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Prenatal Vitamin

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3861. Vitamin E and transfer proteins. (Abstract)

concerning the role of this protein in the transport and supply of vitamin E to tissues such as the central nervous system and the feto-maternal unit. The scavenger receptor class B type I receptor, a membrane-bound protein, is capable of transferring vitamin E into the cell, while the ATP-binding cassette transporter A1 can excrete vitamin E out of the cell. Advances in the area of vitamin E metabolism have shown that alpha-CEHC (2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman) and gamma-CEHC (...) Vitamin E and transfer proteins. Recently, the intracellular transport as well as cellular uptake and excretion of alpha-tocopherol, the major representative of vitamin E, have been elucidated.Alpha-tocopherol transfer protein has been identified as the major intracellular transport protein for vitamin E, mediating alpha-tocopherol secretion into the plasma via a non-Golgi-dependent pathway, while other binding proteins seem to play a less important role. New information has accumulated

2003 Current Opinion in Lipidology

3862. Randomised trial to assess benefits and safety of vitamin A supplementation linked to immunisation in early infancy. WHO/CHD Immunisation-Linked Vitamin A Supplementation Study Group. (Abstract)

Randomised trial to assess benefits and safety of vitamin A supplementation linked to immunisation in early infancy. WHO/CHD Immunisation-Linked Vitamin A Supplementation Study Group. The benefits and safety of vitamin A supplementation linked to immunisation in infancy need to be assessed before it can be widely recommended. We assessed the safety and benefits of maternal postpartum and infant vitamin A supplementation administered with each of the three diphtheria-tetanus-pertussis (DPT (...) ) and poliomyelitis immunisations and with a fourth dose with measles immunisation.From January, 1995, we enrolled 9424 mother-infant pairs from Ghana, India, and Peru in this randomised, double-blind, placebo-controlled trial. 4716 mothers of infants in the vitamin A group received 200000 IU vitamin A, and their infants were given 25000 IU vitamin A with each of the first three doses of DPT/poliomyelitis immunisation at 6, 10, and 14 weeks. In the control group, 4708 mothers and their infants received placebo

1998 Lancet Controlled trial quality: predicted high

3863. Effects of maternal antioxidant supplementation on maternal and fetal antioxidant levels: a randomized, double-blind study. (Abstract)

Effects of maternal antioxidant supplementation on maternal and fetal antioxidant levels: a randomized, double-blind study. We sought to determine whether vitamins C and E could be delivered to the fetal-placental unit through maternal oral supplementation.In a randomized, double-blind study, 20 women received a daily prenatal vitamin with or without 400 IU of vitamin E and 500 mg of vitamin C, starting at 35 weeks' gestation. At randomization, a nutritional questionnaire, plasma vitamin C (...) and E and red blood cell (RBC) vitamin E levels were determined. At delivery, concentrations of maternal and fetal plasma vitamin C and E, maternal and fetal RBC vitamin E, amniotic fluid vitamin C, and chorioamnion vitamin E and tensile strength were determined.Maternal plasma vitamin E levels increased in the supplemented women but not in the control subjects. No changes in maternal vitamin C levels were noted. Maternal plasma vitamin C concentrations at delivery correlated closely with amniotic

2003 American journal of obstetrics and gynecology Controlled trial quality: uncertain

3864. Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. (Abstract)

Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Vitamin D insufficiency is common in women of childbearing age and increasing evidence suggests that the risk of osteoporotic fracture in adulthood could be determined partly by environmental factors during intrauterine and early postnatal life. We investigated the effect of maternal vitamin D status during pregnancy on childhood skeletal growth.In a longitudinal study, we studied 198 (...) children born in 1991-92 in a hospital in Southampton, UK; the body build, nutrition, and vitamin D status of their mothers had been characterised during pregnancy. The children were followed up at age 9 years to relate these maternal characteristics to their body size and bone mass.49 (31%) mothers had insufficient and 28 (18%) had deficient circulating concentrations of 25(OH)-vitamin D during late pregnancy. Reduced concentration of 25(OH)-vitamin D in mothers during late pregnancy was associated

2006 Lancet

3865. Vitamin D nutrition and vitamin D metabolism in the premature human neonate. (Abstract)

-dihydroxyvitamin D was less than 48 pmol/l (20 pg/ml). These findings suggest a considerable degree of maternal vitamin D-deficiency. Maximum attained concentrations of 25-hydroxyvitamin D on treatment were 77.3 nmol/l (30.9 ng/ml), high dose and 86.8 nmol/l (34.7 ng/ml), low dose, the mean rate of increase was greatest during the first two weeks (2.2 nmol/l/d; 0.88 ng/ml/d) and declined over the next 4 weeks. Mean maximum concentrations of 1,25-dihydroxyvitamin D2 were 283 pmol/l, (121 pg/ml), high dose (...) Vitamin D nutrition and vitamin D metabolism in the premature human neonate. The effect of supplementation with daily doses of vitamin D2 (1000 IU or 3000 IU, 25-75 micrograms, 63-189 nmol) has been studied in 39 premature neonates, initial gestational age 25-32 weeks. The initial mean plasma 25-hydroxyvitamin D was 25.8 nmol/l (10.3 ng/ml) but in 12 infants, most of whom were born in the winter months, the level was less than 15 nmol/l (6 ng/ml), and in seven babies plasma 1,25

1986 Clinical endocrinology Controlled trial quality: uncertain

3866. Oral supplementation of vitamin K for pregnant women and effects on levels of plasma vitamin K and PIVKA-II in the neonate. (Abstract)

Oral supplementation of vitamin K for pregnant women and effects on levels of plasma vitamin K and PIVKA-II in the neonate. Levels of plasma vitamin K1 (VK1) and vitamin K2 (VK2) and protein-induced vitamin K absence-II (PIVKA-II) were measured in Japanese mothers and their newborn (N = 33). Twenty milligrams of VK1 (N = 11) or VK2 (N = 12) were given orally to randomly selected mothers 7 to 10 days prior to delivery. Means of plasma VK1 and VK2 concentrations were significantly higher in VK1 (...) (p less than 0.01) and VK2 (p less than 0.01) treated mothers than in the controls at delivery, respectively. Similarly, these levels were significantly elevated in cord plasma in VK1 (p less than 0.05) and VK2 (p less than 0.05) treated groups, compared with findings in the control group, although there was a large concentration gradient between maternal and cord plasma (mostly less than one-tenth). A significant positive correlation was found in VK1 concentration between maternal and cord

1990 Journal of pediatric gastroenterology and nutrition Controlled trial quality: uncertain

3867. Vitamin A supplementation of women postpartum and of their infants at immunization alters breast milk retinol and infant vitamin A status. Full Text available with Trip Pro

of maternal vitamin A supplementation on breast milk retinol and of maternal and infant supplementation on infant vitamin A status. Mothers in the intervention group received 60 mg vitamin A (as retinol palmitate) at 18-42 d postpartum; their infants were given 7.5 mg three times, i.e., at 6, 10 and 14 wk of age with DPT and OPV immunizations. Mothers and infants in the comparison group received a placebo. Maternal supplementation resulted in higher breast milk retinol at 2 mo postpartum [difference (...) in means 7.1, 95% confidence interval (CI), 3.4, 10.8 nmol/g fat] and lower proportion of mothers with breast milk retinol < or = 28 nmol/g fat (15.2 vs. 26.6%, 95% CI of difference -16.6, -4.1%). At 6 and 9 mo, maternal supplementation did not affect breast milk retinol or the proportion of mothers with low breast milk retinol. Vitamin A supplementation of the mothers and their infants reduced the proportion of infants with serum retinol < or = 0.7 micro mol/L (30.4 vs. 37%, 95% CI of difference -13.7

2002 The Journal of nutrition Controlled trial quality: predicted high

3868. Vitamin a status of pregnant women and effect of post partum vitamin a supplementation. (Abstract)

Vitamin a status of pregnant women and effect of post partum vitamin a supplementation. To assess the Vitamin A status of pregnant women in their third trimester using maternal serum retinol levels as the indicator; and (ii) To assess the impact of postpartum Vitamin A supplementation on the Vitamin A status of exclusively breastfed infants.Prospective randomized single blind controlled study.Teaching Hospital.109 apparently healthy primi and second gravida women registered at the antenatal (...) clinic were included in the study and followed up for three months postpartum. Serum retinol levels of pregnant mothers in their third trimester (35-37 weeks) and cord blood levels after delivery were estimated. Mothers were then assigned to two groups. The experimental group included 53 mothers who received a single dose of 2 lakh units of Vitamin A orally. The control group had 56 mothers who did not receive Vitamin A. Mothers and infants were followed up for three months. The serum retinol

2000 Indian pediatrics Controlled trial quality: uncertain

3869. Vitamin A and iron supplementation of Indonesian pregnant women benefits vitamin A status of their infants. (Abstract)

Vitamin A and iron supplementation of Indonesian pregnant women benefits vitamin A status of their infants. Many Indonesian infants have an inadequate nutritional status, which may be due in part to inadequate maternal nutrition during pregnancy. This study was designed to investigate whether infant nutritional status could be improved by maternal vitamin A and Fe supplementation during gestation. Mothers of these infants from five villages had been randomly assigned on an individual basis (...) approximately 4 months after delivery. Infants of mothers supplemented with vitamin A plus Fe had higher serum retinol concentrations than infants of mothers supplemented with Fe alone. However, the proportion of infants with serum retinol concentrations <0.70 micromol/l was >70 % in all groups. Maternal and infant serum retinol concentrations were correlated. Fe status, weight and length of infants were similar in all groups. Fe status of girls was better than that of boys, but boys were heavier and longer

2001 The British journal of nutrition Controlled trial quality: uncertain

3870. Weekly vitamin A and iron supplementation during pregnancy increases vitamin A concentration of breast milk but not iron status in Indonesian lactating women. Full Text available with Trip Pro

Weekly vitamin A and iron supplementation during pregnancy increases vitamin A concentration of breast milk but not iron status in Indonesian lactating women. Studies on the effect of vitamin A and iron supplementation during pregnancy on maternal iron and vitamin A status postpartum are scarce. We investigated whether retinol and iron variables in breast milk and in serum postpartum were enhanced more with weekly vitamin A and iron supplementation during pregnancy than with weekly iron (...) supplementation. During pregnancy, subjects were randomly allocated to two groups and received either (n = 88) a weekly supplement of iron (120 mg Fe as FeSO(4)) and folic acid (500 microg) or (n = 82) the same amount of iron and folic acid plus vitamin A [4800 retinol equivalents (RE)]. Transitional milk (4-7 d postpartum) had higher (P < 0.001) concentrations of retinol and iron than mature milk (3 mo postpartum). Compared with the weekly iron group, the weekly vitamin A and iron group had a greater (P

2001 The Journal of nutrition Controlled trial quality: uncertain

3871. Hypovitaminosis D and vitamin D deficiency in exclusively breast-feeding infants and their mothers in summer: a justification for vitamin D supplementation of breast-feeding infants. (Abstract)

Hypovitaminosis D and vitamin D deficiency in exclusively breast-feeding infants and their mothers in summer: a justification for vitamin D supplementation of breast-feeding infants. To determine the prevalence of hypovitaminosis D in exclusively breast-feeding infants and their mothers in a community where maternal sunshine exposure is low.Serum levels of calcium, phosphate, alkaline phosphatase, 25-hydroxy vitamin D (25-OHD), and intact parathyroid hormone were measured in 90 unsupplemented (...) healthy term breast-feeding Arab/South Asian infants and their mothers in summer. Maternal dietary vitamin D intake was also estimated.The median age of infants was 6 weeks. The median serum 25-OHD concentrations in mothers (8.6 ng/mL) and infants (4.6 ng/mL) were low, and 61% of the mothers and 82% of the 78 infants tested had hypovitaminosis D (serum 25-OHD <10 ng/mL). The infants with hypovitaminosis D had elevated serum alkaline phosphatase and a tendency to higher serum intact parathyroid hormone

2003 Journal of Pediatrics

3872. The effect of formula versus breast feeding and exogenous vitamin K1 supplementation on circulating levels of vitamin K1 and vitamin K-dependent clotting factors in newborns. (Abstract)

at weeks 1 and 6. Oral vitamin K supplementation (n = 22) or i.m. (n = 18) at birth resulted in high serum levels at week 1, while at week 6 the effect had disappeared. Formula fed infants had vitamin K1 values within the normal adult range at all study points. The low serum levels of vitamin K1 were not associated with haemorrhagic disorders or coagulation abnormalities. The mean values of vitamin K1 in maternal sera at weeks 1 and 6 were 2.3 nmol/l and 1.8 nmol/l and in breast milk 2.7 nmol/l and 2.0 (...) nmol/l respectively. No correlation existed between the values in breast milk and maternal serum. To maintain serum levels of vitamin K1 within the adult physiological range, repeated administration of low doses is needed in breast fed newborns beyond 1 week of age.

1993 European journal of pediatrics Controlled trial quality: uncertain

3873. Impact of Maternal Supplementation With Dual Megadose of Vitamin A

Impact of Maternal Supplementation With Dual Megadose of Vitamin A Impact of Maternal Supplementation With Dual Megadose of Vitamin A - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Impact of Maternal (...) Infantil Prof. Fernando Figueira Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate the effect of maternal supplementation with 400,000 IU of oral retinol palmitate in the post-partum, the nutritional situation of the binomial mother-child, on growth and morbidity of children in breastfeeding in the first six months of life. Condition or disease Intervention/treatment Phase Hypovitaminosis Vitamin A Deficiency Dietary Supplement: vitamin A Dietary Supplement

2008 Clinical Trials

3874. Impact of Prenatal Vitamin/Mineral Supplements on Perinatal Mortality

Impact of Prenatal Vitamin/Mineral Supplements on Perinatal Mortality Impact of Prenatal Vitamin/Mineral Supplements on Perinatal Mortality - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Impact of Prenatal (...) Control and Prevention Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether a daily prenatal supplement of iron plus folic acid or a daily prenatal supplement with multiple vitamins and minerals given to women from their first prenatal visit through delivery reduces perinatal mortality compared with a daily prenatal supplement of folic acid alone. Condition or disease Intervention/treatment Phase Perinatal Mortality Stillbirth Neonatal Mortality

2005 Clinical Trials

3875. Trial of the Impact of Vitamin A on Maternal Mortality

A Deficiency Maternal Mortality Maternal Morbidity Dietary Supplement: Vitamin A Phase 3 Detailed Description: Pregnancy accounts for nearly 600,000 deaths of women each year; maternal health problems are the largest contributors to the disease burden of adult women. Conventional primary health care approaches, which included Traditional Birth Attendant training and antenatal screening, had little impact on the maternal mortality ratio. Instead, the Safe Motherhood paradigm now aims to ensure emergency (...) Trial of the Impact of Vitamin A on Maternal Mortality Trial of the Impact of Vitamin A on Maternal Mortality - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Trial of the Impact of Vitamin A on Maternal

2005 Clinical Trials

3876. Prenatal administration of vitamin A alters pulmonary and plasma levels of vascular endothelial growth factor in the developing mouse Full Text available with Trip Pro

Prenatal administration of vitamin A alters pulmonary and plasma levels of vascular endothelial growth factor in the developing mouse Vitamin A and the retinoids play a unique role in mammalian embryonic and foetal development and are essential for both cellular differentiation and the establishment of normal morphogenesis. Vascular endothelial growth factor (VEGF) is a known potent mitogenic factor that plays a key role in lung development and function maintenance. In order to contribute (...) to a better knowledge of the modulating effects of vitamin A in lung development, we investigated the effects of the antenatal administration of vitamin A on VEGF expression in lungs and plasma from foetuses and neonates. Pregnant mice were subjected to subcutaneous administration of vitamin A on the 12th gestational day. The lungs and plasma from foetuses and neonates were collected daily from the 15th gestational day till the day of birth. Our results show that vitamin A modulates VEGF concentrations

2007 International journal of experimental pathology

3877. Maternal vitamin D deficiency, refractory neonatal hypocalcaemia, and nutritional rickets Full Text available with Trip Pro

Maternal vitamin D deficiency, refractory neonatal hypocalcaemia, and nutritional rickets 15781946 2005 05 12 2008 11 20 1468-2044 90 4 2005 Apr Archives of disease in childhood Arch. Dis. Child. Maternal vitamin D deficiency, refractory neonatal hypocalcaemia, and nutritional rickets. 437-8 Shenoy S D SD Swift P P Cody D D Iqbal J J eng Comment Letter England Arch Dis Child 0372434 0003-9888 AIM IM Arch Dis Child. 2004 Aug;89(8):699-701 15269061 Arch Dis Child. 2004 Aug;89(8):781-4 15269083 (...) Adolescent Child Chronic Disease Female Humans Hypocalcemia congenital Infant, Newborn Pregnancy Pregnancy Complications Rickets etiology Vitamin D Deficiency 2005 3 23 9 0 2005 5 13 9 0 2005 3 23 9 0 ppublish 15781946 90/4/437-a 10.1136/adc.2004.065268 PMC1720356

2005 Archives of Disease in Childhood

3878. Compliance with prenatal vitamins: Patients with morning sickness sometimes find it difficult Full Text available with Trip Pro

Compliance with prenatal vitamins: Patients with morning sickness sometimes find it difficult Many pregnant patients cannot tolerate multivitamins because of morning sickness. Is it the tablet size or the iron content that causes the problems, and what can be done?Recent Motherisk studies have shown both tablet size and high iron content to be associated with lower compliance among women with morning sickness. It does appear that tablet size is more likely to affect compliance. Some new

2006 Canadian Family Physician

3879. [The effect of vitamin-mineral supplementation on the level of MDA and activity of glutathione peroxidase and superoxide dismutase in blood of matched maternal-cord pairs]. (Abstract)

[The effect of vitamin-mineral supplementation on the level of MDA and activity of glutathione peroxidase and superoxide dismutase in blood of matched maternal-cord pairs]. The aim of the present study was to investigate the effect of VIBOVITmama (Polfa Kutno S.A.) supplementation on lipid peroxidation (MDA) and activity of superoxide dismutase (SOD) and selenium-dependent glutathione peroxidase (GPx) in blood of pregnant women and in umbilical cord blood of their children. It is shown (...) , that MDA concentration in plasma increased during pregnancy in both studied groups; however in vitamin-mineral C supplemented women it was lower (p < 0.05) than in placebo (p < 0.005). In erythrocytes MDA level was within the same range in both groups, but in women taking vibovit it was (in late pregnancy) lower by 10% than in trimester I. Activity of GPx in red blood cells decreased during pregnancy. In placebo the fall was two-fold more intensive (16%) than in the supplemented group (p < 0.005

2004 Przegla̧d lekarski Controlled trial quality: uncertain

3880. Maternal vitamin A supplementation and immunity to malaria in pregnancy in Ghanaian primigravids. (Abstract)

Maternal vitamin A supplementation and immunity to malaria in pregnancy in Ghanaian primigravids. Vitamin A supplementation is believed to enhance immune responses to infection but few studies have assessed its effects on anti-malarial immunity, especially during pregnancy when women are at increased risk from both vitamin A deficiency and pregnancy-associated malaria. The pathological effects of malaria in pregnancy are believed to be due to the sequestration of parasites in the placenta (...) mediated via binding of variant surface antigens (VSA) expressed on the surface of P. falciparum infected red blood cells to placental chondroitin sulphate A (CSA).We conducted a randomized double-blind controlled trial of vitamin A supplementation in 98 primigravid Ghanaian women to investigate the effects of vitamin A supplementation on levels of IgG antibodies binding to VSA of a clinical, P. falciparum placental isolate and to two isolates selected (or not) for adherence to CSA in vitro (anti

2005 Tropical medicine & international health : TM & IH Controlled trial quality: predicted high

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