens immunology Arthropod Proteins immunology therapeutic use Drug Discovery Host-Pathogen Interactions immunology Humans Insect Vectors immunology Proteomics Tick Infestations prevention & control therapy Tick-Borne Diseases prevention & control therapy Ticks immunology Transcriptome immunology Vaccines immunology bioactive molecules microbiota pathogen therapeutics tick vector-borne disease 2017 03 04 2017 05 15 2017 6 22 6 0 2017 6 22 6 0 2018 8 21 6 0 epublish 28634573 10.3389/fcimb (...) Tick Bioactive Molecules as Novel Therapeutics: Beyond Vaccine Targets 28634573 2018 08 20 2018 11 13 2235-2988 7 2017 Frontiers in cellular and infection microbiology Front Cell Infect Microbiol Tick Bioactive Molecules as Novel Therapeutics: Beyond Vaccine Targets. 222 10.3389/fcimb.2017.00222 Murfin Kristen E KE Section of Infectious Disease, Department of Internal Medicine, Yale University School of MedicineNew Haven, CT, United States. Fikrig Erol E Section of Infectious Disease

2017 Frontiers in cellular and infection microbiology

152. Ticks and associated pathogens in dogs from Greece Full Text available with Trip Pro

Acarol. 2016 Jun;69(2):191-203 27003273 Ann N Y Acad Sci. 2006 Oct;1078:347-51 17114738 Vector Borne Zoonotic Dis. 2011 May;11(5):539-42 20925519 Exp Appl Acarol. 2008 Aug;45(3-4):195-8 18563592 Med Vet Entomol. 2003 Mar;17(1):110-3 12680933 Trans R Soc Trop Med Hyg. 2016 May;110(5):299-304 27198214 Parasitol Res. 2017 Jan;116(1):399-407 27796564 Vet Rec Open. 2015 Aug 28;2(2):e000077 26392908 Ticks Tick Borne Dis. 2013 Apr;4(3):251-5 23403153 Ticks Tick Borne Dis. 2014 Jun;5(4):409-14 24745731 Rev (...) isolation & purification pathogenicity Polymerase Chain Reaction Rhipicephalus microbiology parasitology Tick Infestations epidemiology prevention & control veterinary Tick-Borne Diseases epidemiology microbiology parasitology veterinary Dogs Greece PCR TBDs Tick-borne pathogens Ticks qPCR 2017 04 04 2017 05 30 2017 6 25 6 0 2017 6 25 6 0 2018 6 9 6 0 epublish 28645329 10.1186/s13071-017-2225-2 10.1186/s13071-017-2225-2 PMC5481936 Exp Appl Acarol. 2008 Aug;45(3-4):185-94 18677442 Parasitol Res. 2016 Dec

2017 Parasites & vectors

153. Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control Full Text available with Trip Pro

are regulated, (iii) assembly of host communities and tick-feeding patterns across different habitats, (iv) reservoir competence of host species, and (v) pathogenicity for humans of different genotypes of Borrelia burgdorferi Filling these knowledge gaps will improve Lyme disease prevention and control and provide general insights into the drivers and dynamics of this emblematic multi-host-vector-borne zoonotic disease.This article is part of the themed issue 'Conservation, biodiversity and infectious (...) that determine spatial and temporal variation in both disease risk and human incidence, which hamper effective and efficient prevention and control. Here we describe areas of consensus that can be built on, identify areas of uncertainty and outline research needed to fill these gaps to facilitate predictive models of disease risk and the development of novel disease control strategies. Key areas of uncertainty include: (i) the precise influence of deer abundance on tick abundance, (ii) how tick populations

2017 Philosophical Transactions of the Royal Society B: Biological Sciences

154. Drivers of Rift Valley fever epidemics in Madagascar Full Text available with Trip Pro

Drivers of Rift Valley fever epidemics in Madagascar Rift Valley fever (RVF) is a vector-borne viral disease widespread in Africa. The primary cycle involves mosquitoes and wild and domestic ruminant hosts. Humans are usually contaminated after contact with infected ruminants. As many environmental, agricultural, epidemiological, and anthropogenic factors are implicated in RVF spread, the multidisciplinary One Health approach was needed to identify the drivers of RVF epidemics in Madagascar. We (...) in from infected districts was associated with higher infection risk in slaughterhouse workers. The finding that anthropogenic rather than environmental factors are the main drivers of RVF infection in humans can be used to design better prevention and early detection in the case of RVF resurgence in the region.

2017 Proceedings of the National Academy of Sciences of the United States of America

155. The Many Faces of the Flavivirus NS5 Protein in Antagonism of Type I Interferon Signaling Full Text available with Trip Pro

The Many Faces of the Flavivirus NS5 Protein in Antagonism of Type I Interferon Signaling The vector-borne flaviviruses cause severe disease in humans on every inhabited continent on earth. Their transmission by arthropods, particularly mosquitoes, facilitates large emergence events such as witnessed with Zika virus (ZIKV) or West Nile virus in the Americas. Every vector-borne flavivirus examined thus far that causes disease in humans, from dengue virus to ZIKV, antagonizes the host type I (...) interferon (IFN-I) response by preventing JAK-STAT signaling, suggesting that suppression of this pathway is an important determinant of infection. The most direct and potent viral inhibitor of this pathway is the nonstructural protein NS5. However, the mechanisms utilized by NS5 from different flaviviruses are often quite different, sometimes despite close evolutionary relationships between viruses. The varied mechanisms of NS5 as an IFN-I antagonist are also surprising given that the evolution of NS5

2017 Journal of virology

156. Effect of physicochemical parameters on Anopheles and Culex mosquito larvae abundance in different breeding sites in a rural setting of Muheza, Tanzania Full Text available with Trip Pro

:28 24460952 Am J Trop Med Hyg. 2002 Jul;67(1):32-8 12363061 Annu Rev Entomol. 2013;58:433-53 23020619 Med Vet Entomol. 2010 Jun;24(2):117-23 20374477 J Vector Borne Dis. 2007 Dec;44(4):241-4 18092529 Trans R Soc Trop Med Hyg. 2004 Jul;98(7):400-8 15138076 BMC Infect Dis. 2013 Jul 21;13:335 23870103 Parasit Vectors. 2013 Jan 16;6:13 23324330 Acta Trop. 2013 Dec;128(3):692-700 24135628 PLoS Med. 2010 Feb 09;7(2):e1000209 20161718 Am J Trop Med Hyg. 2002 Jan;66(1):1 12135257 Parasit Vectors. 2014 (...) Apr 11;8:221 25889775 Insect Biochem Mol Biol. 2013 Apr;43(4):407-16 23123179 Ethiop J Health Sci. 2011 Mar;21(1):57-66 22434986 Parasit Vectors. 2012 Feb 09;5:33 22321562 J Am Mosq Control Assoc. 2003 Sep;19(3):251-8 14524547 J Vector Borne Dis. 2008 Mar;45(1):21-8 18399313 Parasit Vectors. 2013 Nov 04;6(1):320 24499518 Parasit Vectors. 2012 Mar 23;5:58 22444032 PLoS One. 2012;7(12):e52084 23272215 Malar J. 2015 Mar 06;14:104 25885457 Malar J. 2014 Aug 24;13:331 25150840 Malar J. 2014 Jan 25;13

2017 Parasites & vectors

157. Response: The Geographic Distribution of Ixodes scapularis (Acari: Ixodidae) Revisited: The Importance of Assumptions About Error Balance Full Text available with Trip Pro

and Prevention, 3156 Rampart Road, Fort Collins, CO 80521. Jarnevich Catherine S CS U.S. Geological Survey, Fort Collins Science Center, 2150 Centre Ave., Bldg. C, Fort Collins, CO 80526. Monaghan Andrew J AJ National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307. Eisen Rebecca J RJ Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, 3156 Rampart Road, Fort Collins, CO 80521. eng Journal Article Comment England J Med Entomol 0375400 0022-2585 IM J Med Entomol (...) Response: The Geographic Distribution of Ixodes scapularis (Acari: Ixodidae) Revisited: The Importance of Assumptions About Error Balance 28874013 2019 01 22 2019 01 22 1938-2928 54 5 2017 09 01 Journal of medical entomology J. Med. Entomol. Response: The Geographic Distribution of Ixodes scapularis (Acari: Ixodidae) Revisited: The Importance of Assumptions About Error Balance. 1104-1106 10.1093/jme/tjx096 Hahn Micah B MB Division of Vector-Borne Diseases, Centers for Disease Control

2017 Journal of medical entomology

158. A decade of arboviral activity—Lessons learned from the trenches Full Text available with Trip Pro

A decade of arboviral activity—Lessons learned from the trenches 28426723 2017 12 04 2019 02 02 1935-2735 11 4 2017 Apr PLoS neglected tropical diseases PLoS Negl Trop Dis A decade of arboviral activity-Lessons learned from the trenches. e0005421 10.1371/journal.pntd.0005421 Powers Ann M AM http://orcid.org/0000-0003-2653-7642 Division of Vector-Borne Diseases, CDC, Fort Collins, Colorado, United States of America. Waterman Stephen H SH Division of Vector-Borne Diseases, CDC, San Juan, Puerto (...) Rico, United States of America. eng Journal Article 2017 04 20 United States PLoS Negl Trop Dis 101291488 1935-2727 0 Viral Vaccines IM Arbovirus Infections epidemiology prevention & control virology Arboviruses physiology Disease Outbreaks Global Health Humans Viral Vaccines immunology 2017 4 21 6 0 2017 4 21 6 0 2017 12 5 6 0 epublish 28426723 10.1371/journal.pntd.0005421 PNTD-D-17-00254 PMC5398473 Wkly Epidemiol Rec. 2016 Jul 29;91(30):349-64 27476189 Nat Biotechnol. 2016 May 6;34(5):449

2017 PLoS neglected tropical diseases

159. Ten years of Chagas disease research: Looking back to achievements, looking ahead to challenges Full Text available with Trip Pro

and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States of America. Herrera Claudia C Department of Tropical Medicine, Vector-Borne Infectious Disease Research Center, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States of America. eng Journal Article 2017 04 20 United States PLoS Negl Trop Dis 101291488 1935-2727 0 Trypanocidal Agents IM Animals Chagas Disease drug therapy epidemiology parasitology prevention & control Global (...) Ten years of Chagas disease research: Looking back to achievements, looking ahead to challenges 28426735 2017 12 04 2018 11 13 1935-2735 11 4 2017 Apr PLoS neglected tropical diseases PLoS Negl Trop Dis Ten years of Chagas disease research: Looking back to achievements, looking ahead to challenges. e0005422 10.1371/journal.pntd.0005422 Dumonteil Eric E http://orcid.org/0000-0001-9376-0209 Department of Tropical Medicine, Vector-Borne Infectious Disease Research Center, School of Public Health

2017 PLoS neglected tropical diseases

160. Study in Healthy Volunteers to Evaluate the Safety and Immunogenicity of AGS-v, a Universal Mosquito-Borne Disease Vaccine

Vector Borne Viruses Vaccine Additional relevant MeSH terms: Layout table for MeSH terms Vaccines Immunologic Factors Physiological Effects of Drugs (...) First Posted : February 16, 2017 Last Update Posted : February 7, 2019 Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Information provided by (Responsible Party): National Institutes of Health Clinical Center (CC) ( National Institute of Allergy and Infectious Diseases (NIAID) ) Study Details Study Description Go to Brief Summary: Background: Mosquitos carry diseases that cause major health problems and death worldwide. The AGS-v vaccine targets proteins in mosquito saliva

2017 Clinical Trials

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