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Preoperative Guidelines for Medications Prior to Surgery

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2441. Exemestane or Docetaxel-Cytoxan in Low Recurrence Score Cancers

of peripheral or sensory neuropathy. Patients with a history of severe hypersensitivity reaction to docetaxel or other drugs formulated with polysorbate 80 are excluded from participation. Serious, uncontrolled, concurrent infection(s). Clinically significant cardiac disease (e.g. congestive heart failure, symptomatic coronary artery disease and cardiac arrhythmias not well controlled with medication) or myocardial infarction within the last 12 months prior to study entry. Major surgery within 28 days (...) exemestane can shrink the size of their breast tumor and allow them to preserve the breast or have less extensive surgery on their breast. Condition or disease Intervention/treatment Phase Breast Cancer Drug: Exemestane Drug: Docetaxel Drug: Cytoxan Phase 2 Detailed Description: The purpose of this study is to assess if chemotherapy using docetaxel and cytoxan (TC) or hormonal therapy using exemestane can shrink the size of your breast tumor and allow you to preserve your breast or have less extensive

2009 Clinical Trials

2442. Clinical Study to Improve Diagnosis and Treatment of Sinusitis

to preoperatively identify patients with CRS earlier in their disease course (possibly prior to the initiation of long courses of empiric antibiotic therapy); aid in the development of non-surgical therapies to eradicate bacterial biofilms with the sinus cavities; result in the identification of an objective biomarker to monitor success with therapies; and ultimately lead to less morbidity and risk for complications compared to conventional surgical therapy. In addition, transforming this paradigm would make (...) Rhinosinusitis Actual Study Start Date : August 2009 Actual Primary Completion Date : November 2013 Actual Study Completion Date : November 2013 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort Chronic Rhinosinusitis Patients with chronic rhinosinusitis as defined by American Academy of Otolaryngology-Head and Neck Surgery and American Rhinologic Society guidelines Control Group Patients undergoing endoscopic sinus surgery for diseases other

2009 Clinical Trials

2443. Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor

of the Kidney Stage I Kidney Wilms Tumor Stage II Kidney Wilms Tumor Stage III Kidney Wilms Tumor Stage IV Kidney Wilms Tumor Stage V Kidney Wilms Tumor Biological: Dactinomycin Drug: Doxorubicin Hydrochloride Radiation: Radiation Therapy Procedure: Therapeutic Conventional Surgery Drug: Vincristine Sulfate Phase 3 Detailed Description: OBJECTIVES: I. To improve 4-year event-free survival (EFS) to 73% for young patients with bilateral Wilms tumor (BWT). II. To prevent complete removal of at least one kidney (...) of undergoing a partial nephrectomy/renal sparing surgery. At week 12 definitive surgery takes place followed by chemotherapy and radiation therapy based on histology and stage. Treatment continues for 25 or 31 weeks depending on histology. Patients are followed for up to 10 years following end of therapy. ARM 2 (Unilateral High Risk tumors bilaterally predisposed): Patients start with either 2 drug or three drug chemotherapy (Regimen VA, VAD) and are evaluated a 6 and 12 weeks for feasibility of undergoing

2009 Clinical Trials

2444. Triathlon® Partial Knee Replacement (PKR) Outcomes Study

(Clinical Trial) Estimated Enrollment : 184 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Prospective, Post-market, Multi-center Study of the Outcomes of the Triathlon® Partial Knee Resurfacing (PKR) Unicondylar Knee System Study Start Date : January 2010 Estimated Primary Completion Date : January 2029 Estimated Study Completion Date : January 2029 Resource links provided by the National Library of Medicine related (...) ] Secondary Outcome Measures : Operating Room (OR) time [ Time Frame: Intraoperative ] Length of Hospital Stay [ Time Frame: Hospital Discharge, expected range of 1-3 days ] Amount of Blood Loss [ Time Frame: Intraoperative ] Range of Motion Improvement at post-surgery visits [ Time Frame: 2 weeks, 6 weeks, 3 months, 1, 2, 5, 7, 10 years ] Knee Society Score improvement at post-surgery visits [ Time Frame: 2 weeks, 6 weeks, 3 months, 1, 2, 5, 7, 10 years ] The Knee Society Clinical Rating System

2009 Clinical Trials

2445. Pharmacokinetics (PK) Study of AC480 for Recurrent Glioma

-month progression-free survival (PFS) and radiographic response. This is a single institution, open label, pharmacokinetic study of AC480 in patients with recurrent malignant glioma. The study will enroll 5 patients who are not on enzyme inducing anti-epileptic drugs (EIAEDs) and are scheduled to undergo salvage surgical resection for preoperative treatment with AC480 at 300 mg orally twice daily (BID) for 14 (plus or minus 2) days before surgery (Part I- Induction Therapy). After surgery (Part II (...) - Maintenance Therapy), patients will continue to be dosed with AC480 until disease progression or intolerance, and will be evaluated after every other cycle (1 cycle is 28 days). Condition or disease Intervention/treatment Phase Glioma Drug: AC480 Phase 1 Detailed Description: Plasma and tumoral pharmacokinetics, as well as FDG-PET data will be analyzed to determine the intratumoral and plasma levels of AC480 obtained and its antiproliferative activity. After recovery from surgery, all patients will resume

2009 Clinical Trials

2446. Massage Therapy and Port-a-Catheter Insertion

States, Massachusetts Boston Medical Center - Ambulatory Surgery Boston, Massachusetts, United States, 02118 Sponsors and Collaborators Boston Medical Center Massage Therapy Foundation Investigators Layout table for investigator information Principal Investigator: Jennifer E Rosen, MD, FACS Boston Medical Center More Information Go to Publications: Layout table for additonal information Responsible Party: Jennifer Rosen, Assistant Professor of Medicine, Boston Medical Center ClinicalTrials.gov (...) Actual Study Completion Date : October 2011 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Massage Therapy Massage therapy provided by a certified Massage Therapist Other: Massage Therapy Two 20 minute chair massages: one before surgery and one after Active Comparator: Control Empathic support conversation Other: Attention Control Two 20 minute sessions where the Massage Therapist will talk

2009 Clinical Trials

2447. Rosuvastatin in Treating Patients With Stage I or Stage II Colon Cancer That Was Removed By Surgery

, resection of the stomach or small bowel, or other disease significantly affecting gastrointestinal function. History of documented upper GI bleeding or upper GI ulcerative disease. Statin use within 30 days prior to randomization. Hyperlipidemia with clinical indication for statin therapy or other prescribed medication. Determination of acceptable fasting lipid values, within 90 days prior to randomization, should be in accordance with current dyslipidemia management guidelines. Unwillingness (...) . Patients must have the ability to swallow oral medication. Patients must have resected adenocarcinoma of the colon staged as American Joint Committee on Cancer (AJCC) Stage 0, I, II, or III. Patients must have had surgical resection of the colon adenocarcinoma with curative intent within 1 year prior to randomization. (Laparoscopically-assisted colectomy is permitted.) Patients must have completed any adjuvant therapy prior to randomization. Patients who are taking cardioprotective low-dose aspirin

2009 Clinical Trials

2448. Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors

Actual Study Start Date : March 2009 Estimated Primary Completion Date : September 2019 Estimated Study Completion Date : September 2019 Resource links provided by the National Library of Medicine resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: MRI The advanced MRI studies will be obtained at the time of the routinely scheduled preoperative planning MRI and/or the routinely scheduled pre-RT planning MRI at approximately 3±2 weeks after surgery. The routine sequences (...) and/or Neurooncology Tumor Board. Advanced brain MRIs with the 2 (or, in some cases, 3) special sequences will be obtained at the time of the clinically scheduled contrast MRIs, which are usually obtained immediately prior to and 1 months±3 weeks after radiation therapy if the patient requires radiation therapy for his/her tumor. The advanced brain MRI may also be obtained before surgery for suspected or confirmed gliomas, as per the standard of care, in some patients who may or may not require radiation therapy

2009 Clinical Trials

2449. The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects

limb. Specific contraindications include the use of tobacco and medications that may impair cell proliferation, such as NSAIDs and immunosuppressive drugs. Patients must be nicotine-free (stop smoking) prior to the procedure, as studies have shown that the oxidative effect of smoking impairs cell function and subsequent healing. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using (...) Director: Abdel Aziz El Singergy, M.D Department of Orthopedic Surgery Cairo University School of Medicine Principal Investigator: Amgad M Haleem, M.Sc(Ortho) Department of Orthopedic Surgery Cairo University School of Medicne Study Director: Hazem M Atta, Ph.D Tissue Culture Unit - Department of Medical Biochemistry - Cairo University School of Medicine More Information Go to Publications of Results: Layout table for additonal information Responsible Party: Amgad Mohammed Haleem Ahmed Amin, M.B.B.S

2009 Clinical Trials

2450. Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma

Meningiomas Study Start Date : June 2009 Actual Primary Completion Date : September 2016 Resource links provided by the National Library of Medicine resources: Arms and Interventions Go to Arm Intervention/treatment No Intervention: Low Risk No treatment given. Experimental: Intermediate Risk 54 Gy radiotherapy Radiation: 54 Gy radiotherapy External beam radiation therapy (EBRT) to a total dose of 54 Gy (RBE) in 30 fractions. 1.8 Gy (RBE) daily, 5 fractions per week, excluding weekends. 3D-CRT or IMRT (...) . The CTCAE v3.0 assigns Grades 1 through 5 with unique clinical descriptions of severity for each AE based on this general guideline: Grade 1 Mild AE, Grade 2 Moderate AE, Grade 3 Severe AE, Grade 4 Life-threatening or disabling AE, Grade 5 Death related to AE. Number of Patients With Grades 2-5 Late Adverse Events in the Following Categories Individually and Combined: Neurology, Ocular/Visual, Dermatologic/Skin [Excluding Alopecia] [ Time Frame: Ninety-one days from start of radiation therapy to last

2009 Clinical Trials

2451. Preoperative Pemetrexed and Carboplatin for Select Stage IB, II, and III Non-Squamous Non-Small-Cell Lung Cancer

Start Date : June 2009 Actual Primary Completion Date : August 2015 Actual Study Completion Date : September 2015 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Pemetrexed/Carboplatin 4 cycles of preoperative treatment (1 Cycle = 21 days): Pemetrexed: 500 mg/m2 intravenously (IV) for 10 minutes on Day 1 each cycle; Carboplatin: AUC 6.0 by IV on Day 1 each cycle. Drug (...) , or resection of adjacent chest wall or mediastinal structures when appropriate. Surgery followed standard guidelines for resection of non-small-cell lung cancer (NSCLC). Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts

2009 Clinical Trials

2452. Rivastigmine in the Treatment of Postoperative Delirium: a Pilot Clinical Trial

information Ages Eligible for Study: 65 Years and older (Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: 65 ≥ y.o. undergoing major elective surgery over 2 hours in length with one or more of the following: Preoperative cognitive impairment Age > 70 y.o. Use of psychoactive medications History of prior delirium Severe illness/co-morbidity Exclusion Criteria: Delirium on admission Profound dementia No spoken/written English An emergent procedure (...) School of Medicine Collaborator: Novartis Information provided by (Responsible Party): New York University School of Medicine Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether preoperative administration of Rivastigmine prevents the incidence of postoperative delirium in patients undergoing major surgery as well as postoperative cognitive dysfunction. Condition or disease Intervention/treatment Phase Delirium Postoperative Cognitive Dysfunction

2009 Clinical Trials

2453. Surgery and transplantation – Guidelines on Parenteral Nutrition, Chapter 18 Full Text available with Trip Pro

) such as in chronic intestinal obstruction with a relevant passage obstruction e.g. a peritoneal carcinoma. If energy and nutrient requirements cannot be met by oral and enteral intake alone, a combination of enteral and parenteral nutrition is indicated. Delaying surgery for a systematic nutrition therapy (enteral and parenteral) is only indicated if severe malnutrition is present. Preoperative nutrition therapy should preferably be conducted prior to hospital admission to lower the risk of nosocomial infections (...) Surgery and transplantation – Guidelines on Parenteral Nutrition, Chapter 18 In surgery, indications for artificial nutrition comprise prevention and treatment of catabolism and malnutrition. Thus in general, food intake should not be interrupted postoperatively and the re-establishing of oral (e.g. after anastomosis of the colon and rectum, kidney transplantation) or enteral food intake (e.g. after an anastomosis in the upper gastrointestinal tract, liver transplantation) is recommended

2009 GMS German Medical Science

2454. Perioperative management and the associated rate of adverse events in dermatological procedures performed by dermatologists in New Zealand. (Abstract)

measurements either preoperatively or intraoperatively. Antibiotic prophylaxis was generally only prescribed if clinically indicated, and anticoagulation and antiplatelet therapies were in the majority of cases never withheld prior to surgery. Infection (<3.5%) and bleeding (<2%) were the most common postoperative complications, with other serious adverse events being extremely rare. Although dermatological surgery continues to be safely performed in the outpatient setting, attempts should still be made (...) Perioperative management and the associated rate of adverse events in dermatological procedures performed by dermatologists in New Zealand. Dermatological surgery performed in an outpatient setting is common and generally perceived as safe, but the potential for serious adverse events does exist. Furthermore, there is a current lack of guidelines regarding preoperative and intraoperative monitoring of such patients. This is a retrospective study that involved a written questionnaire sent

2009 Australasian Journal of Dermatology

2455. Newer Anesthesia and Rehabilitation Protocols Enable Outpatient Hip Replacement in Selected Patients. Full Text available with Trip Pro

and rehabilitation protocol including preoperative teaching, regional anesthesia, and preemptive oral analgesia and antiemetic therapy was implemented around a minimally invasive surgical technique. A rapid rehabilitation pathway was started immediately after surgery and patients had the option of being discharged to home the day of surgery if standard discharge criteria were met. All 150 patients were discharged to home the day of surgery, at which time 131 patients were able to walk without assistive devices (...) . Thirty-eight patients required some additional intervention outside the pathway to resolve nausea, hypotension, or sedation prior to discharge. There were no readmissions for pain, nausea, or hypotension yet there was one readmission for fracture and nine emergency room evaluations in the three month perioperative period. This anesthetic and rehabilitation protocol allowed outpatient total hip arthroplasty to be routinely performed in these consecutive patients undergoing primary total hip

2009 Clinical Orthopaedics and Related Research

2456. Evaluation and implications of natural product use in preoperative patients: a retrospective review. Full Text available with Trip Pro

among patients scheduled for surgery, to improve existing medication reconciliation efforts, and to develop discontinuation guidelines for the use of these products prior to surgery.A retrospective review of surgery patients presenting to the Anesthesia Preoperative Evaluation Clinic (APEC) at the University of Kansas Hospital was conducted to identify the prevalence of natural product use. The following data was collected: patient age; gender; allergy information; date of medication history; number (...) seen in the APEC indicated the use of natural products. Patients taking natural products were significantly older, were more likely to undergo cardiac or chest surgery, and were more likely to be taking more prescription and non-prescription medications (all p < 0.001).Based on the results of this study, it is concluded that there is a need for established guidelines regarding discontinuation of selected natural products prior to surgery and further education is needed concerning the perioperative

2009 BMC Complementary and Alternative Medicine

2457. Iodine

along with compression therapy seems help heal leg ulcers and reduce the chance of a future infection. Possibly effective for... Conjunctivitis (pinkeye) . Research suggests that using eye drops containing iodine in the form of povidone-iodine is more effective than silver nitrate for decreasing the risk of pinkeye in newborns. However, it is not more effective than the medications erythromycin or chloramphenicol. Foot ulcers in diabetes . Applying iodine to foot ulcers might be beneficial (...) of this rash. Thyroid disorders, such as too little thyroid function (hypothyroidism), an enlarged thyroid gland (goiter), or a thyroid tumor : Prolonged use or high doses of iodine might make these conditions worse. Are there interactions with medications? Major Do not take this combination. Medications for an overactive thyroid (Antithyroid drugs) Iodine can decrease thyroid function. Taking iodine along with medications for an overactive thyroid might decrease the thyroid too much. Do not take iodine

2009 National Centre for Complementary and Alternative Medicine

2458. Surgical site infections: prevention and treatment

are at greater risk of surgical site infections being considered for surgery. In addition, increased numbers of infections are now being seen in primary care because patients are allowed home earlier following day case and fast-track surgery. The guideline makes recommendations for prevention and management of surgical site infections based on rigorous evaluation of the best available published evidence. The guideline will assume that prescribers will use a drug's summary of product characteristics (...) Contents Introduction 4 Patient-centred care 6 Key priorities for implementation 7 1 Guidance 9 1.1 Information for patients and carers 9 1.2 Preoperative phase 9 1.3 Intraoperative phase 11 1.4 Postoperative phase 13 T erms used in this guideline 15 More information 16 2 Research recommendations 17 2.1 Nasal decontamination 17 2.2 Maintaining patient homeostasis 17 2.3 Closure methods 18 2.4 Wound dressings 19 2.5 Dressings for wound healing by secondary intention 19 Update information 20 Surgical

2008 National Institute for Health and Clinical Excellence - Clinical Guidelines

2459. Metastatic spinal cord compression in adults: diagnosis and management

surgery may be more effective than radiotherapy at maintaining mobility in a selected subset of patients. The guideline will assume that prescribers will use a drug's summary of product characteristics to inform their decisions for individual patients. [1] Levack P et al (2001) A prospective audit of the diagnosis, management and outcome of malignant cord compression (CRAG 97/08). Edinburgh: CRAG. [2] Loblaw DA, Laperriere NJ, Mackillop WJ (2003) A population-based study of malignant spinal cord (...) kyphoplasty for vertebral compression fractures' (NICE interventional procedure guidance 166). [6] T okuhashi Y et al (2005) A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine 30 (19): 2186–91. [7] See 'Venous thromboembolism' (NICE clinical guideline 46) for information on reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in inpatients undergoing spinal surgery. Metastatic spinal cord compression in adults: risk

2008 National Institute for Health and Clinical Excellence - Clinical Guidelines

2460. Improving outcomes in children and young people with cancer

providers. There are many other current national initiatives of relevance, not least national service frameworks (NSFs) and other Improving Outcomes guidance; care has been taken not to duplicate this work, but adherence to such guidance is expected. The guidance also assumes compliance with the relevant national guidelines on the administration/management of therapies (see Appendix 1) and any relevant legal frameworks. The population, healthcare settings, and services and key areas of clinical (...) The service guidance programme was initiated in 1995 to follow on from the Calman–Hine Report, A Policy Framework for Commissioning Cancer Services. 3 The focus of the cancer service guidance is to guide the commissioning of services and is therefore different from clinical practice guidelines. Health services in England and Wales have organisational arrangements in place for securing improvements in cancer services and those responsible for their operation should take this guidance into account when

2005 National Institute for Health and Clinical Excellence - Clinical Guidelines

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