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Prenatal Vitamin

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141. Effect of Vitamin D Replacement on Maternal and Neonatal Outcomes

) recommends 600 IU of vitamin D per day to reach a 25-Hydroxyvitamin D (25(OH)D) level ≥ 20 ng/ml, the Endocrine Society (ES) recommends 1,500-2,000 IU/day to reach a level ≥ 30 ng/ml, and the WHO guidelines do not recommend any supplementation as part of routine prenatal care. They do however underscore the fact that subjects with the lowest levels may be the ones to benefit most from vitamin D replacement. The benefits of such an approach and the doses needed to reach desirable levels have not been (...) years Vitamin D supplementation ≤ 200 IU daily (If daily vitamin D supplementation > 200 IU daily, at enrollment, the pregnant women will be advised to adjust prenatal multivitamin doses in such a way that total vitamin D supplementation per week doesn't exceed 1400 IU per week, in consultation with primary Obstetric and Gynecology (OB-GYN) physician.) Exclusion Criteria: 25(OH)D level < 10 ng/ml or > 30 ng/ml. Known metabolic bone disease Current medications likely to interfere with vitamin D

2015 Clinical Trials

142. Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial. (Full text)

Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial. Vitamin D regulates bone mineral metabolism and skeletal development. Some observational studies have suggested that prenatal vitamin D deficiency increases the risk of adverse pregnancy and/or birth outcomes; however, there is scant evidence from controlled trials, leading the World Health Organization to advise against (...) ) the effect of maternal prenatal oral vitamin D3 supplementation (4200 IU/wk, 16,800 IU/wk, or 28,000 IU/wk, administered as weekly doses) versus placebo on infant length at 1 year of age and (2) the effect of maternal postpartum oral vitamin D3 supplementation (28,000 IU/wk) versus placebo on length at 1 year of age among infants born to women who received vitamin D 28,000 IU/wk during pregnancy. Generally healthy pregnant women (n = 1300) in the second trimester (17-24 weeks of gestation) are randomized

2015 Trials Controlled trial quality: predicted high

143. Gestational and Early Infancy Exposure to Margarine Fortified with Vitamin D through a National Danish Programme and the Risk of Type 1 Diabetes: The D-Tect Study (Full text)

and consisted of 331,623 individuals. The 1st of June 1985, which was the date of issue of the new ministerial order cancelling mandatory fortification of margarine with vitamin D in Denmark, served as a reference point separating the studied population into various exposure groups. We further modelled birth cohort effects in children developing T1D as a linear spline, and compared the slopes between the birth cohorts with various prenatal and infancy exposures to vitamin D fortification. In total, 886 (...) Gestational and Early Infancy Exposure to Margarine Fortified with Vitamin D through a National Danish Programme and the Risk of Type 1 Diabetes: The D-Tect Study The objective of the study was to assess whether gestational and early infancy exposure to low dose vitamin D from a mandatory margarine fortification programme in Denmark influenced the risk of developing type 1 diabetes (T1D) before age of 15 years. The study population included all individuals born in Denmark from 1983 to 1988

2015 PloS one

144. Influence of Roux-en-Y Gastric Bypass on the Nutritional Status of Vitamin A in Pregnant Women: a Comparative Study. (PubMed)

that pregnancy after RYGB can represent a high-risk situation for VAD. We recommend interdisciplinary monitoring added to the prenatal routine consultations and the conduction of studies addressed to the investigation of a safe and effective dose of oral supplementation of vitamin A to pregnant women undergoing RYGB. (...) Influence of Roux-en-Y Gastric Bypass on the Nutritional Status of Vitamin A in Pregnant Women: a Comparative Study. The objective of the present study is to evaluate the nutritional status of vitamin A through biochemical and functional indicators of pregnant women who underwent Roux-en-Y gastric bypass (RYGB) surgery compared to pregnant women who did not undergo this surgery.The present study is a cross-sectional study of the analytical type with pregnant women paired by age and prepregnancy

2015 Obesity Surgery

145. Vitamin B-12 Status Differs among Pregnant, Lactating, and Control Women with Equivalent Nutrient Intakes. (Full text)

, nonlactating; n = 21) women consumed vitamin B-12 amounts of ∼8.6 μg/d [mixed diet (∼6 μg/d) plus a prenatal multivitamin supplement (2.6 μg/d)]. Serum vitamin B-12, holotranscobalamin (bioactive form of vitamin B-12), methylmalonic acid (MMA), and homocysteine were measured at baseline and study-end.All participants achieved adequate vitamin B-12 status in response to the study dose. Compared with control women, pregnant women had lower serum vitamin B-12 (-21%; P = 0.02) at study-end, whereas lactating (...) Vitamin B-12 Status Differs among Pregnant, Lactating, and Control Women with Equivalent Nutrient Intakes. Limited data are available from controlled studies on biomarkers of maternal vitamin B-12 status.We sought to quantify the effects of pregnancy and lactation on the vitamin B-12 status response to a known and highly controlled vitamin B-12 intake.As part of a 10-12 wk feeding trial, pregnant (26-29 wk gestation; n = 26), lactating (5 wk postpartum; n = 28), and control (nonpregnant

2015 Journal of Nutrition Controlled trial quality: uncertain

146. Maternal Vitamin D for Acute Respiratory Infections in Infancy

of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Placebo Comparator: Group A Prenatal Period 0 IU; Postpartum Period 0 IU (placebo) Overall: The Prenatal Period will start at enrolment (17-24 weeks gestation) and last until delivery. The Postpartum Period will last from delivery until 6 months postpartum. Dietary Supplement: Placebo Experimental: Group B Prenatal Period 4,200 IU/week of vitamin D3; Postpartum Period 0 IU/week (placebo) Dietary Supplement (...) : Vitamin D3 Other Name: Cholecalciferol Experimental: Group C Prenatal Period 16,800 IU/week of vitamin D3; Postpartum Period 0 IU/week (placebo) Dietary Supplement: Vitamin D3 Other Name: Cholecalciferol Experimental: Group D Prenatal Period 28,000 IU/week of vitamin D3; Postpartum Period 0 IU/week (placebo) Dietary Supplement: Vitamin D3 Other Name: Cholecalciferol Experimental: Group E Prenatal Period 28,000 IU/week of vitamin D3; Postpartum Period 28,000 IU/week Dietary Supplement: Vitamin D3 Other

2015 Clinical Trials

147. Trial of Vitamin D Supplements to Raise Calcidiol Levels of Pregnant Women in Mongolia

Collaborators: National Center for Maternal and Child Health Research, Mongolia Zuun Kharaa Hospital Information provided by (Responsible Party): Janet Rich-Edwards, Brigham and Women's Hospital Study Details Study Description Go to Brief Summary: A double-blind randomized, placebo-controlled trial comparing the impact of 600 IU, 2000 IU, or 4000 IU of Vitamin D3 on third trimester 25(OH)D levels and change from baseline. The Vitamin D will be integrated in a standard prenatal vitamin, which will be taken (...) Vitamin D3 in prenatal vitamin Dietary Supplement: 2000 IU Vitamin D3 in prenatal vitamin Dietary Supplement: 4000 IU Vitamin D3 in prenatal vitamin Not Applicable Detailed Description: Vitamin D deficiency (serum 25(OH)D levels <20 ng/ml or 50 nmol/l) is widespread among Mongolians and is nearly universal during the winter months. The investigators have conducted a series of studies which have shown nearly universal Vitamin D deficiency in the winter months. Observational studies in the U.S. have

2015 Clinical Trials

148. Vitamin C supplementation ameliorates the adverse effects of nicotine on placental hemodynamics and histology in nonhuman primates. (Full text)

Vitamin C supplementation ameliorates the adverse effects of nicotine on placental hemodynamics and histology in nonhuman primates. We previously demonstrated that prenatal nicotine exposure decreases neonatal pulmonary function in nonhuman primates, and maternal vitamin C supplementation attenuates these deleterious effects. However, the effect of nicotine on placental perfusion and development is not fully understood. This study utilizes noninvasive imaging techniques and histological (...) analysis in a nonhuman primate model to test the hypothesis that prenatal nicotine exposure adversely effects placental hemodynamics and development but is ameliorated by vitamin C.Time-mated macaques (n = 27) were divided into 4 treatment groups: control (n = 5), nicotine only (n = 4), vitamin C only (n = 9), and nicotine plus vitamin C (n = 9). Nicotine animals received 2 mg/kg per day of nicotine bitartrate (approximately 0.7 mg/kg per day free nicotine levels in pregnant human smokers) from days 26

2015 American Journal of Obstetrics and Gynecology

149. Randomized controlled trial (RCT) of vitamin D supplementation in pregnancy in a population with endemic vitamin D deficiency. (Full text)

Randomized controlled trial (RCT) of vitamin D supplementation in pregnancy in a population with endemic vitamin D deficiency. Vitamin D (vD) deficiency in pregnancy is a global health problem and the amount of vD supplementation to prevent vD deficiency is controversial.The objective of the study was to determine effectiveness and safety of prenatal 2000 IU and 4000 IU/d compared with 400 IU/d vD3 supplementation in a randomized controlled trial in population in which vD deficiency

2013 The Journal of clinical endocrinology and metabolism Controlled trial quality: predicted high

150. Provider Adherence to Recommended Prenatal Care Content: Does It Differ for Obese Women? (Full text)

-income, minority women from 2003 to 2004. Sample content items included procedures delivered at every visit (blood pressure, urinalysis, maternal weight, fetal heart rate check), timed screenings for birth defects and gestational diabetes, prenatal vitamin prescriptions, and depression screening. Weight gain, preterm deliveries, cesareans, and birthweight were compared between obese women with low and medium versus high adherence to PNC content using multivariable logistic regression. High provider (...) Provider Adherence to Recommended Prenatal Care Content: Does It Differ for Obese Women? The objective of this study was to examine provider adherence to prenatal care (PNC) content in obese and non-obese women and perinatal outcomes in obese women experiencing low and medium versus high adherence to PNC content. Provider adherence to PNC content (low <50%, medium 50-79%, and high ≥80%) was compared between obese (n = 69) and non-obese (n = 128) women in a linked database of deliveries to low

2014 Maternal and child health journal

151. Prenatal investments, breastfeeding, and birth order. (PubMed)

Prenatal investments, breastfeeding, and birth order. Mothers have many opportunities to invest in their own or their child's health and well-being during pregnancy and immediately after birth. These investments include seeking prenatal care, taking prenatal vitamins, and breastfeeding. In this paper, we investigate a potential determinant of mothers' investments that has been largely overlooked by previous research-birth order. Data are from the National Longitudinal Study of Youth 1979 (...) that mothers are 6.6 percent less likely to take prenatal vitamins in a fourth or higher-order birth than in a first and are 10.6 percent less likely to receive early prenatal care. Remarkably, mothers are 15.4 percent less likely to breastfeed a second-born child than a first, and are 20.9 percent less likely to breastfeed a fourth or higher-order child. These results are not explained by changing attitudes toward investments over time. These findings suggest that providers may want to increase efforts

2014 Social Science & Medicine

152. Neither absence nor excess of FGF23 disturbs murine fetal-placental phosphorus homeostasis or prenatal skeletal development and mineralization. (Full text)

Neither absence nor excess of FGF23 disturbs murine fetal-placental phosphorus homeostasis or prenatal skeletal development and mineralization. Fibroblast growth factor-23 (FGF23) controls serum phosphorus largely through actions on the kidneys to excrete phosphorus and reduce calcitriol. Although these actions are well established in adults and children, the role that FGF23 plays in regulating fetal phosphorus metabolism has not been previously studied. We used several mouse models to study (...) . Placentas and fetal kidneys abundantly express FGF23 target genes. Cyp24a1 was significantly reduced in Fgf23 null kidneys and was significantly increased in Phex null placentas and fetal kidneys. Phex null kidneys also showed reduced expression of Klotho. However, these changes in gene expression did not disturb any physiological parameter related to phosphorus. A 50% reduction in FGF23 also failed to affect renal phosphorus excretion into amniotic fluid when either PTH or the vitamin D receptor were

2014 Endocrinology

153. Optimizing Periconceptional and Prenatal Folic Acid Supplementation

Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: PregVit-Folic 5®-5 mg folic acid Prenatal multivitamin-mineral supplement called PregVit-folic 5® contains 5 mg of folic acid. All other vitamin and mineral doses are identical between the 2 supplements, except for folic acid. Both supplements are taken as 2 tablets daily, one tablet in the morning (am) and one tablet in the evening (pm). Both multivitamins are appropriate (...) . All other vitamin and mineral doses are identical between the 2 supplements, except for folic acid. Both supplements are taken as 2 tablets daily, one tablet in the morning (am) and one tablet in the evening (pm). Both multivitamins are appropriate for periconceptional, prenatal, and post-partum supplementation. Drug: PregVit® contains 1.1 mg of folic acid Participants are randomly allocated to one of two groups: PregVit-Folic 5® (group1) contains 5 mg folic acid or PregVit® (group 2) contains 1.1

2014 Clinical Trials

154. Maternal Fetal Attachment, Locus of Control and Adherence to STI/HIV Prevention and Prenatal Care Promotion Behaviors in Urban Women (Full text)

this is beneficial, pregnant women in non-monogamous relationships may discount the importance of condom use during pregnancy. Prenatal care providers can provide education about condom use as a beneficial prenatal care behavior similar to taking prenatal vitamins. (...) Maternal Fetal Attachment, Locus of Control and Adherence to STI/HIV Prevention and Prenatal Care Promotion Behaviors in Urban Women Young women of childbearing age are disproportionately affected by sexually transmitted infections (STIs) including HIV. In particular, young women have more frequent and more serious health problems from STI or HIV infection than men, and among women, African American women have especially high rates of infection. Pregnancy is an important time for beginning

2014 International journal of gynecological obstetrical and reproductive medicine research

155. Prenatal Nutrition (Diagnosis)

is not recommended. Both iron and copper compete with zinc at absorption sites. Zinc supplementation is recommended when elemental iron supplementation exceeds 60 mg/d. Likewise, whenever zinc supplements are used, copper should also be supplemented. Different prenatal vitamin formulations contain different amounts of copper and zinc. Usually, copper or zinc supplementation can be accomplished by appropriate selection of a prenatal vitamin formulation. [ ] Sodium Sodium is present in large quantities (...) in the average American diet. The RDA is 1.5 mg during pregnancy, lactation, and the non-pregnant state. Whether pregnant or not, sodium should neither be restricted nor used excessively. [ ] Well-balanced diets "salted to taste" satisfy sodium requirements and obviate any need for supplementation. Pregnant women should be counseled that most processed and pre-prepared foods are high in sodium. [ ] Previous Next: Prenatal Vitamin Supplements A standard prenatal vitamin formulation contains: Iron - 30 mg Zinc

2014 eMedicine.com

156. Prenatal Nutrition (Follow-up)

is not recommended. Both iron and copper compete with zinc at absorption sites. Zinc supplementation is recommended when elemental iron supplementation exceeds 60 mg/d. Likewise, whenever zinc supplements are used, copper should also be supplemented. Different prenatal vitamin formulations contain different amounts of copper and zinc. Usually, copper or zinc supplementation can be accomplished by appropriate selection of a prenatal vitamin formulation. [ ] Sodium Sodium is present in large quantities (...) in the average American diet. The RDA is 1.5 mg during pregnancy, lactation, and the non-pregnant state. Whether pregnant or not, sodium should neither be restricted nor used excessively. [ ] Well-balanced diets "salted to taste" satisfy sodium requirements and obviate any need for supplementation. Pregnant women should be counseled that most processed and pre-prepared foods are high in sodium. [ ] Previous Next: Prenatal Vitamin Supplements A standard prenatal vitamin formulation contains: Iron - 30 mg Zinc

2014 eMedicine.com

157. Prenatal Nutrition (Treatment)

is not recommended. Both iron and copper compete with zinc at absorption sites. Zinc supplementation is recommended when elemental iron supplementation exceeds 60 mg/d. Likewise, whenever zinc supplements are used, copper should also be supplemented. Different prenatal vitamin formulations contain different amounts of copper and zinc. Usually, copper or zinc supplementation can be accomplished by appropriate selection of a prenatal vitamin formulation. [ ] Sodium Sodium is present in large quantities (...) in the average American diet. The RDA is 1.5 mg during pregnancy, lactation, and the non-pregnant state. Whether pregnant or not, sodium should neither be restricted nor used excessively. [ ] Well-balanced diets "salted to taste" satisfy sodium requirements and obviate any need for supplementation. Pregnant women should be counseled that most processed and pre-prepared foods are high in sodium. [ ] Previous Next: Prenatal Vitamin Supplements A standard prenatal vitamin formulation contains: Iron - 30 mg Zinc

2014 eMedicine.com

158. Prenatal Nutrition (Overview)

is not recommended. Both iron and copper compete with zinc at absorption sites. Zinc supplementation is recommended when elemental iron supplementation exceeds 60 mg/d. Likewise, whenever zinc supplements are used, copper should also be supplemented. Different prenatal vitamin formulations contain different amounts of copper and zinc. Usually, copper or zinc supplementation can be accomplished by appropriate selection of a prenatal vitamin formulation. [ ] Sodium Sodium is present in large quantities (...) in the average American diet. The RDA is 1.5 mg during pregnancy, lactation, and the non-pregnant state. Whether pregnant or not, sodium should neither be restricted nor used excessively. [ ] Well-balanced diets "salted to taste" satisfy sodium requirements and obviate any need for supplementation. Pregnant women should be counseled that most processed and pre-prepared foods are high in sodium. [ ] Previous Next: Prenatal Vitamin Supplements A standard prenatal vitamin formulation contains: Iron - 30 mg Zinc

2014 eMedicine.com

159. Text for Prenatal Health Study

Text for Prenatal Health Study Text for Prenatal Health Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Text for Prenatal Health Study The safety and scientific validity of this study (...) Intervention/treatment Phase Prenatal Attitudes and Beliefs About Health Other: Social Media Education Not Applicable Detailed Description: The purpose of this pilot study is to find out if receiving electronic health information (e.g. text messages and Facebook posts) during pregnancy changes how pregnant teens think about their prenatal health and if fetal and maternal health outcomes can be improved. This study aims to: Assess the impact of providing health information to pregnant adolescents (through

2013 Clinical Trials

160. Degree of methylation of ZAC1 (PLAGL1) is associated with prenatal and post-natal growth in healthy infants of the EDEN mother child cohort (Full text)

Degree of methylation of ZAC1 (PLAGL1) is associated with prenatal and post-natal growth in healthy infants of the EDEN mother child cohort The ZAC1 gene, mapped to the 6q24 region, is part of a network of co-regulated imprinted genes involved in the control of embryonic growth. Loss of methylation at the ZAC1 differentially methylated region (DMR) is associated with transient neonatal diabetes mellitus, a developmental disorder involving growth retardation and diabetes in the first weeks (...) at one year of age (respectively, r = 0.15, 0.09, 0.14; P values = 0.01, 0.15, 0.03). However, there were no significant correlations between the ZAC1 DMR MI and cord blood C-peptide levels. Maternal intakes of alcohol and of vitamins B2 were positively correlated with ZAC1 DMR methylation (respectively, r = 0.2 and 0.14; P = 0.004 and 0.04). The influence of ZAC1 seems to start in the second half of pregnancy and continue at least until the first year of life. The maternal environment also appears

2013 Epigenetics

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