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Premature Rupture of Membranes

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21. Amniotic fluid volume at presentation with early preterm premature rupture of the membranes and the association with severe neonatal respiratory morbidity. (Abstract)

Amniotic fluid volume at presentation with early preterm premature rupture of the membranes and the association with severe neonatal respiratory morbidity. Amniotic fluid volume (AFV) plays an important role in early fetal lung development, and oligohydramnios in early pregnancy has been associated with pulmonary hypoplasia. We aimed to evaluate the association between AFV at the time of presentation with early preterm premature rupture of membranes (PPROM) and severe neonatal respiratory

2019 Ultrasound in Obstetrics and Gynecology

22. Prelabor Rupture of Membranes

Prelabor Rupture of Membranes Prelabor Rupture of Membranes | ACOG Clinical Guidance Journals & Publications Patient Education Topics Featured Clinical Topics Hi, Featured Clinical Topics Clinical Guidance Prelabor Rupture of Membranes Practice Bulletin Number 217 March 2020 Jump to Resources Share By reading this page you agree to ACOG's Terms and Conditions. . Prelabor rupture of membranes (PROM) that occurs preterm complicates approximately 2–3% of all pregnancies in the United States (...) , representing a significant proportion of preterm births, whereas term PROM occurs in approximately 8% of pregnancies . The optimal approach to assessment and treatment of women with term and preterm PROM remains challenging. Management decisions depend on gestational age and evaluation of the relative risks of delivery versus the risks (eg, infection, abruptio placentae, and umbilical cord accident) of expectant management when pregnancy is allowed to progress to a later gestational age. The purpose

2020 American College of Obstetricians and Gynecologists

23. Discovery of rare ancestry-specific variants in the fetal genome that confer risk of preterm premature rupture of membranes (PPROM) and preterm birth. Full Text available with Trip Pro

Discovery of rare ancestry-specific variants in the fetal genome that confer risk of preterm premature rupture of membranes (PPROM) and preterm birth. Preterm premature rupture of membranes (PPROM) is the leading identifiable cause of preterm birth, a complication that is more common in African Americans. Attempts to identify genetic loci associated with preterm birth using genome-wide association studies (GWAS) have only been successful with large numbers of cases and controls, and there has (...) yet to be a convincing genetic association to explain racial/ethnic disparities. Indeed, the search for ancestry-specific variants associated with preterm birth has led to the conclusion that spontaneous preterm birth could be the consequence of multiple rare variants. The hypothesis that preterm birth is due to rare genetic variants that would go undetected in standard GWAS has been explored in the present study. The detection and validation of these rare variants present challenges because

2018 BMC Medical Genetics

24. Biomarker tests to help diagnose preterm labour in women with intact membranes

weeks of pregnancy) moderate to late preterm (32 to less than 37 weeks of pregnancy). 2.6 Around 25% of preterm births are planned because of maternal factors such as pre-eclampsia, or fetal factors such as extreme growth restriction. But most preterm births occur because labour starts early naturally. Known risk factors for preterm labour include: previous preterm delivery twins or other multiple pregnancies genital tract infections preterm premature rupture of membranes problems with the uterus (...) Biomarker tests to help diagnose preterm labour in women with intact membranes Biomark Biomarker tests to help diagnose preterm er tests to help diagnose preterm labour in women with intact membr labour in women with intact membranes anes Diagnostics guidance Published: 4 July 2018 nice.org.uk/guidance/dg33 © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility This guidance

2018 National Institute for Health and Clinical Excellence - Diagnostics Guidance

25. Fetal assessment methods for improving neonatal and maternal outcomes in preterm prelabour rupture of membranes. Full Text available with Trip Pro

Fetal assessment methods for improving neonatal and maternal outcomes in preterm prelabour rupture of membranes. Fetal assessment following preterm prelabour rupture of membranes (PPROM) may result in earlier delivery due to earlier detection of fetal compromise. However, early delivery may not always be in the fetal or maternal interest, and the effectiveness of different fetal assessment methods in improving neonatal and maternal outcomes is uncertain.To study the effectiveness of fetal

2014 Cochrane

26. Randomised controlled trial: Expectant management with close monitoring of mother and neonate should be practised after late preterm prelabour rupture of membranes

controlled trial . . Context Preterm prelabour rupture of membranes (PPROM) affects 2–5% of all pregnancies and accounts for 40% of all preterm deliveries. It is associated with maternal and perinatal morbidity and mortality. 1 There is good evidence and consensus that immediate delivery at term will improve outcome and maternal satisfaction. In PPROM prior to 34 0/7 weeks, risks of prematurity outbalance the risks of expectant management. However, when PPROM occurs in late preterm (between 34 and 37 (...) Randomised controlled trial: Expectant management with close monitoring of mother and neonate should be practised after late preterm prelabour rupture of membranes Expectant management with close monitoring of mother and neonate should be practised after late preterm prelabour rupture of membranes | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more

2016 Evidence-Based Medicine

27. Impact of mode of delivery on pregnancy outcomes in women with premature rupture of membranes after 28 weeks of gestation in a low-resource setting: A prospective cohort study. Full Text available with Trip Pro

Impact of mode of delivery on pregnancy outcomes in women with premature rupture of membranes after 28 weeks of gestation in a low-resource setting: A prospective cohort study. Despite the high prevalence of premature rupture of membranes (PROM) in low-resource settings, the preferred mode of delivery remains unclear. We compared the perinatal mortality in a prospective cohort of women with PROM after 28 weeks following vaginal or caesarean delivery at Mulago Hospital with the aim of adopting (...) included chorioamnionitis, failure to administer corticosteroids in preterm PROM, gestational age (28-33 weeks), duration of drainage of liquor (24-48 hours), and presence of maternal complications. Caesarean delivery was associated with increased maternal postpartum infections, admission to the Special Care Unit and maternal death.In low resource settings, vaginal delivery is the preferred mode of delivery for PROM after 28 weeks gestation. It is associated with lesser maternal and perinatal morbidity

2018 PLoS ONE

28. Cervical human papillomavirus infection in women with preterm prelabor rupture of membranes. Full Text available with Trip Pro

Cervical human papillomavirus infection in women with preterm prelabor rupture of membranes. To evaluate the association between cervical human papillomavirus (HPV) infection at the time of admission and the presence of microbial invasion of the amniotic cavity (MIAC) and intra-amniotic inflammation (IAI) in women with preterm prelabor rupture of membranes (PPROM) and to determine the association between cervical HPV infection and short-term neonatal morbidity.One hundred women with singleton

2018 PLoS ONE

30. Effects of progestogens in women with preterm premature rupture of membranes. (Abstract)

Effects of progestogens in women with preterm premature rupture of membranes. Different strategies have been adopted for prevention of spontaneous preterm birth, including use of progestogens. So far, five randomized trials have been published evaluating the efficacy of progestogens in women with PPROM, including a total of 425 partipants. All the five trials enrolled pregnant women with singleton pregnancies randomized between 20 and 34 weeks of gestation. In four trials women were randomized

2018 Minerva ginecologica

31. Erratum to: A Double-Blind, Randomized, Placebo-Controlled Trial of 17 Alpha-hydroxyprogesterone Caproate in the Management of Preterm Premature Rupture of Membranes. (Abstract)

Erratum to: A Double-Blind, Randomized, Placebo-Controlled Trial of 17 Alpha-hydroxyprogesterone Caproate in the Management of Preterm Premature Rupture of Membranes. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

2018 American journal of perinatology Controlled trial quality: predicted high

32. A Double-Blind, Randomized, Placebo-Controlled Trial of 17 Alpha-hydroxyprogesterone Caproate in the Management of Preterm Premature Rupture of Membranes. (Abstract)

A Double-Blind, Randomized, Placebo-Controlled Trial of 17 Alpha-hydroxyprogesterone Caproate in the Management of Preterm Premature Rupture of Membranes.  The objective of this study was to evaluate whether weekly administration of 17 α-hydroxyprogesterone caproate (17-OHPC) increases the number of women who achieve 34 weeks of gestation after preterm premature rupture of membranes (PPROM). We conducted a multicenter double-blind, randomized controlled trial of 17-OHPC versus placebo among (...) outcomes. In this study, 21 women were enrolled. Eleven women received placebo and 10 received 17-OHPC. The study was closed prematurely secondary to poor enrollment. None of the women remained pregnant until 34 weeks of gestation. The median latency periods were 8 and 14.5 days for the placebo and 17-OHPC groups, respectively (p = 0.14). There were no differences in maternal or neonatal outcomes. We did not identify any benefit from administration of 17-OHPC in pregnancies complicated by PPROM.Thieme

2018 American journal of perinatology Controlled trial quality: predicted high

33. Does intact umbilical cord milking increase infection rates in preterm infants with premature prolonged rupture of membranes? (Abstract)

Does intact umbilical cord milking increase infection rates in preterm infants with premature prolonged rupture of membranes? To investigate whether intact umbilical cord milking (I-UCM) can aggravate infection or result in other undesirable complications in preterm infants with premature prolonged rupture of membranes (PPROM).Neonates vaginally delivered between 28 and 37 weeks' gestation and complicated by PPROM before birth were randomly divided into two groups according to the cord clamping (...) procedure: I-UCM before clamping and immediate cord clamping (ICC). Various parameters of the study participants were compared between the two groups.Of 102 preterm infants, 48 and 54 were randomly allocated to the I-UCM and ICC groups, respectively. There were no significant differences between the two groups regarding hematological parameters (platelet count, white blood count, neutrophil ratio, and C-reactive protein) or neonatal outcomes (probable or certain neonatal infection, respiratory distress

2018 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Controlled trial quality: uncertain

34. The impact of time of delivery on gestations complicated by preterm premature rupture of membranes: daytime versus nighttime. (Abstract)

The impact of time of delivery on gestations complicated by preterm premature rupture of membranes: daytime versus nighttime. Perinatal death, in particular intrapartum stillbirth and short-term neonatal death, as well as neonatal short-term and long-term morbidity have been associated with the time of day that the birth occurs. Indeed, evening and nighttime deliveries were associated with an increased risk of an adverse perinatal outcome when compared to similar daytime deliveries. Impact (...) characteristics as well as neonatal and long-term outcomes were compared between deliveries occurring during the daytime versus the nighttime periods. Inclusion criteria consisted of singleton gestations diagnosed with preterm premature rupture of membranes (PPROM). Multifetal gestations and pregnancies with preterm labor without preterm premature rupture of membranes were excluded.A total of 1752 patients met inclusion criteria, 881 delivering during the daytime, while 871 during the nighttime. There were

2018 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Controlled trial quality: uncertain

35. Effect of Progesterone on Latent Phase Prolongation in Patients With Preterm Premature Rupture of Membranes. (Abstract)

Effect of Progesterone on Latent Phase Prolongation in Patients With Preterm Premature Rupture of Membranes. Preterm premature rupture of membranes (PPROM) is a condition leading to an increased risk of maternal and neonatal morbidity and mortality in pregnant women. To prevent this complication, some studies have proposed using prophylactic progesterone. However, due to lack of sufficient relevant data, there is still need for further studies in this regard. This study was performed

2018 Acta medica Iranica Controlled trial quality: uncertain

36. The Value of Amniopatch in Preterm Premature Rupture of Membranes

The Value of Amniopatch in Preterm Premature Rupture of Membranes The Value of Amniopatch in Preterm Premature Rupture of Membranes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Value of Amniopatch (...) in Preterm Premature Rupture of Membranes The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03473210 Recruitment Status : Completed First Posted : March 22, 2018 Last Update Posted : March 22, 2018 Sponsor: Cairo University Information provided by (Responsible Party): Ahmed Maged, Cairo University Study

2018 Clinical Trials

37. Fetal and Maternal Outcome in Preterm Premature Rupture of Membranes (PPROM)

Fetal and Maternal Outcome in Preterm Premature Rupture of Membranes (PPROM) Fetal and Maternal Outcome in Preterm Premature Rupture of Membranes (PPROM) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Fetal and Maternal Outcome in Preterm Premature Rupture of Membranes (PPROM) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03491826 Recruitment Status : Completed First Posted : April 9, 2018 Last Update Posted : April 9, 2018 Sponsor: sarah mohamed hassan Collaborator: Hend Mostafa Hussein Salem

2018 Clinical Trials

38. An extremely rare case of hand prolapse with preterm premature rupture in the membrane of one twin Full Text available with Trip Pro

An extremely rare case of hand prolapse with preterm premature rupture in the membrane of one twin The latency in preterm premature rupture of membranes (PPROM) can last for weeks. We describe an extremely rare case of hand prolapse with PPROM that was exposed for 23 days before delivery. The patient had spontaneous PPROM of twin A at 21.4 weeks of gestation with shoulder presentation. The right arm of the fetus eventually protruded out the vagina and the hand was exposed for extended period (...) of time of 23 days until delivery. Daily dressing by applying collagen to dry skin and silicone to keep moisture was done to the protruding hand to prevent dehydration and desquamation of the skin. Prophylactic antibiotics were used and the patient underwent emergent cesarean section due to uncontrolled preterm labor at 25.2 weeks. To the best of our knowledge, this is the first case of hand prolapse of one twin with extended period of latency before delivery.

2018 Obstetrics & gynecology science

39. A Retrospective Study on the Risk of Respiratory Distress Syndrome in Singleton Pregnancies with Preterm Premature Rupture of Membranes between 24+0 and 36+6 Weeks, Using Regression Analysis for Various Factors Full Text available with Trip Pro

A Retrospective Study on the Risk of Respiratory Distress Syndrome in Singleton Pregnancies with Preterm Premature Rupture of Membranes between 24+0 and 36+6 Weeks, Using Regression Analysis for Various Factors This study aimed to investigate the cause of respiratory distress syndrome (RDS) in neonates from singleton pregnancies with preterm premature rupture of membranes (pPROM) between 24+0 and 36+6 weeks by using regression analysis for various factors.In 175 singleton pregnancies with pPROM (...) ).The main RDS risk factors in premature neonates are gender, abnormal fetoplacental circulation, and fetal distress. The laboratory parameters such as lower RBC and HGB count are observed in infants with RDS.

2018 BioMed research international

40. Placental protein 14 as a potential biomarker for diagnosis of preterm premature rupture of membranes Full Text available with Trip Pro

Placental protein 14 as a potential biomarker for diagnosis of preterm premature rupture of membranes Premature rupture of membranes (PROM) is a common pregnancy complication that frequently results in maternal and perinatal morbidity. The present methods for diagnosing PROM do not satisfy clinical requirements. The present study aimed to examine the proteome profile of amniotic fluid (AF) and maternal plasma, screen unique proteins in AF, and evaluate their diagnostic value for diagnosing PROM (...) and serpin family B member 3 were significantly higher in AF compared with in maternal plasma (P<0.01). Furthermore, PP14 was observed to have excellent diagnostic accuracy for preterm PROM (PPROM), with a respective sensitivity and specificity of 100 and 87.5% when the cutoff value was 0.008 µg/ml. The PP14‑based lateral flow assay demonstrated a visual detection threshold of 0.008 µg/ml. The results from the present study suggested that PP14 may be a novel potential biomarker for PPROM, and may

2018 Molecular medicine reports

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