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Premature Rupture of Membranes

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2881. Vaginal Progesterone to Prevent Preterm Delivery in Women With Preterm Labor

or Bishop score less than 6 cervical changes during hospitalization (more or equal 5 mm between two clinical or US exams) positive fetal fibronectin Age ≥ 18 years old Signed informed consent Possible and accepted follow-up Exclusion Criteria: Multiple gestation Cervical cerclage Hydramnios (AFI >95th percentile for gestational age or greatest pocket >8 cm) Premature rupture of membranes Chorioamnionitis (criteria for clinical diagnosis are: elevated WBC, elevated CRP, maternal tachycardia, fetal (...) , University Hospital, Geneva Study Details Study Description Go to Brief Summary: The administration of vaginal progesterone, in addition to standard tocolysis, will decrease the risk of delivering prematurely and of recurrent preterm labor. We also hypothesize that the reduction in preterm delivery will be associated with a decrease in infant mortality and morbidity. Condition or disease Intervention/treatment Phase Preterm Delivery Morbidity Perinatal Mortality Drug: progesterone Drug: placebo Phase 3

2007 Clinical Trials

2882. Termination of pregnancy among very preterm births and its impact on very preterm mortality: results from ten European population-based cohorts in the MOSAIC study. (Abstract)

and between 4 and 53% of stillbirths. Most terminations were for CAs, although some were for obstetric indications (severe pre-eclampsia, growth restriction, premature rupture of membranes). TOP contributed substantially to overall fetal mortality rates in the two regions with late second-trimester screening. There was no clear association between policies governing screening and pregnancy termination and the proportion of CAs among stillbirths and live births, except in Poland, where neonatal deaths (...) Termination of pregnancy among very preterm births and its impact on very preterm mortality: results from ten European population-based cohorts in the MOSAIC study. To study the impact of terminations of pregnancy (TOP) on very preterm mortality in Europe.European prospective population-based cohort study.Ten regions from nine European countries participating in the MOSAIC (Models of OrganiSing Access to Intensive Care for very preterm babies) study. These regions had different policies

2008 BJOG

2883. Lung and brain damage in preterm newborns, and their association with gestational age, prematurity subgroup, infection/inflammation and long term outcome. (Abstract)

, but not lung, damage appears to be associated with the prematurity subgroup [spontaneous preterm labour and/or preterm prelabour rupture of membranes (PPROM) vs pregnancy-induced hypertension (PIH)]. Part of the association between brain damage and prematurity subgroup might be due to a differential exposure of members of these subgroups to perinatal infection/inflammation. There is a lack of studies evaluating the association of antenatal and perinatal risk factors with late childhood pulmonary (...) Lung and brain damage in preterm newborns, and their association with gestational age, prematurity subgroup, infection/inflammation and long term outcome. Compared with those born at term, preterm newborns are at an increased risk of short term disorders of the lung (bronchopulmonary dysplasia; BPD) and the brain (white matter damage; WMD), and of long term developmental and pulmonary dysfunctions. Although all of these adverse outcomes are associated with low gestational age, brain

2005 BJOG

2884. Preterm delivery predicted by soluble CD163 and CRP in women with symptoms of preterm delivery. (Abstract)

of sCD163 or CRP are associated with an increased risk of preterm delivery in women with symptoms of delivery. Good prediction of preterm delivery before 34 weeks of gestation was obtained by a combination of preterm prelabour rupture of membranes (PPROM), overweight, relaxin, CRP and sCD163. (...) Preterm delivery predicted by soluble CD163 and CRP in women with symptoms of preterm delivery. To evaluate whether soluble CD163 (sCD163) and C-reactive protein (CRP) can predict spontaneous preterm delivery in women with symptoms of preterm delivery.Prospective cohort study. Setting Labour ward at a tertiary university hospital.Ninety-three women with symptoms of preterm delivery before 34 weeks of gestation.sCD163 and CRP were individually examined as predictors of preterm delivery. A model

2005 BJOG

2885. Use of transvaginal ultrasonography to predict preterm birth in women with a history of preterm birth. (Abstract)

Use of transvaginal ultrasonography to predict preterm birth in women with a history of preterm birth. To investigate whether cervical length measured by transvaginal ultrasonography predicts spontaneous preterm birth at < 35 weeks' gestation in women with a history of spontaneous preterm birth, stratified by spontaneous preterm birth history subtype (preterm premature rupture of membranes (PPROM) or preterm labor with intact membranes at onset of labor).This retrospective cohort study included (...) was used to control for potential confounders and calculate odds ratios and 95% confidence intervals. Receiver-operating characteristics (ROC) curves were used to determine the best cut-off for transvaginal ultrasound cervical length in predicting spontaneous preterm birth at < 35 weeks.Women with a history of spontaneous preterm birth with intact membranes at onset of labor (n = 42) had a shorter cervical length (3.28 cm) than women with a history of spontaneous preterm birth with PPROM at onset

2008 Ultrasound in Obstetrics and Gynecology

2886. Induction of labour versus expectant management for prelabour rupture of the membranes at term: an economic evaluation

; Dinoprostone /economics /therapeutic use; Female; Fetal Membranes, Premature Rupture /economics /therapy; Great Britain; Health Care Costs /statistics & Humans; Labor, Induced /economics /methods /statistics & Oxytocics /economics /therapeutic use; Oxytocin /economics /therapeutic use; Pregnancy; Pregnancy Trimester, Third; Statistics, Nonparametric; numerical data; numerical data AccessionNumber 21997008380 Date bibliographic record published 31/10/2000 Date abstract record published 31/10/2000 NHS (...) Induction of labour versus expectant management for prelabour rupture of the membranes at term: an economic evaluation Induction of labour versus expectant management for prelabour rupture of the membranes at term: an economic evaluation Induction of labour versus expectant management for prelabour rupture of the membranes at term: an economic evaluation Gafni A, Goeree R, Myhr T L, Hannah M E, Blackhouse G, Willan A R, Weston J A, Wang E E, Hodnett E D, Hewson S A, Farine D, Ohlsson A Record

1997 NHS Economic Evaluation Database.

2887. The antenatal use of ambroxol (bromhexine metabolite VIII) to prevent hyaline membrane disease: a controlled double-blind study. (Abstract)

The antenatal use of ambroxol (bromhexine metabolite VIII) to prevent hyaline membrane disease: a controlled double-blind study. A prospective double-blind clinical trial was carried out to determine whether ambroxol (bromhexine metabolite VIII) treatment (1000 mg/day for a period of 5 days) reduces the risk of hyaline membrane disease (HMD) in potentially premature infants. Amniocentesis was performed before the first and 24 h after the last application of ambroxol or placebo to assess (...) , particularly before the 33rd week of gestation. Prolonged rupture of the membranes played no protective role against HMD.

1982 International journal of biological research in pregnancy

2888. Safety and efficacy of stripping of membranes at term. (Abstract)

difference was noted in incidence of premature rupture of membranes (PROM), mode of delivery, intrapartum events and perinatal outcome. No increase in neonatal morbidity was seen in association with this procedure. No patient in the study group had clinical evidence of chorioamnionitis. There was no statistically significant difference in the microbiological flora of both groups.Stripping of the fetal membranes is a safe and efficacious procedure for induction of labor. It decreases the incidence (...) Safety and efficacy of stripping of membranes at term. To assess the efficacy of stripping of membranes in initiation of labor and to study its effect on maternal and perinatal morbidity.One-hundred primigravidae with certain gestational dates were randomized at 38 weeks gestation to either receive stripping of membranes or only gentle cervical examination. Cervical swabs were taken before pelvic examination at 38 weeks and again at the onset of labor. Placental membranes were sent

1998 International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Controlled trial quality: uncertain

2889. Hyaline membrane disease and intraventricular haemorrhage in small for gestational age infants. Full Text available with Trip Pro

, presence of premature rupture of membranes, and birth date were comparable in the two groups. Gestational age of both groups was 30 (+/- 1.8) weeks, and birthweights were 919 (+/- 202) g (SGA group) and 1268 (+/- 212) g (AGA group). The incidences of hyaline membrane disease and intraventricular haemorrhage were different: 74 and 42% respectively for AGA neonates, 5 and 11% respectively for SGA infants. We suggest that a stressful environment in utero may enhance maturation and prevent hyaline membrane (...) Hyaline membrane disease and intraventricular haemorrhage in small for gestational age infants. 19 small for gestational age (SGA) infants with gestational ages less than or equal to 32 weeks were matched with 19 appropriate for gestational age (AGA) preterm neonates with similar risk factors for intraventricular haemorrhage and hyaline membrane disease. Gestational age, 1- and 5-minute Apgar scores, type of delivery, survival rate, use of corticosteroids before delivery, sex, twinning

1980 Archives of Disease in Childhood

2890. The role of membrane stripping in prevention of post-term pregnancy: a randomised clinical trial in Ile-lfe, Nigeria. (Abstract)

(4.8 vs. 12.1 days; P<0.001) and less incidence of delivery at 41 weeks or greater (3% vs. 16%; P=0.009). No statistically significant difference was noted in incidence of premature rupture of membranes, clinical evidence of chorioamnionitis, intrapartum characteristics and perinatal outcome. We conclude that membrane stripping is a safe method to reduce the incidence of post-term pregnancy. (...) The role of membrane stripping in prevention of post-term pregnancy: a randomised clinical trial in Ile-lfe, Nigeria. This study was carried out to evaluate the efficacy and safety of membrane stripping at term in reducing the incidence of post-term (41 weeks or greater) pregnancies. One hundred and thirty-seven pregnant women at 38 weeks gestation were randomised to receive either membrane stripping (69) or gentle cervical examination (68). Women who received stripping had earlier delivery

2002 Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology Controlled trial quality: uncertain

2891. Does sweeping of membranes beyond 40 weeks reduce the need for formal induction of labour? (Abstract)

assessed. Maternal and perinatal outcomes were also assessed.The recruitment to delivery interval was significantly shorter among women who had sweeping of membranes (3.2 versus 4.2 days, P < 0.05). The incidence of induction of labour was comparable (35.5% versus 38%, RR 0.91, 95% CI 0.57 - 1.46). The incidences of caesarean section and assisted vaginal delivery were comparable. The incidences of premature rupture of membranes, intrapartum, and postpartum infection were comparable. The perinatal (...) women were randomly allocated to sweeping of membranes and the other 60 women acted as control. The satisfaction for women allocated to sweeping of membranes was assessed by a questionnaire after the procedure. The two groups were assessed on intention-to-treat basis.The incidence of formal induction of labour was compared between the two groups. Possible complications of sweeping of membranes such as rupture of membranes, intrapartum infection, postpartum infection, and neonatal infection were also

2002 BJOG Controlled trial quality: predicted high

2892. IL-1 beta is a better inducer of apoptosis in human fetal membranes than IL-6. (Abstract)

IL-1 beta is a better inducer of apoptosis in human fetal membranes than IL-6. The objective of this study was to compare two of the inflammatory cytokines (IL-1 and IL-6) elevated in both preterm labour and preterm premature rupture of the membranes (pPROM), with respect to their ability to induce fetal membrane apoptosis. Fetal membranes collected from women at term were placed in an organ explant system and stimulated with recombinant human IL-1 beta and IL-6. The expression patterns of pro (...) -apoptotic genes (Fas, FasL, TRADD, FADD) and caspases 2, 3, 8, 9 were studied using PCR. Caspase activity and DNA fragmentation were studied using substrate assays and TUNEL respectively. Caspase 8 and 9 expressions were induced in IL-1 beta and IL-6 treated amniochorion. Caspase 2 expression was seen only in IL-1 beta stimulated tissues. When compared to control, IL-1 beta increased caspase 2, 3, 8 and 9 activities, whereas IL-6 treated membranes did not exhibit a significant change. DNA fragmentation

2003 Placenta

2893. A randomized placebo-controlled trial of erythromycin for the treatment of Ureaplasma urealyticum to prevent premature delivery. The Vaginal Infections and Prematurity Study Group. (Abstract)

these analyses. Erythromycin did not eliminate U. urealyticum from the lower genital tract. There were no significant differences between erythromycin- and placebo-treated women in infant birth weight or gestational age at delivery, in frequency of premature rupture of membranes, or in neonatal outcome. (...) A randomized placebo-controlled trial of erythromycin for the treatment of Ureaplasma urealyticum to prevent premature delivery. The Vaginal Infections and Prematurity Study Group. Ureaplasma urealyticum has been associated with low birth weight and histologic chorioamnionitis and it is a frequent isolate from the chorioamnion of patients who are delivered prematurely. In prior clinical trials using antibiotics active against U. urealyticum, antibiotic treatment was associated with reduced

1991 American journal of obstetrics and gynecology Controlled trial quality: uncertain

2894. Ethnic differences in preterm and very preterm delivery. Full Text available with Trip Pro

, infant sex, and gestational age at initiation of prenatal care resulted in the following odds ratios for preterm delivery: 1.79 (1.55-2.08) for Blacks, 1.40 (1.19-1.63) for Mexican-Americans, 1.40 (1.16-1.69) for Asians, and 1.00 for Whites. The corresponding odds ratios for very preterm delivery were 2.35 (1.72-3.22) for Blacks, 1.31 (0.88-1.94) for Mexican-Americans, 1.10 (0.67-1.83) for Asians, and 1.00 for Whites. Exclusion of cases of premature rupture of membranes, placenta previa, and abruptio (...) Ethnic differences in preterm and very preterm delivery. Ethnic differences in preterm (less than 37 weeks) and very preterm (less than 33 weeks) delivery were evaluated in a prospective cohort of 28,330 women. Blacks had the highest rate of preterm and very preterm delivery, followed by Mexican-Americans, Asians, and Whites. Adjustment for maternal age, education, marital status, employment, parity, number of previous spontaneous or induced abortions, smoking and drinking during pregnancy

1986 American Journal of Public Health

2895. S-relaxin as a predictor of preterm delivery in women with symptoms of preterm labour. (Abstract)

-relaxin was dichotomised to obtain best possible fit and then entered into the model. The same analyses were done for delivery within three days.Median S-relaxin levels varied significantly in the women with preterm prelabour rupture of membranes (PPROM) (316 pg/mL), contractions (222 pg/mL) or ripe cervices (203 pg/mL) (P < 0.05). S-relaxin above the 80th centile (> or = 300 pg/mL) was associated with an increased risk of preterm delivery [crude OR = 4.8; (95% CI: 1.9-12)]. Likelihood ratio (...) S-relaxin as a predictor of preterm delivery in women with symptoms of preterm labour. To evaluate whether serum relaxin (S-relaxin) can predict spontaneous delivery before 34 weeks of gestation in high risk pregnancies.A prospective cohort study.Calculated sample size was reached over a two-year period, during which 9507 women gave birth. Of these, 157 healthy women were eligible for the study as they were admitted with symptoms of delivery before 34 weeks of gestation. Ninety-three women were

2002 BJOG

2896. Amnioinfusion for preterm rupture of membranes. (Abstract)

Amnioinfusion for preterm rupture of membranes. Preterm rupture of membranes places a fetus at risk of cord compression and amnionitis. Amnioinfusion aims to prevent or relieve umbilical cord compression by infusing a solution into the uterine cavity.The objective of this review was to assess the effects of amnioinfusion for preterm rupture of membranes on maternal and perinatal outcomes.The Cochrane Pregnancy and Childbirth Group trials register and the Cochrane Controlled Trials Register were (...) risk 0.55, 95% confidence interval 0.05 to 5.77). In the amnioinfusion group, the number of severe fetal heart rate decelerations per hour during the first stage of labour were reduced (weighted mean difference -1.20, 95% confidence interval -1.83 to -0.57). These outcomes are consistent with those found in the Cochrane review on amnioinfusion for cord compression.There is not enough evidence concerning the use of amnioinfusion for preterm rupture of membranes.

2000 Cochrane

2897. Do antenatal corticosteroids help in the setting of preterm rupture of membranes?

Do antenatal corticosteroids help in the setting of preterm rupture of membranes? Do antenatal corticosteroids help in the setting of preterm rupture of membranes? Do antenatal corticosteroids help in the setting of preterm rupture of membranes? Harding J E, Pang J, Knight D B, Liggins G C Authors' objectives To conduct a meta-analysis of studies investigating the use of corticosteroids before pre-term delivery in mothers with ruptured membranes. Searching The authors did not report how (...) : The authors did not state any implications for practice. Research: The authors state that new trials are needed to address the risks and benefits of repeated doses of corticosteroids in women who remain undelivered a week after receiving the first course. Funding National Child Health Research Foundation; University of Auckland. Bibliographic details Harding J E, Pang J, Knight D B, Liggins G C. Do antenatal corticosteroids help in the setting of preterm rupture of membranes? American Journal

2001 DARE.

2898. Premature rupture of membranes at term: a meta-analysis of three management schemes

Premature rupture of membranes at term: a meta-analysis of three management schemes Premature rupture of membranes at term: a meta-analysis of three management schemes Premature rupture of membranes at term: a meta-analysis of three management schemes Mozurkewich E L, Wolf F M Authors' objectives To compare rates of Caesarean birth, endometritis, chorioamnionitis, and serious neonatal infections among pregnancies complicated by premature rupture of membranes (PROM) at term and managed (...) searches were: 'term', 'premature rupture' and 'fetal membranes'. Study selection Study designs of evaluations included in the review Randomised controlled trials (RCTs). They were classified as either true randomised controlled trials (defined as those in which sealed envelopes or random number tables were used), or controlled clinical trials (in which the randomisation methods were less rigorous or were not detailed). In studies containing both randomised and non-randomised arms, only data from

1997 DARE.

2899. Antibiotics for preterm premature rupture of membranes. (Abstract)

Antibiotics for preterm premature rupture of membranes. The aim of the review was to evaluate the effectiveness and the immediate and long-term safety of the effects of administering antibiotics to women with preterm prelabour rupture of membranes on maternal infectious morbidity, fetal and neonatal morbidity and mortality, and longer term childhood development.All randomized trials identified using the search strategy described by the Cochrane Pregnancy and Childbirth Group.All trials which

2000 Cochrane

2900. Non-invasive Test to Detect Intra-amniotic Infection in Women With Preterm Labor and Intact Amniotic Membranes

, cramping or backache) and one or more of the following: Progressive cervical change with cervical dilation of greater than or equal to 2 cm Effacement of greater than or equal to 50% Cervical length of less than or equal to 30 mm via transvaginal ultrasound Positive fetal fibronectin test Exclusion Criteria: Subject has documented ruptured amniotic membranes Subject has fetus with major fetal anomaly or chromosomal aneuploidy Subject has medical indication for preterm birth (e.g. pre-eclampsia) Subject (...) Non-invasive Test to Detect Intra-amniotic Infection in Women With Preterm Labor and Intact Amniotic Membranes Non-invasive Test to Detect Intra-amniotic Infection in Women With Preterm Labor and Intact Amniotic Membranes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2008 Clinical Trials

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