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Prenatal Vitamin

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141. Maternal and Pediatric Health Outcomes in relation to Gestational Vitamin D Sufficiency (PubMed)

disease, securing vitamin D sufficiency in pregnancy appears to be a simple, safe, and cost-effective measure that can be incorporated into routine preconception and prenatal care in the offices of primary care clinicians. Education on gestational nutritional requirements should be a fundamental part of medical education and residency training, instruction that has been sorely lacking to date. (...) Maternal and Pediatric Health Outcomes in relation to Gestational Vitamin D Sufficiency Juxtaposed with monumental improvement in maternal-fetal outcomes over the last century, there has been the recent emergence of rising rates of gestational complications including preterm birth, operative delivery, and gestational diabetes. At the same time, there has been a burgeoning problem with widespread vitamin D deficiency among populations of many developed nations. This paper provides a brief review

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2015 Obstetrics and gynecology international

142. Gestational and Early Infancy Exposure to Margarine Fortified with Vitamin D through a National Danish Programme and the Risk of Type 1 Diabetes: The D-Tect Study (PubMed)

and consisted of 331,623 individuals. The 1st of June 1985, which was the date of issue of the new ministerial order cancelling mandatory fortification of margarine with vitamin D in Denmark, served as a reference point separating the studied population into various exposure groups. We further modelled birth cohort effects in children developing T1D as a linear spline, and compared the slopes between the birth cohorts with various prenatal and infancy exposures to vitamin D fortification. In total, 886 (...) Gestational and Early Infancy Exposure to Margarine Fortified with Vitamin D through a National Danish Programme and the Risk of Type 1 Diabetes: The D-Tect Study The objective of the study was to assess whether gestational and early infancy exposure to low dose vitamin D from a mandatory margarine fortification programme in Denmark influenced the risk of developing type 1 diabetes (T1D) before age of 15 years. The study population included all individuals born in Denmark from 1983 to 1988

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2015 PloS one

143. Association between vitamin D levels and allergy-related outcomes vary by race and other factors. (PubMed)

Association between vitamin D levels and allergy-related outcomes vary by race and other factors. Allergy-related studies that include biological measurements of vitamin D preceding well-measured outcomes are needed.We sought to examine the associations between early-life vitamin D levels and the development of allergy-related outcomes in the racially diverse Wayne County Health, Environment, Allergy, and Asthma Longitudinal Study birth cohort.25-Hydroxyvitamin D (25[OH]D) levels were measured (...) in stored blood samples from pregnancy, cord blood, and age 2 years. Logistic regression models were used to calculate odds ratios (ORs) with 95% CIs for a 5 ng/mL increase in 25(OH)D levels for the following outcomes at age 2 years: eczema, skin prick tests (SPTs), increased allergen-specific IgE level (≥ 0.35 IU/mL), and doctor's diagnosis of asthma (3-6 years).Prenatal 25(OH)D levels were inversely associated with eczema (OR, 0.85; 95% CI, 0.75-0.96). The association was stronger in white children

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2015 Journal of Allergy and Clinical Immunology

144. Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial. (PubMed)

Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial. Vitamin D regulates bone mineral metabolism and skeletal development. Some observational studies have suggested that prenatal vitamin D deficiency increases the risk of adverse pregnancy and/or birth outcomes; however, there is scant evidence from controlled trials, leading the World Health Organization to advise against (...) ) the effect of maternal prenatal oral vitamin D3 supplementation (4200 IU/wk, 16,800 IU/wk, or 28,000 IU/wk, administered as weekly doses) versus placebo on infant length at 1 year of age and (2) the effect of maternal postpartum oral vitamin D3 supplementation (28,000 IU/wk) versus placebo on length at 1 year of age among infants born to women who received vitamin D 28,000 IU/wk during pregnancy. Generally healthy pregnant women (n = 1300) in the second trimester (17-24 weeks of gestation) are randomized

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2015 Trials

145. Vitamin B-12 Status Differs among Pregnant, Lactating, and Control Women with Equivalent Nutrient Intakes. (PubMed)

, nonlactating; n = 21) women consumed vitamin B-12 amounts of ∼8.6 μg/d [mixed diet (∼6 μg/d) plus a prenatal multivitamin supplement (2.6 μg/d)]. Serum vitamin B-12, holotranscobalamin (bioactive form of vitamin B-12), methylmalonic acid (MMA), and homocysteine were measured at baseline and study-end.All participants achieved adequate vitamin B-12 status in response to the study dose. Compared with control women, pregnant women had lower serum vitamin B-12 (-21%; P = 0.02) at study-end, whereas lactating (...) Vitamin B-12 Status Differs among Pregnant, Lactating, and Control Women with Equivalent Nutrient Intakes. Limited data are available from controlled studies on biomarkers of maternal vitamin B-12 status.We sought to quantify the effects of pregnancy and lactation on the vitamin B-12 status response to a known and highly controlled vitamin B-12 intake.As part of a 10-12 wk feeding trial, pregnant (26-29 wk gestation; n = 26), lactating (5 wk postpartum; n = 28), and control (nonpregnant

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2015 Journal of Nutrition

146. Influence of Roux-en-Y Gastric Bypass on the Nutritional Status of Vitamin A in Pregnant Women: a Comparative Study. (PubMed)

that pregnancy after RYGB can represent a high-risk situation for VAD. We recommend interdisciplinary monitoring added to the prenatal routine consultations and the conduction of studies addressed to the investigation of a safe and effective dose of oral supplementation of vitamin A to pregnant women undergoing RYGB. (...) Influence of Roux-en-Y Gastric Bypass on the Nutritional Status of Vitamin A in Pregnant Women: a Comparative Study. The objective of the present study is to evaluate the nutritional status of vitamin A through biochemical and functional indicators of pregnant women who underwent Roux-en-Y gastric bypass (RYGB) surgery compared to pregnant women who did not undergo this surgery.The present study is a cross-sectional study of the analytical type with pregnant women paired by age and prepregnancy

2015 Obesity Surgery

147. Trial of Vitamin D Supplements to Raise Calcidiol Levels of Pregnant Women in Mongolia

Collaborators: National Center for Maternal and Child Health Research, Mongolia Zuun Kharaa Hospital Information provided by (Responsible Party): Janet Rich-Edwards, Brigham and Women's Hospital Study Details Study Description Go to Brief Summary: A double-blind randomized, placebo-controlled trial comparing the impact of 600 IU, 2000 IU, or 4000 IU of Vitamin D3 on third trimester 25(OH)D levels and change from baseline. The Vitamin D will be integrated in a standard prenatal vitamin, which will be taken (...) Vitamin D3 in prenatal vitamin Dietary Supplement: 2000 IU Vitamin D3 in prenatal vitamin Dietary Supplement: 4000 IU Vitamin D3 in prenatal vitamin Not Applicable Detailed Description: Vitamin D deficiency (serum 25(OH)D levels <20 ng/ml or 50 nmol/l) is widespread among Mongolians and is nearly universal during the winter months. The investigators have conducted a series of studies which have shown nearly universal Vitamin D deficiency in the winter months. Observational studies in the U.S. have

2015 Clinical Trials

148. Maternal Vitamin D for Acute Respiratory Infections in Infancy

of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Placebo Comparator: Group A Prenatal Period 0 IU; Postpartum Period 0 IU (placebo) Overall: The Prenatal Period will start at enrolment (17-24 weeks gestation) and last until delivery. The Postpartum Period will last from delivery until 6 months postpartum. Dietary Supplement: Placebo Experimental: Group B Prenatal Period 4,200 IU/week of vitamin D3; Postpartum Period 0 IU/week (placebo) Dietary Supplement (...) : Vitamin D3 Other Name: Cholecalciferol Experimental: Group C Prenatal Period 16,800 IU/week of vitamin D3; Postpartum Period 0 IU/week (placebo) Dietary Supplement: Vitamin D3 Other Name: Cholecalciferol Experimental: Group D Prenatal Period 28,000 IU/week of vitamin D3; Postpartum Period 0 IU/week (placebo) Dietary Supplement: Vitamin D3 Other Name: Cholecalciferol Experimental: Group E Prenatal Period 28,000 IU/week of vitamin D3; Postpartum Period 28,000 IU/week Dietary Supplement: Vitamin D3 Other

2015 Clinical Trials

149. Vitamin C supplementation ameliorates the adverse effects of nicotine on placental hemodynamics and histology in nonhuman primates. (PubMed)

Vitamin C supplementation ameliorates the adverse effects of nicotine on placental hemodynamics and histology in nonhuman primates. We previously demonstrated that prenatal nicotine exposure decreases neonatal pulmonary function in nonhuman primates, and maternal vitamin C supplementation attenuates these deleterious effects. However, the effect of nicotine on placental perfusion and development is not fully understood. This study utilizes noninvasive imaging techniques and histological (...) analysis in a nonhuman primate model to test the hypothesis that prenatal nicotine exposure adversely effects placental hemodynamics and development but is ameliorated by vitamin C.Time-mated macaques (n = 27) were divided into 4 treatment groups: control (n = 5), nicotine only (n = 4), vitamin C only (n = 9), and nicotine plus vitamin C (n = 9). Nicotine animals received 2 mg/kg per day of nicotine bitartrate (approximately 0.7 mg/kg per day free nicotine levels in pregnant human smokers) from days 26

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2015 American Journal of Obstetrics and Gynecology

150. Practice parameter update: management issues for women with epilepsy - focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding. Report of the Quality Standards Subcommittee and Therapeutics and Technology Asse

in reporting make it difficult to establish whether the review's conclusions are reliable. Authors' objectives To assess the evidence for management issues related to the care of women with epilepsy during pregnancy, including pre-conception folic acid use, prenatal vitamin K use, risk of haemorrhagic disease of the newborn, clinical implications of placental and breast milk transfer of anti-epileptic drugs, risks of breast feeding and change in anti-epileptic drug levels during pregnancy. Searching Search (...) Practice parameter update: management issues for women with epilepsy - focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding. Report of the Quality Standards Subcommittee and Therapeutics and Technology Asse Practice parameter update: management issues for women with epilepsy - focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding. Report of the Quality Standards Subcommittee and Therapeutics

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2009 DARE.

151. Fetal Alcohol Syndrome, Chemo-Biology and OMICS: Ethanol Effects on Vitamin Metabolism During Neurodevelopment as Measured by Systems Biology Analysis (PubMed)

Fetal Alcohol Syndrome, Chemo-Biology and OMICS: Ethanol Effects on Vitamin Metabolism During Neurodevelopment as Measured by Systems Biology Analysis Fetal alcohol syndrome (FAS) is a prenatal disease characterized by fetal morphological and neurological abnormalities originating from exposure to alcohol. Although FAS is a well-described pathology, the molecular mechanisms underlying its progression are virtually unknown. Moreover, alcohol abuse can affect vitamin metabolism and absorption (...) , although how alcohol impairs such biochemical pathways remains to be elucidated. We employed a variety of systems chemo-biology tools to understand the interplay between ethanol metabolism and vitamins during mouse neurodevelopment. For this purpose, we designed interactomes and employed transcriptomic data analysis approaches to study the neural tissue of Mus musculus exposed to ethanol prenatally and postnatally, simulating conditions that could lead to FAS development at different life stages. Our

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2014 Omics : a journal of integrative biology

152. Is Vitamin D Insufficiency and Deficiency Associated With Antepartum and Postpartum Depression?

. On study entry, patients will complete a demographic survey, vitamin D exposure survey, and an Edinburgh Postnatal Depression Score (EPDS) questionnaire. Baseline vitamin D levels will be obtained using a 25 OH D (vitamin D) assay. Women found to be vitamin D deficient/insufficient will be approached for randomization to vitamin D3 (Cholecalciferol) 50,000 IU/week x 8 weeks + prenatal vitamin versus placebo + prenatal vitamin. A repeat 25 OH D sample plus a vitamin D exposure and EPDS questionnaires (...) will be obtained between 24-28 weeks gestation upon completing treatment. All patients will then be kept on maintenance vitamin D until delivery (total vitamin D 800IU/day which includes prenatal vitamin). Delivery 25 OH D samples will be collected on all women. At delivery, these women will also complete vitamin D exposure and EPDS questionnaires. Maternal and fetal outcome data will be collected on all patients. As for vitamin D sufficient patients, they will be followed with vitamin D exposure and EPDS

2014 Clinical Trials

153. Supplementation with multivitamins and vitamin A and incidence of malaria among HIV-infected Tanzanian women. (PubMed)

complex, C, and E), vitamin A alone, both multivitamins and vitamin A, or placebo. Women received malaria prophylaxis during pregnancy and were followed monthly during the prenatal and postpartum periods. Malaria was defined in 2 ways: presumptive diagnosis based on a physician's or nurse's clinical judgment, which in many cases led to laboratory investigations, and periodic examination of blood smears for malaria parasites.Multivitamin supplementation compared with no multivitamins significantly (...) Supplementation with multivitamins and vitamin A and incidence of malaria among HIV-infected Tanzanian women. HIV and malaria infections occur in the same individuals, particularly in sub-Saharan Africa. We examined whether daily multivitamin supplementation (vitamins B complex, C, and E) or vitamin A supplementation altered malaria incidence in HIV-infected women of reproductive age.HIV-infected pregnant Tanzanian women recruited into the study were randomly assigned to daily multivitamins (B

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2014 Journal of acquired immune deficiency syndromes (1999)

154. Deficit of vitamin D in pregnancy and growth and overweight in the offspring. (PubMed)

Deficit of vitamin D in pregnancy and growth and overweight in the offspring. Maternal vitamin D status during fetal development may influence offspring growth and risk of obesity; however, evidence in humans is limited.To investigate whether maternal circulating 25-hydroxyvitamin D3 (25(OH)D3) concentration in pregnancy is associated with offspring prenatal and postnatal growth and overweight.Plasma 25(OH)D3 concentration was measured in pregnant women (median weeks of gestation 14.0, range (...) interval (CI): 1.01-2.21; P = 0.041) or either as EFW ⩾ 90th percentile (OR = 1.47, 95% CI: 1.00-2.16; P = 0.046). No significant associations were found with rapid growth. Deficit of 25(OH)D3 in pregnancy was associated with an increased risk of overweight in offspring at age 1 year (OR = 1.42, 95% CI: 1.02-1.97; P = 0.039); however, the association was attenuated at age 4 years (OR = 1.19, 95% CI: 0.83-1.72; P = 0.341).Vitamin D deficiency in pregnancy may increase the risk of prenatal and early

2014 International Journal of Obesity

155. Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial. (PubMed)

antioxidant vitamins, and 222 received antioxidant vitamins alone. Women had 4-8 prenatal visits while receiving the bars. The incidence of pre-eclampsia was reduced significantly (χ(2) = 19.41; P < 0.001) in women randomised to L-arginine plus antioxidant vitamins compared with placebo (absolute risk reduction 0.17 (95% confidence interval 0.12 to 0.21). Antioxidant vitamins alone showed an observed benefit, but this effect was not statistically significant compared with placebo (χ(2) = 3.76; P = 0.052 (...) Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial. To test the hypothesis that a relative deficiency in L-arginine, the substrate for synthesis of the vasodilatory gas nitric oxide, may be associated with the development of pre-eclampsia in a population at high risk.Randomised, blinded, placebo controlled clinical trial.Tertiary public hospital in Mexico City.Pregnant women

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2011 BMJ

156. Degree of methylation of ZAC1 (PLAGL1) is associated with prenatal and post-natal growth in healthy infants of the EDEN mother child cohort (PubMed)

Degree of methylation of ZAC1 (PLAGL1) is associated with prenatal and post-natal growth in healthy infants of the EDEN mother child cohort The ZAC1 gene, mapped to the 6q24 region, is part of a network of co-regulated imprinted genes involved in the control of embryonic growth. Loss of methylation at the ZAC1 differentially methylated region (DMR) is associated with transient neonatal diabetes mellitus, a developmental disorder involving growth retardation and diabetes in the first weeks (...) at one year of age (respectively, r = 0.15, 0.09, 0.14; P values = 0.01, 0.15, 0.03). However, there were no significant correlations between the ZAC1 DMR MI and cord blood C-peptide levels. Maternal intakes of alcohol and of vitamins B2 were positively correlated with ZAC1 DMR methylation (respectively, r = 0.2 and 0.14; P = 0.004 and 0.04). The influence of ZAC1 seems to start in the second half of pregnancy and continue at least until the first year of life. The maternal environment also appears

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2013 Epigenetics

157. Text for Prenatal Health Study

Text for Prenatal Health Study Text for Prenatal Health Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Text for Prenatal Health Study The safety and scientific validity of this study (...) Intervention/treatment Phase Prenatal Attitudes and Beliefs About Health Other: Social Media Education Not Applicable Detailed Description: The purpose of this pilot study is to find out if receiving electronic health information (e.g. text messages and Facebook posts) during pregnancy changes how pregnant teens think about their prenatal health and if fetal and maternal health outcomes can be improved. This study aims to: Assess the impact of providing health information to pregnant adolescents (through

2013 Clinical Trials

158. Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake. (PubMed)

with a control group of 97 mothers who had healthy children. Mothers were interviewed regarding perinatal characteristics, including use of prenatal vitamin supplements, and gave peripheral blood samples, which were used for polymerase chain reaction-based genotyping of rs1801133 and rs70991108.The risk of having a child with unilateral retinoblastoma was associated with maternal homozygosity for DHFR19bpdel (odds ratio, 3.78; 95% confidence interval, 1.89-7.55; P = .0002), even after controlling (...) Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake. The incidence of unilateral retinoblastoma varies globally, suggesting possible environmental contributors to disease incidence. Maternal intake of naturally occurring folate from vegetables during pregnancy is associated inversely with the risk of retinoblastoma in offspring.The authors used a case-control study design to examine the association between

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2012 Cancer

159. Practice Parameter update: Managment issues for women with epilepsy - Focus on pregnancy: Vitamin K, folic acid, blood levels, and breastfeeding

, MD J. Hopp, MD T.Y. Ting, MD W.A. Hauser, MD D.Thurman,MD,MPH P.W.Kaplan,MB,FRCP J.N. Robinson, MD J.A. French, MD S. Wiebe, MD A.N. Wilner, MD B. Vazquez, MD L. Holmes, MD A. Krumholz, MD R. Finnell, PhD P.O. Shafer, RN, MN C. Le Guen ABSTRACT Objective:To reassess the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid use, prenatal vitamin K use, risk of hemorrhagic disease of the newborn, clinical implications (...) Seepages126and133 SPECIAL ARTICLE 142 Copyright © 2009 by AAN Enterprises, Inc.This parameter summarizes evidence for six im- portant questions relating to the clinical manage- ment of WWE who are pregnant or plan pregnancy: 1. Does preconceptional folic acid supplementation reduce the risk of birth defects in neonates of WWE taking AEDs? 2. What is the risk of hemorrhagic disease in neo- nates born to WWE taking AEDs? 3. Does prenatal vitamin K supplementation reduce theriskofhemorrhagicdiseaseinthenewbornsof

2009 American Epilepsy Society

160. Management issues for women with epilepsy-focus on pregnancy: vitamin k, folic acid, blood levels, and breastfeeding

Formats Make Comment See Comments Downloads 30541 Share Abstract Objective: To reassess the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid use, prenatal vitamin K use, risk of hemorrhagic disease of the newborn, clinical implications of placental and breast milk transfer of antiepileptic drugs (AEDs), risks of breastfeeding, and change in AED levels during pregnancy. Methods: A 20-member committee evaluated (...) folic acid supplementation reduce the risk of birth defects in neonates of WWE taking AEDs? What is the risk of hemorrhagic disease in neonates born to WWE taking AEDs? Does prenatal vitamin K supplementation reduce the risk of hemorrhagic disease in the newborns of WWE taking AEDs? Do maternally ingested AEDs cross the placenta or penetrate into breast milk? Does indirect exposure to maternally ingested AEDs increase the risk of symptomatic effects in the newborn? Are there changes in AED levels

2009 American Academy of Neurology

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