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Prenatal Vitamin

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61. Prenatal Exposures and the Development of Childhood Wheezing Illnesses (PubMed)

suggests an adverse impact of maternal obesity during pregnancy and prenatal exposure to antibiotics on these outcomes. There is insufficient evidence to support an association between in-utero exposure to acetaminophen or prenatal levels of specific nutrients (such as vitamin D, folic acid, or polyunsaturated fatty acids) and childhood wheezing illnesses.Several common potentially modifiable prenatal exposures appear to be consistently associated with childhood wheezing illnesses (e.g. parental (...) Prenatal Exposures and the Development of Childhood Wheezing Illnesses To critically evaluate and summarize studies published between July 2015 and June 2016 linking prenatal exposures and the onset of childhood wheezing illnesses and to discuss future research directions in this field.The aggregated evidence indicates a consistent detrimental effect of prenatal exposure to parental smoking, outdoor air pollution, and maternal stress on childhood wheezing illnesses. Less consistent evidence

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2017 Current Opinion in Allergy and Clinical Immunology

62. Is Nutrient Content and Other Label Information for Prescription Prenatal Supplements Different from Nonprescription Products? (PubMed)

in the United States regarding declared nutrient and nonnutrient ingredients and the presence of dosing and safety-related information.Using two publicly available databases with information about prenatal supplement products, information from prescription and nonprescription product labels were extracted and evaluated. For the 82 prescription and 132 nonprescription products, declared label amounts of seven vitamins and minerals, docosahexaenoic acid (DHA), the presence of other nonnutrient components (...) Is Nutrient Content and Other Label Information for Prescription Prenatal Supplements Different from Nonprescription Products? Prenatal supplements are often recommended to pregnant women to help meet their nutrient needs. Many products are available, making it difficult to choose a suitable supplement because little is known about their labeling and contents to evaluate their appropriateness.To determine differences between prescription and nonprescription prenatal supplements available

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2017 Journal of the Academy of Nutrition and Dietetics

63. Associations among Prenatal Stress, Maternal Antioxidant Intakes in Pregnancy, and Child Temperament at Age 30 Months (PubMed)

events and child temperament, and effect modification by maternal prenatal antioxidant intakes (vitamins A, C, and E, magnesium, zinc, selenium, β-carotene). Analyses revealed that increased maternal prenatal negative life events were associated with higher child Negative Affectivity (β=0.08, P=0.009) but not with child Effortful Control (β=-0.03, P=0.39) or Surgency/Extraversion (β=0.04, P=0.14). Prenatal intakes of zinc and selenium modified this effect: Maternal exposure to prenatal negative life (...) events was associated with higher child Negative Affectivity in the presence of lower intakes of zinc and selenium. Modification effects approached significance for vitamins A and C. The results suggest that the combination of elevated stress exposures and lower antioxidant intakes in pregnancy increases the likelihood of heightened child temperamental negative affectivity. Increased antioxidant intakes during pregnancy may protect against influences of prenatal stress on child temperament.

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2017 Journal of developmental origins of health and disease

64. Prenatal Lipid-Based Nutrient Supplements Affect Maternal Anthropometric Indicators Only in Certain Subgroups of Rural Bangladeshi Women. (PubMed)

Prenatal Lipid-Based Nutrient Supplements Affect Maternal Anthropometric Indicators Only in Certain Subgroups of Rural Bangladeshi Women. Maternal undernutrition and low macro- and micronutrient intake and weight gain during pregnancy have been reported in Bangladesh.We aimed to determine the effects of lipid-based nutrient supplements for pregnant and lactating women (LNS-PL) on weight gain and midupper arm circumference (MUAC) during pregnancy.The Rang-Din Nutrition Study, a cluster (...) -randomized effectiveness trial conducted in Bangladesh, enrolled 4011 pregnant women at ≤20 wk gestation who received either 60 mg Fe + 400 μg folic acid/d or 20 g LNS-PL/d (118 kcal) containing essential fatty acids and vitamins and minerals until delivery. At 36 wk gestation, women were interviewed at home and then attended a follow-up examination at local clinics (n = 2877), where anthropometric measurements were taken.No significant differences between intervention groups in maternal weight gain per

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2017 The Journal of nutrition Controlled trial quality: uncertain

65. Prenatal Lipid-Based Nutrient Supplements Do Not Affect Pregnancy or Childbirth Complications or Cesarean Delivery in Bangladesh: A Cluster-Randomized Controlled Effectiveness Trial. (PubMed)

Prenatal Lipid-Based Nutrient Supplements Do Not Affect Pregnancy or Childbirth Complications or Cesarean Delivery in Bangladesh: A Cluster-Randomized Controlled Effectiveness Trial. Background: Pregnancy and childbirth complications and cesarean delivery are common in Bangladesh.Objective: We evaluated the effect of lipid-based nutrient supplements for pregnant and lactating women (LNS-PL) on pregnancy and childbirth complications and cesarean delivery.Methods: We conducted the Rang-Din (...) Nutrition Study, a cluster-randomized controlled effectiveness trial within a community health program in rural Bangladesh. We enrolled 4011 pregnant women in early pregnancy. Women in 48 clusters received iron and folic acid (IFA; 60 mg Fe + 400 μg folic acid/d) and women in 16 clusters received LNS-PL (20 g/d, 118 kcal) containing essential fatty acids and 22 vitamins and minerals. Pregnancy and childbirth complications and the cesarean delivery rate were secondary outcomes of the study.Results: Women

2017 Journal of Nutrition Controlled trial quality: uncertain

66. Vitamin D in Pregnancy

or longer term growth of the child. 7. Fetal lung development and childhood immune disorders Low maternal vitamin D intake in pregnancy is associated with wheeze and asthma in the offspring. 49 Low cord blood 25(OH)D concentrations have been associated with respiratory syncytial virus bronchiolitis 50 and respiratory infections. 51 There are plausible physiological mechanisms for an association between prenatal vitamin D status and immune development. The metabolite 1,25(OH) 2 D has been shown in animal (...) Vitamin D in Pregnancy Vitamin D in Pregnancy Scientific Impact Paper No. 43 June 2014Vitamin D in Pregnancy 1. Introduction Vitamin D has an increasingly recognised repertoire of nonclassical actions, such as promoting insulin action and secretion, immune modulation and lung development. It therefore has the potential to influence many factors in the developing fetus. This paper investigates the effects of vitamin D on the placento-fetal unit and the mother, in terms of calcium metabolism

2014 Royal College of Obstetricians and Gynaecologists

67. Quantitative ? other: Vitamin D concentration in newborn cord blood is correlated with maternal intake of supplemental vitamin D, and lower levels are associated with increased risk of the infant developing eczema

The human fetus is dependent on maternal vitamin D status during gestation. Vitamin D deficiency rates in pregnant women have been reported as being more than 70% in some clinical practices. 1 Our understanding of prenatal vitamin D's role in modulating immune function and the risk of developing allergic disorders is still in its infancy. Jones and colleagues recently examined whether vitamin D3 levels in cord blood were associated … Request Permissions If you wish to reuse any or all of this article (...) Quantitative ? other: Vitamin D concentration in newborn cord blood is correlated with maternal intake of supplemental vitamin D, and lower levels are associated with increased risk of the infant developing eczema Vitamin D concentration in newborn cord blood is correlated with maternal intake of supplemental vitamin D, and lower levels are associated with increased risk of the infant developing eczema | Evidence-Based Nursing We use cookies to improve our service and to tailor our content

2013 Evidence-Based Nursing

68. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. (PubMed)

trials; systematic review of registered but unpublished trials.Data sources Medline, Embase, PubMed, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials from inception to September 2017; manual searches of reference lists of systematic reviews identified in the electronic search; and online trial registries for unpublished, ongoing, or planned trials.Eligibility criteria for study selection Trials of prenatal vitamin D supplementation with randomised allocation (...) increased mean birth weight of 58.33 g (95% confidence interval 18.88 g to 97.78 g; 37 comparisons) and reduced the risk of small for gestational age births (risk ratio 0.60, 95% confidence interval 0.40 to 0.90; seven comparisons), but findings were not robust in sensitivity and subgroup analyses. There was no effect on preterm birth (1.0, 0.77 to 1.30; 15 comparisons). There was strong evidence that prenatal vitamin D reduced the risk of offspring wheeze by age 3 years (0.81, 0.67 to 0.98; two

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2017 BMJ

69. Cord blood vitamin D status is associated with cord blood insulin and c-peptide in two cohorts of mother-newborn pairs. (PubMed)

Cord blood vitamin D status is associated with cord blood insulin and c-peptide in two cohorts of mother-newborn pairs. Vitamin D may be important for prenatal programming of insulin and glucose regulation, but maternal vitamin D deficiency during pregnancy is common.We examined associations of early vitamin D status with markers of fetal insulin secretion (cord blood insulin and c-peptide). We hypothesized that maternal 25-hydroxyvitamin D (25(OH)D) during pregnancy and cord blood 25(OH)D

2019 Journal of Clinical Endocrinology and Metabolism

70. The Role of the 17q21 Genotype in the Prevention of Early Childhood Asthma and Recurrent Wheeze by Vitamin D. (PubMed)

The Role of the 17q21 Genotype in the Prevention of Early Childhood Asthma and Recurrent Wheeze by Vitamin D. Evidence suggests vitamin D has preventive potential for asthma, however, not all children benefit from this intervention. This study aims to investigate whether variation in the functional 17q21 SNP; rs12936231 affects the preventive potential of vitamin D against asthma.A combined secondary analysis of two randomised-controlled trials of prenatal vitamin D supplementation (...) , vitamin D and genotype (p-interactionvitaminD*genotype*age1:sphingosine-1-phosphate=0.035). In a cellular model, there was a significant difference in the induction of sphingosine-1-phosphate by vitamin D between a control Human bronchial epithelial cell-line and a cell-line overexpressing ORMDL3 (p=0.002).Results suggest prenatal vitamin D supplementation may reduce risk of early childhood asthma/wheeze via alterations of sphingolipid metabolism dependent on 17q21 genotype.clinicaltrials.gov

2019 European Respiratory Journal

71. The effect of an exercise program in pregnancy on vitamin D status among healthy, pregnant Norwegian women: a randomized controlled trial. (PubMed)

The effect of an exercise program in pregnancy on vitamin D status among healthy, pregnant Norwegian women: a randomized controlled trial. Vitamin D insufficiency is common in pregnant women worldwide. Regular prenatal exercise is considered beneficial for maternal and fetal health. There is a knowledge gap regarding the impact of prenatal exercise on maternal vitamin D levels. The objective of this study was to investigate whether a prenatal exercise program influenced serum levels of total (...) training and two home based sessions. The controls (n = 426) received standard prenatal care, and exercising was not denied. Training diaries and group training was used to promote compliance and evaluate adherence. Serum levels of 25(OH)D, parathyroid hormone, calcium, phosphate, magnesium and vitamin D-binding protein were measured before (18-22 weeks' gestation) and after the intervention (32-36 weeks' gestation). Free and bioavailable 25(OH)D concentrations were calculated. Regression analysis

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2019 BMC Pregnancy and Childbirth Controlled trial quality: predicted high

72. Association of High-Dose Vitamin D Supplementation During Pregnancy With the Risk of Enamel Defects in Offspring: A 6-Year Follow-up of a Randomized Clinical Trial. (PubMed)

-dose vitamin D supplementation during pregnancy was associated with approximately 50% reduced odds of enamel defects in the offspring. This suggests prenatal vitamin D supplementation as a preventive intervention for enamel defects, with a clinically important association with dental health.ClinicalTrials.gov identifier: NCT00856947. (...) Association of High-Dose Vitamin D Supplementation During Pregnancy With the Risk of Enamel Defects in Offspring: A 6-Year Follow-up of a Randomized Clinical Trial. Enamel defects of developmental origin affect up to 38% of schoolchildren and is recognized as a global public health challenge. The impaired enamel formation results in pain owing to hypersensitivity, posteruptive breakdowns, rapid caries progression, and extractions in some cases. The etiology is unknown; therefore, prevention

2019 JAMA pediatrics Controlled trial quality: predicted high

73. Prophylactic Vitamin K Administration in Neonates on Prolonged Antibiotic Therapy: A Randomized Controlled Trial. (PubMed)

of antibiotic therapy (except the birth dose), cholestasis or prenatally diagnosed bleeding disorder were excluded.Randomized to receive 1 mg vitamin K (n=41) or no vitamin K (n=39) on the 7th day of antibiotic therapy.Vitamin K deficiency defined as Protein Induced by Vitamin K Absence (PIVKA-II) >2 ng/mL after 7 ± 2 days of enrolment.The prevalence of vitamin K deficiency was 100% (n=80) at enrolment and it remained 100% even after 7 ± 2 days of enrolment in both the groups.Neonates receiving prolonged (...) Prophylactic Vitamin K Administration in Neonates on Prolonged Antibiotic Therapy: A Randomized Controlled Trial. To compare the prevalence of vitamin K deficiency after intramuscular vitamin K or no treatment in neonates with sepsis on prolonged (>7 days) antibiotic therapy.Open label randomized controlled trial.Level 3 Neonatal Intensive Care Unit (NICU).Neonates with first episode of sepsis on antibiotics for ≥7 days were included. Neonates with clinical bleeding, vitamin K prior to start

2019 Indian pediatrics Controlled trial quality: uncertain

74. Calcium and vitamin D supplementation and/or periodontal therapy in the treatment of periodontitis among Brazilian pregnant women: protocol of a feasibility randomised controlled trial (the IMPROVE trial). (PubMed)

, adherence and attrition rate will be evaluated. Data on serum levels of vitamin D, calcium and inflammatory biomarkers; clinical periodontal measurements; anthropometric measurements; and socio-demographic questionnaires are collected at baseline, third trimester and 6-8 weeks postpartum. Qualitative data are collected using focus group, for analysis of favourable factors and barriers related to study adherence.Oral health and mineral/vitamin supplementation are much overlooked in the public prenatal (...) Calcium and vitamin D supplementation and/or periodontal therapy in the treatment of periodontitis among Brazilian pregnant women: protocol of a feasibility randomised controlled trial (the IMPROVE trial). Periodontitis is a common oral inflammation, which is a risk factor for adverse pregnancy outcomes. Intakes of vitamin D and calcium are inversely associated with occurrence and progression of periodontitis. This study aims to assess the feasibility of a multi-component intervention

2019 Pilot and feasibility studies Controlled trial quality: uncertain

75. Maternal vitamin D deficiency and the risk of autism spectrum disorders: population-based study (PubMed)

with and without intellectual disability in relation to lifetime diagnoses of maternal vitamin D deficiency. Although rare, such deficiency was associated with offspring risk of ASD with, but not without, intellectual disability (aORs 2.51, 95% CI 1.22-5.16 and 1.28, 0.68-2.42). Relationships were stronger in non-immigrant children.If reflecting associations for prenatal hypovitaminosis, these findings imply gestational vitamin D substitution as a means of ASD prevention.None.© The Royal College (...) Maternal vitamin D deficiency and the risk of autism spectrum disorders: population-based study Maternal vitamin D deficiency may increase risk of autism spectrum disorder (ASD), but direct evidence is lacking.To clarify the relationship between maternal vitamin D deficiency and offspring risk of ASD with and without intellectual disability.Using a register-based total population study (N=509 639), we calculated adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of ASD

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2016 BJPsych open

76. Prenatal vitamin D status and risk of psychotic experiences at age 18years-a longitudinal birth cohort. (PubMed)

Prenatal vitamin D status and risk of psychotic experiences at age 18years-a longitudinal birth cohort. Low early life vitamin D status is associated with an increased risk of schizophrenia and psychotic experiences. Here we examine if maternal pregnancy vitamin D concentrations are associated with offspring psychotic experiences as young adults.A community sample of 2047 participants was investigated. Maternal prenatal 25 hydroxyvitamin D (25(OH)D) concentrations were assessed with tandem mass (...) subjects met criteria for a psychotic disorder at age 18. Based on this sample, there was no significant association between maternal 25(OH)D and psychotic disorder at 18years.Maternal vitamin D levels were not associated with risk of psychotic experiences nor psychotic disorders in this birth cohort.Copyright © 2013 Elsevier B.V. All rights reserved.

2013 Schizophrenia Research

77. The impact of prenatal vitamin A and zinc supplementation on birth size and neonatal survival - a double-blind, randomized controlled trial in a rural area of Indonesia. (PubMed)

The impact of prenatal vitamin A and zinc supplementation on birth size and neonatal survival - a double-blind, randomized controlled trial in a rural area of Indonesia. Prenatal supplementation with micronutrients may increase birth weight and thus improve infant health and survival in settings where infants and children are at risk of micronutrient deficiencies.To assess whether vitamin A and/or zinc supplementation given during pregnancy can improve birth weight, birth length, neonatal (...) morbidity, or infant mortality.A double-blind, randomized controlled trial supplementing women (n = 2173) in Central Java, Indonesia throughout pregnancy with vitamin A, zinc, combined vitamin A+zinc, or placebo.Out of 2173 supplemented pregnant women, 1956 neonates could be evaluated. Overall, zinc supplementation improved birth length compared to placebo or combined vitamin A+zinc (48.8 vs. 48.5 cm, p = 0.04); vitamin A supplementation improved birth length compared to placebo or combined vitamin

2013 International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition Controlled trial quality: predicted high

78. Randomized placebo-controlled trial of high-dose prenatal third-trimester vitamin D3 supplementation in Bangladesh: the AViDD trial. (PubMed)

Randomized placebo-controlled trial of high-dose prenatal third-trimester vitamin D3 supplementation in Bangladesh: the AViDD trial. Antenatal vitamin D status may be associated with the risk of adverse pregnancy and neonatal outcomes; however, the benefits of vitamin D supplementation during pregnancy remain unknown.We conducted a double-blind placebo-controlled randomized trial to evaluate the effect of high-dose prenatal 3rd trimester vitamin D3 supplementation on maternal and neonatal (cord (...) blood) serum 25-hydroxyvitamin D (25(OH)D) concentration (primary biochemical efficacy outcome) and maternal serum calcium concentration (primary safety measure). Eligibility criteria were pregnant women aged 18 to <35 years, at 26 to 29 weeks gestation, and residing in Dhaka, Bangladesh. 160 women were randomized by 1:1 allocation to one of two parallel intervention groups; placebo (n = 80) or 35,000 IU/week of vitamin D3 (n = 80) until delivery. All participants, study personnel and study

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2013 Nutrition journal Controlled trial quality: predicted high

79. Prenatal vitamin d supplementation and child respiratory health: a randomised controlled trial. (PubMed)

Prenatal vitamin d supplementation and child respiratory health: a randomised controlled trial. Observational studies suggest high prenatal vitamin D intake may be associated with reduced childhood wheezing. We examined the effect of prenatal vitamin D on childhood wheezing in an interventional study.We randomised 180 pregnant women at 27 weeks gestation to either no vitamin D, 800 IU ergocalciferol daily until delivery or single oral bolus of 200,000 IU cholecalciferol, in an ethnically (...) stratified, randomised controlled trial. Supplementation improved but did not optimise vitamin D status. Researchers blind to allocation assessed offspring at 3 years. Primary outcome was any history of wheeze assessed by validated questionnaire. Secondary outcomes included atopy, respiratory infection, impulse oscillometry and exhaled nitric oxide. Primary analyses used logistic and linear regression.We evaluated 158 of 180 (88%) offspring at age 3 years for the primary outcome. Atopy was assessed

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2013 PloS one Controlled trial quality: predicted high

80. Prenatal exposure to maternal bereavement and offspring psoriasis: a Danish nationwide cohort study. (PubMed)

Prenatal exposure to maternal bereavement and offspring psoriasis: a Danish nationwide cohort study. Prenatal stress may alter immune competence of the fetus. Limited data exist on the role of antenatal stress in psoriasis development.To investigate whether prenatal exposure to maternal bereavement increases the risk of offspring psoriasis.This register-based cohort study included 1 811 917 live singletons born from 1978 to 2008 in Denmark. The children were assigned to the bereaved group (...) if their mothers lost a child, partner/spouse, parent or sibling during pregnancy or up to 12 months before pregnancy. Follow-up started at the date of birth and ended at the date of first hospital treatment for psoriasis or a prescription redeemed for topical vitamin D derivatives (often used to treat psoriasis), emigration, death or 31 December 2010, whichever came first. We evaluated the hazard ratio (HR) of psoriasis in bereaved children using Cox proportional hazards regressions, compared

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2016 British Journal of Dermatology

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