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Prenatal Vitamin

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121. Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels (Full text)

Maternal-Cord Blood Vitamin D Correlations Vary by Maternal Levels Vitamin D levels of pregnant women and their neonates tend to be related; however, it is unknown whether there are any subgroups in which they are not related. 25-Hydroxyvitamin D [25(OH)D] was measured in prenatal maternal and child cord blood samples of participants (n = 241 pairs) in a birth cohort. Spearman correlations were examined within subgroups defined by prenatal and delivery factors. Cord blood as a percentage (...) of prenatal 25(OH)D level was calculated and characteristics compared between those who did and did not have ≥25% and ≥50% of the maternal level and those who did and did not have a detectable 25(OH)D level. The correlation among Black children was lower than in White children. When the maternal 25(OH)D level was <15 ng/mL, the overall correlation was r = 0.16. Most children had a 25(OH)D cord blood level less than half of their mother's; 15.4% had a level that was <25% of their mother's. Winter birth

2016 Journal of pregnancy

122. The Impact of Vitamin D Supplementation on Post-Partum Glucose Tolerance and Insulin Resistance in Gestational Diabetes: A Randomized Controlled Trial. (Full text)

The Impact of Vitamin D Supplementation on Post-Partum Glucose Tolerance and Insulin Resistance in Gestational Diabetes: A Randomized Controlled Trial. Hypovitaminosis D has been associated with the development of gestational diabetes mellitus (GDM) in many observational studies.We report the first study of the impact of prenatal vitamin D supplementation on postpartum dysglycemia in GDM patients in a randomized clinical trial.Women with GDM at 12 - 32 weeks of gestation were assigned randomly (...) to either the intervention group (in which serum 25-hydroxy vitamin D [25OHD] levels were measured immediately, n = 48) or the control group (in which the serum was stored and assayed at 6 - 12 weeks post-partum, n = 48). Participants with initial serum 25OHD < 30 ng/mL in the intervention group were instructed to take a total of 700,000 IU vitamin D3 during pregnancy. The primary outcomes were fasting plasma glucose (FPG), insulin, 2-h post 75 g glucose load plasma glucose (2-hPLG), homeostasis model

2016 International journal of endocrinology and metabolism Controlled trial quality: uncertain

123. Vitamin D ? Therapeutic Overview and Review of Evidence

Vitamin D ? Therapeutic Overview and Review of Evidence SKELETAL i Hip fractures (NNT 200)with Ca 48-53 1 Falls 48-53, 111 1 Osteoarthritis 57 i Mortality (NNT 143)with Ca 48-53 Slight h BMD lumbar spine, forearm, with Ca in steroid-induced osteoporosis 55 i Mortality (NNT 290 2-7yrs) 59 n Risk (conflicting results) 27,28,58 n Depression treatment 78,79 May i Parkinson’s progression 77 n ALS prevention or prognosis 84-86 May iMS relapse rate in pts on natalizumab 83 Small i in non-specific (...) in Vit D deficient pts 92 (ViDiCo) n Time to 1 st mod-severe exacerbation or time to 1 st URTI 92 (ViDiCo) PULMONARY Small i acute URTI risk (most benefit in very deficient pts and those not receiving boluses) 93 i Influenza A risk/flu-related asthma attacks in children 95 This figure does not include health conditions where a correlation has been observed with Vitamin D levels but not yet tested with Vitamin D supplementation (these are outlined in Table 2). FIGURE 1: VITAMIN D SUPPLEMENTATION

2010 RxFiles

124. A randomized controlled trial of vitamin D supplementation on perinatal depression: in Iranian pregnant mothers. (Full text)

A randomized controlled trial of vitamin D supplementation on perinatal depression: in Iranian pregnant mothers. Mood disorders in pregnancy and post-partum period are common and considered as a public health issue. Researchers have studied the relationship between low serum vitamin D concentration and perinatal depression, although no clinical trial has been conducted on vitamin D's effects on depression related to childbirth. This study evaluated the effect of vitamin D3 supplementation (...) on perinatal depression scores.This randomized clinical trial was done in pregnant women who were under prenatal care in a teaching hospital in Shiraz, Iran. The inclusion criteria were: being 18 years or older, no history of mental illness and internal diseases, a singleton live fetus, without any pregnancy complications, gestational age of 26-28 weeks upon enrollment, and depression score of 0 to 13. The Edinburgh Postnatal Depression scale was used to evaluate depression scores. A total of 169

2016 BMC Pregnancy and Childbirth Controlled trial quality: uncertain

125. Vitamin D, pre-eclampsia, and preterm birth among pregnancies at high risk for pre-eclampsia: an analysis of data from a low-dose aspirin trial. (PubMed)

Vitamin D, pre-eclampsia, and preterm birth among pregnancies at high risk for pre-eclampsia: an analysis of data from a low-dose aspirin trial. To examine the relation between maternal vitamin D status and risk of pre-eclampsia and preterm birth in women at high risk for pre-eclampsia.Analysis of prospectively collected data and blood samples from a trial of prenatal low-dose aspirin.Thirteen sites across the USA.Women at high risk for pre-eclampsia.We measured 25-hydroxyvitamin D [25(OH)D (...) ] concentrations in stored maternal serum samples drawn at 12-26 weeks' gestation (n = 822). We used mixed effects models to examine the association between 25(OH)D and risk of pre-eclampsia and preterm birth, controlling for confounders including prepregnancy BMI and race.Pre-eclampsia and preterm birth.Twelve percent of women were vitamin D deficient [25(OH)D <30 nmol/l]. Women with 25(OH)D <30 versus ≥75 nmol/l had a 2.4-fold (95% CI 1.0-5.6) higher risk of early-onset pre-eclampsia (<35 weeks' gestation

2016 BJOG

126. Maternal vitamin D supplementation during pregnancy and lactation to prevent acute respiratory infections in infancy in Dhaka, Bangladesh (MDARI trial): protocol for a prospective cohort study nested within a randomized controlled trial. (Full text)

 IU/week from 2nd trimester to delivery plus placebo from 0-6 months postpartum; or, 28,000 IU/week prenatal and until 6-months postpartum. In the Maternal Vitamin D for ARI in Infancy (MDARI) sub-study nested within the MDIG trial, trained personnel conduct weekly postnatal home visits to inquire about ARI symptoms and conduct a standardized clinical assessment. Supplementary home visits between surveillance visits are conducted when caregivers make phone notifications of new infant symptoms. Mid (...) of age, the incidence of microbiologically-confirmed viral ARI will be significantly lower in infants whose mothers received high-dose prenatal/postpartum vitamin D supplements versus placebo. Secondary outcomes include incidence of ARI associated with specific pathogens (influenza A or B, RSV), clinical ARI, and density of pneumococcal carriage.If shown to reduce the risk of viral ARI in infancy, integration of maternal prenatal/postpartum vitamin D supplementation into antenatal care programs

2016 BMC Pregnancy and Childbirth Controlled trial quality: predicted high

127. Factors Influencing the Infant Gut Microbiome at Age 3-6 months: Findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART). (Full text)

Factors Influencing the Infant Gut Microbiome at Age 3-6 months: Findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART). The gut microbiome in infancy influences immune system maturation, and may have an important impact on allergic disease risk.We sought to determine how prenatal and early life factors impact the gut microbiome in a relatively large, ethnically diverse study population of infants at age 3 to 6 months, who were enrolled in Vitamin D Antenatal (...) Asthma Reduction Trial, a clinical trial of vitamin D supplementation in pregnancy to prevent asthma and allergies in offspring.We performed 16S rRNA gene sequencing on 333 infants' stool samples. Microbial diversity was computed using the Shannon index. Factor analysis applied to the top 25 most abundant taxa revealed 4 underlying bacterial coabundance groups; the first dominated by Firmicutes (Lachnospiraceae/Clostridiales), the second by Proteobacteria (Klebsiella/Enterobacter), the third

2016 Journal of Allergy and Clinical Immunology

128. Prevention of Vitamin K deficiency bleeding in newborn infants: a position paper by the ESPGHAN Committee on Nutrition. (PubMed)

and for newborns who have cholestasis or impaired intestinal absorption or are too unwell to take oral vitamin K1, or those whose mothers have taken medications that interfere with vitamin K metabolism. Parents who receive prenatal education about the importance of vitamin K prophylaxis may be more likely to comply with local procedures. (...) Prevention of Vitamin K deficiency bleeding in newborn infants: a position paper by the ESPGHAN Committee on Nutrition. Vitamin K deficiency bleeding (VKDB) due to physiologically low vitamin K plasma concentrations is a serious risk for newborn and young infants and can be largely prevented by adequate vitamin K supplementation. The aim of this position paper is to define the condition, describe the prevalence, discuss current prophylaxis practices and outcomes, and to provide recommendations

2016 Journal of Pediatric Gastroenterology and Nutrition

129. The Impact of Maternal Vitamin D Status on Offspring Brain Development and Function: a Systematic Review. (Full text)

The Impact of Maternal Vitamin D Status on Offspring Brain Development and Function: a Systematic Review. Various studies have examined associations between maternal vitamin D (VD) deficiency and offspring health, including offspring brain health. The purpose of this review was to summarize current evidence concerning the impact of maternal VD deficiency on brain development and function in offspring. A systematic search was conducted within Medline (on Ovid) for studies published through 7 May (...) 2015. Animal and human studies that examined associations between maternal VD status or developmental VD deficiency and offspring brain development and function were included. A total of 26 animal studies and 10 human studies met the inclusion criteria. Several animal studies confirmed the hypothesis that low prenatal VD status may affect brain morphology and physiology as well as behavioral outcomes. In humans, subtle cognitive and psychological impairments in offspring of VD-deficient mothers

2016 Advances in nutrition (Bethesda, Md.)

130. Effect of weekly high-dose vitamin D3 supplementation on serum cholecalciferol concentrations in pregnant women. (PubMed)

-study of a completed randomized double-blind placebo-controlled trial of vitamin D3 (35,000 IU/week) supplementation in late pregnancy (AViDD trial) in Dhaka, Bangladesh. This study included pregnant women enrolled at 26-29 weeks gestation who fully adhered to the prenatal supplement intervention for ≥8 consecutive weeks and for whom serum samples were available for D3 analysis (n=65). Serum D3 was uniformly low at enrolment. Mean D3 increased and was maximal at 1 day after vitamin D dose (...) Effect of weekly high-dose vitamin D3 supplementation on serum cholecalciferol concentrations in pregnant women. Vitamin D status is conventionally defined by the serum concentration of 25-hydroxyvitamin D. However, it has been proposed that the serum cholecalciferol concentration (D3) also determines functional vitamin D sufficiency. The objective of this study was to describe the effect of weekly high-dose vitamin D3 supplementation on inter-dose serum D3 in pregnant women. We conducted a sub

2016 The Journal of steroid biochemistry and molecular biology Controlled trial quality: predicted high

131. Effect of vitamin D replacement on maternal and neonatal outcomes: a randomised controlled trial in pregnant women with hypovitaminosis D. A protocol. (Full text)

Effect of vitamin D replacement on maternal and neonatal outcomes: a randomised controlled trial in pregnant women with hypovitaminosis D. A protocol. The vitamin D recommended doses during pregnancy differ between societies. The WHO guidelines do not recommend routine prenatal supplementation, but they underscore the fact that women with the lowest levels may benefit most. The effects of routine supplementation during pregnancy on maternal and neonatal clinical outcomes have not been (...) investigated in the Middle East, where hypovitaminosis D is prevalent. Our hypothesis is that in Middle Eastern pregnant women, a vitamin D dose of 3000 IU/day is required to reach a desirable maternal 25-hydroxyvitamin D [25(OH)D] level, and to positively impact infant bone mineral content (BMC).This is a multicentre blinded randomised controlled trial. Pregnant women presenting to the Obstetrics and Gynaecology clinics will be approached. Eligible women will be randomised to daily equivalent doses

2016 BMJ open Controlled trial quality: predicted high

132. Mineral- and vitamin-enhanced micronutrient powder reduces stunting in full-term low-birth-weight infants receiving nutrition, health, and hygiene education: a 2 × 2 factorial, cluster-randomized trial in Bangladesh. (Full text)

Mineral- and vitamin-enhanced micronutrient powder reduces stunting in full-term low-birth-weight infants receiving nutrition, health, and hygiene education: a 2 × 2 factorial, cluster-randomized trial in Bangladesh. The causes of stunting are complex but likely include prenatal effects, inadequate postnatal nutrient intake, and recurrent infections. Low-birth-weight (LBW) infants are at high risk of stunting. More than 25% of live births in low- and middle-income countries are at full term (...) with low birth weight (FT-LBW). Evidence on the efficacy of specific interventions to enhance growth in this vulnerable group remains scant.We investigated the independent and combined effects of a directed use of a water-based hand sanitizer (HS) and a mineral- and vitamin-enhanced micronutrient powder (MNP) (22 minerals and vitamins) to prevent infections and improve nutrient intake to reduce stunting in FT-LBW infants.The study was a prospective 2 × 2 factorial, cluster-randomized trial in 467 FT

2016 The American journal of clinical nutrition Controlled trial quality: uncertain

133. Prevalence and Consequences of Vitamin D Deficiency in Pregnant Women in Switzerland

Inselspital, Berne Collaborator: Significantis GmbH Information provided by (Responsible Party): University Hospital Inselspital, Berne Study Details Study Description Go to Brief Summary: The purpose of this study is to determine the prevalence of vitamin D deficiency among the population of pregnant women receiving prenatal care and giving birth at the investigators' clinic. The further purposes are to identify the population at risk for vitamin D deficiency and to analyse whether vitamin D deficiency (...) provided by the National Library of Medicine related topics: available for: Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : Prevalence of vitamin D deficiency [ Time Frame: Between the 1th and the 36th week of pregnancy ] Number of patients with vitamin D deficiency after testing of vitamin D blood level at admission for prenatal care in our clinic Secondary Outcome Measures : BMI as a risk factor for vitamin D deficiency [ Time Frame: Between the 1th and the 36th week

2016 Clinical Trials

134. BMI-based Vitamins in Obese Pregnant Women

Medical Center Information provided by (Responsible Party): Sarbattama Sen, Brigham and Women's Hospital Study Details Study Description Go to Brief Summary: The purpose of this study is to devise and pilot a BMI-based prenatal vitamin for obese pregnant women. Currently, all pregnant women, regardless of body mass index, take the same prenatal vitamin. The investigators have found that obese pregnant women have higher levels of inflammation and oxidative stress, and a concomitant depletion (...) of specific antioxidant micronutrients. The investigators have also found, in an animal model, that decreasing inflammation and oxidative stress during obese pregnancy was associated with improved offspring outcomes. Here the investigators aim to understand whether a BMI-based prenatal vitamin is effective in decreasing markers of inflammation and oxidative stress in pregnancies complicated by obesity. Condition or disease Intervention/treatment Phase Obesity Dietary Supplement: BMI-based prenatal vitamin

2016 Clinical Trials

135. A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy

to their patients. As such, the American Congress of Obstetricians and Gynecologists (ACOG) has called for high quality studies to address whether the use of Vitamin D supplementation beyond that found in prenatal vitamins is beneficial. In an effort to elucidate the potential benefit of Vitamin D supplementation in an unscreened population, the investigators propose conducting a randomized control trial in which Vitamin D prophylaxis is provided to a cohort of pregnant women regardless of their Vitamin D (...) links provided by the National Library of Medicine related topics: related topics: available for: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: Vitamin D Prophylaxis Participants will be provided Vitamin D 3000 IU daily or Vitamin D 4000 IU daily with and without concurrent use of prenatal vitamins, respectively. Drug: Vitamin D3 Vitamin D prophylaxis Other Name: Vitamin D No Intervention: No Vitamin D Prophylaxis Participants will not receive additional Vitamin D

2016 Clinical Trials

136. Calcium-vitamin D & Periodontal Therapy for Improving Metabolic and Inflammatory Profile Among Pregnant Women

, as necessary throughout pregnancy, up to delivery Other Name: Early non-surgical periodontal therapy Dietary Supplement: Fortified Milk participants will be advised to take two servings of a powdered milk-based drink enriched with calcium and vitamin D daily during breakfast and afternoon snack or supper to avoid concomitant intake of the prenatal iron supplements routinely prescribed for consumption with hot main meals (e.g. lunch or dinner). Women will be advised to consume 20 g of commercially available (...) until after delivery. Other Name: Delayed non-surgical periodontal therapy Dietary Supplement: Fortified Milk participants will be advised to take two servings of a powdered milk-based drink enriched with calcium and vitamin D daily during breakfast and afternoon snack or supper to avoid concomitant intake of the prenatal iron supplements routinely prescribed for consumption with hot main meals (e.g. lunch or dinner). Women will be advised to consume 20 g of commercially available semi-skimmed milk

2016 Clinical Trials

137. Maternal and Pediatric Health Outcomes in relation to Gestational Vitamin D Sufficiency (Full text)

disease, securing vitamin D sufficiency in pregnancy appears to be a simple, safe, and cost-effective measure that can be incorporated into routine preconception and prenatal care in the offices of primary care clinicians. Education on gestational nutritional requirements should be a fundamental part of medical education and residency training, instruction that has been sorely lacking to date. (...) Maternal and Pediatric Health Outcomes in relation to Gestational Vitamin D Sufficiency Juxtaposed with monumental improvement in maternal-fetal outcomes over the last century, there has been the recent emergence of rising rates of gestational complications including preterm birth, operative delivery, and gestational diabetes. At the same time, there has been a burgeoning problem with widespread vitamin D deficiency among populations of many developed nations. This paper provides a brief review

2015 Obstetrics and gynecology international

138. Early pregnancy vitamin D status and risk for adverse maternal and infant outcomes in a bi-ethnic cohort: the Behaviors Affecting Baby and You (B.A.B.Y.) Study. (Full text)

Early pregnancy vitamin D status and risk for adverse maternal and infant outcomes in a bi-ethnic cohort: the Behaviors Affecting Baby and You (B.A.B.Y.) Study. Vitamin D deficiency is common during pregnancy and higher in Hispanic as compared with non-Hispanic white women. However, the association between vitamin D deficiency and adverse pregnancy outcomes remains unclear and may vary across ethnic groups, in part because of genetic variation in the metabolism of vitamin D. Few studies have (...) included Hispanic women. Therefore, we investigated this association among 237 participants in the Behaviors Affecting Baby and You Study, a randomised trial of an exercise intervention among ethnically diverse prenatal care patients in Massachusetts. Baseline serum 25-hydroxyvitamin D (25(OH)D) was measured at 15·2 (sd 4·7) weeks' gestation. Information on adverse pregnancy outcomes was abstracted from medical records. Mean 25(OH)D was 30·4 (sd 12·0) ng/ml; 53·2 % of participants had insufficient (<30

2015 The British journal of nutrition Controlled trial quality: uncertain

139. Vitamin D deficiency in BALB/c mouse pregnancy increases placental transfer of glucocorticoids. (Full text)

the fetus from inappropriate glucocorticoid exposure. There was a corresponding increase in placental and fetal expression of the highly glucocorticoid-sensitive factor glucocorticoid-induced leucine zipper. Furthermore, placental expression of the angiogenic factor vascular endothelial growth factor-A was reduced in vitamin D-deficient pregnancies, with a corresponding decline in fetal capillary volume within the placenta. Overall, we show that prenatal vitamin D deficiency leads to an increase (...) Vitamin D deficiency in BALB/c mouse pregnancy increases placental transfer of glucocorticoids. The prevalence of vitamin D deficiency in pregnancy is increasing and implicated in adverse consequences for the health of offspring in later life. The aim of this study was to determine whether vitamin D deficiency increases fetal exposure to glucocorticoids, which are known to alter fetal development and result in adverse adult health outcomes. Female BALB/c mice were placed on either a vitamin D

2015 Endocrinology

140. Association between vitamin D levels and allergy-related outcomes vary by race and other factors. (Full text)

Association between vitamin D levels and allergy-related outcomes vary by race and other factors. Allergy-related studies that include biological measurements of vitamin D preceding well-measured outcomes are needed.We sought to examine the associations between early-life vitamin D levels and the development of allergy-related outcomes in the racially diverse Wayne County Health, Environment, Allergy, and Asthma Longitudinal Study birth cohort.25-Hydroxyvitamin D (25[OH]D) levels were measured (...) in stored blood samples from pregnancy, cord blood, and age 2 years. Logistic regression models were used to calculate odds ratios (ORs) with 95% CIs for a 5 ng/mL increase in 25(OH)D levels for the following outcomes at age 2 years: eczema, skin prick tests (SPTs), increased allergen-specific IgE level (≥ 0.35 IU/mL), and doctor's diagnosis of asthma (3-6 years).Prenatal 25(OH)D levels were inversely associated with eczema (OR, 0.85; 95% CI, 0.75-0.96). The association was stronger in white children

2015 Journal of Allergy and Clinical Immunology

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