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Prenatal Vitamin

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41. Maternal vitamin D and neonatal anthropometrics and markers of neonatal glycaemia: Belfast HAPO study Full Text available with Trip Pro

Maternal vitamin D and neonatal anthropometrics and markers of neonatal glycaemia: Belfast HAPO study Vitamin D deficiency is a common occurrence globally, and particularly so in pregnancy. There is conflicting evidence regarding the role of vitamin D during pregnancy in non-skeletal health outcomes for both the mother and the neonate. The aim of this study was to investigate the associations of maternal total 25-hydroxy vitamin D (25OHD) with neonatal anthropometrics and markers of neonatal (...) glycaemia in the Belfast centre of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study. Serological samples (n 1585) were obtained from pregnant women in the Royal Jubilee Maternity Hospital, Belfast, Northern Ireland, between 24 and 32 weeks' gestation as part of the HAPO study. 25OHD concentrations were measured by liquid chromatography tandem-MS. Cord blood and neonatal anthropometric measurements were obtained within 72 h of birth. Statistical analysis was performed. After adjustment

2018 The British journal of nutrition

42. Vitamin D deficiency associated with dilated cardiomyopathy in early infancy caused by maternal cholestasis Full Text available with Trip Pro

Vitamin D deficiency associated with dilated cardiomyopathy in early infancy caused by maternal cholestasis Breast feeding is known to be a major cause of vitamin D deficiency in infants because the content of vitamin D in breast milk is significantly lower than that in formula. We report a case of a 1-mo-old boy who developed hypocalcemic seizures and dilated cardiomyopathy caused by vitamin D deficiency despite being fed a sufficient amount of regular formula. The cause of vitamin D (...) deficiency in this case was maternal vitamin deficiency due to severe hyperemesis and insufficient sunlight exposure, induced mainly by the malabsorption of fat-soluble vitamins caused by maternal cholestasis. We should carefully consider maternal conditions during pregnancy and the postpartum period to detect and prevent vitamin D deficiency in the fetus and infant.

2018 Clinical Pediatric Endocrinology

43. Heavy metal contamination of prenatal vitamins Full Text available with Trip Pro

Heavy metal contamination of prenatal vitamins Prenatal vitamins are often consumed daily during gestation and postnatally for up to 18-24 months with the belief that supplementation achieves better outcomes. Detrimental effects of gestational exposure to adverse chemical agents are gathering increasing attention. This study was designed to assess toxic element contamination in prenatal supplements. Twenty-six commonly used prenatal vitamin brands including one prescription brand were collected (...) and Thallium were detected in all samples. Cumulative intake of prenatal supplement over many months may constitute a significant source of toxic element exposure to the mother and offspring. With several samples exceeding known standards for gestational toxic element exposure, guidelines for routine monitoring and reporting are required. In keeping with recommendations from the International Federation of Obstetrics and Gynecology, industry regulation would be welcomed to protect expectant mothers

2018 Toxicology reports

44. A Genome-Wide Search for Gene-Environment Effects in Isolated Cleft Lip with or without Cleft Palate Triads Points to an Interaction between Maternal Periconceptional Vitamin Use and Variants in ESRRG Full Text available with Trip Pro

A Genome-Wide Search for Gene-Environment Effects in Isolated Cleft Lip with or without Cleft Palate Triads Points to an Interaction between Maternal Periconceptional Vitamin Use and Variants in ESRRG Background: It is widely accepted that cleft lip with or without cleft palate (CL/P) results from the complex interplay between multiple genetic and environmental factors. However, a robust investigation of these gene-environment (GxE) interactions at a genome-wide level is still lacking (...) for isolated CL/P. Materials and Methods: We used our R-package Haplin to perform a genome-wide search for GxE effects in isolated CL/P. From a previously published GWAS, genotypes and information on maternal periconceptional cigarette smoking, alcohol intake, and vitamin use were available on 1908 isolated CL/P triads of predominantly European or Asian ancestry. A GxE effect is present if the relative risk estimates for gene-effects in the offspring are different across exposure strata. We tested

2018 Frontiers in genetics

45. Vitamin D Enhances Alveolar Development in Antenatal Lipopolysaccharide-Treated Rats through the Suppression of Interferon-γ Production Full Text available with Trip Pro

Vitamin D Enhances Alveolar Development in Antenatal Lipopolysaccharide-Treated Rats through the Suppression of Interferon-γ Production Bronchopulmonary dysplasia (BPD) is characterized by the premature arrest of alveolar development. Antenatal exposure to inflammation inhibits lung morphogenesis, thereby increasing the risk for the development of BPD. Here, we investigated whether vitamin D (VitD) enhances alveolar development in antenatal lipopolysaccharide (LPS)-treated rats, which (...) chromatography tandem mass spectrometry in maternal serum samples collected from 86 pregnant women in a prospective birth cohort enrolled from 2012 to 2013. Our results showed that VitD effectively alleviated the simplification of the lung alveolar structure in BPD rats and suppressed LPS-induced IFN-γ expression in the lung and spleen tissues. Further investigation revealed that VitD suppressed IFN-γ production in CD8+ T cells. Specifically, VitD increased the methylation percentage of the VDRE in the IFN-γ

2018 Frontiers in immunology

46. The effect of maternal vitamin D deficiency during pregnancy on body fat and adipogenesis in rat offspring Full Text available with Trip Pro

The effect of maternal vitamin D deficiency during pregnancy on body fat and adipogenesis in rat offspring To evaluate the effects of maternal vitamin D deficiency on body fat and adipogenesis in offspring rats, and explore the potential mechanism, we constructed a vitamin D deficient rat model and performed metabolic activity evaluation, body fat monitoring, biochemical analysis, adipogenesis assay, methylation microarray and RNA-seq for their offspring rats. We found the weight of vitamin D (...) that compared to CTL group, 608 promoters and 204 CpG islands were differentially methylated in the VDD group, involving 305 genes. When combined with the results of RNA-seq, 141 genes of the methylated genes were differentially expressed. In conclusion, vitamin D deficiency during pregnancy may promote the proliferation and differentiation of pre-adipocytes, which may be associated with methylation alterations of genes, ultimately leading to offspring obesity.

2018 Scientific reports

47. Maternal Vitamin D Supplementation during Pregnancy Full Text available with Trip Pro

Maternal Vitamin D Supplementation during Pregnancy Maternal vitamin D status in pregnancy has been linked to many health outcomes in mother and offspring. A wealth of observational studies have reported on both obstetric outcomes and complications, including pre-eclampsia, gestational diabetes, mode and timing of delivery. Many foetal and childhood outcomes are also linked to vitamin D status, including measures of foetal size, body composition and skeletal mineralization, in addition to later (...) childhood outcomes, such as asthma.Synthesis of systematic and narrative reviews.The findings are generally inconsistent in most areas, and, at present, there is a lack of data from high-quality intervention studies to confirm a causal role for vitamin D in these outcomes. In most areas, the evidence tends towards maternal vitamin D being of overall benefit, but often does not reach statistical significance in meta-analyses.The most conclusive evidence is in the role of maternal vitamin D

2018 British medical bulletin

48. Maternal and early-life vitamin D deficiency enhances allergic reaction in an ovalbumin-sensitized BALB/c mouse model Full Text available with Trip Pro

Maternal and early-life vitamin D deficiency enhances allergic reaction in an ovalbumin-sensitized BALB/c mouse model Recent studies have shown that vitamin D deficiency may contribute to the high prevalence of food allergy but the underlying mechanisms are far from clear.The present study was designed to investigate the effect of maternal and early-life vitamin D deficiency in the development of food allergy.BALB/c mice were treated with ovalbumin (OVA) to trigger allergic reactions, under (...) vitamin D-deficient (by maternal and early-life feeding of vitamin D deprived chow diet) or vitamin D-sufficient conditions.Increased occurrence and severity of allergic diarrhea as well as decreased rectal temperature were observed after OVA sensitization. For vitamin D deficiency groups, OVA-specific IgE and IL-4 levels were significantly increased, while IFN-γ levels were unchanged. Vitamin D deficiency also attenuated the structure of small intestinal villi and decreased the expression

2018 Food & nutrition research

49. Ethnic differences in the association between maternal vitamin D status and offspring asthma and wheeze: Findings from the Born in Bradford cohort study. Full Text available with Trip Pro

Ethnic differences in the association between maternal vitamin D status and offspring asthma and wheeze: Findings from the Born in Bradford cohort study. 29572850 2018 06 25 1398-9995 73 7 2018 Jul Allergy Allergy Ethnic differences in the association between maternal vitamin D status and offspring asthma and wheeze: Findings from the Born in Bradford cohort study. 1544-1546 10.1111/all.13447 Santorelli G G http://orcid.org/0000-0003-0427-1783 Bradford Institute for Health Research, Bradford

2018 Allergy

50. Antenatal vitamin D exposure and childhood eczema, food allergy, asthma and allergic rhinitis at 2 and 5 years of age in the atopic disease-specific Cork BASELINE Birth Cohort Study. (Abstract)

Antenatal vitamin D exposure and childhood eczema, food allergy, asthma and allergic rhinitis at 2 and 5 years of age in the atopic disease-specific Cork BASELINE Birth Cohort Study. Prospective studies of antenatal and infant vitamin D exposure and atopic disease from extensively characterised, disease-specific, maternal-infant cohorts with gold standard analysis of vitamin D status and clinically validated atopic outcomes are lacking. This study aimed to investigate associations between (...) with and without atopic disease. Neither maternal (aOR [95% CI]: 1.02 [0.97, 1.08], P = 0.450) nor cord 25(OH)D (aOR [95% CI]: 1.00 [0.91, 1.09], P = 0.991) were significant predictors of atopic disease outcomes in fully adjusted models.These data in a disease-specific cohort with prospectively collected, validated atopic outcomes do not support an association between antenatal exposure to vitamin D and atopic disease outcomes in childhood.© 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley

2018 Allergy

51. Maternal and infant vitamin B12 status during infancy predict linear growth at 5 years. (Abstract)

Maternal and infant vitamin B12 status during infancy predict linear growth at 5 years. Many children worldwide have poor vitamin B12 status. The objective of this study was to estimate association between maternal and infant vitamin B12 status and long-term growth.We randomly selected 500 Nepali mother-infant pairs and measured maternal intake and infant and maternal vitamin B12 status using plasma cobalamin, total plasma homocysteine, and methylmalonic acid concentrations. We revisited (...) available children when they were 5 years old and measured growth. The associations between intake and maternal and infant markers of vitamin B12 and growth were estimated in multiple linear regression models adjusting for relevant confounders (n = 331).Maternal vitamin B12 intake and status and vitamin B12 status in infancy predicted linear growth at 5 years of age, but not during infancy. Each microgram increase in the vitamin B12 intake of the mother during infancy was associated with an increase

2018 Pediatric Research

52. Effectiveness of prenatal vitamin D deficiency screening and treatment program: a stratified randomized field trial. Full Text available with Trip Pro

Effectiveness of prenatal vitamin D deficiency screening and treatment program: a stratified randomized field trial. Despite evidence on the association between hypovitaminosis D and adverse pregnancy outcomes and the positive impact of vitamin D supplementation, no evidence exists supporting a universal screening program in pregnancy as part of routine prenatal care.We sought to determine the effectiveness of a prenatal screening program on optimizing 25-hydroxyvitamin D [25(OH)D] levels (...) %, and 40%, respectively, in the screening site. A D3 injection in addition to monthly 50,000 IU maintenance therapy contributed the most to achievement of sufficient levels at delivery.A prenatal vitamin D screening and treatment program is an effective approach in detecting deficient women, improving 25(OH)D levels, and decreasing pregnancy adverse outcomes.

2018 Journal of Clinical Endocrinology and Metabolism Controlled trial quality: uncertain

53. Infant Serum and Maternal Milk Vitamin B-12 Are Positively Correlated in Kenyan Infant-Mother Dyads at 1-6 Months Postpartum, Irrespective of Infant Feeding Practice. Full Text available with Trip Pro

Infant Serum and Maternal Milk Vitamin B-12 Are Positively Correlated in Kenyan Infant-Mother Dyads at 1-6 Months Postpartum, Irrespective of Infant Feeding Practice. Vitamin B-12 is an essential nutrient required for many functions including DNA synthesis, erythropoiesis, and brain development. If maternal milk vitamin B-12 concentrations are low, infants may face elevated risks of deficiency when exclusively breastfed.We evaluated cross-sectional associations between infant serum vitamin B-12 (...) concentrations and maternal milk vitamin B-12 concentrations at 1-6 mo postpartum among an unsupplemented population in rural western Kenya, and assessed biological demographic, and dietary characteristics associated with adequate infant serum vitamin B-12.We modeled 1) infant serum vitamin B-12 using maternal milk vitamin B-12 concentration with linear regression; and 2) adequate (>220 pmol/L) infant serum vitamin B-12 using hypothesized biological, demographic, and dietary predictors with logistic

2018 Journal of Nutrition Controlled trial quality: uncertain

54. Effect of Maternal Smoking on Plasma and Urinary Measures of Vitamin E Isoforms in the First Month after Extreme Preterm Birth. Full Text available with Trip Pro

Effect of Maternal Smoking on Plasma and Urinary Measures of Vitamin E Isoforms in the First Month after Extreme Preterm Birth. We examined the effect of maternal smoking on plasma and urinary levels of vitamin E isoforms in preterm infants. Maternal smoking during pregnancy decreased infant plasma alpha- and gamma-tocopherol concentrations at 1 week and 4 weeks, with 45% of infants of smokers deficient in alpha-tocopherol at 1 month after birth.Copyright © 2017 Elsevier Inc. All rights

2018 Journal of Pediatrics

55. Correlation Between Maternal Vitamin D Level And Preterm Birth

Correlation Between Maternal Vitamin D Level And Preterm Birth Correlation Between Maternal Vitamin D Level And Preterm Birth - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Correlation Between Maternal (...) Vitamin D Level And Preterm Birth The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03638037 Recruitment Status : Recruiting First Posted : August 20, 2018 Last Update Posted : October 9, 2018 See Sponsor: Ain Shams Maternity

2018 Clinical Trials

56. Associations between maternal vitamin D levels during pregnancy and allergic outcomes in the offspring in the first 5 years of life. Full Text available with Trip Pro

Pediatr Allergy Immunol 9106718 0905-6157 1406-16-2 Vitamin D IM Adult Child, Preschool Cohort Studies Female Humans Hypersensitivity epidemiology etiology Infant Male Pregnancy Prenatal Exposure Delayed Effects Prospective Studies Risk Factors Singapore Skin Tests Vitamin D blood Vitamin D Deficiency complications epidemiology allergic outcomes eczema family history of allergy maternal vitamin D 2019 08 01 2018 10 20 6 0 2019 3 20 6 0 2018 10 20 6 0 ppublish 30338862 10.1111/pai.12995 PMC6358006 (...) Associations between maternal vitamin D levels during pregnancy and allergic outcomes in the offspring in the first 5 years of life. 30338862 2019 03 19 2019 03 19 1399-3038 30 1 2019 02 Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Pediatr Allergy Immunol Associations between maternal vitamin D levels during pregnancy and allergic outcomes in the offspring in the first 5 years of life. 117-122 10.1111/pai.12995 Loo Evelyn

2018 Pediatric Allergy and Immunology

57. Association between maternal mid-gestation vitamin D status and neonatal abdominal adiposity. Full Text available with Trip Pro

Association between maternal mid-gestation vitamin D status and neonatal abdominal adiposity. Lower vitamin D status has been associated with adiposity in children through adults. However, the evidence of the impact of maternal vitamin-D status during pregnancy on offspring's adiposity is mixed. The objective of this study was to examine the associations between maternal vitamin-D [25(OH)D] status at mid-gestation and neonatal abdominal adipose tissue (AAT) compartments, particularly the deep (...) subcutaneous adipose tissue linked with metabolic risk.Participants (N = 292) were Asian mother-neonate pairs from the mother-offspring cohort, Growing Up in Singapore Towards healthy Outcomes. Neonates born at ≥34 weeks gestation with birth weight ≥2000 g had magnetic resonance imaging (MRI) within 2-weeks post-delivery. Maternal plasma glucose using an oral glucose tolerance test and 25(OH)D concentrations were measured. 25(OH)D status was categorized into inadequate (≤75.0 nmol/L) and sufficient (>75.0

2018 International Journal of Obesity

58. Maternal Diets Deficient in Vitamin D Increase the Risk of Kyphosis in Offspring: A Novel Kyphotic Porcine Model. Full Text available with Trip Pro

Maternal Diets Deficient in Vitamin D Increase the Risk of Kyphosis in Offspring: A Novel Kyphotic Porcine Model. The purpose of this study was to explore the role of perinatal vitamin-D intake on the development and characterization of hyperkyphosis in a porcine model.The spines of 16 pigs were assessed at 9, 13, and 17 weeks of age with radiography and at 17 weeks with computed tomography (CT), magnetic resonance imaging (MRI), histology, and bone-density testing. An additional 169 pigs (...) exposed to 1 of 3 maternal dietary vitamin-D levels from conception through the entire lactation period were fed 1 of 4 nursery diets supplying different levels of vitamin D, calcium, and phosphorus. When the animals were 13 weeks of age, upright lateral spinal radiography was performed with use of a custom porcine lift and sagittal Cobb angles were measured in triplicate to determine the degree of kyphosis in each pig.The experimental animals had significantly greater kyphotic sagittal Cobb angles

2018 The Journal of Bone and Joint Surgery. American Volume

59. Vitamin E status and associations in maternal-infant Dyads in the Midwestern United States. (Abstract)

Vitamin E status and associations in maternal-infant Dyads in the Midwestern United States. Oxidative stress has been associated with adverse neonatal outcomes, and vitamin E has powerful anti-oxidant properties. Vitamin E occurs in several different isoforms which differ in their ability to modulate inflammation and oxidative stress. Therefore, the purpose of this study was to evaluate the status of α-, γ- and δ-tocopherol in maternal-infant pairs, and the impact on maternal-newborn (...) of γ- and δ-tocopherols is higher than α-tocopherol and may be mediated by either different or more efficient methods, conversely tissue uptake of α-tocopherol by the developing fetus may be higher. As serum levels of maternal tocopherols are positively associated with outcomes while higher cord levels show a negative impact, uptake and tissue deposition of vitamin E by the fetus may be crucial in growth and development. More research into the role of maternal diet, placental regulation, and fetal

2018 Clinical nutrition (Edinburgh, Scotland)

60. Comparison of the effect of daily versus bolus dose maternal vitamin D<sub>3</sub> supplementation on the 24,25-dihydroxyvitamin D<sub>3</sub> to 25-hydroxyvitamin D<sub>3</sub> ratio. Full Text available with Trip Pro

Comparison of the effect of daily versus bolus dose maternal vitamin D3 supplementation on the 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 ratio. Supplementing lactating mothers with high doses of vitamin D3 can adequately meet vitamin D requirements of the breastfed infant. We compared the effect of bolus versus daily vitamin D3 dosing in lactating mothers on vitamin D3 catabolism. We hypothesized that catabolism of 25(OH)D3 to 24,25(OH)2D3 would (...) be greater in the bolus than in the daily dose group.Randomized controlled trial (clinicaltrials.govNCT01240265) in 40 lactating women.Subjects were randomized to receive vitamin D3 orally, either a single dose of 150,000IU or 5000IU daily for 28days. Vitamin D metabolites were measured in serum and breast milk at baseline, 1, 3, 7, 14 and 28days.Temporal changes in the serum 24,25(OH)2D3/25(OH)D3 ratio.The concentration of serum 24,25(OH)2D3 was directly related to that of 25(OH)D in both groups (r2

2018 Bone Controlled trial quality: uncertain

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