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Prenatal Vitamin

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21. Hollis BW, Wagner CL, Howard CR, et al. Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial. Full Text available with Trip Pro

Hollis BW, Wagner CL, Howard CR, et al. Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial. 31253738 2019 07 23 1098-4275 144 1 2019 Jul Pediatrics Pediatrics Hollis BW, Wagner CL, Howard CR, et al. Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial. Pediatrics. 2015;136(4):625-634. e20191063 10.1542/peds.2019-1063 eng Journal Article Published Erratum United States Pediatrics 0376422 0031-4005

2019 Pediatrics Controlled trial quality: predicted high

22. Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers, and maternal and neonatal outcomes. Full Text available with Trip Pro

Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers, and maternal and neonatal outcomes. Hypovitaminosis D during pregnancy is suggested to have a link with complications in both mother and infant. We aimed to evaluate the efficacy of two doses of vitamin D3 supplementation during pregnancy on maternal and cord blood vitamin D status, inflammatory biomarkers and maternal and neonatal outcomes. A total of 84 pregnant women (gestational age of <12 weeks (...) ) were randomly allocated to one of two groups: (a) 1000 IU/d vitamin D, (b) 2000 IU/d. Biochemical assessments (25-hydroxycalciferol (25(OH)D), hs-CRP and cell-culture supernatant concentrations of IL-1β, IL-6 and TNF-α) of mothers were performed at the beginning and 34 weeks of gestation. Assessments of infants at delivery comprised cord blood serum concentrations of 25(OH)D, hs-CRP, IL-1β, IL-6, TNF-α, birth sizes and Apgar score. Circulating concentrations of 25(OH)D increased in both

2019 Maternal & child nutrition Controlled trial quality: uncertain

23. Maternal plasma vitamin D levels and associated determinants in late pregnancy in Harare, Zimbabwe: a cross-sectional study. Full Text available with Trip Pro

Maternal plasma vitamin D levels and associated determinants in late pregnancy in Harare, Zimbabwe: a cross-sectional study. The importance of vitamin D in bone health and calcium homeostasis has been well documented. However, emerging evidence supports the role of vitamin D beyond its recognised traditional roles. In pregnancy, vitamin D levels are crucial in sustaining both the maternal stores and optimal growth of the foetus. In Southern Africa, there is paucity of data on vitamin D (...) in pregnancy and related outcomes. To expand this body of knowledge, we assessed vitamin D levels in late pregnancy and (if any) associated maternal determinants in Harare, Zimbabwe.Study participants comprised of 138 pregnant Zimbabwean women in their third trimester. These were stratified by HIV status; sampling median (IQR) gestation for HIV negative study participants was 34 weeks (26-41) and 31 weeks (20-40) in the HIV positive participants. Maternal plasma 25 hydroxyvitamin (OH) Dlevels were measured

2019 BMC Pregnancy and Childbirth

24. Prenatal vitamin D and cord blood insulin-like growth factors in Dhaka, Bangladesh. Full Text available with Trip Pro

Prenatal vitamin D and cord blood insulin-like growth factors in Dhaka, Bangladesh. Fetal growth restriction is linked to adverse health outcomes and is prevalent in low- and middle-income countries; however, determinants of fetal growth are still poorly understood. The objectives were to determine the effect of prenatal vitamin D supplementation on the insulin-like growth factor (IGF) axis at birth, to compare concentrations of IGF-I in newborns in Bangladesh to a European reference population (...) was negatively associated with birth anthropometry. In conclusion, prenatal vitamin D supplementation does not alter or enhance fetal IGF pathways.

2019 Endocrine connections Controlled trial quality: uncertain

25. Factors Associated with Increased Alpha-Tocopherol Content in Milk in Response to Maternal Supplementation with 800 IU of Vitamin E. Full Text available with Trip Pro

Factors Associated with Increased Alpha-Tocopherol Content in Milk in Response to Maternal Supplementation with 800 IU of Vitamin E. Vitamin E supplementation might represent an efficient strategy to increase the vitamin E content in milk. The present study aimed to evaluate the impact of supplementation with 800 IU RRR-alpha-tocopherol on the alpha-tocopherol content of milk and the factors associated with the increase in vitamin E.Randomized clinical trial with 79 lactating women from Brazil (...) ) was associated with the level of this vitamin in milk after supplementation (β = 0.927, p < 0.001), and binary logistic regression showed that the dietary intake was the only determinant for the greater effect of supplementation in milk.The pre-existing vitamin level in milk and diet are determinants for the efficacy of supplementation in milk, suggesting that in populations with vitamin E deficiency, high-dose supplementation can be used to restore its level in milk.

2019 Nutrients Controlled trial quality: uncertain

26. Natural sunlight plus vitamin D supplementation ameliorate delayed early motor development in newborn infants from maternal perinatal depression. Full Text available with Trip Pro

Natural sunlight plus vitamin D supplementation ameliorate delayed early motor development in newborn infants from maternal perinatal depression. Increased cortisol has been shown to be negatively correlated with infant motor development. Sunlight help decrease the level of cortisol. Vitamin D is associated with infant motor development. The present study aimed to determine whether natural sunlight exposure plus vitamin D supplements could ameliorate delayed early motor development in little (...) infants from maternal perinatal depression.The term pregnant women waiting for delivery from the department of gynecology and obstetrics were assessed depressive symptoms by Hamilton Rating Scale for Depression (HAMD). 120 normal and 229 depressed subjects were recruited. During 2 days postpartum, infant motor development were assessed by Neonatal Behavioral Assessment Scale (NBAS). Infants of 2-day-old in maternal depression group were divided into four groups: control group, conventional vitamin D

2019 Journal of Affective Disorders Controlled trial quality: uncertain

27. Response to Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". Full Text available with Trip Pro

Response to Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". 30202978 2018 12 19 1945-7197 104 2 2019 Feb 01 The Journal of clinical endocrinology and metabolism J. Clin. Endocrinol. Metab. Response to Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". 339-340 10.1210/jc.2018-01799 Ramezani Tehrani Fahimeh F

2019 The Journal of clinical endocrinology and metabolism Controlled trial quality: uncertain

28. Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". Full Text available with Trip Pro

Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". 30202903 2018 12 19 1945-7197 104 2 2019 Feb 01 The Journal of clinical endocrinology and metabolism J. Clin. Endocrinol. Metab. Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". 337-338 10.1210/jc.2018-01731 Shub Alexis A Department of Obstetrics and Gynecology

2019 The Journal of clinical endocrinology and metabolism Controlled trial quality: uncertain

29. Association of Maternal Vitamin D Deficiency with Early Childhood Caries. (Abstract)

Association of Maternal Vitamin D Deficiency with Early Childhood Caries. Alaska Native (AN) children experience one of the highest reported rates of severe early childhood caries (S-ECC). Serum vitamin D concentrations in AN childbearing women in the Yukon Kuskokwim Delta (YKD) region have decreased since the 1960s to currently low levels, related to a decrease in traditional marine diet. Recent studies suggest an association between prenatal vitamin D (25(OH)D) concentrations in mothers and S (...) had "sufficient" versus "insufficient" 25(OH)D during prenatal visits (9.0 vs. 7.4; P = 0.48). In this small sample, children with deficient vitamin D levels in cord blood had a dmft score at 12 to 35 mo 2-fold higher than children with nondeficient cord blood. Maternal 25(OH)D may influence the primary dentition, and improving vitamin D status in pregnant women might affect ECC rates in their infants.

2019 Journal of Dental Research

30. Use of High Dose Vitamin D and its Association with COVID-19

and rhinosinusitis. Another perspective could be maternal vitamin D supplementation during pregnancy and breastfeeding in order to reduce future RTIs in offspring, though the ideal dose of supplementation is still difficult to define. Studies with vitamin D supplementation revealed conflicting results as to whether supplementation may be of benefit, and at what doses. 6 There was no evidence retrieved to suggest the role of Vitamin D as determinants of risk and severity of COVID-19 infections. However, available (...) Use of High Dose Vitamin D and its Association with COVID-19 Vitamin D is an essential fat-soluble vitamin obtained from the diet or can be produced in the skin. Dietary vitamin D can be obtained through naturally occurring vitamin D2 (ergocalciferol) or D3 (cholecalciferol) in food, dietary supplementation, or food fortification. Vitamin D enters the circulation and is bound to the vitamin D binding protein. It is transported to the liver or other tissues in which it is hydroxylated by one

2020 MaHTAS Covid-19 Rapid Evidence Updates

31. Effect of maternal antenatal and newborn supplementation with vitamin A on cognitive development of school-aged children in rural Bangladesh: a follow-up of a placebo-controlled, randomized trial. Full Text available with Trip Pro

Effect of maternal antenatal and newborn supplementation with vitamin A on cognitive development of school-aged children in rural Bangladesh: a follow-up of a placebo-controlled, randomized trial. Background: The impact of early vitamin A supplementation on neurodevelopmental function has not been adequately studied. In rural Bangladesh we examined cognitive and motor function and scholastic achievement in a cohort of children who were exposed to vitamin A in utero or at birth.Objective (...) , there was no impact of either maternal or newborn supplementation with vitamin A on intelligence, memory, and motor function. Compared with placebo, children who received both interventions had significantly better performance in reading, spelling, and math computation, with increased mean (95% CI) scores of 8.0 (2.2, 13.8), 6.8 (1.9, 11.7), and 4.8 (0.6, 9.0), respectively.Conclusions: General intelligence or memory and motor functions were not affected by antenatal or newborn supplementation with vitamin

2017 American Journal of Clinical Nutrition Controlled trial quality: predicted high

32. Low maternal prenatal 25-hydroxy vitamin D blood levels are associated with childhood atopic dermatitis Full Text available with Trip Pro

Low maternal prenatal 25-hydroxy vitamin D blood levels are associated with childhood atopic dermatitis 28202402 2018 08 22 2018 11 13 1523-1747 137 6 2017 06 The Journal of investigative dermatology J. Invest. Dermatol. Low Maternal Prenatal 25-Hydroxyvitamin D Blood Levels Are Associated with Childhood Atopic Dermatitis. 1380-1384 S0022-202X(17)30174-4 10.1016/j.jid.2017.01.029 Blomberg Maria M Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute (...) 1406-16-2 Vitamin D A288AR3C9H 25-hydroxyvitamin D IM Biomarkers blood Child Child, Preschool Cohort Studies Confidence Intervals Dermatitis, Atopic blood physiopathology Female Fetal Blood metabolism Humans Male Odds Ratio Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Prenatal Care Prognosis Retrospective Studies Risk Assessment Vitamin D administration & dosage analogs & derivatives blood 2016 08 19 2017 01 11 2017 01 24 2017 2 17 6 0 2018 8 23 6 0 2017 2 17 6 0 ppublish

2017 The Journal of investigative dermatology

33. Erratum for Ziaei et al. A prenatal multiple micronutrient supplement produces higher maternal vitamin B-12 concentrations and similar folate, ferritin, and zinc concentrations as the standard 60-mg iron plus 400-μg folic acid supplement in rural Banglad Full Text available with Trip Pro

Erratum for Ziaei et al. A prenatal multiple micronutrient supplement produces higher maternal vitamin B-12 concentrations and similar folate, ferritin, and zinc concentrations as the standard 60-mg iron plus 400-μg folic acid supplement in rural Banglad 28373594 2017 12 14 1541-6100 147 4 2017 04 The Journal of nutrition J. Nutr. Erratum for Ziaei et al. A prenatal multiple micronutrient supplement produces higher maternal vitamin B-12 concentrations and similar folate, ferritin, and zinc

2017 The Journal of nutrition

34. Effect of maternal vitamin D3 supplementation on maternal health, birth outcomes, and infant growth among HIV-infected Tanzanian pregnant women: study protocol for a randomized controlled trial Full Text available with Trip Pro

Effect of maternal vitamin D3 supplementation on maternal health, birth outcomes, and infant growth among HIV-infected Tanzanian pregnant women: study protocol for a randomized controlled trial Vitamin D has significant immunomodulatory effects on both adaptive and innate immune responses. Observational studies indicate that adults infected with HIV with low vitamin D status may be at increased risk of mortality, pulmonary tuberculosis, and HIV disease progression. Growing observational (...) evidence also suggests that low vitamin D status in pregnancy may increase the risk of adverse birth and infant health outcomes. As a result, antiretroviral therapy (ART) adjunct vitamin D3 supplementation may improve the health of HIV-infected pregnant women and their children.The Trial of Vitamins-5 (ToV5) is an individually randomized, double-blind, placebo-controlled trial of maternal vitamin D3 (cholecalciferol) supplementation conducted among 2300 HIV-infected pregnant women receiving triple-drug

2017 Trials Controlled trial quality: predicted high

35. Vitamin D supplementation for women during pregnancy. Full Text available with Trip Pro

Vitamin D supplementation for women during pregnancy. Vitamin D supplementation during pregnancy may be needed to protect against adverse pregnancy outcomes. This is an update of a review that was first published in 2012 and then in 2016.To examine whether vitamin D supplementation alone or in combination with calcium or other vitamins and minerals given to women during pregnancy can safely improve maternal and neonatal outcomes.For this update, we searched Cochrane Pregnancy and Childbirth's (...) of maternal adverse events, vitamin D supplementation may reduce the risk of severe postpartum haemorrhage (RR 0.68, 95% CI 0.51 to 0.91; 1 trial, 1134 women, low-certainty evidence). There were no cases of hypercalcaemia (1 trial, 1134 women, low-certainty evidence), and we are very uncertain as to whether vitamin D increases or decreases the risk of nephritic syndrome (RR 0.17, 95% CI 0.01 to 4.06; 1 trial, 135 women, very low-certainty evidence). However, given the scarcity of data in general

2019 Cochrane Controlled trial quality: predicted high

36. Regimens of vitamin D supplementation for women during pregnancy. (Abstract)

that received no vitamin D, as that comparison is assessed in another Cochrane Review.Two review authors independently: i) assessed the eligibility of studies against the inclusion criteria; ii) extracted data from included studies, and iii) assessed the risk of bias of the included studies. Our primary maternal outcomes were: pre-eclampsia, gestational diabetes, and any adverse effects; our primary infant outcomes were preterm birth and low birthweight. Data were checked for accuracy. The certainty (...) Regimens of vitamin D supplementation for women during pregnancy. Vitamin D deficiency during pregnancy increases the risk of pre-eclampsia, gestational diabetes, preterm birth, and low birthweight. In a previous Cochrane Review we found that supplementing pregnant women with vitamin D alone compared to no vitamin D supplementation may reduce the risk of pre-eclampsia, gestational diabetes, and low birthweight and may increase the risk of preterm births if it is combined with calcium. However

2019 Cochrane

37. Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial. (Abstract)

Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial. Objectives To examine the effects of oral maternal vitamin B12 supplementation during pregnancy and early lactation on cognitive development in children. Method We studied 218 children born to mothers enrolled in a placebo-controlled, randomized trial of vitamin B12 supplementation during pregnancy through 6 weeks post-partum. Cognitive functions were assessed (...) at 30 months using the Bayley Scales of Infant Development- 3rd edition (BSID III). The association of maternal sociodemographic characteristics, maternal biochemical status during pregnancy, birth weight and home environment with each sub-domain of BSID-III was examined using linear regression analysis. Separate multiple linear regression analyses for each of the BSID-III sub-domains with maternal trimester specific nutritional biomarker status was conducted. Results Children of mothers who

2018 Maternal and child health journal Controlled trial quality: uncertain

38. Maternal 25-hydroxy Vitamin D Level and Adverse Outcomes in Near Term and Full Term Neonates

Maternal 25-hydroxy Vitamin D Level and Adverse Outcomes in Near Term and Full Term Neonates Maternal 25-hydroxy Vitamin D Level and Adverse Outcomes in Near Term and Full Term Neonates - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Maternal 25-hydroxy Vitamin D Level and Adverse Outcomes in Near Term and Full Term Neonates The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03451864 Recruitment Status : Completed First Posted : March 2, 2018 Last Update Posted : March 2, 2018 Sponsor: Cairo University

2018 Clinical Trials

39. Associations of maternal and fetal vitamin D status with childhood body composition and cardiovascular risk factors. Full Text available with Trip Pro

Associations of maternal and fetal vitamin D status with childhood body composition and cardiovascular risk factors. Maternal vitamin D deficiency during pregnancy may have persistent adverse effects on childhood growth and development. We examined whether 25-hydroxyvitamin D (25(OH)D) concentrations during pregnancy and at cord blood were associated with childhood body composition and cardiovascular outcomes. This study was embedded in a population-based prospective cohort in Rotterdam (...) ; and serum cholesterol, triglycerides, and insulin concentrations. Compared with children from mothers with optimal 25(OH)D concentrations (≥75.0 nmol/L), those of severely deficient vitamin D (<25.0 nmol/L) mothers had a 0.12 standard deviation score (SDS); (95% Confidence Interval (CI) [0.03, 0.21]) higher fat mass percentage and a 0.13 SDS (95% CI [-0.22, -0.04]) lower lean mass percentage. These associations remained after adjustment for current child vitamin D status. Maternal and cord blood 25(OH)D

2018 Maternal & child nutrition

40. Vitamin D Regulates Maternal T-Helper Cytokine Production in Infertile Women Full Text available with Trip Pro

Vitamin D Regulates Maternal T-Helper Cytokine Production in Infertile Women Vitamin D (VD) deficiency is associated with reproductive failure. However, the relationship between VD and maternal immunity remains unclear. We investigated the clinical efficacy of VD in maternal T-helper (Th) cytokines in 276 infertile women and examined for Th1 and Th2 cells based on the deficient, insufficient, and sufficient serum 25-hydroxyvitamin D3 (25[OH]VD) levels (<12, 12⁻30, and >30 ng/mL, respectively (...) level and Th1/Th2 cell ratio (p = 0.032 and 0.010, respectively), whereas no significant differences in Th1/Th2 cell ratio were recognized in the insufficient group. Furthermore, mid-luteal endometrial biopsies (n = 18) were processed for primary cultures and measured interferon [IFN]-γ and interleukin [IL]-4 in condition media. Decidualizing cultures with 1,25-dihydroxvitamin D3 (1,25[OH]₂VD) decreased IFN-γ. Sufficient VD supplementation in women with insufficient VD may optimize maternal T-helper

2018 Nutrients

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