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Prenatal Vitamin

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21. Prenatal exposure to vitamin D from fortified margarine and risk of fractures in late childhood: period and cohort results from 222 000 subjects in the D-tect observational study (Full text)

Prenatal exposure to vitamin D from fortified margarine and risk of fractures in late childhood: period and cohort results from 222 000 subjects in the D-tect observational study Prenatal low vitamin D may have consequences for bone health. By means of a nationwide mandatory vitamin D fortification programme, we examined the risk of fractures among 10-18-year-old children from proximate birth cohorts born around the date of the termination of the programme. For all subjects born in Denmark (...) was increased among both girls and boys who were born before the vitamin D fortification terminated in 1985 (rate ratio (RR) exposed v. non-exposed girls: 1·15 (95 % CI 1·11, 1·20); RR exposed v. non-exposed boys: 1·11 (95 % CI 1·07, 1·14). However, these associations no longer persisted after including the period effects. There was no interaction between season of birth and vitamin D availability in relation to fracture risk. The study did not provide evidence that prenatal exposure to extra vitamin D from

2017 The British journal of nutrition

22. Prenatal Vitamin D Intake, Cord Blood 25-Hydroxyvitamin D, and Offspring Body Composition: The Healthy Start Study (Full text)

Prenatal Vitamin D Intake, Cord Blood 25-Hydroxyvitamin D, and Offspring Body Composition: The Healthy Start Study Vitamin D deficiency in pregnancy may be associated with increased offspring adiposity, but evidence from human studies is inconclusive. We examined associations between prenatal vitamin D intake, 25-hydroxyvitamin D (25(OH)D) in cord blood, and offspring size and body composition at birth and 5 months. Participants included 605 mother-offspring dyads from the Healthy Start study (...) , an ongoing, pre-birth prospective cohort study in Denver, Colorado, USA. Prenatal vitamin D intake was assessed with diet recalls and questionnaires, and offspring body composition was measured via air displacement plethysmography at birth and 5 months. General linear univariate models were used for analysis, adjusting for maternal age, race/ethnicity, pre-pregnancy body mass index (BMI), offspring sex, and gestational age at birth. Non-Hispanic white race, lower pre-pregnancy BMI, higher prenatal

2017 Nutrients

23. Vitamin D prenatal programming of childhood metabolomics profiles at age 3 y. (Full text)

Vitamin D prenatal programming of childhood metabolomics profiles at age 3 y. Background: Vitamin D deficiency is implicated in a range of common complex diseases that may be prevented by gestational vitamin D repletion. Understanding the metabolic mechanisms related to in utero vitamin D exposure may therefore shed light on complex disease susceptibility.Objective: The goal was to analyze the programming role of in utero vitamin D exposure on children's metabolomics profiles.Design: First (...) . The clusters differed in concentrations of inflammatory mediators, and cluster membership was influenced by in utero vitamin D exposure, suggesting a prenatal programming role of vitamin D on the child's metabolome. This trial was registered at clinicaltrials.gov as NCT00920621.© 2017 American Society for Nutrition.

2017 American Journal of Clinical Nutrition Controlled trial quality: uncertain

24. Iodine Contents in Prenatal Vitamins in the U.S. (Full text)

Iodine Contents in Prenatal Vitamins in the U.S. 28599614 2018 10 18 2018 11 13 1557-9077 27 8 2017 08 Thyroid : official journal of the American Thyroid Association Thyroid Iodine Contents in Prenatal Vitamins in the United States. 1101-1102 10.1089/thy.2017.0097 Lee Sun Y SY 1 Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine , Boston, Massachusetts. Stagnaro-Green Alex A 2 Department of Obstetrics and Gynecology and Medical Education, University (...) United States Thyroid 9104317 1050-7256 0 Vitamins 9679TC07X4 Iodine IM Dietary Supplements Female Humans Iodine analysis Pregnancy Prenatal Care United States Vitamins chemistry 2017 6 11 6 0 2018 10 20 6 0 2017 6 11 6 0 ppublish 28599614 10.1089/thy.2017.0097 PMC5912719 Public Health Nutr. 2007 Dec;10(12A):1606-11 18053287 N Engl J Med. 2009 Feb 26;360(9):939-40 19246372 Thyroid. 2017 Mar;27(3):315-389 28056690

2017 Thyroid

25. Current Recommended Vitamin D Prenatal Supplementation and Fetal Growth: Results from China-Anhui Birth Cohort Study. (Full text)

Current Recommended Vitamin D Prenatal Supplementation and Fetal Growth: Results from China-Anhui Birth Cohort Study. Maternal vitamin D insufficiency has been associated with fetal growth restriction. However, the effect of maternal vitamin D supplementation on fetal growth has not been confirmed.To assess the effect of maternal vitamin D supplementation recommended by the Institute of Medicine (IOM) during pregnancy on the neonatal vitamin D status and the risk of small for gestational age (...) (SGA).As part of the China-Anhui Birth Cohort study, maternal sociodemographic characteristics, food intake, lifestyle, information on vitamin D supplementation, and birth outcomes were prospectively collected. For participants, 600 IU/d of vitamin D3 was routinely advised to take during pregnancy. Cord blood levels of 25-hydroxyvitamin D [25(OH)D], calcium, and phosphorus were measured in 1491 neonates who were divided into three groups based on the duration of maternal vitamin D supplementation

2017 Journal of Clinical Endocrinology and Metabolism

26. Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial. (Full text)

Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial. Asthma and wheezing begin early in life, and prenatal vitamin D deficiency has been variably associated with these disorders in offspring.To determine whether prenatal vitamin D (cholecalciferol) supplementation can prevent asthma or recurrent wheeze in early childhood.The Vitamin D Antenatal Asthma Reduction Trial was a randomized, double-blind (...) , placebo-controlled trial conducted in 3 centers across the United States. Enrollment began in October 2009 and completed follow-up in January 2015. Eight hundred eighty-one pregnant women between the ages of 18 and 39 years at high risk of having children with asthma were randomized at 10 to 18 weeks' gestation. Five participants were deemed ineligible shortly after randomization and were discontinued.Four hundred forty women were randomized to receive daily 4000 IU vitamin D plus a prenatal vitamin

2016 JAMA Controlled trial quality: predicted high

27. Prenatal Vitamin

Prenatal Vitamin Prenatal Vitamin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Prenatal Vitamin Prenatal Vitamin Aka: Prenatal (...) Vitamin II. Indications Start prior to conception of pregnancy III. Preparations: Key components (Higher doses than standard Vitamins) 400 mcg or 600 Dietary Equivalents or DFE (See for references) Dose is higher if increased risk 4000 mcg started 3 months before pregnancy (continue for first trimester) Prior Use of or 800 mcg daily (1200 Dietary Equivalents or DFE) Anti-epileptic drugs other than or Most important component in Prenatal Vitamins Reduces s by 50% at conception Reduced fetal risk

2018 FP Notebook

28. Guidelines for vitamin K prophylaxis in newborns

Guidelines for vitamin K prophylaxis in newborns Newborns are at risk for vitamin K deficiency bleeding (VKDB) caused by inadequate prenatal storage and deficiency of vitamin K in breast milk. Systematic review of evidence to date suggests that a single intramuscular (IM) injection of vitamin K at birth effectively prevents VKDB. Current scientific data suggest that single or repeated doses of oral (PO) vitamin K are less effective than IM vitamin K in preventing VKDB. The Canadian Paediatric (...) Society and the College of Family Physicians of Canada recommend routine IM administration of a single dose of vitamin K at 0.5 mg to 1.0 mg to all newborns. Administering PO vitamin K (2.0 mg at birth, repeated at 2 to 4 and 6 to 8 weeks of age), should be confined to newborns whose parents decline IM vitamin K. Health care providers should clarify with parents that newborns are at increased risk of VKDB if such a regimen is chosen. Current evidence is insufficient to recommend routine intravenous

2018 CPG Infobase

29. Vitamin A supplements for reducing mother-to-child HIV transmission. (Full text)

may not be practical, feasible, or affordable. Simple, inexpensive, and effective interventions (that could potentially be implemented even in the absence of prenatal HIV testing programmes) would be valuable. Vitamin A, which plays a role in immune function, is one low-cost intervention that has been suggested in such settings.To summarize the effects of giving vitamin A supplements to HIV-positive women during pregnancy and after delivery.We searched the Cochrane Central Register of Controlled (...) Vitamin A supplements for reducing mother-to-child HIV transmission. Strategies to reduce the risk of mother-to-child transmission of the human immunodeficiency virus (HIV) include lifelong antiretroviral therapy (ART) for HIV-positive women, exclusive breastfeeding from birth for six weeks plus nevirapine or replacement feeding plus nevirapine from birth for four to six weeks, elective Caesarean section delivery, and avoiding giving children chewed food. In some settings, these interventions

2017 Cochrane

30. The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review. (PubMed)

may be effective in reducing prenatal stress and salivary cortisol and may reduce anxiety during premenstrual syndrome and during menopause in the absence of depression. Magnesium and vitamin B6 may be effective in combination in reducing premenstrual stress, and vitamin B6 alone may reduce anxiety effectively in older women. High-dose sustained-release vitamin C may reduce anxiety and mitigate increased blood pressure in response to stress.Essential fatty acids may be effective in reducing (...) prenatal stress and salivary cortisol levels, and premenstrual or menopausal anxiety in the absence of depression. Combining magnesium and vitamin B6 may reduce premenstrual anxiety and vitamin B6 may reduce anxiety in older women. High-dose sustained-release vitamin C may reduce anxiety and mitigate increased blood pressure in response to stress.Investigating supplementation in longer term studies is warranted and should include compliance testing, the use of inert substances as controls and reliable

2017 JBI database of systematic reviews and implementation reports

31. Prenatal vitamin D and enamel hypoplasia in human primary maxillary central incisors: a pilot study (Full text)

Prenatal vitamin D and enamel hypoplasia in human primary maxillary central incisors: a pilot study Enamel hypoplasia (EH) increases risk for dental caries and also is associated with vitamin D deficiencies. This pilot study evaluates the feasibility to determine the association of human maternal circulating vitamin D concentrations during pregnancy and EH in infant's teeth that develop in utero.A pilot population of 37 children whose mothers participated in a RCT of vitamin D supplementation (...) %) of the children. Maternal mean 25(OH)D concentrations were generally lower for those children with EH.Preliminary results suggest follow-up of children of mothers in a vitamin D supplementation RCT during pregnancy provides an important approach to study the etiology of EH in the primary teeth. Further study is needed to discern thresholds and timing of maternal serum 25(OH)D concentrations during pregnancy associated with absence of EH in teeth that develop in utero. Potential dental public health

2016 Pediatric dental journal : international journal of Japanese Society of Pediatric Dentistry

32. Prenatal, perinatal, and childhood vitamin D exposure and their association with childhood allergic rhinitis and allergic sensitization. (Full text)

Prenatal, perinatal, and childhood vitamin D exposure and their association with childhood allergic rhinitis and allergic sensitization. The role of early-life vitamin D in childhood allergy is controversial.We sought to assess vitamin D exposure in early life by multiple modalities and ascertain its association with childhood allergic rhinitis and allergic sensitization.One thousand two hundred forty-eight mother-child pairs from a US prebirth cohort unselected for any disease were studied (...) . Vitamin D exposure was assessed by measures of maternal intake during the first and second trimesters of pregnancy and serum 25-hydroxyvitamin D (25[OH]D) levels in mothers during pregnancy, cord blood, and children at school age (median age, 7.7 years; interquartile range, 1.0 years). Tests for associations between vitamin D exposure with ever allergic rhinitis, serum total IgE level, and allergen sensitization at school age were conducted.The correlations between maternal intake of vitamin D during

2016 Journal of Allergy and Clinical Immunology

33. Prenatal Intake of Vitamins and Allergic Outcomes in the Offspring: A Systematic Review and Meta-Analysis. (Full text)

Prenatal Intake of Vitamins and Allergic Outcomes in the Offspring: A Systematic Review and Meta-Analysis. Allergic diseases have seen a rise worldwide, with children suffering the highest burden. Thus, early prevention of allergic diseases is a public health priority.To synthesize the evidence from randomized controlled trials (RCTs) assessing the effect of vitamin interventions during pregnancy on developing allergic diseases in offspring.We searched CENTRAL, MEDLINE, SCOPUS, World Health (...) were rated as low risk of bias for blinding of outcome assessment. We did not perform meta-analysis with vitamin C or vitamin C + E studies due to high heterogeneity between the 2 included studies. However, we did conduct a meta-analysis with trials on vitamin D (including 1493 children) and the results showed an association between the prenatal intake of vitamin D and the risk of developing recurrent wheeze in offspring (relative risk (RR), 0.812; 95% CI, 0.67-0.98).The current evidence suggests

2016 The journal of allergy and clinical immunology. In practice

34. Prenatal high-dose vitamin D3 supplementation has balanced effects on cord blood Th1 and Th2 responses. (Full text)

Prenatal high-dose vitamin D3 supplementation has balanced effects on cord blood Th1 and Th2 responses. Antenatal vitamin D3 (vitD3) supplementation significantly increases maternal and neonatal 25-hydroxyvitamin D3 (25(OH)D3) concentration, yet the effect of an improvement in maternal-fetal vitamin D status on the neonatal immune response is unclear.To assess the effect of prenatal vitD3 supplementation on cord blood T cell function, healthy pregnant Bangladeshi women (n = 160) were randomized (...) recognition receptors (PRRs) in the vitamin D group (vitD group).Third-trimester high-dose vitD3 supplementation in healthy pregnant women had balanced effects on biomarkers of cord blood Th1 and Th2 responses.ClinicalTrials.gov ( NCT01126528 ).

2016 Nutrition journal Controlled trial quality: uncertain

35. A Prenatal Multiple Micronutrient Supplement Produces Higher Maternal Vitamin B-12 Concentrations and Similar Folate, Ferritin, and Zinc Concentrations as the Standard 60-mg Iron Plus 400-μg Folic Acid Supplement in Rural Bangladeshi Women. (Full text)

A Prenatal Multiple Micronutrient Supplement Produces Higher Maternal Vitamin B-12 Concentrations and Similar Folate, Ferritin, and Zinc Concentrations as the Standard 60-mg Iron Plus 400-μg Folic Acid Supplement in Rural Bangladeshi Women. The effects of prenatal food and micronutrient supplementation on maternal micronutrient status are not well known.We compared the efficacy and effectiveness of 3 different micronutrient supplements on maternal micronutrient status when combined with food (...) supplementation.In the MINIMat (Maternal and Infant Nutrition Intervention, Matlab) trial in Bangladesh, 4436 pregnant women were randomly assigned to daily intake of 3 types of micronutrient capsules: 30 mg Fe and 400 μg folic acid (Fe30F), 60 mg Fe and 400 μg folic acid (Fe60F), or multiple micronutrient supplements (MMNs) combined with early (week 9 of pregnancy) or usual (week 20 of pregnancy) food supplementation in a 2 by 3 factorial design. Plasma concentrations of vitamin B-12, folate, ferritin, and zinc

2016 Journal of Nutrition Controlled trial quality: uncertain

36. PP170. Prenatal vitamin C and E supplementation is associated with a reduction in placental abruption and preterm birth in smokers. (PubMed)

PP170. Prenatal vitamin C and E supplementation is associated with a reduction in placental abruption and preterm birth in smokers. Maternal tobacco use increases the incidence of numerous adverse pregnancy outcomes including miscarriage, small for gestational age infants, spontaneous preterm birth and placental abruption.We evaluated the relationship between prenatal vitamin C/E supplementation and perinatal outcomes by maternal smoking status.Secondary analysis of a multicenter trial (...) ). The effect of prenatal vitamin C/E on the risk preeclampsia or pregnancy associated hypertension composite outcome did not differ by smoking status. Vitamin C/E was protective for placental abruption and preterm birth among smokers.The effect of vitamin C/E supplementation on preeclampsia/pregnancy associated hypertension did not differ by smoking status. However, vitamin C/E supplementation was associated with a >40% reduction in placental abruption and >30% reduction in preterm birth among smokers

2015 Pregnancy Hypertension Controlled trial quality: uncertain

37. PRENATAL VITAMIN COMPOUNDS AVAILABLE IN BRAZIL ARE NOT SUITABLE FOR ADEQUATE IODINE SUPPLEMENTATION OF PREGNANT WOMEN. (PubMed)

PRENATAL VITAMIN COMPOUNDS AVAILABLE IN BRAZIL ARE NOT SUITABLE FOR ADEQUATE IODINE SUPPLEMENTATION OF PREGNANT WOMEN. 26700644 2016 11 10 2016 12 30 1557-9077 26 2 2016 Feb Thyroid : official journal of the American Thyroid Association Thyroid Prenatal Vitamin Compounds Available in Brazil are not Suitable for Adequate Iodine Supplementation of Pregnant Women. 322 10.1089/thy.2015.0462 Villagelin Danilo D 1 Department of Endocrinology and Metabolism, Pontifical University Catholic of Campinas (...) Vitamins 9679TC07X4 Iodine IM Brazil Dietary Supplements Female Geography Humans Iodine administration & dosage deficiency Pregnancy Prevalence Sodium Chloride, Dietary Vitamins administration & dosage 2015 12 25 6 0 2015 12 25 6 0 2016 11 12 6 0 ppublish 26700644 10.1089/thy.2015.0462

2015 Thyroid

38. Population and Public Health Prenatal Care Pathway

Population and Public Health Prenatal Care Pathway Perinatal Services BC Provincial Perinatal Guidelines Population and Public Health Prenatal Care Pathway Table of Contents INTRODUCTION ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 3 About the Prenatal Care Pathway ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 3 Who Developed the Prenatal Care Pathway ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 3 Approaches to Care ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 3 Women-Centred (...) Care ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 3 Family Centred Care ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 4 Trauma and Violence Informed Care ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 4 Culturally Competent Care ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 4 Role of Public Health Nurses in the Prenatal Period ? ? ? ? ? ? ? ? ? ? 4 Collaboration with Other Service Providers ? ? ? ? ? ? ? ? ? ? ? 5 Resources Supporting Prenatal Care ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 5 THE PUBLIC HEALTH

2014 British Columbia Perinatal Health Program

39. Prenatal oxidative balance and risk of asthma and allergic disease in adolescence. (PubMed)

in Project Viva. Exposures of interest were maternal prepregnancy body mass index and prenatal nutrients (energy-adjusted intakes of vitamins D, C, and E; β-carotene; folate; choline; and n-3 and n-6 polyunsaturated fatty acids [PUFAs]), air pollutant exposures (residence-specific third-trimester black carbon or particulate matter with a diameter of less than 2.5 μm [PM2.5]), acetaminophen, and smoking. Outcomes were offspring's current asthma, allergic rhinitis, and allergen sensitization at a median (...) ). Black carbon and PM2.5 were associated with an approximately 30% increased risk for allergen sensitization. No multiplicative interactions were observed for protective nutrient intakes with sources of oxidative stress.We identified potential protective prenatal nutrients (vitamin D and n-3 PUFAs), as well as adverse prenatal pro-oxidant exposures that might alter the risk of asthma and allergic disease into adolescence.Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published

2019 Journal of Allergy and Clinical Immunology

40. Prenatal and childhood exposures are associated with thymulin concentrations in young adolescent children in rural Nepal. (PubMed)

Prenatal and childhood exposures are associated with thymulin concentrations in young adolescent children in rural Nepal. The thymus undergoes a critical period of growth and development early in gestation and, by mid-gestation, immature thymocytes are subject to positive and negative selection. Exposure to undernutrition during these periods may permanently affect phenotype. We measured thymulin concentrations, as a proxy for thymic size and function, in children (n = 290; aged 9-13 years (...) ) born to participants in a cluster-randomized trial of maternal vitamin A or β-carotene supplementation in rural Nepal (1994-1997). The geometric mean (95% confidence interval) thymulin concentration was 1.37 ng/ml (1.27, 1.47). A multivariate model of early-life exposures revealed a positive association with gestational age at delivery (β = 0.02; P = 0.05) and higher concentrations among children born to β-carotene-supplemented mothers (β = 0.19; P < 0.05). At ∼9-12 years of age, thymulin

2019 Journal of developmental origins of health and disease Controlled trial quality: uncertain

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