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Premature Rupture of Membranes

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101. Management of premature rupture of membranes at term: the need to correct a recurring mistake in articles, chapters, and recommendations of professional organizations. (Abstract)

Management of premature rupture of membranes at term: the need to correct a recurring mistake in articles, chapters, and recommendations of professional organizations. Recommendations about the management of premature rupture of membranes at term are based, in part, on a large, randomized controlled trial published in 1996: the TERMPROM trial. The original article contained an error in Table 1, in which "Interval from membrane rupture to delivery" was listed instead of "Interval from membrane (...) rupture to study entry." While the authors and journal corrected this error, the mistake published in the original paper has made its way into subsequent publications and even in guidelines or practice bulletins issued by professional organizations, textbooks, and other publications around the world. The mistake, that half of women with premature rupture of membranes at term who were managed expectantly delivered within 5 hours and 95% delivered within 28 hours of membrane rupture, should be replaced

2017 American Journal of Obstetrics and Gynecology

102. Cervicovaginal Bacteriology and Antibiotic Sensitivity Patterns among Women with Premature Rupture of Membranes in Mulago Hospital, Kampala, Uganda: A Cross-Sectional Study Full Text available with Trip Pro

Cervicovaginal Bacteriology and Antibiotic Sensitivity Patterns among Women with Premature Rupture of Membranes in Mulago Hospital, Kampala, Uganda: A Cross-Sectional Study Background. A 2013 Cochrane review concluded that the choice of antibiotics for prophylaxis in PROM is not clear. In Uganda, a combination of oral erythromycin and amoxicillin is the 1st line for prophylaxis against ascending infection. Our aim was to establish the current cervicovaginal bacteriology and antibiotic (...) and dilution method. Pearson's chi-squared (χ2) test and the paired t-test were applied, at a P value of 0.05. Results. Thirty percent of the cultures were positive and over 90% were aerobic microorganisms. Resistance to erythromycin, ampicillin, cotrimoxazole, and ceftriaxone was 44%, 95%, 96%, and 24%, respectively. Rupture of membranes (>12 hrs), late preterm, and term PROM were associated with more positive cultures. Conclusion. The spectrum of bacteria associated with PROM has not changed

2017 Infectious diseases in obstetrics and gynecology

103. Vaginal Fluid Urea and Creatinine in the Diagnosis of Premature Rupture of Membranes in Resource Limited Community Settings Full Text available with Trip Pro

Vaginal Fluid Urea and Creatinine in the Diagnosis of Premature Rupture of Membranes in Resource Limited Community Settings Objective: Diagnosis of premature rupture of membranes (PROM) is difficult in equivocal cases with traditional methods. This study aimed to evaluate the reliability of vaginal washing fluid urea and creatinine for diagnosis of PROM and to determine the cut off value. Materials and methods: The current study was a prospective case control. Women having gestational age of 28

2017 Journal of family & reproductive health

104. 32-week premature rupture of membranes caused by oropharyngeal microbiota Full Text available with Trip Pro

32-week premature rupture of membranes caused by oropharyngeal microbiota Introduction. Preterm premature rupture of membranes (PPROM) usually has a multifactorial etiology that is often unknown, although the most frequently reported cause is infection by group B Streptococcus. Therefore, the etiology of PPROM, although probably infectious, remains unknown in most cases. This case describes a PPROM caused by infection from oropharyngeal microbiota. Case presentation. We report the case of a 26

2017 JMM Case Reports

105. Healing of Preterm Ruptured Fetal Membranes Full Text available with Trip Pro

Healing of Preterm Ruptured Fetal Membranes Preterm premature rupture of membrane (pPROM) is associated with 30-40% of preterm births. Infection is considered a leading cause of pPROM due to increased levels of proinflammatory cytokines in amniotic fluid. Only 30%, however, are positive for microbial organisms by amniotic fluid culture. Interestingly, in some pregnancies complicated by preterm premature rupture of membranes (pPROM), membranes heal spontaneously and pregnancy continues until (...) term. Here, we investigated mechanisms of amnion healing. Using a preclinical mouse model, we found that small ruptures of the fetal membrane closed within 72 h whereas healing of large ruptures was only 40%. Small rupture induced transient upregulation of cytokines whereas large ruptures elicited sustained upregulation of proinflammatory cytokines in the fetal membranes. Fetal macrophages from amniotic fluid were recruited to the wounded amnion where macrophage adhesion molecules were highly

2017 Scientific reports

106. Correlation Between Premature Rupture of Membranes and Early-onset Neonatal Infections

Correlation Between Premature Rupture of Membranes and Early-onset Neonatal Infections Correlation Between Premature Rupture of Membranes and Early-onset Neonatal Infections - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Correlation Between Premature Rupture of Membranes and Early-onset Neonatal Infections The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03251898 Recruitment Status : Recruiting First Posted : August 16

2017 Clinical Trials

107. Is procalcitonin a reliable predictor of chorioamnionitis in preterm rupture of membranes? A systematic review and meta-analysis

Is procalcitonin a reliable predictor of chorioamnionitis in preterm rupture of membranes? A systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

108. Premature rupture of membranes in lupus pregnancy: a systematic review

Premature rupture of membranes in lupus pregnancy: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation

2019 PROSPERO

109. Prostaglandins versus oxytocin for the induction of labour in women with premature rupture of membranes at term: a systematic review and meta-analysis

Prostaglandins versus oxytocin for the induction of labour in women with premature rupture of membranes at term: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

110. Predictive Score for Neonatal Mortality for Women With Premature Rupture of Membranes Between 22 and 28 Weeks of Gestation

our for details. ClinicalTrials.gov Identifier: NCT03108404 Recruitment Status : Recruiting First Posted : April 11, 2017 Last Update Posted : May 12, 2017 See Sponsor: Centre Hospitalier Universitaire, Amiens Information provided by (Responsible Party): Centre Hospitalier Universitaire, Amiens Study Details Study Description Go to Brief Summary: Pretern premature rupture of the membranes (PPROM) remains the leading cause of preterm deliveries and neonatal mortality and morbidity. PPROM is defined (...) as rupture of the fetal membranes prior to 37 weeks' gestation. PPROM complicates 2-4% of all pregnancies and accounts for approximately 30 % of preterm births. The etiology of PPROM remains elusive. PPROM is one of the main causes of prematurity and its complications, such as newborn respiratory distress syndrome, neonatal sepsis, necrotizing enterocolitis, intraventricular hemorrhage, perventricular leucomalacia, varying degrees of lung hypoplasia and bronchopulmonary dysplasia. All these factors

2017 Clinical Trials

111. Intra-amniotic Dye Alternatives for the Diagnosis of Preterm Prelabor Rupture of Membranes. (Abstract)

Intra-amniotic Dye Alternatives for the Diagnosis of Preterm Prelabor Rupture of Membranes. Intra-amniotic dye instillation is a useful tool for evaluation of equivocal cases of preterm prelabor rupture of membranes and for genetic amniocentesis in multifetal gestation. Indigo carmine, the most used and studied dye, is no longer available. We sought to provide a resource of potential dyes for clinical use that summarizes dosing along with maternal, fetal, and neonatal outcomes. We reviewed (...) the literature evaluating the use of alternative agents. Sodium fluorescein has proven clinical usefulness but has side effects when used intravenously. Phenol-sulfonphthalein has reported clinical utility with no cases of maternal, fetal, or neonatal side effects; however, it is not currently available in the United States. Indocyanine green has been used in pregnancy for other indications. Oral phenazopyridine hydrochloride may lead to a false-positive diagnosis of preterm prelabor rupture of membranes

2017 Obstetrics and Gynecology

112. High Diversity and Variability in the Vaginal Microbiome in Women following Preterm Premature Rupture of Membranes (PPROM): A Prospective Cohort Study. Full Text available with Trip Pro

High Diversity and Variability in the Vaginal Microbiome in Women following Preterm Premature Rupture of Membranes (PPROM): A Prospective Cohort Study. To characterize the vaginal microbiota of women following preterm premature rupture of membranes (PPROM), and determine if microbiome composition predicts latency duration and perinatal outcomes.A prospective cohort study.Canada.Women with PPROM between 24+0 and 33+6 weeks gestational age (GA).Microbiome profiles, based on pyrosequencing (...) samples were dominated by Lactobacillus spp. Microbiome profiles at the time of membrane rupture did not cluster by gestational age at PPROM, latency duration, presence of chorioamnionitis or by infant outcomes. Mycoplasma and/or Ureaplasma were detected by PCR in 81% (29/36) of women, and these women had significantly lower GA at delivery and correspondingly lower birth weight infants than Mycoplasma and/or Ureaplasma negative women.Women with PPROM had mixed, abnormal vaginal microbiota

2016 PLoS ONE

113. Premature Rupture of Membranes

of Membranes Premature Rupture of Membranes Aka: Premature Rupture of Membranes , Preterm Premature Rupture of Membranes , Rupture of Membranes , PROM , PPROM From Related Chapters II. Definitions Premature Rupture of Membranes (PROM) Rupture of Membranes >1 prior to labor onset Preterm Premature Rupture of Membranes (PPROM) PROM that occurs prior to 37 weeks gestation III. Epidemiology Premature Rupture of Membranes (PROM): 8% Preterm Premature Rupture of Membranes (PPROM): 2% IV. Symptoms Gushing (...) of Membranes (PROM) Indications Fetus 36 weeks gestation or Weight >2500 grams or adequate by Protocol Expectant management Consider induction of labor Spontaneous labor onset within 48 hours in 90% decreases PROM infection rates does not increase ceserean rates in PROM Consider if unfavorable Decreases risk of in PROM Does not increase ceserean rate in PROM Indications for Prolonged ruptured membranes anticipated >18 hours >38 degrees Celsius XIV. Management: Preterm Premature Rupture Membranes (PPROM

2018 FP Notebook

114. Amnioinfusion versus usual care in women with premature rupture of membranes in pre-viable period: systematic review and individual participant data meta-analysis

Amnioinfusion versus usual care in women with premature rupture of membranes in pre-viable period: systematic review and individual participant data meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr

2018 PROSPERO

115. Progesterone administration after preterm premature rupture of membranes

Progesterone administration after preterm premature rupture of membranes Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect

2017 PROSPERO

116. Outcome at Two Years of Very Preterm Infants Born after Rupture of Membranes before Viability. Full Text available with Trip Pro

Outcome at Two Years of Very Preterm Infants Born after Rupture of Membranes before Viability. To compare the respiratory and neurological outcomes at two years of age of preterm children born before 33 weeks of gestation (WG) after early preterm premature rupture of membranes (EPPROM) between 14 and 24 WG with preterm children without EPPROM.This single-center case-control retrospective study was conducted at Rouen University Hospital between 1st January 2000 and 31st December 2010. All (...) the cases with EPPROM born from 26WG to 32WG were included. Each newborn was matched by sex, gestational age (GA) and year of birth to two very preterm children, born without EPPROM. At two years of corrected age, motor and cognitive abilities were assessed by routine score based on the Amiel-Tison and Denver developmental scales.Ninety-four cases with EPPROM before 24WG have been included. The 31 children born from 26WG to 32WG were matched with 62 controls. The EPPROM group had poorer clinical

2016 PLoS ONE

117. Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study. Full Text available with Trip Pro

Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study. A genetic predisposition to Preterm Labor (PTL) and Preterm Premature Rupture of Membranes (PPROM) has been suggested; however the relevance of polymorphisms and ancestry to susceptibility to PTL and PPROM in different populations remains unclear. The aim of this study was to evaluate the contribution of maternal

2016 BMC Pregnancy and Childbirth

118. Chorioamniotic Membrane Separation and Preterm Premature Rupture of Membranes Complicating In Utero Myelomeningocele Repair. (Abstract)

Chorioamniotic Membrane Separation and Preterm Premature Rupture of Membranes Complicating In Utero Myelomeningocele Repair. Since the results of the Management of Myelomeningocele Study were published, maternal-fetal surgery for the in utero treatment of spina bifida has become accepted as a standard of care alternative. Despite promise with fetal management of myelomeningocele repair, there are significant complications to consider. Chorioamniotic membrane separation and preterm premature (...) rupture of membranes are known complications of invasive fetal procedures. Despite their relative frequency associated with fetal procedures, few data exist regarding risk factors that may be attributed to their occurrence or the natural history of pregnancies that are affected with chorionic membrane separation or preterm premature rupture of membranes related to the procedure.The objective of this study was to review chorioamniotic membrane separation and preterm premature rupture of membranes

2015 American Journal of Obstetrics and Gynecology

119. Timing of Histologic Progression from Chorio-Deciduitis to Chorio-Deciduo-Amnionitis in the Setting of Preterm Labor and Preterm Premature Rupture of Membranes with Sterile Amniotic Fluid Full Text available with Trip Pro

Timing of Histologic Progression from Chorio-Deciduitis to Chorio-Deciduo-Amnionitis in the Setting of Preterm Labor and Preterm Premature Rupture of Membranes with Sterile Amniotic Fluid Histologic chorio-deciduitis and chorio-deciduo-amnionitis (amnionitis) in extra-placental membranes are known to represent the early and advanced stages of ascending intra-uterine infection. However, there are no data in humans about the time required for chorio-deciduitis to develop and for chorio-deciduitis (...) without amnionitis to progress to chorio-deciduitis with amnionitis, and the effect of prolongation of pregnancy on the development of chorio-deciduitis and amnionitis in patients with preterm labor and intact membranes (PTL) and preterm premature rupture of membranes (preterm-PROM). We examined these issues in this study.The study population consisted of 289 women who delivered preterm (133 cases with PTL, and 156 cases with preterm-PROM) and who had sterile amniotic fluid (AF) defined as a negative

2015 PloS one

120. Determinants of the competing outcomes of intrauterine infection, abruption, or spontaneous preterm birth after preterm premature rupture of membranes. (Abstract)

Determinants of the competing outcomes of intrauterine infection, abruption, or spontaneous preterm birth after preterm premature rupture of membranes. Patients with PPROM are at risk for a variety of outcomes, including chorioamnionitis (CA), placental abruption (PA), or preterm labor (PTL). Competing risk regression can analyze a cohort's risk of individual outcomes while accounting for ongoing deliveries secondary to competing events.A secondary analysis of the subjects from MFMU BEAM study (...) of neuroprotection after preterm birth (BEAM) with conservative PPROM management. Deliveries were categorized as: PA, CA, PTL, "elective" or "indicated". The association between outcomes of PA, CA or PTL and clinical predictors of twins, ethnicity, parity, gestational age at rupture, bleeding, contractions, cervical dilation, preterm birth history, weight, and genitourinary infections were evaluated via competing risk regression.1970 subjects were included. The significance and directionality of predictors

2015 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Controlled trial quality: uncertain

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