How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,718 results for

Premature Rupture of Membranes

by
...
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

121. Collagen Type 1 Accelerates Healing of Ruptured Fetal Membranes (PubMed)

Collagen Type 1 Accelerates Healing of Ruptured Fetal Membranes Preterm premature rupture of membranes (pPROM) is a major cause of preterm birth. Recently, extracellular matrix-directed treatment is applied for wound healing. Here, we used a pregnant mouse model to test the efficacy of collagen type 1 gel for healing of the prematurely ruptured fetal membranes. Although injection of PBS into the ruptured fetal membranes resulted in 40% closure, injection of collagen type 1 improved closure

Full Text available with Trip Pro

2018 Scientific reports

122. Nitric Oxide Donor Isosorbide Mono Nitrate for Induction of Labor With Pre-labor Rupture of Membranes

(IPD) Sharing Statement: Plan to Share IPD: No Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Rupture Fetal Membranes, Premature Rupture Wounds and Injuries Obstetric Labor Complications Pregnancy Complications Nitric Oxide Isosorbide Dinitrate Isosorbide-5-mononitrate Isosorbide Nitric Oxide Donors Pyridoxine Pyridoxal Vitamin B 6 Bronchodilator Agents (...) Nitric Oxide Donor Isosorbide Mono Nitrate for Induction of Labor With Pre-labor Rupture of Membranes Nitric Oxide Donor Isosorbide Mono Nitrate for Induction of Labor With Pre-labor Rupture of Membranes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2018 Clinical Trials

123. Progestogens in singleton gestations with preterm prelabor rupture of membranes: a systematic review and meta-analysis of randomized controlled trials. (PubMed)

rupture of membranes.Searches were performed in MEDLINE, OVID, Scopus, EMBASE, ClinicalTrials.gov, and the Cochrane Central Register of Controlled Trials with the use of a combination of keywords and text words related to "progesterone," "progestogen," "prematurity," and "preterm premature rupture of membranes" from the inception of the databases until January 2018. We included all randomized controlled trials of singleton gestations after preterm prelabor rupture of membranes that were randomized (...) Progestogens in singleton gestations with preterm prelabor rupture of membranes: a systematic review and meta-analysis of randomized controlled trials. Preterm prelabor rupture of membranes occurs in 3% of all pregnancies. Neonatal benefit is seen in uninfected women who do not deliver immediately after preterm prelabor rupture of membranes. The purpose of this study was to evaluate whether the administration of progestogens in singleton pregnancies prolongs pregnancy after preterm prelabor

2018 American Journal of Obstetrics and Gynecology

124. Outcomes in cephalic vs noncephalic presentation in the setting of preterm premature rupture of membranes (PubMed)

Outcomes in cephalic vs noncephalic presentation in the setting of preterm premature rupture of membranes This study was conducted to determine whether fetal position at the time of preterm premature rupture of membranes (PPROM) diagnosis affects outcomes.A retrospective study was designed to assess differences in outcomes between cephalic and noncephalic presentation at PPROM diagnosis between 24 and 34 weeks' gestation.Five hundred sixty-six cases of PPROM were identified; 108 cases (19.1 (...) %) were noncephalic at time of PPROM diagnosis. The 2 groups were similar with regard to demographics. Although membrane rupture and delivery occurred earlier in the noncephalic group, there was no difference in latency between groups (cephalic group, 6.22 days vs noncephalic group, 7.85 days; P = .07). Noncephalic pregnancies were substantially more likely to be complicated by oligohydramnios, abruption, intrauterine fetal death, and infectious morbidity.Noncephalic presentation at the time

2013 EvidenceUpdates

125. AmniSure versus Fern Testing to Assess the Rupture of Fetal Membranes in Pregnant Women: A Review of the Comparative Accuracy, Cost-Effectiveness, and Guidelines

of AmniSure compared with conventional clinical criteria for assessing fetal membrane rupture. Studies were conducted in Thailand, 7 Kuwait, 8 South Korea, 9 and the United States of America. 10 Patients in the included studies were recruited between 2005 and 2009. 7-9 One study, published in 2005, did not state the observation period. 10 Population One study 8 included pregnant women who had reached term (37 weeks gestation) undergoing induction of labor due to premature rupture of membrane. Three (...) -866-898-8439 www.cadth.ca Amnisure to Assess Fetal Membrane Rupture 6 REFERENCES 1. van der Ham DP, van Melick MJ, Smits L, Nijhuis JG, Weiner CP, van Beek JH, et al. Methods for the diagnosis of rupture of the fetal membranes in equivocal cases: a systematic review. Eur J Obstet Gynecol Reprod Biol. 2011 Aug;157(2):123-7. 2. Bornstein J, Geva A, Solt I, Fait V, Schoenfeld A, Shoham HK, et al. Nonintrusive diagnosis of premature ruptured amniotic membranes using a novel polymer. Am J Perinatol

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

126. Premature newborn care

preterm premature rupture of membranes (PPROM) pre-eclampsia/pregnancy-induced hypertension abruption/antepartum haemorrhage abnormal amniotic fluid volume severe bacterial vaginosis multiple gestation previous preterm birth fetal abnormality cervical incompetence/uterine abnormality gestational diabetes maternal surgery during pregnancy chronic maternal illness short inter-pregnancy time interval drug use (tobacco, cocaine, heroin) maternal pregnancy body mass index <19 or >35 stress/depression non (...) Premature newborn care Premature newborn care - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Premature newborn care Last reviewed: February 2019 Last updated: February 2019 Summary A premature infant is an infant born before 37 weeks' gestation. In addition to immediate post-birth resuscitation, efforts to reduce excessive oxygen exposure, hyperventilation, hypothermia, and hypoglycaemia must be made. Consultation

2019 BMJ Best Practice

127. Outcome at Two Years of Very Preterm Infants Born after Rupture of Membranes before Viability. (PubMed)

Outcome at Two Years of Very Preterm Infants Born after Rupture of Membranes before Viability. To compare the respiratory and neurological outcomes at two years of age of preterm children born before 33 weeks of gestation (WG) after early preterm premature rupture of membranes (EPPROM) between 14 and 24 WG with preterm children without EPPROM.This single-center case-control retrospective study was conducted at Rouen University Hospital between 1st January 2000 and 31st December 2010. All

Full Text available with Trip Pro

2016 PLoS ONE

128. The Role of Epithelial to Mesenchymal Transition in Human Amniotic Membrane Rupture. (PubMed)

The Role of Epithelial to Mesenchymal Transition in Human Amniotic Membrane Rupture. Biochemical weakening of the amnion is a major factor preceding preterm premature rupture of membranes (PPROMs), leading to preterm birth. Activation of matrix metalloproteinases (MMPs) is known to play a key role in collagen degradation of the amnion; however, epithelial to mesenchymal transition (EMT) that is also induced by MMP activation has not been investigated as a mechanism for amnion weakening.To (...) measure amniotic EMT associated with vaginal delivery (VD) compared with unlabored cesarean sections (CSs), and to assess changes in amniotic mechanical strength with pharmacologic inhibitors and inducers of EMT, thus testing the hypothesis that EMT is a key biochemical event that promotes amniotic rupture.(1) Amnions taken from VD contained a significantly increased number of mesenchymal cells relative to epithelial cells compared with unlabored CS by fluorescence-activated cell sorting analysis (60

Full Text available with Trip Pro

2017 Journal of Clinical Endocrinology and Metabolism

129. Urea and Creatinine Level in Vaginal Fluid as a Predicator for Length of Latency Period in Prelabour Membranes Rupture

and 35 weeks gestation. Condition or disease Rupture of Membranes; Premature Detailed Description: 60 pregnant women with PROM with singleton pregnancies with a gestational age between 32- 35 gestational weeks History taking followed by examination All women will be put in dorsal lithotomy position, using a proper light source and sterile gloves; sterile speculum free of gel will be placed into vagina. For every woman a specimen of vaginal fluid will be taken as follows: 5 ml of sterile saline (...) in Prelabour Membranes Rupture Study Start Date : January 2017 Estimated Primary Completion Date : July 10, 2017 Estimated Study Completion Date : July 10, 2017 Resource links provided by the National Library of Medicine related topics: (AHRQ) related information: Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : delivery interval in Premature rupture of membranes [ Time Frame: 48 hours ] The time needed from the onset of PROM till time of onset of labour Eligibility Criteria Go

2017 Clinical Trials

130. Cook Balloon Versus Propess After 12 Hours of Rupture of Membranes

. Condition or disease Intervention/treatment Phase PROM (Premature Rupture Of Foetal Membrane) Drug: Propess® (dinoprostone) Device: cook cervical pipening balloon Phase 4 Detailed Description: The inclusion begins after 12 hours of PROM for a pregnant woman who has an unfavourable cervix and no B streptococcus. The case is discussed during the obstetric staff every morning. If the cervix is unfavourable (cervical Bishop's score <6), the information of the study is given to the patient and the consent (...) of Unfavourable Cervix After 12 Hours of Premature Rupture of Membranes (PROM) at Term: Cook Cervical Ripening + Oxytocine From 6 Hours Versus Dinoprostone Vaginal Insert Actual Study Start Date : February 14, 2018 Estimated Primary Completion Date : April 1, 2020 Estimated Study Completion Date : July 1, 2020 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Cook cervical ripening the device

2017 Clinical Trials

131. The Use of Quantitative Pregnancy Test in Amniotic Fluid as a Diagnostic Tool for Rupture of Fetal Membranes

. Quantitative and qualitative pregnancy tests will be measured in this fluid. Condition or disease Intervention/treatment Phase Premature Rupture of Membrane Diagnostic Test: assessment of beta subunit of human chorionic gonadotropin Not Applicable Detailed Description: Beta subunit of human chorionic gonadotropin assay will be measured in the vaginal washing in two groups. The first group are pregnant women in the second or third trimester. These women have definite rupture of membranes diagnosed by visual (...) Purpose: Diagnostic Official Title: Use of Beta Subunit of Human Chorionic Gonadotropin Assay as a Diagnostic Tool for Premature Rupture of Membranes Actual Study Start Date : April 10, 2017 Actual Primary Completion Date : June 29, 2017 Actual Study Completion Date : July 7, 2017 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Rupture of membranes group Pregnant women with definite

2017 Clinical Trials

132. Healing of Preterm Ruptured Fetal Membranes (PubMed)

Healing of Preterm Ruptured Fetal Membranes Preterm premature rupture of membrane (pPROM) is associated with 30-40% of preterm births. Infection is considered a leading cause of pPROM due to increased levels of proinflammatory cytokines in amniotic fluid. Only 30%, however, are positive for microbial organisms by amniotic fluid culture. Interestingly, in some pregnancies complicated by preterm premature rupture of membranes (pPROM), membranes heal spontaneously and pregnancy continues until (...) term. Here, we investigated mechanisms of amnion healing. Using a preclinical mouse model, we found that small ruptures of the fetal membrane closed within 72 h whereas healing of large ruptures was only 40%. Small rupture induced transient upregulation of cytokines whereas large ruptures elicited sustained upregulation of proinflammatory cytokines in the fetal membranes. Fetal macrophages from amniotic fluid were recruited to the wounded amnion where macrophage adhesion molecules were highly

Full Text available with Trip Pro

2017 Scientific reports

133. The physiology of fetal membrane rupture: insight gained from the determination of physical properties. (PubMed)

The physiology of fetal membrane rupture: insight gained from the determination of physical properties. Premature rupture of the fetal membranes is a major cause of preterm birth and its associated infant morbidity and mortality. Recently, it has become clear that rupture of the fetal membranes, term or preterm, is not merely the result of the stretch and shear forces of uterine contractions, but is, in significant part, the consequence of a programmed weakening process. Work in the rat model (...) collagen remodeling and apoptosis. These findings provide strong support for the concept of programmed fetal membrane weakening prior to labor. Our model has also been used to establish the physical properties of individual fetal membrane components (amnion, chorion), determine the sequence of events during the fetal membrane rupture process, and demonstrate that treatment of fetal membranes with TNF or IL-1beta, in vitro, induces weakness and the identical biochemical markers of collagen remodeling

2017 Placenta

134. The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes

The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02635451 Recruitment Status : Unknown Verified December 2015 by Mohamed Hussein Mostafa, Ain Shams Maternity

2015 Clinical Trials

135. Antibiotic prophylaxis for term or near-term premature rupture of membranes: metaanalysis of randomized trials. (PubMed)

Antibiotic prophylaxis for term or near-term premature rupture of membranes: metaanalysis of randomized trials. The objective of the study was to evaluate the efficacy of antibiotic prophylaxis in women with term or near-term premature rupture of membranes.Searches were performed in MEDLINE, OVID, Scopus, ClinicalTrials.gov, the PROSPERO International Prospective Register of Systematic Reviews, EMBASE, ScienceDirect.com, MEDSCAPE, and the Cochrane Central Register of Controlled Trials (...) with the use of a combination of key words and text words related to antibiotics, premature rupture of membranes, term, and trials from inception of each database to September 2014. We included all randomized trials of singleton gestations with premature rupture of membranes at 36 weeks or more, who were randomized to antibiotic prophylaxis or control (either placebo or no treatment). The primary outcomes included maternal chorioamnionitis and neonatal sepsis. A subgroup analysis on studies with latency

2015 American Journal of Obstetrics and Gynecology

136. Preterm Premature Rupture of Membranes, Outpatient Management vs Inpatient Management

Preterm Premature Rupture of Membranes, Outpatient Management vs Inpatient Management Preterm Premature Rupture of Membranes, Outpatient Management vs Inpatient Management - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Preterm Premature Rupture of Membranes, Outpatient Management vs Inpatient Management The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02548013 Recruitment Status : Unknown Verified September 2015 by dina mostafa ibrahim, Ain Shams Maternity Hospital. Recruitment status was: Recruiting

2015 Clinical Trials

137. Amnioinfusion versus usual care in women with premature rupture of membranes in pre-viable period: systematic review and individual participant data meta-analysis

Amnioinfusion versus usual care in women with premature rupture of membranes in pre-viable period: systematic review and individual participant data meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr

2018 PROSPERO

138. Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes

Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes (ACSinPROM) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our

2015 Clinical Trials

139. Short-Term and Long-Term Postnatal Outcomes of Expectant Management After Previable Preterm Premature Rupture of Membranes With and Without Persistent Oligohydramnios. (PubMed)

Short-Term and Long-Term Postnatal Outcomes of Expectant Management After Previable Preterm Premature Rupture of Membranes With and Without Persistent Oligohydramnios. To compare postnatal outcomes in pregnancies managed expectantly after previable preterm premature rupture of membranes (PROM) in relation to amniotic fluid volume.A retrospective cohort study was performed in 92 women with amniotic fluid leakage for more than a week after previable preterm PROM (gestational age 14 1/7-24 0/7 (...) weeks) who delivered a liveborn neonate at or after 24 1/7 weeks of gestation from 2002 to 2014. Short-term (sepsis, intracerebral hemorrhage, retinopathy of prematurity, respiratory distress syndrome, bronchopulmonary dysplasia) and long-term (cerebral palsy and developmental delay) outcomes were compared between women with (n=58) and without persistent oligohydramnios (n=34), defined as maximal vertical pocket less than 2 cm or amniotic fluid index less than 5 cm. We analyzed discrete data using

Full Text available with Trip Pro

2015 Obstetrics and Gynecology

140. Persistent microbial dysbiosis in preterm premature rupture of membranes from onset until delivery (PubMed)

Persistent microbial dysbiosis in preterm premature rupture of membranes from onset until delivery Background. Preterm Premature Rupture of Membranes (PPROM) is a major leading cause of preterm births. While the cause for PPROM remains unidentified, it is anticipated to be due to subclinical infection, since a large proportion of PPROM patients display signs of chorioamnionitis. Since subclinical infections can be facilitated by dysbiosis, our goal was to characterize the vaginal microbiome

Full Text available with Trip Pro

2015 PeerJ

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>