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Prenatal Vitamin

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101. Vitamin D Status and Metabolism in Human Pregnancy

status consumed equivalent intakes of vitamin D (511 IU/d), calcium (1.6 g/d) and phosphorus (1.9 g/d) from the study diet and prenatal multivitamin supplement (Pregnancy Plus; Fairhaven Health LLC) for ≥ 10 weeks. Dependent variables: Blood biomarkers of vitamin D metabolism at week 0 (study-baseline) and week 10 (representing study-end) Placental biomarkers of vitamin D metabolism at delivery Markers of bone metabolism in maternal and fetal cord blood as well as maternal urine Ethical (...) Vitamin D Status and Metabolism in Human Pregnancy Vitamin D Status and Metabolism in Human Pregnancy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Vitamin D Status and Metabolism in Human Pregnancy

2017 Clinical Trials

102. Marginal vitamin A deficiency facilitates Alzheimer's pathogenesis. (PubMed)

Marginal vitamin A deficiency facilitates Alzheimer's pathogenesis. Deposition of amyloid β protein (Aβ) to form neuritic plaques in the brain is the unique pathological hallmark of Alzheimer's disease (AD). Aβ is derived from amyloid β precursor protein (APP) by β- and γ-secretase cleavages and turned over by glia in the central nervous system (CNS). Vitamin A deficiency (VAD) has been shown to affect cognitive functions. Marginal vitamin A deficiency (MVAD) is a serious and widespread public (...) health problem among pregnant women and children in developing countries. However, the role of MVAD in the pathogenesis of AD remains elusive. Our study showed that MVAD is approximately twofold more prevalent than VAD in the elderly, and increased cognitive decline is positively correlated with lower VA levels. We found that MVAD, mostly prenatal MVAD, promotes beta-site APP cleaving enzyme 1 (BACE1)-mediated Aβ production and neuritic plaque formation, and significantly exacerbates memory deficits

2017 Acta neuropathologica

103. High maternal vitamin D levels in early pregnancy may protect against behavioral difficulties at preschool age: the Rhea mother-child cohort, Crete, Greece. (PubMed)

High maternal vitamin D levels in early pregnancy may protect against behavioral difficulties at preschool age: the Rhea mother-child cohort, Crete, Greece. Animal studies suggest that prenatal vitamin D status may affect fetal brain growth. However, human studies are scarce with conflicting results. We aimed to investigate the association of maternal 25-hydroxyvitamin D [25(OH) D] levels with multiple neurodevelopmental outcomes at 4 years of age. We included 487 mother-child pairs from (...) the prospective pregnancy cohort, "Rhea" in Crete, Greece. Maternal serum 25(OH) D concentrations were measured at the first prenatal visit (13 ± 2.4 weeks). Cognitive functions at 4 years were assessed by means of the McCarthy Scales of Children's Abilities. Behavioral difficulties were assessed by means of Strengths and Difficulties Questionnaire and Attention Deficit Hyperactivity Disorder Test. Children of women in the high 25(OH) D tertile (>50.7 nmol/l) had 37% decreased number of hyperactivity

2017 European child & adolescent psychiatry

104. Developmental Vitamin D Deficiency Affects Spatial Learning in Wistar Rats. (PubMed)

Developmental Vitamin D Deficiency Affects Spatial Learning in Wistar Rats. Background: Vitamin D deficiency is a global problem. Recent evidence suggests that vitamin D is involved in brain development and function. Vitamin D deficiency has been associated with poor cognitive function in adults, but the effect of developmental vitamin D deficiency (DVDD) on cognitive function and brain development in children has not been well established.Objective: We explored the effects of DVDD on cognitive (...) functions and brain morphology of rat pups.Methods: Wistar rat pups born to control and vitamin D-deficient dams were divided into 4 groups: control (C), deficient during gestation (dG), deficient during lactation (dL), and deficient during gestation and lactation (dGL). Spatial learning and memory were assessed by the Morris water maze test at postnatal day (PND) 24 and PND 45. Cortical thickness at the level of the hippocampus was measured at PND 63, and synapses were counted in specified areas

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2017 Journal of Nutrition

105. Neonatal vitamin D status from archived dried blood spots and future risk of fractures in childhood: results from the D-tect study, a population-based case-cohort study. (PubMed)

maternal vitamin D status and childhood fractures. Further studies are needed to examine fracture risk in relation to prenatal vitamin D status in a randomized controlled setting.© 2017 American Society for Nutrition. (...) Neonatal vitamin D status from archived dried blood spots and future risk of fractures in childhood: results from the D-tect study, a population-based case-cohort study. Background: Whether antenatal and neonatal vitamin D status have clinical relevance in fracture prevention has not been examined extensively, although observational studies indicate that fetal life may be a sensitive period in relation to bone growth and mineralization during childhood.Objective: We examined whether 25

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2017 American Journal of Clinical Nutrition

106. Vitamin D Deficiency Increases the Risk of Adverse Neonatal Outcomes in Gestational Diabetes. (PubMed)

prenatal monitoring were included in this cohort and had blood sampled for 25-hydroxyvitamin D measurement. Vitamin D was measured by chemiluminescence and deficiency was defined as < 20 ng/mL. Participants were followed until puerperium and adverse neonatal outcomes were evaluated.Newborns of women with vitamin D deficiency had higher incidences of hospitalization in intensive care units (ICU) (32 vs 19%, P = 0.048), of hypoglycemia (any, 17.3 vs 7.1%, P = 0.039requiring ICU, 15.3 vs 3.6%, P = 0.008 (...) Vitamin D Deficiency Increases the Risk of Adverse Neonatal Outcomes in Gestational Diabetes. Gestational diabetes mellitus (GDM) and vitamin D deficiency have been associated with increased risk of adverse perinatal outcomes but the consequences of both conditions simultaneously present in pregnancy have not yet been evaluated. Our objective was to study the influence of vitamin D deficiency in neonatal outcomes of pregnancies with GDM.184 pregnant women with GDM referred to specialized

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2016 PLoS ONE

107. Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation (PubMed)

Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation Prenatal exposure to infection is a recognized environmental risk factor for neuropsychiatric disorders of developmental origins such as autism or schizophrenia. Experimental work in animals indicates that this link is mediated by maternal immune activation (MIA) involving interactions between cytokine-associated inflammatory events, oxidative stress, and other (...) that were exposed to MIA, juveniles display similar deficits in social approach behavior. Juvenile MIA offspring also show abnormal stereotyped digging and impaired acquisition and expression of tone-cued fear conditioning. Importantly, our study reveals that prenatal administration of 1,25OHD abolishes all these behavioral deficits in poly(I:C)-treated juveniles. However, prenatal administration of vitamin D had no effect on pro-inflammatory cytokine levels in dams or in fetal brains suggesting

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2017 Molecular autism

108. Relationship between the Nutritional Status of Vitamin A per Trimester of Pregnancy with Maternal Anthropometry and Anemia after Roux-en-Y Gastric Bypass (PubMed)

above the recommended range showed 100% of inadequacy of this nutrient in the third trimester. Among the pregnant women with anemia, 90.9% had VAD and 86.4% had NB. This study highlights the importance of monitoring the nutritional status of vitamin A in prenatal care, due to its relationship with TGWG and the high percentage of VAD and NB found since the beginning of pregnancy. It also reaffirms the use of the cut-off <1.05 μmol/L for determining VAD. (...) Relationship between the Nutritional Status of Vitamin A per Trimester of Pregnancy with Maternal Anthropometry and Anemia after Roux-en-Y Gastric Bypass The aim of this study was to compare the nutritional status of vitamin A per trimester of pregnancy, as well as to assess its influence on pre-pregnancy BMI, total gestational weight gain (TGWG) and presence of anemia in women who had previously undergone Roux-en-Y gastric bypass (RYGB). An analytical, longitudinal and retrospective study

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2017 Nutrients

109. Untangling the most probable role for vitamin D3 in autism (PubMed)

Untangling the most probable role for vitamin D3 in autism Recent studies indicate an important role for vitamin D3 in autism spectrum disorder (ASD), although its mechanism is not completely understood. The most puzzling aspect of ASD is that identical twins, who share identical DNA, do not have 100% concordance rates (∼88% for identical and ∼31% for fraternal twins). These findings provide major clues into the etiology: ASD must involve an environmental factor present in the prenatal milieu (...) that both identical twins are not always exposed to because they do not always share it (i.e., placentas). Combined with the exponential increasing rates of ASD around the world, these observations suggest a contagious disease is probably transferred to the fetus via the placenta becoming infected by a cervical virus. Vitamin D3 boosts immune responses clearing viral infections and increases serotonin and estrogen brain levels. Here we review the different roles and untangle the most probable one

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2017 Dermato-endocrinology

110. Vitamin D levels and perinatal depressive symptoms in women at risk: a secondary analysis of the mothers, omega-3, and mental health study. (PubMed)

Vitamin D levels and perinatal depressive symptoms in women at risk: a secondary analysis of the mothers, omega-3, and mental health study. Vitamin D insufficiency may be associated with depressive symptoms in non-pregnant adults. We performed this study to evaluate whether low maternal vitamin D levels are associated with depressive symptoms in pregnancy.This study was a secondary analysis of a randomized trial designed to assess whether prenatal omega-3 fatty acid supplementation would (...) prevent depressive symptoms. Pregnant women from Michigan who were at risk for depression based on Edinburgh Postnatal Depression Scale Score or history of depression were enrolled. Participants completed the Beck Depression Inventory (BDI) and Mini International Neuropsychiatric Interview at 12-20 weeks, 26-28 weeks, 34-36 weeks, and 6-8 weeks postpartum. Vitamin D levels were measured at 12-20 weeks (N = 117) and 34-36 weeks (N = 112). Complete datasets were available on 105 subjects. Using

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2017 BMC pregnancy and childbirth Controlled trial quality: uncertain

111. The impact of prenatal vitamin A and zinc supplementation on growth of children up to 2 years of age in rural Java, Indonesia. (PubMed)

The impact of prenatal vitamin A and zinc supplementation on growth of children up to 2 years of age in rural Java, Indonesia. To determine whether prenatal vitamin A and/or Zn supplementation affects postnatal growth.Follow-up of a randomized controlled trial monitoring growth in children from birth up to 24 months of age.Central Java, Indonesia.Children (n 343) of mothers participating in a double-blinded, randomized controlled study of vitamin A and/or Zn supplementation during pregnancy. We (...) report the effects of prenatal supplementation on infant growth, measured as weight-for-age Z-scores (WAZ), height-for-age Z-scores (HAZ) and weight-for-height Z-scores (WHZ ), from 0 to 24 months, as well as differences in growth faltering among the supplementation groups.For HAZ, the absolute differences between the vitamin A-only and vitamin A + Zn groups at 3 and 9 months were 0·34 SD and 0·37 SD, respectively, and the absolute difference between the vitamin A-only and Zn-only groups at 18 months

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2011 Public health nutrition Controlled trial quality: predicted high

112. Vitamin K in Prenatal Prevention and Postnatal Treatment of Haemorrhagic Disease of the Newborn (PubMed)

Vitamin K in Prenatal Prevention and Postnatal Treatment of Haemorrhagic Disease of the Newborn 21032171 2011 03 30 2018 11 13 0003-9888 15 82 1940 Archives of disease in childhood Arch. Dis. Child. Vitamin K in Prenatal Prevention and Postnatal Treatment of Haemorrhagic Disease of the Newborn. 97-102 Kugelmass I N IN eng Journal Article England Arch Dis Child 0372434 0003-9888 2010 10 30 6 0 1940 1 1 0 0 1940 1 1 0 1 ppublish 21032171 PMC1987724 Biochem J. 1936 Jun;30(6):1075-9 16746121

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1940 Archives of Disease in Childhood

113. Evaluation, Treatment, and Prevention of Vitamin D Deficiency

women who take a prenatal vitamin and a calcium supplement with vitamin D remain at high risk for vitamin D deficiency ( – ). Causes of Vitamin D Deficiency The major source of vitamin D for children and adults is exposure to natural sunlight ( , , – ). Very few foods naturally contain or are fortified with vitamin D. Thus, the major cause of vitamin D deficiency is inadequate exposure to sunlight ( – , ). Wearing a sunscreen with a sun protection factor of 30 reduces vitamin D synthesis in the skin (...) at the time of birth, despite the fact that during pregnancy, the mothers ingested about 600 IU/d of vitamin D from a prenatal supplement and consumption of two glasses of milk. Infants depend on either sunlight exposure or dietary vitamin D to meet their requirement from birth. Human breast milk and unfortified cow's milk have very little vitamin D ( ). Thus, infants who are fed only human breast milk are prone to developing vitamin D deficiency, especially during the winter when neither they nor

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2011 The Endocrine Society

114. Vitamin A supplementation during pregnancy for reducing the risk of mother-to-child transmission of HIV

transmission of HIV. 1.Vitamin A – administration and dosage. 2.Vitamin A deficiency – complications. 3.Pregnancy. 4.Disease transmission, Vertical – prevention and control. 5.HIV infections – prevention and control. 6.Prenatal nutrition. 7.Guidelines. I.World Health Organization. ISBN 978 92 4 150180 4 (NLM classification: WD 110) © World Health Organization 2011 All rights reserved. Publications of the World Health Organization are available on the WHO web site (www.who.int) or can be purchased from WHO (...) Vitamin A supplementation during pregnancy for reducing the risk of mother-to-child transmission of HIV Guideline: Vitamin A supplementation in pregnancy for reducing the risk of mother-to-child transmission of HIV ii Vitamin A supplementation in pregnancy for reducing the risk of mother-to-child transmission of HIV WHO | Guideline Suggested citation WHO Library Cataloguing-in-Publication Data Guideline: vitamin A supplementation in pregnancy for reducing the risk of mother-to-child

2011 World Health Organisation HIV Guidelines

115. Racial disparities in cord blood vitamin D levels and its association with small-for-gestational-age infants (PubMed)

race, Medicaid status, mean body mass index at delivery and lack of prenatal vitamin use were associated with vitamin D deficiency. Black infants had 3.6 greater adjusted odds (95% confidence interval (CI): 2.4, 5.6) of vitamin D deficiency when compared with white infants. Black infants with vitamin D deficiency had 2.4 greater adjusted odds (95% CI: 1.0, 5.8) of SGA. Vitamin D deficiency was not significantly associated with SGA in white infants.Identification of risk factors (black race (...) , Medicaid status, obesity and lack of prenatal vitamin use) can lead to opportunities for targeted prenatal vitamin supplementation to reduce the risk of neonatal vitamin D deficiency and SGA status.

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2016 Journal of Perinatology

116. Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy (PubMed)

Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy Reports on the effect of prenatal vitamin D status on fetal immune development and infectious diseases in childhood are limited. The aim of this study was to investigate the role of maternal and cord blood vitamin D level in TLR-related innate immunity and its effect on infectious outcome. Maternal and cord blood 25 (OH)D level were examined from 372 (...) maternal-neonatal pairs and their correlation with TLR-triggered TNF-α, IL-6, and IL-10 response at birth was assessed. Clinical outcomes related to infection at 12 months of age were also evaluated. The result showed that 75% of the pregnant mothers and 75.8% of the neonates were vitamin deficient. There was a high correlation between maternal and cord 25(OH)D levels (r = 0.67, p < 0.001). Maternal vitamin D level was inversely correlated with IL-10 response to TLR3 (p = 0.004) and TLR7-8 stimulation

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2016 Mediators of inflammation

117. A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy

to their patients. As such, the American Congress of Obstetricians and Gynecologists (ACOG) has called for high quality studies to address whether the use of Vitamin D supplementation beyond that found in prenatal vitamins is beneficial. In an effort to elucidate the potential benefit of Vitamin D supplementation in an unscreened population, the investigators propose conducting a randomized control trial in which Vitamin D prophylaxis is provided to a cohort of pregnant women regardless of their Vitamin D (...) links provided by the National Library of Medicine related topics: related topics: available for: resources: Arms and Interventions Go to Arm Intervention/treatment Experimental: Vitamin D Prophylaxis Participants will be provided Vitamin D 3000 IU daily or Vitamin D 4000 IU daily with and without concurrent use of prenatal vitamins, respectively. Drug: Vitamin D3 Vitamin D prophylaxis Other Name: Vitamin D No Intervention: No Vitamin D Prophylaxis Participants will not receive additional Vitamin D

2016 Clinical Trials

118. Prevalence and Consequences of Vitamin D Deficiency in Pregnant Women in Switzerland

Inselspital, Berne Collaborator: Significantis GmbH Information provided by (Responsible Party): University Hospital Inselspital, Berne Study Details Study Description Go to Brief Summary: The purpose of this study is to determine the prevalence of vitamin D deficiency among the population of pregnant women receiving prenatal care and giving birth at the investigators' clinic. The further purposes are to identify the population at risk for vitamin D deficiency and to analyse whether vitamin D deficiency (...) provided by the National Library of Medicine related topics: available for: Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : Prevalence of vitamin D deficiency [ Time Frame: Between the 1th and the 36th week of pregnancy ] Number of patients with vitamin D deficiency after testing of vitamin D blood level at admission for prenatal care in our clinic Secondary Outcome Measures : BMI as a risk factor for vitamin D deficiency [ Time Frame: Between the 1th and the 36th week

2016 Clinical Trials

119. BMI-based Vitamins in Obese Pregnant Women

Medical Center Information provided by (Responsible Party): Sarbattama Sen, Brigham and Women's Hospital Study Details Study Description Go to Brief Summary: The purpose of this study is to devise and pilot a BMI-based prenatal vitamin for obese pregnant women. Currently, all pregnant women, regardless of body mass index, take the same prenatal vitamin. The investigators have found that obese pregnant women have higher levels of inflammation and oxidative stress, and a concomitant depletion (...) of specific antioxidant micronutrients. The investigators have also found, in an animal model, that decreasing inflammation and oxidative stress during obese pregnancy was associated with improved offspring outcomes. Here the investigators aim to understand whether a BMI-based prenatal vitamin is effective in decreasing markers of inflammation and oxidative stress in pregnancies complicated by obesity. Condition or disease Intervention/treatment Phase Obesity Dietary Supplement: BMI-based prenatal vitamin

2016 Clinical Trials

120. Factors Influencing the Infant Gut Microbiome at Age 3-6 months: Findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART). (PubMed)

Factors Influencing the Infant Gut Microbiome at Age 3-6 months: Findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART). The gut microbiome in infancy influences immune system maturation, and may have an important impact on allergic disease risk.We sought to determine how prenatal and early life factors impact the gut microbiome in a relatively large, ethnically diverse study population of infants at age 3 to 6 months, who were enrolled in Vitamin D Antenatal (...) Asthma Reduction Trial, a clinical trial of vitamin D supplementation in pregnancy to prevent asthma and allergies in offspring.We performed 16S rRNA gene sequencing on 333 infants' stool samples. Microbial diversity was computed using the Shannon index. Factor analysis applied to the top 25 most abundant taxa revealed 4 underlying bacterial coabundance groups; the first dominated by Firmicutes (Lachnospiraceae/Clostridiales), the second by Proteobacteria (Klebsiella/Enterobacter), the third

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2016 Journal of Allergy and Clinical Immunology

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