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Premature Rupture of Membranes

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21. Expression and Clinical Significance of NOD-Like Receptor Protein 3 (NLRP3) and Caspase-1 in Fetal Membrane and Placental Tissues of Patients with Premature Rupture of Membrane (PubMed)

Expression and Clinical Significance of NOD-Like Receptor Protein 3 (NLRP3) and Caspase-1 in Fetal Membrane and Placental Tissues of Patients with Premature Rupture of Membrane BACKGROUND In this study, we aimed to investigate the expression of NOD-like receptor protein 3 (NLRP3) and caspase-1 in fetal membrane and placental tissues of patients with premature rupture of membrane (PROM), and to explore their role in PROM. MATERIAL AND METHODS Ninety women participated in this study: a control (...) group of 30 healthy pregnant women, 30 with PPROM, and 30 with TPROM. Immunohistochemistry streptavidin-peroxidase (SP) assay was used to detect the protein expression of NLRP3 and caspase-1 in the fetal membrane and placental tissues. RT-PCR was used to detect the mRNA expression of NLRP3 and caspase-1 in fetal membrane and placental tissues. RESULTS The results of SP showed that NLRP3 and caspase-1 were mainly expressed in the cytoplasm of epithelial cells, mesenchymal cells, and trophoblast cells

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2018 Medical science monitor : international medical journal of experimental and clinical research

22. Care of Women Presenting with Suspected Preterm Prelabour Rupture of Membranes from 24+0 Weeks of Gestation

search strategy PDF document, 121.8 KB Appendix S2. PPROM search strategy top up PDF document, 142.2 KB PDF document, 1.2 MB Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1 Mercer, BM . Preterm premature rupture of the membranes . Obstet Gynecol 2003 ; 101 : 178 – 93 . 2 Morris, JM , Roberts, CL (...) , Bowen, JPJ , Bond, DM , Algert, CS , Thornton, JG , Crowther, CA . Immediate delivery compared with expectant management after preterm pre‐labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial . Lancet 2016 ; 387 : 444 – 52 . 3 Peaceman, AM , Lai, Y , Rouse, DJ , Spong, CY , Mercer, BM , Varner, MW , et al. Length of latency with preterm premature rupture of membranes before 32 weeks’ gestation . Am J Perinatol 2015 ; 32 : 57 – 62 . 4 Dale, PO , Tanbo, T

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2019 Royal College of Obstetricians and Gynaecologists

23. Frequency and clinical significance of short cervix in patients with preterm premature rupture of membranes. (PubMed)

Frequency and clinical significance of short cervix in patients with preterm premature rupture of membranes. Cervical length measurement has been uggested as a useful tool for predicting intra-amniotic infection/inflammation in preterm labor, but little information is available in the setting of preterm premature rupture of membranes (pPROM). We aimed to determine whether a short cervical length is independently associated with an increased risk of intra-amniotic infection or inflammation

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2017 PLoS ONE

24. Clinical significance of histologic chorioamnionitis with a negative amniotic fluid culture in patients with preterm labor and premature membrane rupture. (PubMed)

Clinical significance of histologic chorioamnionitis with a negative amniotic fluid culture in patients with preterm labor and premature membrane rupture. To evaluate the effect of histological chorioamnionitis (HCA) with a negative amniotic fluid (AF) culture on adverse pregnancy and neonatal outcomes and inflammatory status in the AF compartment in women with preterm labor or preterm premature rupture of membranes (PPROM).This is a retrospective cohort study of 153 women diagnosed as having (...) with increased risks of preterm birth, intense intra-amniotic inflammatory response, and prematurity-associated composite neonatal morbidity, and its risks are similar to the risk posed by positive AF culture.

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2017 PLoS ONE

25. The Delta Neutrophil Index as a predictive marker of histological chorioamnionitis in patients with preterm premature rupture of membranes: A retrospective study. (PubMed)

The Delta Neutrophil Index as a predictive marker of histological chorioamnionitis in patients with preterm premature rupture of membranes: A retrospective study. Histological chorioamnionitis (HCA) is related to perinatal morbidity. However, there is no definite diagnostic method for detecting chorioamnionitis before delivery.We evaluated whether the delta neutrophil index (DNI) was an effective early marker of HCA in patients with preterm premature rupture of membranes (PPROM). We

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2017 PLoS ONE

26. Rare mutations and potentially damaging missense variants in genes encoding fibrillar collagens and proteins involved in their production are candidates for risk for preterm premature rupture of membranes. (PubMed)

Rare mutations and potentially damaging missense variants in genes encoding fibrillar collagens and proteins involved in their production are candidates for risk for preterm premature rupture of membranes. Preterm premature rupture of membranes (PPROM) is the leading identifiable cause of preterm birth with ~ 40% of preterm births being associated with PPROM and occurs in 1% - 2% of all pregnancies. We hypothesized that multiple rare variants in fetal genes involved in extracellular matrix (...) synthesis would associate with PPROM, based on the assumption that impaired elaboration of matrix proteins would reduce fetal membrane tensile strength, predisposing to unscheduled rupture. We performed whole exome sequencing (WES) on neonatal DNA derived from pregnancies complicated by PPROM (49 cases) and healthy term deliveries (20 controls) to identify candidate mutations/variants. Genotyping for selected variants from the WES study was carried out on an additional 188 PPROM cases and 175 controls

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2017 PLoS ONE

27. ShortGUIDE: Term prelabour rupture of membranes (PROM)

, Perde MP. Premature rupture of membranes at term in nulliparous women: a hazard? Obstet Gynecol 1990;76(4):671-4. 3. Conway DI, Prendiville WJ, Morris A, Speller DC, Stirrat GM. Management of spontaneous rupture of the membranes in the absence of labor in primigravid women at term. Am J Obstet Gynecol 1984;150(8):947-51. 4. Egan D, O'herlihy C. Expectant management of spontaneous rupture of membranes at term. Journal of Obstetrics and Gynaecology 1988;8(3):243-7. 5. Gunn GC, Mishell DR, Jr., Morton (...) DG. Premature rupture of the fetal membranes: a review. Am J Obstet Gynecol 1970;106(3):469-83. 6. Hannah ME, Hodnett ED, Willan A, Foster GA, Di Cecco R, Helewa M. Prelabor rupture of the membranes at term: expectant management at home or in hospital? The TermPROM Study Group. Obstet Gynecol 2000;96(4):533-8. 7. Kappy KA, Cetrulo CL, Knuppel RA, Ingardia CJ, Sbarra AJ, Scerbo JC, et al. Premature rupture of the membranes at term: a comparison of induced and spontaneous labors. J Reprod Med

2019 Queensland Health

28. ShortGUIDE: Preterm prelabour rupture of membranes (PPROM)

is unclear. 23,24 Aspect Considerations Near term · Between 34+0 and 36+6 weeks there is limited and inconsistent evidence to guide practice Less than 34+0 weeks · The risks of prematurity are generally greater than the risks of expectant management Consider expediting birth · If active labour establishes · If concern for maternal or fetal wellbeing at initial presentation or during subsequent care short GUIDE Queensland Clinical Guidelines Preterm prelabour rupture of membranes Available from (...) . No.: CD008053.) DOI:10.1002/14651858.CD008053.pub3. 3. Simhan HN, TP. C. Preterm premature rupture of membranes: diagnosis, evaluation and management strategies. British Journal of Obstetrics and Gynaecology 2005;112 (1):32-7. 4. Goldenberg RL, Culhane JF, Iams JD, R. R. Epidemiology and causes of preterm birth. Lancet 2008;371(9606):75-84. 5. Queensland Clinical Guidelines. Normal birth. Guideline No. MN17.25-V3-R22. [Internet]. Queensland Health. 2017. [cited 2018 June 26]. Available from: http

2019 Queensland Health

29. Preterm Premature Rupture of Membranes: A Review of 3 National Guidelines. (PubMed)

Preterm Premature Rupture of Membranes: A Review of 3 National Guidelines. Preterm premature rupture of membranes (PPROM) is a major cause of perinatal mortality and morbidity.The aim of this study was to compare recommendations from published national guidelines for pregnancies complicated with PPROM.A descriptive review of 3 national guidelines on PPROM was performed: the Royal College of Obstetricians and Gynaecologists on "Preterm Prelabour Rupture of Membranes," the American College (...) of Obstetricians and Gynecologists on "Premature Rupture of Membranes," and the Society of Obstetricians and Gynaecologists of Canada on "Antibiotic Therapy in Preterm Premature Rupture of the Membranes." Guidelines were compared in the diagnosis and management of PPROM. Recommendations and strength of evidence were reviewed based on each guideline's method of reporting. The references were compared with regard to their total number, total number of randomized controlled trials, Cochrane reviews

2018 Obstetrical & Gynecological Survey

30. Infection-Induced Thrombin Production: A Potential Novel Mechanism for Preterm Premature Rupture of Membranes (PPROM). (PubMed)

Infection-Induced Thrombin Production: A Potential Novel Mechanism for Preterm Premature Rupture of Membranes (PPROM). Preterm premature rupture of membranes is a leading contributor to maternal and neonatal morbidity and death. Epidemiologic and experimental studies have demonstrated that thrombin causes fetal membrane weakening and subsequently preterm premature rupture of membranes. Although blood is suspected to be the likely source of thrombin in fetal membranes and amniotic fluid (...) of patients with preterm premature rupture of membranes, this has not been proved. Ureaplasma parvum is emerging as a pathogen involved in prematurity, which includes preterm premature rupture of membranes; however, until now, prothrombin production that has been induced directly by bacteria in fetal membranes has not been described.This study was designed to investigate whether Ureaplasma parvum exposure can induce prothrombin production in fetal membranes cells.Primary fetal membrane cells (amnion

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2018 American Journal of Obstetrics and Gynecology

31. Predicting premature preterm rupture of the membranes after fetal surgery. (PubMed)

Predicting premature preterm rupture of the membranes after fetal surgery. 29878553 2019 02 28 2019 02 28 1471-0528 125 10 2018 09 BJOG : an international journal of obstetrics and gynaecology BJOG Predicting premature preterm rupture of the membranes after fetal surgery. 1293 10.1111/1471-0528.15316 Belfort M A MA Texas Children's Pavilion for Women, Texas Medical Center, Houston, TX, USA. eng Journal Article Comment 2018 06 28 England BJOG 100935741 1470-0328 33X04XA5AT Lactic Acid EC (...) 3.4.24.34 Matrix Metalloproteinase 8 AIM IM BJOG. 2018 Sep;125(10):1288-1292 29786973 Amniotic Fluid Fetal Membranes, Premature Rupture Humans Infant, Newborn Lactic Acid Matrix Metalloproteinase 8 Obstetric Labor, Premature 2018 6 8 6 0 2019 3 1 6 0 2018 6 8 6 0 ppublish 29878553 10.1111/1471-0528.15316

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2018 BJOG

32. An extremely rare case of hand prolapse with preterm premature rupture in the membrane of one twin (PubMed)

An extremely rare case of hand prolapse with preterm premature rupture in the membrane of one twin The latency in preterm premature rupture of membranes (PPROM) can last for weeks. We describe an extremely rare case of hand prolapse with PPROM that was exposed for 23 days before delivery. The patient had spontaneous PPROM of twin A at 21.4 weeks of gestation with shoulder presentation. The right arm of the fetus eventually protruded out the vagina and the hand was exposed for extended period

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2018 Obstetrics & gynecology science

33. Cervical bacterial colonization in women with preterm premature rupture of membrane and pregnancy outcomes: A cohort study (PubMed)

Cervical bacterial colonization in women with preterm premature rupture of membrane and pregnancy outcomes: A cohort study One of the most important etiologies in pretermpremature rupture of membranes (PPROM) is cervical bacterial colonization.This study evaluated cervical bacterial colonization in women with PPROM and the pregnancy outcomes.In this cohort study, 200 pregnant women with PPROM at 27-37 wk of gestation who were admitted in an academic hospital of Mashhad University of Medical

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2018 International Journal of Reproductive Biomedicine

34. Placental protein 14 as a potential biomarker for diagnosis of preterm premature rupture of membranes (PubMed)

Placental protein 14 as a potential biomarker for diagnosis of preterm premature rupture of membranes Premature rupture of membranes (PROM) is a common pregnancy complication that frequently results in maternal and perinatal morbidity. The present methods for diagnosing PROM do not satisfy clinical requirements. The present study aimed to examine the proteome profile of amniotic fluid (AF) and maternal plasma, screen unique proteins in AF, and evaluate their diagnostic value for diagnosing PROM

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2018 Molecular medicine reports

35. The Value of Amniopatch in Preterm Premature Rupture of Membranes

The Value of Amniopatch in Preterm Premature Rupture of Membranes The Value of Amniopatch in Preterm Premature Rupture of Membranes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Value of Amniopatch (...) in Preterm Premature Rupture of Membranes The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03473210 Recruitment Status : Completed First Posted : March 22, 2018 Last Update Posted : March 22, 2018 Sponsor: Cairo University Information provided by (Responsible Party): Ahmed Maged, Cairo University Study

2018 Clinical Trials

36. Fetal and Maternal Outcome in Preterm Premature Rupture of Membranes (PPROM)

Fetal and Maternal Outcome in Preterm Premature Rupture of Membranes (PPROM) Fetal and Maternal Outcome in Preterm Premature Rupture of Membranes (PPROM) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Fetal and Maternal Outcome in Preterm Premature Rupture of Membranes (PPROM) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03491826 Recruitment Status : Completed First Posted : April 9, 2018 Last Update Posted : April 9, 2018 Sponsor: sarah mohamed hassan Collaborator: Hend Mostafa Hussein Salem

2018 Clinical Trials

37. Premature Rupture of Membranes at 34 to 37 Weeks' Gestation

Premature Rupture of Membranes at 34 to 37 Weeks' Gestation Premature Rupture of Membranes at 34 to 37 Weeks' Gestation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Premature Rupture of Membranes at 34 (...) for the majority of women labour will start spontaneously within 24 hours following term PROM, up to 4%of women will not experience spontaneous onset of labour within seven days. Condition or disease Intervention/treatment Phase Premature Rupture of Membrane Procedure: induction of labor Procedure: follow up Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 120 participants Allocation: Randomized Intervention Model: Parallel

2018 Clinical Trials

38. Use of Placental Alpha Microglobulin-1(PAMG-1) to Diagnose Premature Rupture of Membranes in Pregnant Women

Use of Placental Alpha Microglobulin-1(PAMG-1) to Diagnose Premature Rupture of Membranes in Pregnant Women Use of Placental Alpha Microglobulin-1(PAMG-1) to Diagnose Premature Rupture of Membranes in Pregnant Women - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Use of Placental Alpha Microglobulin-1(PAMG-1) to Diagnose Premature Rupture of Membranes in Pregnant Women (PAMG-1) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03715530 Recruitment Status : Terminated (Data collection has halted due

2018 Clinical Trials

39. Hospital Admission Versus Home Management in Women With Premature Rupture of Membranes :RCT

Hospital Admission Versus Home Management in Women With Premature Rupture of Membranes :RCT Hospital Admission Versus Home Management in Women With Premature Rupture of Membranes :RCT - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Hospital Admission Versus Home Management in Women With Premature Rupture of Membranes :RCT The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03435263 Recruitment Status : Recruiting First Posted

2018 Clinical Trials

40. Risk Factors for Neonatal Sepsis in Pregnant Women with Premature Rupture of the Membrane (PubMed)

Risk Factors for Neonatal Sepsis in Pregnant Women with Premature Rupture of the Membrane Premature rupture of the membrane (PROM) is associated with high maternal as well as perinatal morbidity and mortality risks. It occurs in 5 to 10% of all pregnancy while incidence of amniotic membrane infection varies from 6 to 10%. This study aimed to determine the incidence of neonatal sepsis in Cipto Mangunkusumo Hospital and the risk factors.A cross-sectional study was done in Cipto Mangunkusumo (...) . The analysis showed that risk of neonatal sepsis was higher in pregnant women with prolonged rupture of membrane for ≥ 18 hours before hospital admission (OR 3.08), prolonged rupture of membrane for ≥ 15 hours during hospitalization (OR 7.32), and prolonged rupture of membrane for ≥ 48 hours until birth (OR 5.77). The risk of neonatal sepsis was higher in preterm pregnancy with gestational age of <37 weeks (OR 18.59).Risk of neonatal sepsis is higher in longer duration of prolonged rupture of membrane

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2018 Journal of pregnancy

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