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Premature Rupture of Membranes

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141. AmniSure versus Fern Testing to Assess the Rupture of Fetal Membranes in Pregnant Women: A Review of the Comparative Accuracy, Cost-Effectiveness, and Guidelines

. 2006 Aug;23(6):351-4. 3. Di Renzo GC, Roura LC, Facchinetti F, Antsaklis A, Breborowicz G, Gratacos E, et al. Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth. J Matern Fetal Neonatal Med [Internet]. 2011 May [cited 2012 Mar 12];24(5):659-67. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267524/pdf/djmf24-659.pdf 4. El-Messidi A, Cameron (...) preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth. J Matern Fetal Neonatal Med [Internet]. 2011 May [cited 2012 Apr 02];24(5):659- 67. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267524 Term pre-labour rupture of membranes (PROM) guideline [Internet]. Version 2.4. Clayton (AU): Southern Health; 2009 [cited 2012 Mar 15]. Available from: http://www.southernhealth.org.au/icms_docs

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

142. Nitric Oxide Donor Isosorbide Mono Nitrate for Induction of Labor With Pre-labor Rupture of Membranes

(IPD) Sharing Statement: Plan to Share IPD: No Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Rupture Fetal Membranes, Premature Rupture Wounds and Injuries Obstetric Labor Complications Pregnancy Complications Nitric Oxide Isosorbide Dinitrate Isosorbide-5-mononitrate Isosorbide Nitric Oxide Donors Pyridoxine Pyridoxal Vitamin B 6 Bronchodilator Agents (...) Nitric Oxide Donor Isosorbide Mono Nitrate for Induction of Labor With Pre-labor Rupture of Membranes Nitric Oxide Donor Isosorbide Mono Nitrate for Induction of Labor With Pre-labor Rupture of Membranes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2018 Clinical Trials

143. Collagen Type 1 Accelerates Healing of Ruptured Fetal Membranes Full Text available with Trip Pro

Collagen Type 1 Accelerates Healing of Ruptured Fetal Membranes Preterm premature rupture of membranes (pPROM) is a major cause of preterm birth. Recently, extracellular matrix-directed treatment is applied for wound healing. Here, we used a pregnant mouse model to test the efficacy of collagen type 1 gel for healing of the prematurely ruptured fetal membranes. Although injection of PBS into the ruptured fetal membranes resulted in 40% closure, injection of collagen type 1 improved closure

2018 Scientific reports

144. ACOG Practice Bulletin No. 188 Summary: Prelabor Rupture of Membranes. (Abstract)

ACOG Practice Bulletin No. 188 Summary: Prelabor Rupture of Membranes. Preterm delivery occurs in approximately 12% of all births in the United States and is a major factor that contributes to perinatal morbidity and mortality (1, 2). Preterm prelabor rupture of membranes (also referred to as premature rupture of membranes) (PROM) complicates approximately 3% of all pregnancies in the United States (3). The optimal approach to clinical assessment and treatment of women with term and preterm

2018 Obstetrics and Gynecology

145. ACOG Practice Bulletin No. 188: Prelabor Rupture of Membranes. (Abstract)

ACOG Practice Bulletin No. 188: Prelabor Rupture of Membranes. Preterm delivery occurs in approximately 12% of all births in the United States and is a major factor that contributes to perinatal morbidity and mortality (1, 2). Preterm prelabor rupture of membranes (also referred to as premature rupture of membranes) (PROM) complicates approximately 3% of all pregnancies in the United States (3). The optimal approach to clinical assessment and treatment of women with term and preterm PROM

2018 Obstetrics and Gynecology

146. Early-onset neonatal infection in pregnancies with prelabor rupture of membranes in Kosovo: A major challenge Full Text available with Trip Pro

and their newborns. Participant demographics included: the majority were young, aged between 20 and 29 years (67%), primiparous (67.5%), unemployed (92%), completed secondary level of education (83%), and with middle socioeconomic status (86%). Overall, 13% of the newborns had early-onset neonatal infection, and sepsis was proven in 5% of cases. Newborns of mothers with risk factors such as preterm (<37 weeks) PROM, low gestational weight at birth, prolonged rupture of membranes, maternal colonization, and low (...) Early-onset neonatal infection in pregnancies with prelabor rupture of membranes in Kosovo: A major challenge Prelabor rupture of membranes (PROM) is a common event in obstetrics that has a major impact in pregnancy outcome. This condition is linked to a number of pregnancy and birth complications with early-onset neonatal infection (EONI) being one of the major threats. This study was undertaken to determine the rate of neonatal infection in newborn infants with a maternal history of PROM

2018 Turkish Journal of Obstetrics and Gynecology

147. Persistent microbial dysbiosis in preterm premature rupture of membranes from onset until delivery Full Text available with Trip Pro

Persistent microbial dysbiosis in preterm premature rupture of membranes from onset until delivery Background. Preterm Premature Rupture of Membranes (PPROM) is a major leading cause of preterm births. While the cause for PPROM remains unidentified, it is anticipated to be due to subclinical infection, since a large proportion of PPROM patients display signs of chorioamnionitis. Since subclinical infections can be facilitated by dysbiosis, our goal was to characterize the vaginal microbiome (...) further investigation into mitigating approaches. Discussion. PPROM is responsible for one third of all preterm births. It is thought that subclinical infection is a crucial factor in the pathophysiology of PPROM because 25-40% of patients present signs of chorioamnionitis on amniocentesis. Here we sought to directly assess the bacterial content of the vagina and leaking amniotic fluid of subjects at presentation, throughout treatment and up until delivery, in order to search for common pathogens

2015 PeerJ

148. Pilot Randomized Controlled Trial to Evaluate the Impact of Bed Rest on Maternal and Fetal Outcomes in Women with Preterm Premature Rupture of the Membranes. (Abstract)

Pilot Randomized Controlled Trial to Evaluate the Impact of Bed Rest on Maternal and Fetal Outcomes in Women with Preterm Premature Rupture of the Membranes. Preterm premature rupture of the membranes (PPROM) is spontaneous rupture of membranes before 37 weeks' gestation before the onset of labor. The standard of care is inpatient management with antibiotics and monitoring. Bed rest has not been shown to be beneficial in the setting of PPROM and has adverse maternal effects. We conducted

2015 American journal of perinatology Controlled trial quality: predicted high

149. Short-Term and Long-Term Postnatal Outcomes of Expectant Management After Previable Preterm Premature Rupture of Membranes With and Without Persistent Oligohydramnios. (Abstract)

Short-Term and Long-Term Postnatal Outcomes of Expectant Management After Previable Preterm Premature Rupture of Membranes With and Without Persistent Oligohydramnios. To compare postnatal outcomes in pregnancies managed expectantly after previable preterm premature rupture of membranes (PROM) in relation to amniotic fluid volume.A retrospective cohort study was performed in 92 women with amniotic fluid leakage for more than a week after previable preterm PROM (gestational age 14 1/7-24 0/7 (...) weeks) who delivered a liveborn neonate at or after 24 1/7 weeks of gestation from 2002 to 2014. Short-term (sepsis, intracerebral hemorrhage, retinopathy of prematurity, respiratory distress syndrome, bronchopulmonary dysplasia) and long-term (cerebral palsy and developmental delay) outcomes were compared between women with (n=58) and without persistent oligohydramnios (n=34), defined as maximal vertical pocket less than 2 cm or amniotic fluid index less than 5 cm. We analyzed discrete data using

2015 Obstetrics and Gynecology

150. Behavioural and neurodevelopmental outcome of 2-year-old children after preterm premature rupture of membranes: follow-up of a randomised clinical trial comparing induction of labour and expectant management. (Abstract)

Behavioural and neurodevelopmental outcome of 2-year-old children after preterm premature rupture of membranes: follow-up of a randomised clinical trial comparing induction of labour and expectant management. We recently reported that induction of labour does not improve short term neonatal outcome in women with late preterm premature rupture of membranes (PPROM) as compared to expectant management (PPROMEXIL trial). In this study the neurodevelopmental and behavioural outcome of the children (...) from this trial at 2 years of age was studied.We studied outcome of offspring of women randomised in the PPROMEXIL study. These women had >24h of ruptured membranes and were between 34 and 37 weeks of pregnancy when they were randomised to induction of labour (IoL) or expectant management (EM). Two years after delivery, the parents received the ages and stages questionnaire (ASQ), the child behaviour checklist (CBCL) and a general questionnaire.Follow-up data were obtained from 234 children (121

2015 European journal of obstetrics, gynecology, and reproductive biology Controlled trial quality: uncertain

151. Effect of magnesium sulfate administration for neuroprotection on latency in women with preterm premature rupture of membranes. Full Text available with Trip Pro

Effect of magnesium sulfate administration for neuroprotection on latency in women with preterm premature rupture of membranes. This study aims to evaluate whether magnesium sulfate administration for neuroprotection prolongs latency in women with preterm premature rupture of membranes (PPROM) between 24 and 31(6/7) weeks' gestation.This is a secondary analysis of a randomized controlled trial of magnesium sulfate for prevention of cerebral palsy. Gravid women with a singleton pregnancy between (...) , necrotizing enterocolitis, retinopathy of prematurity, or death.A total of 1,259 women were included. The rate of delivery < 48 hours was not different in the magnesium sulfate and the placebo groups (22.2 and 20.7%, p = 0.51). Delivery < 7 days was similar between groups (55.4 and 51.4%, p = 0.16). Median latency was also similar between groups (median [interquartile range], 6.0 days [range, 2.4-13.8 days] and 6.6 days [range, 2.4-15.1 days], p = 0.29). Composite neonatal outcomes did not differ between

2015 American journal of perinatology Controlled trial quality: predicted high

152. Antenatal corticosteroids for preterm premature rupture of membranes: single or repeat course? Full Text available with Trip Pro

Antenatal corticosteroids for preterm premature rupture of membranes: single or repeat course? The aim of this article is to determine the risk of maternal chorioamnionitis and neonatal morbidity in women with preterm premature rupture of membranes (PPROM) exposed to one corticosteroid course versus a single repeat corticosteroid steroid course.Secondary analysis of a cohort of women with singleton pregnancies and PPROM. The primary outcome was a clinical diagnosis of maternal chorioamnionitis (...) . Using multivariate logistic regression, we controlled for maternal age, race, body mass index, diabetes, gestational age at membrane rupture, preterm labor, and antibiotic administration. Neonatal morbidities were compared between groups controlling for gestational age at delivery.Of 1,652 women with PPROM, 1,507 women received one corticosteroid course and 145 women received a repeat corticosteroid course. The incidence of chorioamnionitis was similar between groups (single course = 12.3% vs

2015 American journal of perinatology Controlled trial quality: uncertain

153. The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes

The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02635451 Recruitment Status : Unknown Verified December 2015 by Mohamed Hussein Mostafa, Ain Shams Maternity

2015 Clinical Trials

154. Preterm Premature Rupture of Membranes, Outpatient Management vs Inpatient Management

Preterm Premature Rupture of Membranes, Outpatient Management vs Inpatient Management Preterm Premature Rupture of Membranes, Outpatient Management vs Inpatient Management - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Preterm Premature Rupture of Membranes, Outpatient Management vs Inpatient Management The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02548013 Recruitment Status : Unknown Verified September 2015 by dina mostafa ibrahim, Ain Shams Maternity Hospital. Recruitment status was: Recruiting

2015 Clinical Trials

155. Transvaginal Cervical length and Amniotic Fluid Index: Can it predict delivery latency following Preterm Premature Rupture of Membranes? (Abstract)

Transvaginal Cervical length and Amniotic Fluid Index: Can it predict delivery latency following Preterm Premature Rupture of Membranes? We sought to determine whether transvaginal cervical length (TVCL), amniotic fluid index (AFI), or a combination of both can predict delivery latency within 7 days in women presenting with preterm premature rupture of membranes (PPROM).This was a prospective observational study of TVCL measurements in 106 singleton pregnancies with PPROM between 23-33 weeks

2015 American Journal of Obstetrics and Gynecology

156. Planned home versus hospital care for preterm prelabour rupture of the membranes (PPROM) prior to 37 weeks' gestation. Full Text available with Trip Pro

Planned home versus hospital care for preterm prelabour rupture of the membranes (PPROM) prior to 37 weeks' gestation. Preterm prelabour rupture of membranes (PPROM) is associated with increased risk of maternal and neonatal morbidity and mortality. Women with PPROM have been predominantly managed in hospital. It is possible that selected women could be managed at home after a period of observation. The safety, cost and women's views about home management have not been established.To assess

2010 Cochrane

157. Management of late-preterm premature rupture of membranes: the PPROMEXIL-2 trial (Abstract)

Management of late-preterm premature rupture of membranes: the PPROMEXIL-2 trial The evidence for the management of near term prelabor rupture of membranes is poor. From January 2007 until September 2009, we performed the PPROM Expectant Management versus Induction of Labor (PPROMEXIL) trial. In this trial, we showed that in women with preterm prelabor rupture of membranes (PPROM), the incidence of neonatal sepsis was low, and the induction of labor (IoL) did not reduce this risk. Because

2012 EvidenceUpdates Controlled trial quality: predicted high

158. Periodontal pathogens in the placenta and membranes in term and preterm birth. (Abstract)

between the groups fetal risk factors or co-morbidities, except the preterm group had a significantly higher (p=<0.05) rate of premature rupture of membrane (PROM). There were significantly (p=<0.01) more Fusobacterium spp. in the placentas from term births than preterm births.This study found that the common periodontal pathogen, Fusobacterium spp., is not detected more in placentas from preterm birth and may potentially be lower, possibly resulting from bacterial ecological factors in term (...) Periodontal pathogens in the placenta and membranes in term and preterm birth. Preterm birth is a common cause of adverse neonatal and childhood outcomes. It is commonly associated with infection of the maternal-fetal interface. The relationship between periodontitis and preterm labour is controversial.Control placental tissues from uncomplicated term births were compared with those from spontaneous preterm births for incidence of common periodontal bacteria. A chi-square analysis was used

2018 Placenta

159. 11β-HSD 1 in human fetal membranes as a potential therapeutic target for preterm birth. Full Text available with Trip Pro

11β-HSD 1 in human fetal membranes as a potential therapeutic target for preterm birth. Human parturition is a complex process involving interactions between the myometrium and signals derived from the placenta, fetal membranes, and fetus. Signals originating from fetal membranes are crucial components that trigger parturition, which is clearly illustrated by the labor-initiating consequence of membrane rupture. It has been recognized for a long time that among fetal tissues in late gestation (...) regeneration develops in human fetal membranes at late gestation. Therefore, inhibition of 11β-HSD1 may provide a potential therapeutic target for prevention of preterm birth. This review summarizes the current understanding of the functional role of cortisol regeneration by 11β-HSD1 in human fetal membranes.

2018 Endocrine Reviews

160. AmniSure ROM test (Qiagen NV) for detection of fetal membrane rupture

Technology Brief Publication. 2012 Authors' conclusions During pregnancy, the fetal membrane protects the developing fetus and its surrounding fluid from infection. Although tearing or rupture of membranes (ROM) normally occurs during labor, in approximately 12% of pregnancies, this membrane ruptures before initiation of labor. For pregnancies that are at term ( 37 weeks of development), labor must be induced after premature ROM (PROM). Fetal membrane rupture at < 37 weeks of development is referred (...) Fluid; Fetal Membranes, Premature Ruptures; Insulin-Like Growth Factor Binding Protein 1; Predictive Value of Tests; Pregnancy; Prenatal Diagnosis Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218 Email: hayesinfo@hayesinc.com AccessionNumber 32013000218 Date abstract record published 27/03/2013

2012 Health Technology Assessment (HTA) Database.

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