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Prenatal Vitamin

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81. Dietary Nutrient Intake in School-Aged Children with Heavy Prenatal Alcohol Exposure (PubMed)

Dietary Nutrient Intake in School-Aged Children with Heavy Prenatal Alcohol Exposure Nutrition is an important factor that affects brain development. Nutritional deficiencies can exacerbate alcohol's damaging effects. Conversely, nutritional supplementation can serve a protective role against alcohol damage and may prove to be a worthwhile intervention strategy. This study investigated dietary intake in school-aged children with heavy prenatal alcohol exposure to understand their nutritional (...) status, compared to a national sample of typically developing children and Dietary Reference Intakes.Dietary intake data were collected from children with confirmed histories of heavy prenatal alcohol exposure (5 to 10 years, n = 55) using the Automated Self-Administered 24-Hour Dietary Recall (ASA24). Observed nutrient levels were compared to the Dietary Reference Intakes to evaluate adequacy of nutrient intake as well as to national averages for same-aged children (What We Eat in America, NHANES

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2016 Alcoholism, clinical and experimental research

82. Investigation of 7-dehydrocholesterol reductase pathway to elucidate off-target prenatal effects of pharmaceuticals: a systematic review. (PubMed)

Investigation of 7-dehydrocholesterol reductase pathway to elucidate off-target prenatal effects of pharmaceuticals: a systematic review. Mendelian diseases contain important biological information regarding developmental effects of gene mutations that can guide drug discovery and toxicity efforts. In this review, we focus on Smith-Lemli-Opitz syndrome (SLOS), a rare Mendelian disease characterized by compound heterozygous mutations in 7-dehydrocholesterol reductase (DHCR7) resulting in severe (...) fetal deformities. We present a compilation of SLOS-inducing DHCR7 mutations and the geographic distribution of those mutations in healthy and diseased populations. We observed that several mutations thought to be disease causing occur in healthy populations, indicating an incomplete understanding of the condition and highlighting new research opportunities. We describe the functional environment around DHCR7, including pharmacological DHCR7 inhibitors and cholesterol and vitamin D synthesis. Using

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2016 The pharmacogenomics journal

83. Neonatal Metabolomic Profiles Related to Prenatal Arsenic Exposure (PubMed)

Neonatal Metabolomic Profiles Related to Prenatal Arsenic Exposure Prenatal inorganic arsenic (iAs) exposure is associated with health effects evident at birth and later in life. An understanding of the relationship between prenatal iAs exposure and alterations in the neonatal metabolome could reveal critical molecular modifications, potentially underpinning disease etiologies. In this study, nuclear magnetic resonance (NMR) spectroscopy-based metabolomic analysis was used to identify (...) metabolites in neonate cord serum associated with prenatal iAs exposure in participants from the Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort, in Gómez Palacio, Mexico. Through multivariable linear regression, ten cord serum metabolites were identified as significantly associated with total urinary iAs and/or iAs metabolites, measured as %iAs, %monomethylated arsenicals (MMAs), and %dimethylated arsenicals (DMAs). A total of 17 metabolites were identified as significantly associated

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2016 Environmental science & technology

84. Maternal prenatal intake of one-carbon metabolism nutrients and risk of childhood leukemia (PubMed)

Maternal prenatal intake of one-carbon metabolism nutrients and risk of childhood leukemia Folate, vitamins B12 and B6, riboflavin, and methionine are critical nutrients for the one-carbon metabolism cycle involved in DNA synthesis and epigenetic processes. We examined the association between maternal intake of these nutrients before pregnancy and risk of childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in a matched case-control study.Maternal dietary intake (...) and vitamin supplement use in the year before pregnancy was assessed by food frequency questionnaire for 681 ALL cases, 103 AML cases, and 1076 controls. Principal component analysis was used to construct a variable representing combined nutrient intake, and conditional logistic regression estimated the odds ratio (OR) and 95% confidence interval (CI) for the association of ALL and AML with the principal component and each nutrient.Higher maternal intake of one-carbon metabolism nutrients from food

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2016 Cancer causes & control : CCC

85. Vitamin D Supplementation Attenuates Asthma Development Following Traffic-Related Particulate Matter Exposure. (PubMed)

, asthma exacerbation, and/or airway inflammation and to determine the timing of vitamin D supplementation that confers maximal health benefit.Using established mouse models of asthma, we examined the effect of prenatal and postnatal vitamin D supplementation on asthma development, as well as the utility of vitamin D as a treatment for established asthma in the context of diesel exhaust particle (DEP) exposure.DEP and allergen coexposure resulted in increased airway hyperresponsiveness (AHR (...) ) and accumulation of pathogenic TH2/TH17 cells in the lungs of vitamin D-deficient mice compared with control mice. Prenatal and postnatal vitamin D supplementation significantly attenuated the development of AHR and decreased pulmonary accumulation of TH2/TH17 cells after coexposure to TRAP and allergen but not to allergen alone. Restoration of normal vitamin D status had no effect on AHR once asthma was already established.Our data establish that vitamin D confers protection against asthma development

2018 Journal of Allergy and Clinical Immunology

86. Vitamin B-12 content in breast milk of vegan, vegetarian, and nonvegetarian lactating women in the United States. (PubMed)

the use of a B-complex vitamin and prenatal vitamin were not predictive of vitamin B-12 milk concentration (P > 0.05).Almost 20% of our study participants were classified as having low breast-milk vitamin B-12 concentrations (<310 pmol/L), independent of maternal diet pattern. Approximately 85% of participants categorized as having low vitamin B-12 were taking vitamin B-12 supplements at doses in excess of the Recommended Dietary Allowance, which suggests that more research is needed to determine (...) Vitamin B-12 content in breast milk of vegan, vegetarian, and nonvegetarian lactating women in the United States. The nutritional profile of human milk varies significantly between women, and the impact of maternal diet on these variations is not well understood.We analyzed breast-milk vitamin B-12 concentration and vitamin B-12 supplement use pattern among women who adhered to different dietary patterns: vegan, vegetarian, and nonvegetarian.A total of 74 milk samples, 29 from vegan, 19 from

2018 American Journal of Clinical Nutrition

87. Maternal Anthropometry and Its Relationship with the Nutritional Status of Vitamin D, Calcium, and Parathyroid Hormone in Pregnant Women After Roux-en-Y Gastric Bypass. (PubMed)

attention to the importance of monitoring the nutritional status of vitamin D3 and calcium in the prenatal period due to its relationship with pre-pregnancy BMI, TGWG, and surgical success. (...) Maternal Anthropometry and Its Relationship with the Nutritional Status of Vitamin D, Calcium, and Parathyroid Hormone in Pregnant Women After Roux-en-Y Gastric Bypass. To assess the influence of pre-pregnancy body mass index (BMI), total gestational weight gain (TGWG), and pre-pregnancy surgical success on the nutritional status of vitamin D, calcium, and parathyroid hormone (PTH) in the trimesters of pregnancy of women who previously underwent Roux-en-Y gastric bypass (RYGB

2018 Obesity Surgery

88. Foetal, neonatal and child vitamin D status and enamel hypomineralization. (PubMed)

Foetal, neonatal and child vitamin D status and enamel hypomineralization. Recent literature suggested that higher vitamin D concentrations in childhood are associated with a lower prevalence of molar incisor hypomineralization (MIH). As tooth development already starts in utero, we aimed to study whether vitamin D status during foetal, postnatal and childhood periods is associated with the presence of hypomineralized second primary molars (HSPMs) and/or MIH at the age of six.Our study (...) : 0.84-1.07) by the age of six. Finally, we did not find higher 25(OH)D concentrations at the age of six to be associated with a significant change in the odds of having HSPM (OR 0.97, 95% CI: 0.92-1.02) or MIH (OR 1.07, 95% CI: 0.98-1.16).25(OH)D concentrations in prenatal, early postnatal and later postnatal life are not associated with the presence of HPSMs or with MIH at the age of six. Future observational research is required to replicate our findings. Furthermore, it is encouraged to focus

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2018 Community Dentistry and Oral Epidemiology

89. Acetaminophen, antibiotics, ear infection, breastfeeding, vitamin D drops, and autism: an epidemiological study (PubMed)

Acetaminophen, antibiotics, ear infection, breastfeeding, vitamin D drops, and autism: an epidemiological study While many studies have examined environmental risk factors for autism spectrum disorder (ASD), much of the research focus has been on prenatal or perinatal factors. Yet, the postnatal environment may affect the risk of ASD as well.To determine whether a set of five postnatal variables are associated with ASD. These variables are: acetaminophen exposure, antibiotic exposure, incidence (...) of ear infection, decreased duration of breastfeeding, and decreased consumption of oral vitamin D drops.An Internet-based survey was conducted. Participants were parents living in the USA with at least one biological child between 3 and 12 years of age. Potential participants were informed about the survey via postings on social media, websites, and listservs and were offered an opportunity to participate in a raffle as well. Participants were also recruited through the Interactive Autism

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2018 Neuropsychiatric disease and treatment

90. Vitamins A and E during Pregnancy and Allergy Symptoms in an Early Childhood—Lack of Association with Tobacco Smoke Exposure (PubMed)

children who were prenatally exposed or not exposed to tobacco smoke. The study participants included 252 mother-child pairs from Polish Mother and Child Cohort. Vitamin concentrations were measured using the HPLC-UV method, smoking status—as saliva cotinine level using the HPLC-MS/MS technique. Children’s health status was assessed using a questionnaire and pediatricians/allergists examination. Cord plasma vitamin concentrations were significantly lower than their levels in maternal plasma (...) Vitamins A and E during Pregnancy and Allergy Symptoms in an Early Childhood—Lack of Association with Tobacco Smoke Exposure Epidemiological studies have suggested an association between maternal antioxidant levels during pregnancy and development of allergic diseases in their offspring. The aim of the study was to determine plasma vitamins A and E concentration in the 1st trimester of pregnancy, at delivery and in cord blood and to search for a relationship with allergy in up to 2-year-old

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2018 International journal of environmental research and public health

91. Vitamin B12 Pregnancy Supplementation

Comparator: Receiving treatment Adding vitamin B12 at a dose of 5 μg / 100 days, custom folic acid therapy and iron supplements Dietary Supplement: vitamin b12 Vitamin B12 has been added to the experimental group of pregnant women, at a dose of 5 μg / 100 days No Intervention: Control group Standard prenatal care (custom folic acid therapy and iron supplements) Outcome Measures Go to Primary Outcome Measures : Change of Red blood cells (RBC) count in first and second trimester [ Time Frame: at two time (...) Vitamin B12 Pregnancy Supplementation Vitamin B12 Pregnancy Supplementation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Vitamin B12 Pregnancy Supplementation The safety and scientific validity

2018 Clinical Trials

92. Position Statement: Guidelines for vitamin K prophylaxis in newborns: A joint statement of the Canadian Paediatric Society and the College of Family Physicians of Canada (PubMed)

Position Statement: Guidelines for vitamin K prophylaxis in newborns: A joint statement of the Canadian Paediatric Society and the College of Family Physicians of Canada Newborns are at risk for vitamin K deficiency bleeding (VKDB) caused by inadequate prenatal storage and deficiency of vitamin K in breast milk. Systematic review of evidence to date suggests that a single intramuscular (IM) injection of vitamin K at birth effectively prevents VKDB. Current scientific data suggest that single (...) or repeated doses of oral (PO) vitamin K are less effective than IM vitamin K in preventing VKDB. The Canadian Paediatric Society and the College of Family Physicians of Canada recommend routine IM administration of a single dose of vitamin K at 0.5 mg to 1.0 mg to all newborns. Administering PO vitamin K (2.0 mg at birth, repeated at 2 to 4 and 6 to 8 weeks of age) should be confined to newborns whose parents decline IM vitamin K. Health care providers should clarify with parents that newborns

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2018 Canadian Family Physician

93. In utero exposure to extra vitamin D from food fortification and the risk of subsequent development of gestational diabetes: the D-tect study (PubMed)

-ecological study is based on the cancellation in 1985 of the mandatory policy to fortify margarine with vitamin D in Denmark, with inclusion of entire national adjacent birth cohorts either exposed or unexposed to extra vitamin D in utero. The identification of GDM cases later in life among both exposure groups was based on the Danish national health registers. Logistic regression analyses generating odds ratios (ORs) and 95% confidence intervals (95% CIs) were performed.Women who were prenatally exposed (...) to the extra vitamin D from fortification tended to have a lower risk of subsequently developing GDM than unexposed women (OR 0.87, 95%CI 0.74,1.02, P = 0.08). When analyses were stratified by women's season of birth, exposed women born in spring had a lower risk of developing GDM compared to unexposed subjects (OR 0.68, 95%CI 0.50,0.94, p = 0.02).This study suggests that prenatal exposure to extra vitamin D from mandatory fortification may lower the risk of developing gestational diabetes among spring

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2018 Nutrition journal

94. Associations between maternal vitamin D levels during pregnancy and allergic outcomes in the offspring in the first 5 years of life. (PubMed)

Pediatr Allergy Immunol 9106718 0905-6157 1406-16-2 Vitamin D IM Adult Child, Preschool Cohort Studies Female Humans Hypersensitivity epidemiology etiology Infant Male Pregnancy Prenatal Exposure Delayed Effects Prospective Studies Risk Factors Singapore Skin Tests Vitamin D blood Vitamin D Deficiency complications epidemiology allergic outcomes eczema family history of allergy maternal vitamin D 2019 08 01 2018 10 20 6 0 2019 3 20 6 0 2018 10 20 6 0 ppublish 30338862 10.1111/pai.12995 PMC6358006 (...) Associations between maternal vitamin D levels during pregnancy and allergic outcomes in the offspring in the first 5 years of life. 30338862 2019 03 19 2019 03 19 1399-3038 30 1 2019 02 Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Pediatr Allergy Immunol Associations between maternal vitamin D levels during pregnancy and allergic outcomes in the offspring in the first 5 years of life. 117-122 10.1111/pai.12995 Loo Evelyn

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2018 Pediatric Allergy and Immunology

95. Association Between Vitamin D Supplementation During Pregnancy and Offspring Growth, Morbidity, and Mortality: A Systematic Review and Meta-analysis. (PubMed)

% to -10.34%) without risk of fetal or neonatal mortality (RR, 0.72; 95% CI, 0.47 to 1.11) or congenital abnormality (RR, 0.94; 95% CI, 0.61 to 1.43). Neonates with prenatal vitamin D supplementation had higher 25(OH)D levels (MD, 13.50 ng/mL; 95% CI, 10.12 to 16.87 ng/mL), calcium levels (MD, 0.19 mg/dL; 95% CI, 0.003 to 0.38 mg/dL), and weight at birth (MD, 75.38 g; 95% CI, 22.88 to 127.88 g), 3 months (MD, 0.21 kg; 95% CI, 0.13 to 0.28 kg), 6 months (MD, 0.46 kg; 95% CI, 0.33 to 0.58 kg), 9 months (MD (...) Association Between Vitamin D Supplementation During Pregnancy and Offspring Growth, Morbidity, and Mortality: A Systematic Review and Meta-analysis. Whether vitamin D supplementation during pregnancy is beneficial and safe for offspring is unclear.To systematically review studies of the effects of vitamin D supplementation during pregnancy on offspring growth, morbidity, and mortality.Searches of Medline, Embase, and the Cochrane Database of Systematic Reviews were conducted up to October 31

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2018 JAMA pediatrics

96. Effects of Maternal Vitamin D Supplementation on the Maternal and Infant Epigenome. (PubMed)

and lactation alters DNA methylation in mothers and breastfed infants. Additional work is needed to fully elucidate the short- and long-term biologic effects of vitamin D supplementation at varying doses, which could hold important implications for establishing clinical recommendations for prenatal and offspring health promotion. (...) Effects of Maternal Vitamin D Supplementation on the Maternal and Infant Epigenome. Mothers and infants are at high risk for inadequate vitamin D status. Mechanisms by which vitamin D may affect maternal and infant DNA methylation are poorly understood.This study quantified the effects of vitamin D3 supplementation on DNA methylation in pregnant and lactating women and their breastfed infants.In this randomized controlled pilot study, pregnant women received vitamin D3 400 international units

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2018 Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine Controlled trial quality: uncertain

97. Vitamin A Supplementation during Pregnancy Enhances Pandemic H1N1 Vaccine Response in Mothers, but Enhancement of Transplacental Antibody Transfer May Depend on When Mothers Are Vaccinated during Pregnancy. (PubMed)

pregnancy and postpartum increases the breast-milk vitamin A concentration and enhances prenatal H1N1-vaccine responses in mothers, but the benefits of maternal VAS in transplacental antibody transfer may depend on the time of gestation when mothers were vaccinated. This trial was registered at clinicaltrials.gov as NCT00817661. (...) Vitamin A Supplementation during Pregnancy Enhances Pandemic H1N1 Vaccine Response in Mothers, but Enhancement of Transplacental Antibody Transfer May Depend on When Mothers Are Vaccinated during Pregnancy. In the growing embryo, the vitamin A requirement is tightly regulated. Maternal vitamin A deficiency during pregnancy may alter maternal immune function to accommodate the fetus.Our primary objective was to determine the effect of oral vitamin A supplementation (VAS) during pregnancy

2018 Journal of Nutrition Controlled trial quality: predicted high

98. Vitamin D supplementation: Recommendations for Canadian mothers and infants

for their supply of vitamin D, which crosses the placenta and is reflected both in infant stores and in the amount of vitamin D available in breast milk. It is important that mothers have levels of vitamin D sufficient to meet their own needs and those of their infants. How much maternal supplementation is sufficient? Health Canada has suggested 200 IU/day (5 µg/day) . The existing prenatal supplements contain 400 IU of vitamin D3 per suggested daily dose. Subscripts refer to the type of vitamin D used – D 3 (...) Vitamin D supplementation: Recommendations for Canadian mothers and infants Vitamin D supplementation: Recommendations for Canadian mothers and infants | Canadian Paediatric Society CPS In this section Protecting and promoting the health and well-being of children and youth CPS Policy & Advocacy Clinical Practice Education & Events News & Publications Programs Membership About the CPS Position statement Vitamin D supplementation: Recommendations for Canadian mothers and infants Posted: Oct 1

2012 Canadian Paediatric Society

99. The protective role of vitamin E on the testicular tissue in rats exposed to sodium arsenite during the prenatal stage till sex maturity: A stereological analysis (PubMed)

The protective role of vitamin E on the testicular tissue in rats exposed to sodium arsenite during the prenatal stage till sex maturity: A stereological analysis Vitamin E is an effective antioxidant, protecting cells against oxidative stress.In this investigation the protective effect of vitamin E on the testis during development and spermatogenesis in rats exposed to sodium arsenite was evaluated.Pregnant Wistar rats were divided into 4 groups (n=8) control, sodium arsenite (8 mg/kg/day (...) , spermatocyte, spermatid and sertoli cells reduced significantly in sodium arsenite group compared to the control. Co-administration of vitamin E and sodium arsenite compensated the adverse effects of sodium arsenite on the above parameters.We concluded co-treatment of rats with sodium arsenite and vitamin E could prevent the adverse effects of sodium arsenite exposure on the testicular tissue during the prenatal stage till sex maturity.

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2012 Iranian Journal of Reproductive Medicine

100. Prenatal Vitamin

Prenatal Vitamin Prenatal Vitamin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Prenatal Vitamin Prenatal Vitamin Aka: Prenatal (...) Vitamin II. Indications Start prior to conception of pregnancy III. Preparations: Key components (Higher doses than standard Vitamins) 400 mcg or 600 Dietary Equivalents or DFE (See for references) Dose is higher if increased risk 4000 mcg started 3 months before pregnancy (continue for first trimester) Prior Use of or 800 mcg daily (1200 Dietary Equivalents or DFE) Anti-epileptic drugs other than or Most important component in Prenatal Vitamins Reduces s by 50% at conception Reduced fetal risk

2015 FP Notebook

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