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Prenatal Vitamin

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1201. Vitamin supplementation of HIV-infected women improves postnatal child growth. (PubMed)

a randomized placebo-controlled trial in 886 mother-infant pairs in Tanzania. At the first prenatal visit, HIV-infected women were randomly assigned to 1 of 4 daily oral regimens in a 2 x 2 factorial fashion: multivitamins (MV: thiamine, riboflavin, vitamin B-6, niacin, vitamin B-12, vitamin C, vitamin E, and folic acid), preformed vitamin A + beta-carotene (VA/BC), MV including VA/BC, or placebo. Supplementation continued during the first 2 y postpartum and thereafter. Children were weighed and measured (...) Vitamin supplementation of HIV-infected women improves postnatal child growth. Linear growth retardation and wasting are common in children born to HIV-infected women. Inexpensive interventions that could improve the postnatal growth pattern of such children are needed.The objective was to examine the effect of supplementing HIV-infected women with multivitamins or vitamin A and beta-carotene, during and after pregnancy, on the growth of their children during the first 2 y of life.We conducted

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2005 The American journal of clinical nutrition

1202. Effect of vitamin supplementation to HIV-infected pregnant women on the micronutrient status of their infants. (PubMed)

to receive a daily oral dose of one of four regimens: vitamin A, multivitamins (B, C, and E), multivitamins including A, or placebo. Supplementation started at first prenatal visit and continued after delivery throughout the breastfeeding period. The serum concentration of vitamins A, E and B12 was measured in infants at 6 weeks and 6 months postpartum.Maternal vitamin A supplementation increased serum retinol in the infants at 6 weeks (mean difference=0.09 micromol/l, P<0.0001) and 6 months (mean (...) Effect of vitamin supplementation to HIV-infected pregnant women on the micronutrient status of their infants. We examined whether supplementation with vitamin A and/or vitamins B, C, and E to HIV-infected women during pregnancy and lactation is related to increased concentrations of vitamins A, B12, and E in their infants during the first 6 months of life.We carried out a randomized clinical trial among 716 mother-infant pairs in Dar-es-Salaam, Tanzania. Women were randomly allocated

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2005 European journal of clinical nutrition

1203. High-dose vitamin D3 supplementation in a cohort of breastfeeding mothers and their infants: a 6-month follow-up pilot study. (PubMed)

received one of two treatments for a 6-month study period: 0 or 6000 IU vitD(3) plus a prenatal vitamin containing 400 IU vitD(3). The infants of mothers assigned to the control group received 300 IU vitD(3)/day; those infants of mothers in the high-dose group received 0 IU (placebo). Maternal serum and milk vitD and 25(OH)D were measured at baseline then monthly; infant serum vitD and 25(OH)D were measured at baseline, and months 4 and 7. Urinary calcium/creatinine ratios were measured monthly in both (...) High-dose vitamin D3 supplementation in a cohort of breastfeeding mothers and their infants: a 6-month follow-up pilot study. To examine the effect of high-dose maternal vitamin D(3) (vitD) supplementation on the nutritional vitD status of breastfeeding (BF) women and their infants compared with maternal and infant controls receiving 400 and 300 IU vitD/day, respectively.Fully lactating women (n = 19) were enrolled at 1-month postpartum into a randomized- control pilot trial. Each mother

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2006 Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

1204. Is antenatal vitamin K prophylaxis needed for pregnant women taking anticonvulsants? (PubMed)

disease was observed, and the incidence of bleeding tendencies was not higher in infants exposed to these drugs compared with control infants, despite no prenatal vitamin K supplementation in all but 1 epileptic woman. (...) Is antenatal vitamin K prophylaxis needed for pregnant women taking anticonvulsants? The objective of this cohort study of a consecutive sample of infants exposed during pregnancy to anticonvulsant drugs was to determine if the mother received late pregnancy prophylaxis with vitamin K, and if any infants had signs of hemorrhagic disease. The medical records of 204 neonates exposed to anticonvulsant drugs in utero and 77 unexposed control neonates were retrospectively reviewed. No hemorrhagic

2004 American Journal of Obstetrics and Gynecology

1205. Vitamin C intake and the risk of preterm delivery. (PubMed)

Vitamin C intake and the risk of preterm delivery. Ascorbic acid deficiency may lead to premature rupture of the membranes.The study included a prospective cohort of pregnant women, aged >/=16 years, with singleton gestations who received care at one of four prenatal clinics in central North Carolina from 1995 through 1998. Vitamin C intake preconceptionally and during the second trimester was examined for its association with preterm delivery and subsets of preterm labor, premature rupture (...) of the membranes, and medical induction in 2064 women.Women who had total vitamin C intakes of <10th percentile preconceptionally had twice the risk of preterm delivery because of premature rupture of the membranes (relative risk, 2.2; 95% CI, 1.1, 4.5). This risk was attenuated slightly for second-trimester intake (relative risk, 1.7; 95% CI, 0.8, 3.5). The elevated risk of preterm premature rupture of the membranes was greatest for women with a low vitamin C intake during both time periods.Because diet

2003 American Journal of Obstetrics and Gynecology

1206. Maternal vitamin D deficiency increases the risk of preeclampsia. (PubMed)

Maternal vitamin D deficiency increases the risk of preeclampsia. Vitamin D has direct influence on molecular pathways proposed to be important in the pathogenesis of preeclampsia, yet the vitamin D-preeclampsia relation has not been studied.We aimed to assess the effect of maternal 25-hydroxyvitamin D [25(OH)D] concentration on the risk of preeclampsia and to assess the vitamin D status of newborns of preeclamptic mothers.We conducted a nested case-control study of pregnant women followed from (...) less than 16 wk gestation to delivery (1997-2001) at prenatal clinics and private practices.Patients included nulliparous pregnant women with singleton pregnancies who developed preeclampsia (n = 55) or did not develop preeclampsia (n = 219). Women's banked sera were newly measured for 25(OH)D.The main outcome measure was preeclampsia (new-onset gestational hypertension and proteinuria for the first time after 20 wk gestation). Our hypotheses were formulated before data collection.Adjusted serum 25

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2007 Journal of Clinical Endocrinology and Metabolism

1207. Nutritional vitamin D status during pregnancy: reasons for concern (PubMed)

Journal Article Canada CMAJ 9711805 0820-3946 1406-16-2 Vitamin D AIM IM CMAJ. 2006 Apr 25;174(9):1273-7 16636326 Adult Animals Birth Weight Diet Dietary Supplements Female Humans Infant, Newborn Milk Nutritional Requirements Pregnancy Prenatal Care Risk Vitamin D administration & dosage metabolism 2006 4 26 9 0 2006 4 28 9 0 2006 4 26 9 0 ppublish 16636329 174/9/1287 10.1503/cmaj.060149 PMC1435950 Cochrane Database Syst Rev. 2000;(2):CD000228 10796185 Breastfeed Med. 2006 Spring;1(1):27-35 17661558 (...) Nutritional vitamin D status during pregnancy: reasons for concern 16636329 2006 04 27 2018 11 13 1488-2329 174 9 2006 Apr 25 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Nutritional vitamin D status during pregnancy: reasons for concern. 1287-90 Hollis Bruce W BW Pediatric Nutritional Sciences, Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA. hollisb@musc.edu Wagner Carol L CL eng Comment

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2006 CMAJ : Canadian Medical Association Journal

1208. Association of low intake of milk and vitamin D during pregnancy with decreased birth weight. (PubMed)

Association of low intake of milk and vitamin D during pregnancy with decreased birth weight. Some pregnant women may be advised or choose to restrict milk consumption and may not take appropriate supplements. We hypothesized that maternal milk restriction during pregnancy, which can reduce intakes of protein, calcium, riboflavin and vitamin D, might represent a health risk by lowering infant birth weight.We screened women between the ages of 19 and 45 years who were attending prenatal programs (...) circumferences were similar. Women who restricted milk intake had statistically significantly lower intakes of protein and vitamin D as well. In multivariate analyses controlled for previously established predictors of infant birth weight, milk consumption and vitamin D intake were both significant predictors of birth weight. Each additional cup of milk daily was associated with a 41 g increase in birth weight (95% confidence interval [CI] 14.0-75.1 g); each additional microgram of vitamin D, with an 11 g

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2006 Canadian Medical Association Journal

1209. Vitamin A improves Pax3 expression that is decreased in the heart of rats with experimental diaphragmatic hernia. (PubMed)

normal near term. Vitamin A up-regulates this expression on the 3 end points. The mechanism of action of Pax3 should be further investigated because it could be one of the targets for future prenatal transplacental intervention. (...) Vitamin A improves Pax3 expression that is decreased in the heart of rats with experimental diaphragmatic hernia. Rats with nitrofen-induced congenital diaphragmatic hernia (CDH) have hypoplasia and malformations of the heart. The mechanism of action of nitrofen involves changes in neural crest signaling. Pax3 function is required for cardiac neural crest cells to complete their migration to the developing heart. Vitamin A improves heart hypoplasia. The aims of this study were to examine

2006 Journal of Pediatric Surgery

1210. Antenatal vitamin A administration attenuates lung hypoplasia by interfering with early instead of late determinants of lung underdevelopment in congenital diaphragmatic hernia. (PubMed)

these results that antenatal administration of vitamin A attenuates lung hypoplasia in CDH by interfering with early determinants of lung underdevelopment. This finding may have clinical implications because prenatal diagnosis of human CDH commonly occurs after 16 weeks' gestation when late determinants of lung hypoplasia likely predominate. (...) Antenatal vitamin A administration attenuates lung hypoplasia by interfering with early instead of late determinants of lung underdevelopment in congenital diaphragmatic hernia. Early and late lung underdevelopment in congenital diaphragmatic hernia (CDH) is likely caused by nonmechanical (directly mediated by nitrofen) and mechanical (mediated by thoracic herniation) factors, respectively. The authors investigated if vitamin A enhances lung growth because of effects on both early and late

2005 Journal of Pediatric Surgery

1211. Effects of antioxidant vitamins on molecular regulators involved in lung hypoplasia induced by nitrofen. (PubMed)

Effects of antioxidant vitamins on molecular regulators involved in lung hypoplasia induced by nitrofen. Oxidant herbicide nitrofen (2,4-dichloro-4'-nitrodiphenyl ether) induces in rat embryos congenital diaphragmatic hernia (CDH) with lung hypoplasia. The present study aims at examining whether antioxidant vitamins A, E, and C reverse the effects of the teratogen in the lungs of exposed rats and how they modify the expression of molecular regulators known to be involved (...) in their pathogenesis.Wet lung weight-body weight ratio, total DNA, and total protein were determined. Thyroid transcription factor 1 (TTF-1), hepatocyte nuclear factor 3beta (HNF-3beta), and surfactant protein B (SP-B) proteins were measured by immunoblot assay in lung homogenates from rat fetuses exposed in utero to either nitrofen 100 mg intragastrically or vehicle. The coexpression of these factors in the alveolar epithelium was demonstrated by immunohistochemistry. The effects of the addition of vitamins A, C

2006 Journal of Pediatric Surgery

1212. Prenatal Multi-micronutrient Supplementation and Pregnancy Outcome

Prenatal Multi-micronutrient Supplementation and Pregnancy Outcome Prenatal Multi-micronutrient Supplementation and Pregnancy Outcome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Prenatal Multi (...) , Denmark Information provided by: Bandim Health Project Study Details Study Description Go to Brief Summary: Prenatal maternal micronutrient supplementation has been suggested as a means to reduce the proportion of low birth weight babies in low-income countries. The effects of prenatal multi-micronutrient supplements on birth weight and perinatal mortality were studied in a randomised controlled trial among 2100 pregnant women in Guinea-Bissau. Women up to 37 weeks pregnant were individually

2005 Clinical Trials

1213. Protection against Prenatal Alcohol-Induced Damage (PubMed)

Protection against Prenatal Alcohol-Induced Damage 16605309 2006 06 01 2018 11 13 1549-1676 3 4 2006 Apr PLoS medicine PLoS Med. Protection against prenatal alcohol-induced damage. e196 Spong Catherine Y CY Pregnancy and Perinatology Branch, The National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. spongc@mail.nih.gov eng Comment Journal Article 2006 04 18 United States PLoS Med 101231360 1549-1277 0 Central Nervous System Depressants (...) 12001-76-2 Vitamin B Complex 25X51I8RD4 Niacinamide 3K9958V90M Ethanol IM PLoS Med. 2006 Apr;3(4):e101 16478293 Adult Animals Central Nervous System Depressants toxicity Disease Models, Animal Ethanol toxicity Female Fetal Alcohol Spectrum Disorders prevention & control Humans Mice Niacinamide pharmacology Pregnancy Vitamin B Complex pharmacology 2006 4 12 9 0 2006 6 2 9 0 2006 4 12 9 0 ppublish 16605309 06-PLME-P-0141 10.1371/journal.pmed.0030196 PMC1435787 J Pharmacol Exp Ther. 2001 May;297(2):774

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2006 PLoS medicine

1214. Effect of vitamin D supplementation during pregnancy on foetal growth. (PubMed)

Female Humans Infant, Newborn Pregnancy Pregnancy Trimester, Third Prenatal Care Vitamin D administration & dosage 1988 12 1 1988 12 1 0 1 1988 12 1 0 0 ppublish 3243609 (...) Effect of vitamin D supplementation during pregnancy on foetal growth. 3243609 1989 05 26 2013 04 18 0971-5916 88 1988 Dec The Indian journal of medical research Indian J. Med. Res. Effect of vitamin D supplementation during pregnancy on foetal growth. 488-92 Marya R K RK Rathee S S Dua V V Sangwan K K eng Clinical Trial Journal Article Randomized Controlled Trial India Indian J Med Res 0374701 0971-5916 1406-16-2 Vitamin D IM Adult Anthropometry Birth Weight Embryonic and Fetal Development

1989 The Indian journal of medical research

1215. Serum osteocalcin as a marker for vitamin K-status in pregnant women and their newborn babies. (PubMed)

from mother and child. Whether the maternal HBC value may be used as a prenatal marker for estimating the fetal vitamin K-status remains to be seen. (...) Serum osteocalcin as a marker for vitamin K-status in pregnant women and their newborn babies. Osteocalcin (bone Gla-protein) is a vitamin K-dependent protein synthesized by osteoblasts. Its hydroxylapatite binding capacity (HBC) is generally used to estimate the Gla-content of circulating osteocalcin. Here we have used the HBC of serum osteocalcin as a marker for the vitamin K-status in pregnant women and their offspring. For all cases investigated the HBC values in the cord samples were

1992 Thrombosis and haemostasis

1216. Effects of vitamin A supplementation during pregnancy and early lactation on body weight of South African HIV-infected women. (PubMed)

. Patients were randomized to receive placebo or 5,000 IU of retinyl palmitate and 30 mg of beta-carotene daily during pregnancy. At delivery, patients received placebo or 200,000 IU of retinyl palmitate. The main outcome measures were prenatal and postnatal maternal weight and weight loss at three months after delivery as measured in body mass index (BMI). Supplementation of vitamin A was not associated with improvements in prepartum weight gain but was significantly associated with improved weight (...) Effects of vitamin A supplementation during pregnancy and early lactation on body weight of South African HIV-infected women. Effects of vitamin A supplementation during pregnancy and early lactation on maternal weight among HIV-1-seropositive South African women were examined. Three hundred twelve HIV-seropositive pregnant women between 28 and 32 weeks gestation were studied as part of a randomized, double-blind, placebo-controlled trial at the King Edward VIII Hospital in Durban, South Africa

2001 Journal of health, population, and nutrition

1217. Vitamins in early pregnancy. (PubMed)

Vitamins in early pregnancy. 8688768 1996 08 29 2018 11 13 0959-8138 313 7050 1996 Jul 20 BMJ (Clinical research ed.) BMJ Vitamins in early pregnancy. 128-9 Smithells D D eng Editorial England BMJ 8900488 0959-8138 11103-57-4 Vitamin A 935E97BOY8 Folic Acid AIM IM Congenital Abnormalities etiology Female Folic Acid administration & dosage Humans Infant, Newborn Neural Tube Defects prevention & control Pregnancy Prenatal Care Vitamin A adverse effects 1996 7 20 1996 7 20 0 1 1996 7 20 0 0

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1996 BMJ : British Medical Journal

1218. Use of vitamin-mineral supplements by AFDC children. (PubMed)

One-A-Day vitamins, generic prenatal vitamins, and Neo-Vadrin with Iron. Data on shopping behavior and sources of products indicate that the population may not be making the best use of products or funds. Informal counseling by pharmacists at the point of sale has the potential to reduce these problems. (...) Use of vitamin-mineral supplements by AFDC children. Slightly more than 11 percent of the 1,616 children in Northern Mississippi households receiving Aid to Families with Dependent Children regularly used vitamins, according to the 540 personal interviews conducted in this study. Of the vitamins used, about 20 percent were obtained by prescription. Participation in Early and Periodic Screening, Diagnosis and Treatment (EPSDT) was found not to be related to vitamin use. The pharmacy was the main

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1985 Public Health Reports

1219. Maternal antenatal administration of vitamin K1 results in increasing the activities of vitamin K-dependent coagulation factors in umbilical blood and in decreasing the incidence rate of periventricular-intraventricular hemorrhage in premature infants. (PubMed)

: (1) to determine the umbilical blood activity levels of vitamin K-dependent coagulation factors II, VII, IX and X; (2) to investigate the change in activities of these factors in premature infants' umbilical blood after prenatal administration of vitamin K1 to the mothers; and (3) to study the prophylactic effects on PIVH after maternal antenatal supplemental vitamin K1.Pregnant women in preterm labor at less than 35 weeks of gestation were randomly selected to receive antenatal vitamin K1 10 mg (...) Maternal antenatal administration of vitamin K1 results in increasing the activities of vitamin K-dependent coagulation factors in umbilical blood and in decreasing the incidence rate of periventricular-intraventricular hemorrhage in premature infants. Infants less than 35 weeks' gestation age are susceptible to periventricular-intraventricular hemorrhage (PIVH). This may be partially attributable to low concentrations of vitamin K-dependent coagulation factors. The purposes of this study were

2006 Journal of perinatal medicine

1220. Defined, in-home, prenatal nutrition intervention for low-income women. (PubMed)

Defined, in-home, prenatal nutrition intervention for low-income women. The purpose of this project was to develop a detailed, in-home, prenatal nutrition intervention protocol for low-income women and to assess the effectiveness of the intervention in improving their dietary intake. A secondary objective was to identify predictors of infant birth weight.A defined protocol was developed and nutritionists followed it to conduct in-home nutrition sessions that included nutrition assessment (...) the intervention revealed significant increases in total energy (2,269 to 2,431 kcal, P < .05), folate (345 to 412 micrograms, P < .01), vitamin B-6 (2.1 to 2.5 mg, P < .01), iron (17.5 to 21.2 mg, P < .01), zinc (13.6 to 14.7 mg, P < .01), and calcium (1,175 mg to 1,299 mg, P < .01) and significant (P < .01) increases in daily servings from the vegetable group (1.5 +/- 1.0 to 2.2 +/- 1.1 serving per day) and breads/grains groups (3.4 +/- 1.4 to 4.1 +/- 1.5 servings per day). There was no significant

1999 Journal of the American Dietetic Association

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