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Prenatal Vitamin

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181. Preventing Health Disparities During Pregnancy Through Vitamin D Supplementation

: Medical University of South Carolina Collaborator: W.K. Kellogg Foundation Information provided by (Responsible Party): Medical University of South Carolina Study Details Study Description Go to Brief Summary: The purpose of this study is to give all mothers the best chance for a healthy pregnancy through vitamin D supplementation. We will study women of diverse racial/ethnic backgrounds who will receive either the current vitamin D standard of 400 IU/day (in the prenatal vitamin) or 4000 IU/day (dose (...) Actual Study Start Date : January 2013 Actual Primary Completion Date : April 30, 2017 Actual Study Completion Date : April 30, 2018 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Vitamin D 4000 IU Subjects randomized into this arm will receive supplementation with 4000 IU/day vitamin D3 in gummy vitamin form, plus the standard prenatal vitamin (containing 400 IU vitamin D3. Drug

2013 Clinical Trials

182. Maternal Vitamin D for Infant Growth (MDIG) Trial

Gates Foundation Information provided by (Responsible Party): Daniel Roth, The Hospital for Sick Children Study Details Study Description Go to Brief Summary: The primary aims of this study are: 1) to determine whether maternal prenatal vitamin D3 supplementation (4200 IU/week, 16,800 IU/week, or 28,000 IU/week) versus placebo increases or decreases infant length at 1 year of age, and 2) to determine whether maternal postpartum vitamin D3 supplementation (28,000 IU/week) versus placebo increases (...) until 6 months postpartum. Dietary Supplement: Placebo This product will be identical in appearance, taste and texture to the experimental formulation but will not include any vitamin D3. Experimental: Group B Prenatal Period 4,200 IU/week of vitamin D3 (=600 IU/d); Postpartum Period 0 IU/week (placebo) Dietary Supplement: Vitamin D3 (cholecalciferol) The intervention is an oral tablet containing vitamin D3 (cholecalciferol). This vitamin D supplement will be provided in the form of small tablets

2013 Clinical Trials

183. Vitamin D study in pregnant women and their babies (PubMed)

Vitamin D study in pregnant women and their babies Vitamin D deficiency is very common in pregnant women. Deficiencies have been prevalent even in studies where over 90% of the women took prenatal vitamins. The current guidelines for vitamin D intake during pregnancy of 200-400 IU has little scientific support and has been recently challenged. We conducted this study to determine the prevalence of vitamin D deficiency among pregnant women and to evaluate the effectiveness and level of weekly (...) oral 50,000 IU of vitamin D supplementation for the mother and the newborn.Prospective study at Hamad Medical Corporation outpatient unit and delivery room.Ninety seven pregnant women were recruited in their first trimester between December 2007 and March 2010. Weekly oral vitamin D (50,000 IU) were prescribed after an initial testing for serum level of 25-hydroxyvitamin D, parathyroid hormone, calcium, phosphorus, total protein and albumin. Other multivitamins supplementations were allowed during

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2013 Qatar Medical Journal

184. Maternal Vitamin D3 Supplementation during the Third Trimester of Pregnancy: Effects on Infant Growth in a Longitudinal Follow-Up Study in Bangladesh. (PubMed)

Maternal Vitamin D3 Supplementation during the Third Trimester of Pregnancy: Effects on Infant Growth in a Longitudinal Follow-Up Study in Bangladesh. To estimate the effects of prenatal vitamin D supplementation on infant growth in Dhaka, Bangladesh.Longitudinal follow-up of infants born at term or late preterm (≥34 weeks) to participants in a randomized double-blind trial of maternal third-trimester vitamin D3 (35 000 IU/wk; vitamin D ) vs placebo. Anthropometry was performed at birth, 1, 2 (...) , 4, 6, 9, and 12 months of age. The primary analysis (n = 145 overall; n = 134 at 1 year) was a comparison of mean length-for-age z-score (LAZ) based on World Health Organization standards.LAZ was similar between groups at birth, but 0.44 (95% CI, 0.06-0.82) higher in vitamin D vs placebo at 1 year, corresponding to a sex-adjusted increase of 1.1 cm (95% CI, 0.06-2.0). Mean change in LAZ from birth to 1 month was significantly greater in vitamin D (0.53 per month) vs placebo (0.19 per month; P

2013 Journal of Pediatrics Controlled trial quality: predicted high

185. Pharmacokinetics of high-dose weekly oral vitamin D3 supplementation during the third trimester of pregnancy in Dhaka, Bangladesh. (PubMed)

Pharmacokinetics of high-dose weekly oral vitamin D3 supplementation during the third trimester of pregnancy in Dhaka, Bangladesh. A pharmacokinetic study was conducted to assess the biochemical dose-response and tolerability of high-dose prenatal vitamin D3 supplementation in Dhaka, Bangladesh (23°N). Pregnant women at 27-30 weeks gestation (n = 28) were randomized to 70,000 IU once + 35,000 IU/week vitamin D3 (group PH: pregnant, higher dose) or 14,000 IU/week vitamin D3 (PL: pregnant, lower (...) = 0.044). ∆[25(OH)D] at modeled steady-state was lower in PH versus NH but the difference was not significant (-15 nmol/L, 95% CI -34 to 5; p = 0.13). In PH, 100% attained [25(OH)D] ≥ 50 nmol/L and 90% attained [25(OH)D] ≥ 80 nmol/L; in PL, 89% attained [25(OH)D] ≥ 50 nmol/L but 56% attained [25(OH)D] ≥ 80 nmol/L. Cord [25(OH)D] (n = 23) was slightly higher in PH versus PL (117 nmol/L vs. 98 nmol/L; p = 0.07). Vitamin D3 was well tolerated; there were no supplement-related serious adverse clinical

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2013 Nutrients Controlled trial quality: predicted high

186. Prenatal micronutrient supplementation and intellectual and motor function in early school-aged children in Nepal. (PubMed)

Prenatal micronutrient supplementation and intellectual and motor function in early school-aged children in Nepal. Iron and zinc are important for the development of both intellectual and motor skills. Few studies have examined whether iron and zinc supplementation during gestation, a critical period of central nervous system development, affects children's later functioning.To examine intellectual and motor functioning of children whose mothers received micronutrient supplementation during (...) pregnancy.Cohort follow-up of 676 children aged 7 to 9 years in June 2007-April 2009 who had been born to women in 4 of 5 groups of a community-based, double-blind, randomized controlled trial of prenatal micronutrient supplementation between 1999 and 2001 in rural Nepal. Study children were also in the placebo group of a subsequent preschool iron and zinc supplementation trial.Women whose children were followed up had been randomly assigned to receive daily iron/folic acid, iron/folic acid/zinc, or multiple

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2010 JAMA Controlled trial quality: predicted high

187. Effects of Taking Prenatal Vitamin-mineral Supplements During Lactation on Iron Status and Markers of Oxidation

Effects of Taking Prenatal Vitamin-mineral Supplements During Lactation on Iron Status and Markers of Oxidation Effects of Taking Prenatal Vitamin-mineral Supplements During Lactation on Iron Status and Markers of Oxidation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Effects of Taking Prenatal Vitamin-mineral Supplements During Lactation on Iron Status and Markers of Oxidation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01047098 Recruitment Status : Completed First Posted : January 12, 2010

2010 Clinical Trials

188. A Retrospective Analysis of Neevo® and NeevoDHA® Compared to a Standard Prenatal Vitamin in Anemia During Pregnancy

A Retrospective Analysis of Neevo® and NeevoDHA® Compared to a Standard Prenatal Vitamin in Anemia During Pregnancy A Retrospective Analysis of Neevo® and NeevoDHA® Compared to a Standard Prenatal Vitamin in Anemia During Pregnancy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. A Retrospective Analysis of Neevo® and NeevoDHA® Compared to a Standard Prenatal Vitamin in Anemia During Pregnancy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01193192 Recruitment Status : Terminated (Inadequate number

2010 Clinical Trials

189. A Retrospective Analysis of Neevo®/Neevo®DHA Compared to a Standard Prenatal Vitamin in Anemia During Pregnancy

A Retrospective Analysis of Neevo®/Neevo®DHA Compared to a Standard Prenatal Vitamin in Anemia During Pregnancy A Retrospective Analysis of Neevo®/Neevo®DHA Compared to a Standard Prenatal Vitamin in Anemia During Pregnancy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. A Retrospective Analysis of Neevo®/Neevo®DHA Compared to a Standard Prenatal Vitamin in Anemia During Pregnancy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01062958 Recruitment Status : Completed First Posted : February 4, 2010

2010 Clinical Trials

190. Vitamin A Deficiency in Pregnancy: Perspectives after Bariatric Surgery. (PubMed)

percentage of VAD in the postoperative period is a cause for concern, especially considering the function of this vitamin in certain biological moments and in moments of intense nutritional demand. This vitamin serum evaluation is recommended during the prenatal period. (...) Vitamin A Deficiency in Pregnancy: Perspectives after Bariatric Surgery. This study aims to describe the clinical consequences of vitamin A deficiency (VAD) in pregnant women after bariatric surgery. Included are studies on VAD during pregnancy and after bariatric surgery conducted in humans from 1993 to 2011. There are few investigations on the relationship between pregnancy and bariatric surgery and on the damage to the binomial mother-child resulting from VAD in this relationship. The high

2012 Obesity Surgery

191. Gestational Exposure to Urban Air Pollution Related to a Decrease in Cord Blood Vitamin D Levels. (PubMed)

Gestational Exposure to Urban Air Pollution Related to a Decrease in Cord Blood Vitamin D Levels. Vitamin D deficiency has been implicated in the increased risk of several diseases. Exposure to air pollution has been suggested as a contributor to vitamin D deficiency. However, studies that have examined the effects of air pollution on vitamin D status are few and have never focused on prenatal life as an exposure window.Our aim was to investigate the associations between gestational exposure (...) during pregnancy. Cord blood samples were collected at birth and were analyzed for levels of 25(OH)D.Maternal exposure to ambient urban levels of NO(2) and PM(10) during the whole pregnancy was a strong predictor of low vitamin D status in newborns. After adjustment, log-transformed 25(OH)D decreased by 0.15 U (P = 0.05) and 0.41 U (P = 0.04) for a 10-μg/m(3) increase in NO(2) and PM(10) pregnancy levels, respectively. The association was strongest for third-trimester exposures (P = 0.0003 and P

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2012 Journal of Clinical Endocrinology and Metabolism

192. The Effect Of Vitamin D On Measures Of Bone Health And Gene Expression

that 76% of mothers and 81% of newborns were vitamin D deficient despite the fact that the mother was taking a prenatal vitamin containing 400 IU vitamin D and drinking two glasses of milk a day. The investigators also reported 30-80% vitamin D deficiency rates in white and black children, healthy young, middle aged and older adults. There have been numerous epidemiologic and clinical observations relating vitamin D deficiency to many chronic diseases and there are many isolated but no comprehensive (...) The Effect Of Vitamin D On Measures Of Bone Health And Gene Expression The Effect Of Vitamin D On Measures Of Bone Health And Gene Expression - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effect

2012 Clinical Trials

193. Effect of Calcium Plus Vitamin D Supplementation on Adolescent Mother and Infant Bone Health

Effect of Calcium Plus Vitamin D Supplementation on Adolescent Mother and Infant Bone Health Effect of Calcium Plus Vitamin D Supplementation on Adolescent Mother and Infant Bone Health - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Effect of Calcium Plus Vitamin D Supplementation on Adolescent Mother and Infant Bone Health The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01732328 Recruitment Status : Unknown Verified November 2012 by Flavia Fioruci Bezerra, Rio de Janeiro State University. Recruitment

2012 Clinical Trials

194. Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function

Infant Wheeze In-utero Nicotine Second Hand Smoke Dietary Supplement: Vitamin C +prenatal vitamin Dietary Supplement: Placebo tablet+prenatal vitamin Phase 2 Phase 3 Detailed Description: Smoking during pregnancy remains a major public health problem as at least 12% of pregnant women cannot quit smoking during pregnancy. This addiction is the largest preventable cause of childhood respiratory illness, including asthma, and children whose mothers smoked during pregnancy show lifetime decreases (...) , in infants delivered to smoking mothers who are randomized to 500 mg/day of supplemental vitamin C versus placebo at less than or equal to 22 weeks of pregnancy. We will recruit 278 smoking pregnant women into the study. Patients will meet with research personnel at each prenatal visit and smoking cessation will be actively encouraged. Patients will be monitored with a set of serial biomarkers to assess smoking and medication compliance, including urine cotinine levels, smoking questionnaires, pill

2012 Clinical Trials

195. Predictors of anaemia and iron deficiency in HIV-infected pregnant women in Tanzania: a potential role for vitamin D and parasitic infections. (PubMed)

Predictors of anaemia and iron deficiency in HIV-infected pregnant women in Tanzania: a potential role for vitamin D and parasitic infections. Anaemia is common during pregnancy, and prenatal Fe supplementation is the standard of care. However, the persistence of anaemia despite Fe supplementation, particularly in HIV infection, suggests that its aetiology may be more complex and warrants further investigation. The present study was conducted to examine predictors of incident haematological (...) outcomes in HIV-infected pregnant women in Tanzania.Prospective cohort study. Cox proportional hazards and binomial regression models were used to identify predictors of incident haematological outcomes: anaemia (Hb < 110 g/l), severe anaemia (Hb < 85 g/l) and hypochromic microcytosis, during the follow-up period.Antenatal clinics in Dar es Salaam, Tanzania.Participants were 904 HIV-infected pregnant women enrolled in a randomized trial of vitamins (1995-1997).Malaria, pathogenic protozoan and hookworm

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2012 Public health nutrition Controlled trial quality: uncertain

196. Iron, folate and vitamin B12 levels in first trimester pregnancies in the Southwest region of Turkey (PubMed)

and vegetables is commonly consumed.Two hundred and one low-middle income pregnant women were recruited during their first prenatal visit. Hemoglobin, ferritin, folate and vitamin B12 levels were evaluated and a structured questionnaire was given to gather information including age, gravida, parity, frequency of pregnancy, history of abortion, and intrauterine device usage. Based on WHO and international guidelines, anemia was defined as hemoglobin <11 g/dl, and iron deficiency as ferritin <15 μg/L. Serum (...) Iron, folate and vitamin B12 levels in first trimester pregnancies in the Southwest region of Turkey Iron, folate and vitamin B12 play important roles in the healthy development of the fetus in pregnancy. Preconceptional levels of these micronutrients is influenced by dietary habits. The purpose of this study was to investigate the status of iron, vitamin B12 and folate in first trimester pregnancies in the southwest region of Turkey where the Mediterranean Cuisine, rich in fresh fruit

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2011 Journal of the Turkish German Gynecological Association

197. Routine screening for vitamin D deficiency in early pregnancy: past its due date? (PubMed)

Prenatal Care Vitamin D Deficiency prevention & control 2011 4 8 6 0 2011 4 8 6 0 2011 6 3 6 0 ppublish 21470080 ebl10010_fm (...) Routine screening for vitamin D deficiency in early pregnancy: past its due date? 21470080 2011 06 02 2011 11 09 1326-5377 194 7 2011 Apr 04 The Medical journal of Australia Med. J. Aust. Routine screening for vitamin D deficiency in early pregnancy: past its due date? 332-3 Ebeling Peter R PR eng Comment Editorial Australia Med J Aust 0400714 0025-729X IM Med J Aust. 2011 Oct 3;195(7):384-5 21978339 Med J Aust. 2011 Apr 4;194(7):334-7 21470081 Australia Female Humans Mass Screening Pregnancy

2011 Medical Journal of Australia

198. Vitamin D status during pregnancy: maternal, fetal, and postnatal outcomes. (PubMed)

, and periodontal disease had lower vitamin D status at mid-gestation or delivery compared with controls. Maternal vitamin D status early in pregnancy was associated with risk of low birth weight and small-for-gestational age infants in one study, whereas another study found this relation only among white women. Polymorphisms in the vitamin D receptor gene may contribute to vitamin D-related disparities in fetal growth. Evidence from recent studies suggests an early prenatal influence of maternal vitamin D (...) Vitamin D status during pregnancy: maternal, fetal, and postnatal outcomes. To consider evidence from recent studies linking maternal vitamin D status during pregnancy with maternal, fetal, and postnatal outcomes.Several studies have demonstrated an association between poor maternal vitamin D status and severe preeclampsia, though results are inconsistent and cannot be generalized to nonsevere preeclampsia. Pregnant women with gestational diabetes, intrahepatic cholestasis of pregnancy

2011 Current Opinion in Obstetrics and Gynecology

199. Effects of Vitamin D Supplementation During Pregnancy on Clinical Outcomes and Immune Function

Actual Study Completion Date : May 2013 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Placebo Comparator: 400 IU Vitamin D3 Women in this study arm receive 400 IU of vitamin D3 per day, or what is in a standard prenatal multivitamin. They also receive a placebo study supplement. Dietary Supplement: 400 IU vitamin D3 Women in this study arm receive 400 IU of vitamin D3 per day, or what is in a standard (...) prenatal multivitamin. They also receive a placebo study supplement. Experimental: 2,000 IU Vitamin D3 Women in this arm receive 2,000 IU vitamin D per day: 400 IU from a standard prenatal multivitamin plus an additional 1,600 IU vitamin D3 in the study supplement. Dietary Supplement: 2,000 IU Vitamin D3 Women in this arm receive 2,000 IU vitamin D per day: 400 IU from a standard prenatal multivitamin plus an additional 1,600 IU vitamin D3 in the study supplement. Outcome Measures Go to Primary Outcome

2011 Clinical Trials

200. Vitamin K does not prevent soft tissue mineralization in a mouse model of pseudoxanthoma elasticum (PubMed)

in the regulation of mineralization processes as a co-factor in the carboxylation of calcification inhibitors such as Matrix Gla Protein (MGP). Vitamin K precursor or a conjugated form has been proposed as potential substrate(s) for ABCC6. We investigated whether an enriched diet of vitamin K1 or vitamin K2 (MK4) could stop or slow the disease progression in Abcc6 (-/-) mice. Abcc6 (-/-) mice were placed on a diet of either vitamin K1 or MK4 at 5 or 100 mg/kg at prenatal, 3 weeks or 3 months of age. Disease (...) Vitamin K does not prevent soft tissue mineralization in a mouse model of pseudoxanthoma elasticum Pseudoxanthoma elasticum (PXE) is a heritable disease characterized by calcified elastic fibers in cutaneous, ocular, and vascular tissues. PXE is caused by mutations in ABCC6, which encodes a protein of the ATP-driven organic anion transporter family. The inability of this transporter to secrete its substrate into the circulation is the likely cause of PXE. Vitamin K plays a role

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2011 Cell Cycle

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