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Prenatal Vitamin

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141. Vitamin D: increasing supplement use in at-risk groups

to assess local uptake, for example, orders for supplements and information collected in personal child health records, maternal antenatal notes and computerised prompts (see recommendation 8). Use monitoring data to improve activities related to the awareness of, access to and uptake of vitamin D supplements. Vitamin D: supplement use in specific population groups (PH56) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page (...) to be fortified with vitamin D (this is voluntary for formula milks for toddlers). Infants who are exclusively breastfed, or have less than 500 ml a day of infant formula, may not get enough vitamin D to meet their needs. (See NICE guidance on antenatal care and maternal and child nutrition.) Infants from Asian families are at particular risk. The Asian Feeding Survey (Infant feeding in Asian families, 1994–1996 Office for National Statistics) found that up to a third of Indian, Bangladeshi or Pakistani

2014 National Institute for Health and Clinical Excellence - Clinical Guidelines

142. Optimizing ultraviolet B radiation exposure to prevent vitamin D deficiency among pregnant women in the tropical zone: report from cohort study on vitamin D status and its impact during pregnancy in Indonesia. Full Text available with Trip Pro

women from 4 cities of the most populated province, West Java, Indonesia which represented 70-80% percent of pregnancy per year. A 3-day notes on duration, time and type of outdoor activity and the clothing wore by the women were collected. UVB intensity radiation were obtained. Calculation on body surface area exposed to direct UVB radiation and UVB radiation intensity were done. Measurement of vitamin D level in sera were done on the same week.The median of maternal sera vitamin D level was 13.6 (...)  ng/mL and the mean exposed area was around 0.48 m2 or 18.59% of total body surface area. Radiation intensity reached its peak around 10.00 and 13.00, but the mean duration of exposure to UVB during this window was lower than expected. Significant correlation was found between maternal sera vitamin D level and exposed body surface area (r = 0.36, p < 0.002) or percentage of exposed body surface (r = 0.39, p < 0.001) and radiation intensity (r = 0.15, p = 0.029). Further analysis showed

2019 BMC Pregnancy and Childbirth

143. Combined consumption of a single high-dose vitamin A supplement with provision of vitamin A fortified oil to households maintains adequate milk retinol concentrations for 6 months in lactating Moroccan women. (Abstract)

maternal VA status during lactation is not known. The purpose of the study is to evaluate the effect of post-partum high dose VA supplementation and provision of VA fortified oil for household consumption on plasma and milk retinol concentrations of lactating Moroccan women during the first 6 mo post-partum. Post-partum women aged 19-40 y received a VA supplement and thereafter were randomly assigned to one of two groups to receive weekly vitamin A Fortified Oil (FO) or Non-Fortified Oil (NFO) for 6 (...) Combined consumption of a single high-dose vitamin A supplement with provision of vitamin A fortified oil to households maintains adequate milk retinol concentrations for 6 months in lactating Moroccan women. In Morocco, post-partum women systematically receive a single high-dose of vitamin A (VA) (200 000 IU) within the first month of giving birth and vegetable oil is fortified to increase the VA intake. The efficacy of this combined approach of supplementation and fortification for increasing

2019 Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme Controlled trial quality: uncertain

144. A Prenatal Multiple Micronutrient Supplement Produces Higher Maternal Vitamin B-12 Concentrations and Similar Folate, Ferritin, and Zinc Concentrations as the Standard 60-mg Iron Plus 400-μg Folic Acid Supplement in Rural Bangladeshi Women. Full Text available with Trip Pro

A Prenatal Multiple Micronutrient Supplement Produces Higher Maternal Vitamin B-12 Concentrations and Similar Folate, Ferritin, and Zinc Concentrations as the Standard 60-mg Iron Plus 400-μg Folic Acid Supplement in Rural Bangladeshi Women. The effects of prenatal food and micronutrient supplementation on maternal micronutrient status are not well known.We compared the efficacy and effectiveness of 3 different micronutrient supplements on maternal micronutrient status when combined with food (...) supplementation.In the MINIMat (Maternal and Infant Nutrition Intervention, Matlab) trial in Bangladesh, 4436 pregnant women were randomly assigned to daily intake of 3 types of micronutrient capsules: 30 mg Fe and 400 μg folic acid (Fe30F), 60 mg Fe and 400 μg folic acid (Fe60F), or multiple micronutrient supplements (MMNs) combined with early (week 9 of pregnancy) or usual (week 20 of pregnancy) food supplementation in a 2 by 3 factorial design. Plasma concentrations of vitamin B-12, folate, ferritin, and zinc

2016 Journal of Nutrition Controlled trial quality: uncertain

145. Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels Full Text available with Trip Pro

Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels Vitamin D levels of pregnant women and their neonates tend to be related; however, it is unknown whether there are any subgroups in which they are not related. 25-Hydroxyvitamin D [25(OH)D] was measured in prenatal maternal and child cord blood samples of participants (n = 241 pairs) in a birth cohort. Spearman correlations were examined within subgroups defined by prenatal and delivery factors. Cord blood as a percentage (...) of prenatal 25(OH)D level was calculated and characteristics compared between those who did and did not have ≥25% and ≥50% of the maternal level and those who did and did not have a detectable 25(OH)D level. The correlation among Black children was lower than in White children. When the maternal 25(OH)D level was <15 ng/mL, the overall correlation was r = 0.16. Most children had a 25(OH)D cord blood level less than half of their mother's; 15.4% had a level that was <25% of their mother's. Winter birth

2016 Journal of pregnancy

146. Maternal BMI Associations with Maternal and Cord Blood Vitamin D Levels in a North American Subset of Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Participants Full Text available with Trip Pro

Maternal BMI Associations with Maternal and Cord Blood Vitamin D Levels in a North American Subset of Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Participants Obesity in pregnancy may be associated with reduced placental transfer of 25-hydroxyvitamin D (25-OHD). The objective of this study was to examine associations between maternal BMI and maternal and cord blood levels of 25-OHD in full term neonates born to a single racial cohort residing at similar latitude. Secondary (...) objectives were to examine associations between maternal glucose tolerance with maternal levels of 25-OHD and the relationship between cord blood 25-OHD levels and neonatal size.This study was conducted among participants of the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) Study meeting the following criteria: residing at latitudes 41-43°, maternal white race, and gestational age 39-41 weeks. Healthy pregnant women underwent measures of height, weight, and a 75-g fasting oral glucose tolerance

2016 PloS one

147. High-Dose Monthly Maternal Cholecalciferol Supplementation during Breastfeeding Affects Maternal and Infant Vitamin D Status at 5 Months Postpartum: A Randomized Controlled Trial. Full Text available with Trip Pro

High-Dose Monthly Maternal Cholecalciferol Supplementation during Breastfeeding Affects Maternal and Infant Vitamin D Status at 5 Months Postpartum: A Randomized Controlled Trial. Many countries recommend daily infant vitamin D supplementation during breastfeeding, but compliance is often poor. A monthly, high-dose maternal regimen may offer an alternative strategy, but its efficacy is unknown.The objective of the study was to determine the effect of 2 different monthly maternal doses (...) as changes in maternal and infant serum 25(OH)D from baseline to week 20 postpartum by using a linear fixed-effects regression model. Additional secondary analyses, adjusted for potential confounders such as season of birth, vitamin D-fortified formula intake, and infant or maternal skin color, were also conducted.After 16 wk of supplementation, changes in maternal serum 25(OH)D were significantly higher in the 50,000-IU/mo (12.8 nmol/L; 95% CI: 0.4, 25.2 nmol/L) and 100,000-IU/mo (21.5 nmol/L; 95% CI

2016 Journal of Nutrition Controlled trial quality: predicted high

148. Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age. Full Text available with Trip Pro

in infants one to six months of age in low- and middle-income countries, irrespective of maternal antenatal or postnatal vitamin A supplementation status, on mortality, morbidity and adverse effects.We used the standard search strategy of Cochrane Neonatal to search the Cochrane Central Register of Controlled Trials (CENTRAL 2016, Issue 2), MEDLINE via PubMed (1966 to 5 March 2016), Embase (1980 to 5 March 2016) and CINAHL (1982 to 5 March 2016). We also searched clinical trials databases, conference (...) Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age. Vitamin A deficiency is a significant public health problem in low- and middle-income countries. Vitamin A supplementation provided to infants less than six months of age is one of the strategies to improve the nutrition of infants at high risk of vitamin A deficiency and thus potentially reduce their mortality and morbidity.To evaluate the effect of synthetic vitamin A supplementation

2016 Cochrane

149. Prenatal Care

Oversight Team Karl T. Rew, MD R. Van Harrison, PhD Literature search service Taubman Health Sciences Library For more information: 734-936-9771 www.uofmhealth.org/provi der/clinical-care-guidelines © Regents of the University of Michigan Prenatal Care Patient population: Women of childbearing age, pregnant women, and their fetuses. Objectives: (1) Promote maternal and infant health. (2) Reduce maternal mortality and morbidity and fetal loss. (3) Reduce preterm birth, intrauterine growth restriction (...) . Maternal ABO and Rh blood type and blood antibody status should be documented at the first prenatal visit. Women who are Rh negative and not Rh sensitized should have a repeat antibody screen performed at 24-28 weeks then receive RhoD Immune Globulin (Rhogam) 300 mcg intramuscularly at 28 to 29 weeks prenatally. If the newborn is Rh positive, RhoD Immune Globulin (Rhogam) should be administered again within 72 hours of delivery at a dose dictated by blood bank studies. Unsensitized patients who are Rh

2020 University of Michigan Health System

150. Association of High-Dose Vitamin D Supplementation During Pregnancy With the Risk of Enamel Defects in Offspring: A 6-Year Follow-up of a Randomized Clinical Trial (Abstract)

-dose vitamin D supplementation during pregnancy was associated with approximately 50% reduced odds of enamel defects in the offspring. This suggests prenatal vitamin D supplementation as a preventive intervention for enamel defects, with a clinically important association with dental health.ClinicalTrials.gov identifier: NCT00856947. (...) Association of High-Dose Vitamin D Supplementation During Pregnancy With the Risk of Enamel Defects in Offspring: A 6-Year Follow-up of a Randomized Clinical Trial Enamel defects of developmental origin affect up to 38% of schoolchildren and is recognized as a global public health challenge. The impaired enamel formation results in pain owing to hypersensitivity, posteruptive breakdowns, rapid caries progression, and extractions in some cases. The etiology is unknown; therefore, prevention

2019 EvidenceUpdates

151. Efficacy and safety of Vitamin D supplementation during pregnancy: A randomized trial of two different levels of dosing on maternal and neonatal Vitamin D outcome. Full Text available with Trip Pro

Efficacy and safety of Vitamin D supplementation during pregnancy: A randomized trial of two different levels of dosing on maternal and neonatal Vitamin D outcome. Pregnant women represent a typical group susceptible to dietary and mineral deficiencies. This study was sought to assess the efficacy and safety of various doses of 25-hydroxyvitamin D (25[OH]D) supplementation during pregnancy and ratify the inadequacy of the recommended daily allowance for Vitamin D in vulnerable groups.A total (...) of 100 pregnant women were included in this open-label, parallel group, prospective, randomized, and controlled trial. Study subjects were assigned to four treatment groups: Group 1 (n = 26), 1000 IU of Vitamin D daily; Group 2 (n = 21), 30,000 IU of Vitamin D monthly; Group 3 (n = 27), 2000 IU of Vitamin D daily; and Group 4 (n = 26), 60,000 IU Vitamin D monthly. Group 1 and 2 were further analyzed together as Group 1K (1000 IU daily and 30,000 IU monthly), and Group 3 and 4 as Group 2K (2000 IU

2016 Indian journal of endocrinology and metabolism Controlled trial quality: uncertain

152. Erratum for March et al. Maternal vitamin D3 supplementation at 50 µg/d protects against low serum 25-hydroxyvitamin D in infants at 8 wk of age: a randomized controlled trial of 3 doses of vitamin D beginning in gestation and continued in lactation. Am Full Text available with Trip Pro

Erratum for March et al. Maternal vitamin D3 supplementation at 50 µg/d protects against low serum 25-hydroxyvitamin D in infants at 8 wk of age: a randomized controlled trial of 3 doses of vitamin D beginning in gestation and continued in lactation. Am 27802998 2017 11 20 1938-3207 104 5 2016 11 The American journal of clinical nutrition Am. J. Clin. Nutr. Erratum for March et al. Maternal vitamin D3 supplementation at 50 µg/d protects against low serum 25-hydroxyvitamin D in infants at 8 wk (...) of age: a randomized controlled trial of 3 doses of vitamin D beginning in gestation and continued in lactation. Am J Clin Nutr2015;102:402-10. 1491 eng Journal Article Published Erratum United States Am J Clin Nutr 0376027 0002-9165 Am J Clin Nutr. 2015 Aug;102(2):402-10 26156737 2016 11 3 6 0 2016 11 3 6 1 2016 11 3 6 0 ppublish 27802998 104/5/1491 10.3945/ajcn.116.145250

2016 The American journal of clinical nutrition Controlled trial quality: uncertain

153. Antenatal care - uncomplicated pregnancy: Scenario: Antenatal care - uncomplicated pregnancy

advice on the different stages of the baby's development. The Department of Health has published , which discusses the different stages of the baby's development and most other aspects of pregnancy. Give information on: Antenatal classes available locally, including those run by the . Breastfeeding, including workshops available locally. Maternity benefits. Exercise, including pelvic floor exercises. The . Options for the place of birth. For more information, see the National Institute for Health (...) and Care Excellence (NICE) guideline on . Give the woman her hand-held maternity records. The woman should take these records to each subsequent antenatal appointment (including secondary care) and any visit to a healthcare professional. Discuss mental health issues. For more information, see the NICE guideline on and the CKS topic on . How should I manage a woman at her 16 week appointment? Review and record the results of any screening tests offered at the booking appointment. If the woman's

2019 NICE Clinical Knowledge Summaries

154. Serum level of vitamin D in preterm infants and its association with premature-related respiratory complications: a case-control study Full Text available with Trip Pro

examined 160 preterm infants weighing less than 2000 grams and born at less than 34 weeks' gestation. Serum vitamin D levels were measured in preterm infants without- and those with respiratory distress, and their mothers. Neonatal characteristics, including age, sex, birth weight, gestational age, Apgar score and needs for oxygen, resuscitation, ventilation and surfactant were documented. The data were analyzed using SPSS version 16.0.Means serum level of maternal vitamin D in control and case groups (...) were 16.66±14.29 ng/dl and 21.23±15.19 ng/dl, respectively (p=0.029). In addition, mean serum level of neonatal vitamin D in control and case groups were 11.69±8.66 ng/dl 17.9±12.55 ng/dl, respectively (p=0.001). Vitamin D levels in premature neonates without respiratory distress and their mothers were significantly different from other preterm neonates with respiratory distress (p=0.029). There was a direct correlation with neonatal and maternal vitamin D levels (r=0.713, p=0.001). The duration

2018 Electronic physician

155. Vitamin K1 Prophylaxis

hours of life, is associated with maternal medications that interfere with vitamin K metabolism. These include some anticonvulsants, cephalosporins, tuberculostatics and anticoagulants. 2. Classic VKDB appears within the first week of life, but is rarely seen after the administration of vitamin K. 3. Late VKDB appears within three to eight weeks of age and is associated with inadequate intake of vitamin K (exclusive breastfeeding without vitamin K prophylaxis) or malabsorption. The incidence of late (...) for less than 1500 grams premature or ill infants is preferred by some providers in tertiary centers. This route may not fully protect against late VKDB. Recommendations 1. To prevent early VKDB (which occurs within the first 24 hours of life), administer Vitamin K 1 to expectant mothers who take drugs that impair vitamin K metabolism. 2. Administer Vitamin K 1 within the first 6 hours after birth following initial stabilization of the newborn and an appropriate opportunity for maternal (family

2016 British Columbia Perinatal Health Program

156. What guidance is there available on the use of vitamin K for the management of obstetric cholestasis?

there are very limited published data to assess the impact of antenatal use of vitamin K in patients with OC, there are good physiological reasons why this may be beneficial. Current RCOG guidelines recommend that women with OC should be counselled about vitamin K supplementation and where the prothrombin time is prolonged, the use of menadiol in doses of 5–10mg daily is indicated. Women should be advised that when prothrombin time is normal, menadiol in low doses should be used, however, women should (...) What guidance is there available on the use of vitamin K for the management of obstetric cholestasis? Available through Specialist Pharmacy Service at www.sps.nhs.uk Medicines Q&As What guidance is there available on the use of vitamin K for the management of obstetric cholestasis? Prepared by UK Medicines Information (UKMi) pharmacists for NHS healthcare professionals Before using this Q&A, read the disclaimer at https://www.sps.nhs.uk/articles/about-ukmi-medicines-qas/ Date prepared: January

2017 Specialist Pharmacy Services

157. Both Mother and Infant Require a Vitamin D Supplement to Ensure That Infants’ Vitamin D Status Meets Current Guidelines Full Text available with Trip Pro

Both Mother and Infant Require a Vitamin D Supplement to Ensure That Infants’ Vitamin D Status Meets Current Guidelines We examined the association between maternal vitamin D intake during breastfeeding with their infants' vitamin D status in infants who did or did not receive vitamin D supplements to determine whether infant supplementation was sufficient. Using plasma from a subset of breastfed infants in the APrON (Alberta Pregnant Outcomes and Nutrition) cohort, vitamin D status (...) was measured by liquid chromatography-tandem mass spectrometry. Maternal and infants' dietary data were obtained from APrON's dietary questionnaires. The median maternal vitamin D intake was 665 International Units (IU)/day, while 25% reported intakes below the recommended 400 IU/day. Of the 224 infants in the cohort, 72% were exclusively breastfed, and 90% were receiving vitamin D supplements. Infants' median 25(OH)D was 96.0 nmol/L (interquartile ranges (IQR) 77.6-116.2), and 25% had 25(OH)D < 75 nmol/L

2018 Nutrients

158. Serum vitamin D and vitamin D-binding protein levels in mother-neonate pairs during the lactation period Full Text available with Trip Pro

ranges on postpartum/postnatal days 5-10 were classified into two groups by their serum vitamin D concentrations (Group A: < 10 ng/ml and Group B: > 20 ng/ml). Both maternal and neonatal Ca, P, Mg, ALP, and PTH concentrations in group A and B were not different. Maternal and neonatal serum DBP levels were measured in two groups. The mother-neonate pairs in both groups were given 400 IU/d vitamin D orally. The same biochemical markers in group A were remeasured on days 45-60 of the lactation period.In (...) group A, the mean maternal and neonatal vitamin D levels on postpartum/postnatal days 5-10 were significantly lower and the DBP levels were significantly higher than those in group B (P = 0.000; P = 0.000 and P = 0.04; P = 0.004, respectively). On lactation days 45-60, the maternal and neonatal DBP concentrations were not different from those on postpartum/postnatal days 5-10. However, the maternal and neonatal vitamin D levels were significantly increased (P = 0.000 and P = 0.000, respectively

2018 Italian journal of pediatrics

159. Maternal Vitamin D Supplementation During Pregnancy Prevents Vitamin D Deficiency in the Newborn: An Open Label Randomised Controlled Trial. Full Text available with Trip Pro

Maternal Vitamin D Supplementation During Pregnancy Prevents Vitamin D Deficiency in the Newborn: An Open Label Randomised Controlled Trial. To determine whether maternal vitamin D supplementation, in the vitamin D deficient mother, prevents neonatal vitamin D deficiency.Open-label randomized controlled trial.Metropolitan Melbourne, Australia, tertiary hospital routine antenatal outpatient clinic.Seventy-eight women with singleton pregnancies with vitamin D deficiency/insufficiency (serum 25-OH (...) Vit D < 75 nmol/l) at their first antenatal appointment at 12-16-week gestation were recruited.Participants were randomized to vitamin D supplementation (2000-4000 IU cholecalciferol) orally daily until delivery or no supplementation.The primary outcome was neonatal serum 25-OH vit D concentration at delivery. The secondary outcome was maternal serum 25-OH vit D concentration at delivery.Baseline mean maternal serum 25-OH vit D concentrations were similar (P = 0·9) between treatment (32 nmol/l, 95

2015 Clinical endocrinology Controlled trial quality: predicted high

160. Maternal vitamin D3 supplementation at 50 μg/d protects against low serum 25-hydroxyvitamin D in infants at 8 wk of age: a randomized controlled trial of 3 doses of vitamin D beginning in gestation and continued in lactation. Full Text available with Trip Pro

Maternal vitamin D3 supplementation at 50 μg/d protects against low serum 25-hydroxyvitamin D in infants at 8 wk of age: a randomized controlled trial of 3 doses of vitamin D beginning in gestation and continued in lactation. Vitamin D supplementation is recommended for breastfed infants. Maternal supplementation beginning in gestation is a potential alternative, but its efficacy in maintaining infant 25-hydroxyvitamin D [25(OH)D] concentration after birth is unknown.We determined the effect (...) of 3 doses of maternal vitamin D supplementation beginning in gestation and continued in lactation on infant serum 25(OH)D and compared the prevalence of infant serum 25(OH)D cutoffs (>30, >40, >50, and >75 nmol/L) by dose at 8 wk of age.Pregnant women (n = 226) were randomly allocated to receive 10, 25, or 50 μg vitamin D₃/d from 13 to 24 wk of gestation until 8 wk postpartum, with no infant supplementation. Mother and infant blood was collected at 8 wk postpartum.At 8 wk postpartum, mean [nmol/L

2015 The American journal of clinical nutrition Controlled trial quality: predicted high

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