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Prenatal Vitamin

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1. Prenatal vitamin D supplementation and infant vitamin D status in Bangladesh. (PubMed)

Prenatal vitamin D supplementation and infant vitamin D status in Bangladesh. To determine the effect of prenatal maternal vitamin D supplementation on infant vitamin D status in a tropical region where vitamin D supplementation is not routine.A prospective observational follow-up of a randomized trial.Maternal-child health facility in Dhaka, Bangladesh (23°N).Infants born to pregnant women (n 160) randomized to receive 875 µg (35 000 IU) cholecalciferol (vitamin D3) per week (VD) or placebo (...) infant 25(OH)D increased to 78 (95 % CI 67, 88) nmol/l by 6 months of age (n 34). 25(OH)D was higher with infant formula-feeding and higher in summer v. winter.Prenatal third-trimester vitamin D supplementation (875 µg (35 000 IU)/week) significantly ameliorated infant vitamin D status during the neonatal period when the risk of vitamin D deficiency is greatest. Further research is warranted to determine factors that contribute to the rise in 25(OH)D during the first 6 months of life among breast-fed

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2018 Public health nutrition Controlled trial quality: uncertain

2. Association of Maternal Prenatal Vitamin Use With Risk for Autism Spectrum Disorder Recurrence in Young Siblings. (PubMed)

Association of Maternal Prenatal Vitamin Use With Risk for Autism Spectrum Disorder Recurrence in Young Siblings. Maternal use of folic acid supplements has been inconsistently associated with reduced risk for autism spectrum disorder (ASD) in the child. No study to date has examined this association in the context of ASD recurrence in high-risk families.To examine the association between maternal prenatal vitamin use and ASD recurrence risk in younger siblings of children with ASD.This (...) December 1, 2006, and June 30, 2015, and completed a final clinical assessment within 6 months of their third birthday. Prenatal vitamin use during pregnancy was reported by mothers during telephone interviews. Data analysis for this study was conducted from January 1, 2017, to December 3, 2018.Autism spectrum disorder, other nontypical development (non-TD), and typical development (TD) were algorithmically defined according to Autism Diagnostic Observation Schedule and Mullen Scales of Early Learning

2019 JAMA psychiatry (Chicago, Ill.)

3. Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". (PubMed)

Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". 30202903 2018 12 19 1945-7197 104 2 2019 Feb 01 The Journal of clinical endocrinology and metabolism J. Clin. Endocrinol. Metab. Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". 337-338 10.1210/jc.2018-01731 Shub Alexis A Department of Obstetrics and Gynecology

2019 The Journal of clinical endocrinology and metabolism Controlled trial quality: uncertain

4. Response to Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". (PubMed)

Response to Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". 30202978 2018 12 19 1945-7197 104 2 2019 Feb 01 The Journal of clinical endocrinology and metabolism J. Clin. Endocrinol. Metab. Response to Letter to the Editor: "Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial". 339-340 10.1210/jc.2018-01799 Ramezani Tehrani Fahimeh F

2019 The Journal of clinical endocrinology and metabolism Controlled trial quality: uncertain

5. Prenatal vitamin D and cord blood insulin-like growth factors in Dhaka, Bangladesh. (PubMed)

Prenatal vitamin D and cord blood insulin-like growth factors in Dhaka, Bangladesh. Fetal growth restriction is linked to adverse health outcomes and is prevalent in low- and middle-income countries; however, determinants of fetal growth are still poorly understood. The objectives were to determine the effect of prenatal vitamin D supplementation on the insulin-like growth factor (IGF) axis at birth, to compare concentrations of IGF-I in newborns in Bangladesh to a European reference population (...) was negatively associated with birth anthropometry. In conclusion, prenatal vitamin D supplementation does not alter or enhance fetal IGF pathways.

2019 Endocrine connections Controlled trial quality: uncertain

6. Vitamin D supplementation in pregnancy, prenatal 25(OH)D levels, race, and subsequent asthma or recurrent wheeze in offspring: Secondary analyses from the Vitamin D Antenatal Asthma Reduction Trial. (PubMed)

Vitamin D supplementation in pregnancy, prenatal 25(OH)D levels, race, and subsequent asthma or recurrent wheeze in offspring: Secondary analyses from the Vitamin D Antenatal Asthma Reduction Trial. Nutrient trials differ from drug trials because participants have varying circulating levels at entry into the trial.We sought to study the effect of a vitamin D intervention in pregnancy between subjects of different races and the association between 25-hydroxyvitamin D3 (25[OH]D) levels (...) in pregnancy and the risk of asthma/recurrent wheeze in offspring.The Vitamin D Antenatal Asthma Reduction Trial is a randomized trial of pregnant women at risk of having children with asthma randomized to 4400 international units/d vitamin D or placebo plus 400 international units/d vitamin D. Asthma and recurrent wheezing until age 3 years were recorded.African American (AA) women (n = 312) had lower initial levels of 25(OH)D (mean [SD], 17.6 ng/mL [8.3 ng/mL]) compared with non-AA women (n = 400; 27.1

2017 Journal of Allergy and Clinical Immunology Controlled trial quality: predicted high

7. Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta-analysis of observational studies. (PubMed)

Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta-analysis of observational studies. Prenatal vitamin D status may influence offspring's respiratory and allergic outcomes; however, evidence is inconclusive. A systematic review and meta-analysis were conducted on the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or cord blood at birth with the risk of offspring's respiratory and allergic conditions.Two independent (...) researchers conducted systematic searches for observational studies published until May 2017 using defined keywords on vitamin D and health outcomes, including respiratory tract infections (RTIs), wheeze, asthma, atopic eczema, allergic rhinitis, allergic sensitization, and lung function. Random-effects meta-analyses were conducted.A total of 34 from 547 retrieved articles were included. Increased prenatal exposure to 25(OH)D was inversely associated with risk of RTIs. Comparing the highest

2018 Pediatric Allergy and Immunology

8. Prenatal vitamin D status and offspring's growth, adiposity and metabolic health: a systematic review and meta-analysis.

Prenatal vitamin D status and offspring's growth, adiposity and metabolic health: a systematic review and meta-analysis. In this systematic review and meta-analysis of observational studies, we aimed to estimate the associations between prenatal vitamin D status and offspring growth, adiposity and metabolic health. We searched the literature in human studies on prenatal vitamin D status and offspring growth in PubMed, up to July 2017. Studies were selected according to their methodological (...) status was based on each study's cut-off for low 25(OH)D levels. Low prenatal vitamin D levels were associated with lower birth weight (g) (MD -100·69; 95 % CI -162·25, -39·13), increased risk of small-for-gestational-age (OR 1·55; 95 % CI 1·16, 2·07) and an elevated weight (g) in infant at the age of 9 months (g) (MD 119·75; 95 % CI 32·97, 206·52). No associations were observed between prenatal vitamin D status and other growth parameters at birth, age 1 year, 4-6 years or 9 years, nor with diabetes

2018 The British journal of nutrition

9. Maternal Vitamin D Prevents Abnormal Dopaminergic Development and Function in a Mouse Model of Prenatal Immune Activation (PubMed)

Maternal Vitamin D Prevents Abnormal Dopaminergic Development and Function in a Mouse Model of Prenatal Immune Activation Dysfunction in dopamine (DA) systems is a prominent feature in schizophrenia patients and may result from the abnormal development of mesencephalic (mes)DA systems. Maternal immune activation (MIA) and developmental vitamin D (DVD)-deficiency both induce schizophrenia-relevant dopaminergic abnormalities in adult offspring. In this study, we investigated whether maternal (...) administration of the vitamin D hormone (1,25OHD, VITD) could prevent MIA-induced abnormalities in DA-related behaviors and mesDA development. We administrated the viral mimetic polyriboinosinic-polyribocytidylic (poly (I:C)) simultaneously with 1,25OHD and/or their vehicles, to pregnant mouse dams at gestational day 9. Maternal treatment with VITD prevented MIA-induced hypersensitivity to acute DA stimulation induced by amphetamine, whereas it failed to block prepulse inhibition deficiency in MIA-exposed

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2018 Scientific reports

10. the Effect of Prenatal Vitamins on the Tooth Structure

the Effect of Prenatal Vitamins on the Tooth Structure the Effect of Prenatal Vitamins on the Tooth Structure - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. the Effect of Prenatal Vitamins on the Tooth (...) by (Responsible Party): Dina mounir elkady, Cairo University Study Details Study Description Go to Brief Summary: the effect of mother prenatal care on the teeth of the newborn children, if it affect the tooth structure or not Condition or disease Intervention/treatment Dental Caries Other: intervention Detailed Description: teeth lost due to normal shedding will be collected,it will be classified into mother that take pregnancy vitamins and mother that doesn't take pregnancy vitamins, the female will be from

2018 Clinical Trials

11. The Prevalence of Vitamin A Deficiency and Associated Factors in Pregnant Women Receiving Prenatal Care at a Reference Maternity Hospital in Northeastern Brazil (PubMed)

The Prevalence of Vitamin A Deficiency and Associated Factors in Pregnant Women Receiving Prenatal Care at a Reference Maternity Hospital in Northeastern Brazil Vitamin A is essential for mother and child; however, vitamin A deficiency (VAD) remains a public health issue in various countries, affecting around 19 million pregnant women. In Brazil, the scarcity and inconsistency of data have prevented the prevalence and epidemiological status of VAD from being established. This study aimed (...) to analyze vitamin A nutritional status in women receiving prenatal care at a reference center in northeastern Brazil. A cross-sectional study was conducted with a sample of 676 women. Serum retinol was measured by high-performance liquid chromatography. Subclinical infection was detected by measuring C-reactive protein (CRP). The World Health Organization criteria were used in the prevalence analysis, VAD classification level, and CRP effect evaluation. The prevalence of VAD (serum retinol <0.70 μmol/L

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2018 Nutrients

12. Heavy metal contamination of prenatal vitamins (PubMed)

Heavy metal contamination of prenatal vitamins Prenatal vitamins are often consumed daily during gestation and postnatally for up to 18-24 months with the belief that supplementation achieves better outcomes. Detrimental effects of gestational exposure to adverse chemical agents are gathering increasing attention. This study was designed to assess toxic element contamination in prenatal supplements. Twenty-six commonly used prenatal vitamin brands including one prescription brand were collected (...) and Thallium were detected in all samples. Cumulative intake of prenatal supplement over many months may constitute a significant source of toxic element exposure to the mother and offspring. With several samples exceeding known standards for gestational toxic element exposure, guidelines for routine monitoring and reporting are required. In keeping with recommendations from the International Federation of Obstetrics and Gynecology, industry regulation would be welcomed to protect expectant mothers

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2018 Toxicology reports

13. Impact of Parental Asthma, Prenatal Maternal Asthma Control and Vitamin D Status on Risk of Asthma and Recurrent Wheeze in 3-Year Old Children. (PubMed)

Impact of Parental Asthma, Prenatal Maternal Asthma Control and Vitamin D Status on Risk of Asthma and Recurrent Wheeze in 3-Year Old Children. While familial clustering of asthma is known, few studies have reported on the relative roles of paternal and maternal asthma and the role of maternal asthma control in pregnancy on the risk for asthma in the child.We aimed to investigate the relative roles of paternal asthma, maternal asthma, and maternal asthma control during pregnancy on the risk (...) of asthma or recurrent wheeze in 3-year-old children and how prenatal and cord blood vitamin D status might affect this risk.Data from 806 women, their partners (biologic fathers of the infants), and their children participated in the Vitamin D Antenatal Asthma Reduction Trail (VDAART, clinicaltrials.gov identification number NCT00920621) were used for this cohort analysis. The parental report of physician-diagnosed asthma or recurrent wheeze in offspring was the main outcome. Weibull regression models

2018 Clinical and Experimental Allergy

14. Effectiveness of prenatal vitamin D deficiency screening and treatment program: a stratified randomized field trial. (PubMed)

Effectiveness of prenatal vitamin D deficiency screening and treatment program: a stratified randomized field trial. Despite evidence on the association between hypovitaminosis D and adverse pregnancy outcomes and the positive impact of vitamin D supplementation, no evidence exists supporting a universal screening program in pregnancy as part of routine prenatal care.We sought to determine the effectiveness of a prenatal screening program on optimizing 25-hydroxyvitamin D [25(OH)D] levels (...) %, and 40%, respectively, in the screening site. A D3 injection in addition to monthly 50,000 IU maintenance therapy contributed the most to achievement of sufficient levels at delivery.A prenatal vitamin D screening and treatment program is an effective approach in detecting deficient women, improving 25(OH)D levels, and decreasing pregnancy adverse outcomes.

2018 Journal of Clinical Endocrinology and Metabolism Controlled trial quality: uncertain

15. Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial. (PubMed)

Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial. Asthma and wheezing begin early in life, and prenatal vitamin D deficiency has been variably associated with these disorders in offspring.To determine whether prenatal vitamin D (cholecalciferol) supplementation can prevent asthma or recurrent wheeze in early childhood.The Vitamin D Antenatal Asthma Reduction Trial was a randomized, double-blind (...) , placebo-controlled trial conducted in 3 centers across the United States. Enrollment began in October 2009 and completed follow-up in January 2015. Eight hundred eighty-one pregnant women between the ages of 18 and 39 years at high risk of having children with asthma were randomized at 10 to 18 weeks' gestation. Five participants were deemed ineligible shortly after randomization and were discontinued.Four hundred forty women were randomized to receive daily 4000 IU vitamin D plus a prenatal vitamin

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2016 JAMA Controlled trial quality: predicted high

16. Current Recommended Vitamin D Prenatal Supplementation and Fetal Growth: Results from China-Anhui Birth Cohort Study. (PubMed)

Current Recommended Vitamin D Prenatal Supplementation and Fetal Growth: Results from China-Anhui Birth Cohort Study. Maternal vitamin D insufficiency has been associated with fetal growth restriction. However, the effect of maternal vitamin D supplementation on fetal growth has not been confirmed.To assess the effect of maternal vitamin D supplementation recommended by the Institute of Medicine (IOM) during pregnancy on the neonatal vitamin D status and the risk of small for gestational age (...) (SGA).As part of the China-Anhui Birth Cohort study, maternal sociodemographic characteristics, food intake, lifestyle, information on vitamin D supplementation, and birth outcomes were prospectively collected. For participants, 600 IU/d of vitamin D3 was routinely advised to take during pregnancy. Cord blood levels of 25-hydroxyvitamin D [25(OH)D], calcium, and phosphorus were measured in 1491 neonates who were divided into three groups based on the duration of maternal vitamin D supplementation

2017 Journal of Clinical Endocrinology and Metabolism

17. Iodine Contents in Prenatal Vitamins in the U.S. (PubMed)

Iodine Contents in Prenatal Vitamins in the U.S. 28599614 2018 10 18 2018 11 13 1557-9077 27 8 2017 08 Thyroid : official journal of the American Thyroid Association Thyroid Iodine Contents in Prenatal Vitamins in the United States. 1101-1102 10.1089/thy.2017.0097 Lee Sun Y SY 1 Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine , Boston, Massachusetts. Stagnaro-Green Alex A 2 Department of Obstetrics and Gynecology and Medical Education, University (...) United States Thyroid 9104317 1050-7256 0 Vitamins 9679TC07X4 Iodine IM Dietary Supplements Female Humans Iodine analysis Pregnancy Prenatal Care United States Vitamins chemistry 2017 6 11 6 0 2018 10 20 6 0 2017 6 11 6 0 ppublish 28599614 10.1089/thy.2017.0097 PMC5912719 Public Health Nutr. 2007 Dec;10(12A):1606-11 18053287 N Engl J Med. 2009 Feb 26;360(9):939-40 19246372 Thyroid. 2017 Mar;27(3):315-389 28056690

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2017 Thyroid

18. Low maternal prenatal 25-hydroxy vitamin D blood levels are associated with childhood atopic dermatitis (PubMed)

Low maternal prenatal 25-hydroxy vitamin D blood levels are associated with childhood atopic dermatitis 28202402 2018 08 22 2018 11 13 1523-1747 137 6 2017 06 The Journal of investigative dermatology J. Invest. Dermatol. Low Maternal Prenatal 25-Hydroxyvitamin D Blood Levels Are Associated with Childhood Atopic Dermatitis. 1380-1384 S0022-202X(17)30174-4 10.1016/j.jid.2017.01.029 Blomberg Maria M Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute (...) 1406-16-2 Vitamin D A288AR3C9H 25-hydroxyvitamin D IM Biomarkers blood Child Child, Preschool Cohort Studies Confidence Intervals Dermatitis, Atopic blood physiopathology Female Fetal Blood metabolism Humans Male Odds Ratio Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Prenatal Care Prognosis Retrospective Studies Risk Assessment Vitamin D administration & dosage analogs & derivatives blood 2016 08 19 2017 01 11 2017 01 24 2017 2 17 6 0 2018 8 23 6 0 2017 2 17 6 0 ppublish

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2017 The Journal of investigative dermatology

19. Effect of Prenatal versus Postnatal Vitamin D Deficiency on Pulmonary Structure and Function in Mice (PubMed)

Effect of Prenatal versus Postnatal Vitamin D Deficiency on Pulmonary Structure and Function in Mice Epidemiologic studies have linked gestational vitamin D deficiency to respiratory diseases, although mechanisms have not been defined. We hypothesized that antenatal vitamin D deficiency would impair airway development and alveolarization in a mouse model. We studied the effect of antenatal vitamin D deficiency by inducing it in pregnant mice and then compared lung development and function (...) in their offspring to littermate controls. Postnatal vitamin D deficiency and sufficiency models from each group were also studied. We developed a novel tracheal ultrasound imaging technique to measure tracheal diameter in vivo. Histological analysis estimated tracheal cartilage total area and thickness. We found that vitamin D-deficient pups had reduced tracheal diameter with decreased tracheal cartilage minimal width. Vitamin D deficiency increased airway resistance and reduced lung compliance, and led

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2017 American journal of respiratory cell and molecular biology

20. Erratum for Ziaei et al. A prenatal multiple micronutrient supplement produces higher maternal vitamin B-12 concentrations and similar folate, ferritin, and zinc concentrations as the standard 60-mg iron plus 400-μg folic acid supplement in rural Banglad (PubMed)

Erratum for Ziaei et al. A prenatal multiple micronutrient supplement produces higher maternal vitamin B-12 concentrations and similar folate, ferritin, and zinc concentrations as the standard 60-mg iron plus 400-μg folic acid supplement in rural Banglad 28373594 2017 12 14 1541-6100 147 4 2017 04 The Journal of nutrition J. Nutr. Erratum for Ziaei et al. A prenatal multiple micronutrient supplement produces higher maternal vitamin B-12 concentrations and similar folate, ferritin, and zinc

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2017 The Journal of nutrition

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