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Prenatal Vitamin

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121. Vitamin C Prevents Offspring DNA Methylation Changes Associated with Maternal Smoking in Pregnancy. Full Text available with Trip Pro

Vitamin C Prevents Offspring DNA Methylation Changes Associated with Maternal Smoking in Pregnancy. Infants whose mothers smoked during pregnancy demonstrate lifelong decreases in pulmonary function. DNA methylation changes associated with maternal smoking during pregnancy have been described in placenta and cord blood at delivery, in fetal lung, and in buccal epithelium and blood during childhood. We demonstrated in a randomized clinical trial ( ClinicalTrials.gov identifier, NCT00632476 (...) ) that vitamin C supplementation to pregnant smokers can lessen the impact of maternal smoking on offspring pulmonary function and decrease the incidence of wheeze at 1 year of age.To determine whether vitamin C supplementation reduces changes in offspring methylation in response to maternal smoking and whether methylation at specific CpGs is also associated with respiratory outcomes.Targeted bisulfite sequencing was performed with a subset of placentas, cord blood samples, and buccal samples collected

2017 American Journal of Respiratory and Critical Care Medicine Controlled trial quality: uncertain

122. Asthma Control Status in Pregnancy, BMI, and Maternal Vitamin D Levels. Full Text available with Trip Pro

Asthma Control Status in Pregnancy, BMI, and Maternal Vitamin D Levels. 28606587 2018 11 13 1097-6825 140 5 2017 Nov The Journal of allergy and clinical immunology J. Allergy Clin. Immunol. Asthma control status in pregnancy, body mass index, and maternal vitamin D levels. 1453-1456.e7 S0091-6749(17)30928-4 10.1016/j.jaci.2017.03.053 Mirzakhani Hooman H Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. O'Connor

2017 Journal of Allergy and Clinical Immunology Controlled trial quality: uncertain

123. Response to antenatal cholecalciferol supplementation is associated with common vitamin D related genetic variants. Full Text available with Trip Pro

supplementation.Within-randomization group analysis of the Maternal Vitamin D Osteoporosis Study trial of antenatal cholecalciferol supplementation.Hospital antenatal clinics.In total, 682 women of white ethnicity (351 placebo, 331 cholecalciferol) were included. SNPs at rs12785878 (DHCR7), rs10741657 (CYP2R1), rs6013897 (CYP24A1), and rs2282679 (GC) were genotyped.1000 IU/d cholecalciferol from 14 weeks of gestation until delivery.25(OH)D at randomization and 34 weeks of gestation were measured in a single batch (...) Response to antenatal cholecalciferol supplementation is associated with common vitamin D related genetic variants. Single-nucleotide polymorphisms (SNPs) in genes related to vitamin D metabolism have been associated with serum 25-hydroxyvitamin D [25(OH)D] concentration, but these relationships have not been examined following antenatal cholecalciferol supplementation.To determine whether SNPs in DHCR7, CYP2R1, CYP24A1, and GC are associated with the response to gestational cholecalciferol

2017 Journal of Clinical Endocrinology and Metabolism Controlled trial quality: predicted high

124. Iodine Contents in Prenatal Vitamins in the U.S. Full Text available with Trip Pro

Iodine Contents in Prenatal Vitamins in the U.S. 28599614 2018 10 18 2018 11 13 1557-9077 27 8 2017 08 Thyroid : official journal of the American Thyroid Association Thyroid Iodine Contents in Prenatal Vitamins in the United States. 1101-1102 10.1089/thy.2017.0097 Lee Sun Y SY 1 Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine , Boston, Massachusetts. Stagnaro-Green Alex A 2 Department of Obstetrics and Gynecology and Medical Education, University (...) United States Thyroid 9104317 1050-7256 0 Vitamins 9679TC07X4 Iodine IM Dietary Supplements Female Humans Iodine analysis Pregnancy Prenatal Care United States Vitamins chemistry 2017 6 11 6 0 2018 10 20 6 0 2017 6 11 6 0 ppublish 28599614 10.1089/thy.2017.0097 PMC5912719 Public Health Nutr. 2007 Dec;10(12A):1606-11 18053287 N Engl J Med. 2009 Feb 26;360(9):939-40 19246372 Thyroid. 2017 Mar;27(3):315-389 28056690

2017 Thyroid

125. Higher maternal vitamin D concentrations are associated with longer leukocyte telomeres in newborns. Full Text available with Trip Pro

Higher maternal vitamin D concentrations are associated with longer leukocyte telomeres in newborns. Gestational vitamin D insufficiency is related with increased risks of various diseases and poor health outcomes later in life. Telomere length at birth or early in life is known to be a predictor of individual health. Both vitamin D and telomere length are related with various health conditions, and vitamin D concentrations are associated with leukocyte telomere lengths in women. We (...) investigated the association between maternal vitamin D concentrations and newborn leukocyte telomere lengths. This cross-sectional study included 106 healthy pregnant women without adverse obstetric outcomes and their offspring. We examined the maternal age, weight before pregnancy, health behaviours, and nutritional intakes, along with each newborn's sex and birthweight, and we measured maternal height, telomere length, total white blood cell count, and glycosylated haemoglobin as covariates. Pearson's

2017 Maternal & child nutrition

126. Iron, Zinc, and Vitamin D Supplementation During Breastfeeding

groups during the study or at 3 years of age. 35,37 In addition to study of direct infant supplementation with vitamin D, recent investigation has focused on methods to providevitaminDtotheinfantbysupplementingthemother and thereby augmenting the level of vitamin D in her breast milk. These studies have addressed the question—is there a maternal vitamin D dosethat is ef?cacious andsafe for both the mother and infant? Two studies, based on previous re- search, 28,38 were designed and performed (...) to address this question. One randomized, blinded clinical trial compared maternal intake of 10, 60, and 160lg/day (400, 2,400, and 6,400 IU/day) in 334 mother/infant dyads. 39 For the group with maternal dose of 10lg/day (400 IU/day), the infant also received 10lg/day (400 IU/day). For the other two groups, no vitamin D was provided to the infant. The ma- ternal60lg/day(2,400IU/day)dosegroupwasdiscontinued early due to vitamin D de?ciency in the infant, demonstrat- ingthatmaternal60lg/day(2,400IU/day

2018 Academy of Breastfeeding Medicine

127. Maternal vitamin D biomarkers are associated with maternal and fetal bone turnover among pregnant women consuming controlled amounts of vitamin D, calcium, and phosphorus. Full Text available with Trip Pro

Maternal vitamin D biomarkers are associated with maternal and fetal bone turnover among pregnant women consuming controlled amounts of vitamin D, calcium, and phosphorus. Vitamin D plays a central role in calcium homeostasis; however, its relationship with bone turnover during pregnancy remains unclear due to a lack of studies that have rigorously controlled for vitamin D and other nutrients known to influence bone metabolism. Similarly, prior investigations of the effect of pregnancy on bone (...) turnover relative to the nonpregnant state may have been confounded by varying intakes of these nutrients. Nested within a controlled intake study, the present investigation sought to quantify associations between maternal vitamin D biomarkers and biochemical markers of bone turnover among pregnant (versus nonpregnant) women and their fetuses under conditions of equivalent and adequate intakes of vitamin D and related nutrients. Changes in markers of bone turnover across the third trimester were also

2016 Bone

128. Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial. Full Text available with Trip Pro

Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial. Asthma and wheezing begin early in life, and prenatal vitamin D deficiency has been variably associated with these disorders in offspring.To determine whether prenatal vitamin D (cholecalciferol) supplementation can prevent asthma or recurrent wheeze in early childhood.The Vitamin D Antenatal Asthma Reduction Trial was a randomized, double-blind (...) containing 400 IU vitamin D, and 436 women were randomized to receive a placebo plus a prenatal vitamin containing 400 IU vitamin D.Coprimary outcomes of (1) parental report of physician-diagnosed asthma or recurrent wheezing through 3 years of age and (2) third trimester maternal 25-hydroxyvitamin D levels.Eight hundred ten infants were born in the study, and 806 were included in the analyses for the 3-year outcomes. Two hundred eighteen children developed asthma or recurrent wheeze: 98 of 405 (24.3

2016 JAMA Controlled trial quality: predicted high

129. Neurodevelopmental effects of prenatal vitamin D in humans: systematic review and meta-analysis

Neurodevelopmental effects of prenatal vitamin D in humans: systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address

2018 PROSPERO

130. Maternal vitamin D level during pregnancy and the risk of eczema, wheezing and respiratory infections in the first year of life: a systematic review

Maternal vitamin D level during pregnancy and the risk of eczema, wheezing and respiratory infections in the first year of life: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith

2018 PROSPERO

131. Prenatal Vitamin

Prenatal Vitamin Prenatal Vitamin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Prenatal Vitamin Prenatal Vitamin Aka: Prenatal (...) Vitamin II. Indications Start prior to conception of pregnancy III. Preparations: Key components (Higher doses than standard Vitamins) 400 mcg or 600 Dietary Equivalents or DFE (See for references) Dose is higher if increased risk 4000 mcg started 3 months before pregnancy (continue for first trimester) Prior Use of or 800 mcg daily (1200 Dietary Equivalents or DFE) Anti-epileptic drugs other than or Most important component in Prenatal Vitamins Reduces s by 50% at conception Reduced fetal risk

2018 FP Notebook

132. Implications of maternal vitamin D deficiency: a systematic review

Implications of maternal vitamin D deficiency: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect measures

2018 PROSPERO

133. What is the role of maternal vitamin D on oral health of an offspring (child, infant)? A systematic review and meta-analysis

What is the role of maternal vitamin D on oral health of an offspring (child, infant)? A systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2018 PROSPERO

134. The association between maternal Body Mass Index(BMI) and vitamin B12 levels during pregnancy: a systematic review

The association between maternal Body Mass Index(BMI) and vitamin B12 levels during pregnancy: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence

2018 PROSPERO

135. Active B12 assay for diagnosing vitamin B12 deficiency

and women eliminate unlawful discrimination on grounds of race, disability, age, sex, gender reassignment, pregnancy and maternity (including women post-delivery), sexual orientation, and religion or belief (these are protected characteristics under the Equality Act 2010). T esting for vitamin B12 deficiency is recommended for people of all ages in whom deficiency is clinically suspected. Vitamin B12 deficiency is more common in older people. T esting for holoTC may be particularly advantageous (...) Active B12 assay for diagnosing vitamin B12 deficiency Activ Active B12 assa e B12 assay for diagnosing vitamin B12 y for diagnosing vitamin B12 deficiency deficiency Medtech innovation briefing Published: 30 September 2015 nice.org.uk/guidance/mib40 pathways Summary Summary The Abbott ARCHITECT Active-B12 assay is a test for detecting levels of serum holotranscobalamin, which is the metabolically available component of vitamin B12, and can be used as a marker of vitamin B12 deficiency. Four

2015 National Institute for Health and Clinical Excellence - Advice

136. Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years: A Prespecified Secondary Analysis of a Double-Blinded, Randomized Clinical Trial

and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. 2 Department of Clinical Physiology and Nuclear Medicine, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. 3 Department of Pediatrics, Naestved Hospital, Naestved, Denmark. PMID: 32091548 PMCID: (available on 2021-02-24 ) DOI: Item in Clipboard Full-text links Cite Abstract Importance: Studies suggest an association between maternal vitamin D status during pregnancy and offspring anthropometry and bone (...) Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years: A Prespecified Secondary Analysis of a Double-Blinded, Randomized Clinical Trial Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years: A Prespecified Secondary Analysis of a Double-Blinded, Randomized Clinical Trial - PubMed This site needs JavaScript to work properly. Please enable

2020 EvidenceUpdates

137. Guidance for maternal medicine in the evolving coronavirus (COVID-19) pandemic

the COVID-19 pandemic. 3 General considerations for the modification of antenatal care services during the COVID-19 pandemic can be found in the RCOG guidance. 2. General advice for the adaptation of maternal medicine services during the COVID-19 pandemic A senior obstetrician with a specialist interest in maternal medicine, or an obstetric physician should assess all new referrals of pregnant women with medical disorders. Particular consideration should be made to combine additional blood tests (...) with medical co- morbidities. In response to the current COVID-19 pandemic and potential effect on service capacity in sonography and fetal medicine departments, the following documents have been published by the RCOG and NHS England on how to prioritise ultrasound referrals: RCOG guidance for the COVID-19 pandemic which is relevant to the modification of maternal medicine services includes: service configurations for antenatal and postnatal care in low risk women, antenatal screening and ultrasound, fetal

2020 Royal College of Obstetricians and Gynaecologists

138. Impact of vitamin D and vitamin D receptor on the trophoblast survival capacity in preeclampsia. Full Text available with Trip Pro

. There was a significant difference between these groups in the MAP1LC3B/BECN1 ratio as marker of the trophoblast survival capacity with a significantly reduced ratio in villous trophoblast of early-onset preeclampsia. Maternal vitamin D deficiency was found in all pathological pregnancies combined with significantly reduced staining levels of placental VDR in IUGR. Finally, there was a strong and significant negative correlation between the survival capacity (MAP1LC3B/BECN1) and both maternal vitamin D and placental (...) Impact of vitamin D and vitamin D receptor on the trophoblast survival capacity in preeclampsia. Preeclampsia and intra-uterine growth restriction (IUGR) are major health problems during pregnancy affecting both mother and child. Defective placental development and failure of trophoblast differentiation during pregnancy are important aspects in the pathogenesis of both syndromes. Recent studies have shown that autophagy is involved in the trophoblast survival capacity. As vitamin D has

2018 PLoS ONE

139. Fortification of maize flour and corn meal with vitamins and minerals

Fortification of maize flour and corn meal with vitamins and minerals WHO GUIDELINE: FORTIFICATION OF MAIZE FLOUR AND CORN MEAL WITH VITAMINS AND MINERALSWHO GUIDELINE: FORTIFICATION OF MAIZE FLOUR AND CORN MEAL WITH VITAMINS AND MINERALSWHO guideline: fortification of maize flour and corn meal with vitamins and minerals. ISBN 978-92-4-154993-6 © World Health Organization 2016 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO (...) CITATION WHO guideline: fortification of maize flour and corn meal with vitamins and minerals. Geneva: World Health Organization; 2016. Licence: CC BY-NC-SA 3.0 IGO.v WHO GUIDELINE: FORTIFICATION OF MAIZE FLOUR AND CORN MEAL WITH VITAMINS AND MINERALS CONTENTS Publication history vii Acknowledgements vii Financial support viii Executive summary 1 Purpose of the guideline 1 Guideline development methodology 2 Available evidence 2 Recommendations 3 Remarks 3 Research gaps 4 Scope and purpose 5 Background

2017 World Health Organisation Guidelines

140. Maternal Vitamin D Status at Week 30 of Gestation and Offspring Cardio-Metabolic Health at 20 Years: A Prospective Cohort Study over Two Decades. Full Text available with Trip Pro

Maternal Vitamin D Status at Week 30 of Gestation and Offspring Cardio-Metabolic Health at 20 Years: A Prospective Cohort Study over Two Decades. Vitamin D deficiency is common among pregnant women and since the fetus relies exclusively on maternal supply, deficiency could potentially interfere with fetal development. Vitamin D blood concentrations during pregnancy have been associated with offspring cardio-metabolic health in a few previous studies but the evidence is still inconsistent (...) and only one previous study has followed the offspring into adulthood. The aim of the present study was to investigate the association between maternal serum concentration of vitamin D (25(OH)D) in week 30 of gestation and offspring cardio-metabolic risk factors at 20 years.A follow up study of a Danish birth cohort from 1988-89 (n = 965) was conducted. A blood sample was drawn from the women in week 30 of gestation. In 2008-2009, 95% of the original mother and child dyads could be identified

2016 PLoS ONE

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