How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

3,156 results for

Premature Rupture of Membranes

by
...
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

2841. Can preterm deliveries be prevented? (Abstract)

assigned to the Preterm Labor Prevention Clinic or serve as high-risk controls. Sixty-four women assigned to the Preterm Labor Prevention Clinic and 68 high-risk control women have been delivered of their infants. No significant differences were noted for the percentages of preterm infants, mean gestational age, or birth weight. Preterm rupture of the membranes accounted for 40% of preterm deliveries in all high-risk patients. Thirty percent of preterm births were indicated for maternal or fetal (...) Can preterm deliveries be prevented? Our hospital serves poor, inner-city women who have a 17% preterm delivery rate. Middle-class women in San Francisco at high risk for preterm delivery have benefited from an antepartum program which emphasized patient education and close follow-up. Using a controlled, randomized design, we are investigating the impact of similar interventions. Patients determined to be at high risk before 18 weeks' gestation on the basis of the Creasy system are randomly

1985 American journal of obstetrics and gynecology Controlled trial quality: uncertain

2842. A randomized trial of electronic fetal monitoring in preterm labor: mothers' views. (Abstract)

A randomized trial of electronic fetal monitoring in preterm labor: mothers' views. To determine if perceptions of preterm labor and birth differed between women who were monitored by electronic fetal monitoring (EFM) or by periodic auscultation, 135 subjects were randomly assigned to one of two treatment groups on admission to a tertiary perinatal care setting. The first group received external monitoring by continuous Doppler and tocodynamometer when membranes were intact (...) , and with an internal fetal scalp electrode and pressure catheter once membranes were ruptured. The second group received periodic monitoring with a DeLee fetoscope or amplified Doppler. All women were cared for on a one-to-one basis by expert study nurses. Subjects completed a questionnaire about their labor experience during their postpartum hospital stay. There was no statistically significant difference between the two groups on the study measures [T2(7,81) = 13.65; F = 1.82; P greater than 0.05]. Forty-four

1989 Birth Controlled trial quality: uncertain

2843. Antenatal administration of betamethasone to prevent respiratory distress syndrome in preterm infants: report of a UK multicentre trial. (Abstract)

less than 0.01) in this subgroup. Betamethasone did not provoke earlier delivery. Premature rupture of the membranes and maternal hypertension did not seem to contraindicate the use of steroids: there was no increase in maternal or neonatal sepsis nor in stillbirth in hypertensive pregnancies in the steroid group. Neonatal jaundice was significantly less frequent in the steroid (55/129) than in the placebo group (81/127; P less than 0.01) but not in the subgroups born before 34 completed weeks (...) Antenatal administration of betamethasone to prevent respiratory distress syndrome in preterm infants: report of a UK multicentre trial. In a prospective, randomized, double-blind, multicentre trial the effect of antenatal treatment with betamethasone phosphate was compared with placebo in the prevention of the respiratory distress syndrome (RDS) in preterm infants. The dose of betamethasone was 4 mg every 8 h for six doses, unless delivery occurred. The 251 women who were enrolled gave birth

1989 British journal of obstetrics and gynaecology Controlled trial quality: predicted high

2844. Randomized comparative trial of indomethacin and ritodrine for the long-term treatment of preterm labor. (Abstract)

who required magnesium sulfate therapy, percentage of patients who were readmitted with premature rupture of membranes, absence of recurrent preterm labor, and infant birth weight. More than 80% of mothers who received ritodrine voiced complaints of beta-sympathomimetic side effects, and one patient discontinued treatment as the result of intolerance. There were minimal patient complaints with indomethacin use. No statistically significant differences were noted in neonatal outcome as defined (...) Randomized comparative trial of indomethacin and ritodrine for the long-term treatment of preterm labor. A randomized prospective trial was performed to compare the efficacy and safety of ritodrine and indomethacin in the long-term treatment of preterm labor. Forty patients with intact membranes in preterm labor at 23 to 34 weeks' gestation were randomized to receive either intravenous ritodrine or oral indomethacin as the first-line tocolytic agent. Successful intravenous ritodrine therapy

1991 American journal of obstetrics and gynecology Controlled trial quality: uncertain

2845. Controlled trial of a Preterm Labor Detection program: efficacy and costs. (Abstract)

age at delivery, mean birth weight, or percentage delivering before term as a result of preterm labor or premature rupture of membranes (PROM). Evaluations of inpatient charges revealed no significant differences due to participation in this program, although outpatient clinic utilization and charges were increased significantly for Preterm Labor Detection Clinic patients. Failure of this program to reduce preterm birth may relate to the relatively low overall rate of women presenting in preterm (...) Controlled trial of a Preterm Labor Detection program: efficacy and costs. Patient education regarding the signs and symptoms of preterm labor combined with frequent clinical evaluations has been advocated as a means to reduce preterm births. Over a 3.5-year period, the risk for preterm labor was determined in 943 indigent black inner-city women using the Papiernik-Creasy scoring system. High-risk women were allocated randomly to a Preterm Labor Detection Clinic or to serve as high-risk

1989 Obstetrics and Gynecology Controlled trial quality: uncertain

2846. Placental transfer of vitamin K1 in preterm pregnancy. (Abstract)

Placental transfer of vitamin K1 in preterm pregnancy. Seventy-eight women at earlier than 35 weeks' gestation with premature rupture of membranes and/or preterm labor were randomly assigned to receive either 10 mg vitamin K1 intramuscularly (IM) or no treatment. If delivery did not occur within 4 days, the dose of vitamin K1 was repeated. Women whose pregnancies continued beyond 8 days received 20 mg of vitamin K1 orally every day until the end of the 34th week or until delivery, whichever (...) of the latter group, however, had significantly higher median cord plasma levels (0.42 versus 0.017 ng/mL; P less than .001). There was no correlation between cord plasma vitamin K1 levels and gestational age or duration of maternal supplementation with vitamin K1. We conclude that, in preterm pregnancies, vitamin K1 crosses the placenta slowly and to a limited degree.

1990 Obstetrics and Gynecology Controlled trial quality: uncertain

2847. Adjunctive clindamycin therapy for preterm labor: results of a double-blind, placebo-controlled trial. (Abstract)

streptococcus, Chlamydia trachomatis, Trichomonas vaginalis, or Staphylococcus aureus were more likely to have preterm premature rupture of membranes (p = 0.01). Clindamycin treatment of these women reduced the incidence of preterm premature rupture of membranes to that of uninfected subjects. Stratification by gestational age at enrollment showed clindamycin treatment to be associated with an increased interval to delivery only among mothers enrolled before 33 weeks' gestation (clindamycin-treated group (...) Adjunctive clindamycin therapy for preterm labor: results of a double-blind, placebo-controlled trial. A double-blind, placebo-controlled, randomized trial was conducted to evaluate the efficacy, safety, and tolerance of a course of clindamycin (administered for 3 days intravenously and 4 days orally) among hospitalized women with preterm labor at less than or equal to 34 weeks' gestation who were treated with tocolytics. One hundred three woman-perinate pairs were analyzed. Univariate analysis

1991 American journal of obstetrics and gynecology Controlled trial quality: predicted high

2848. Phase III Randomized, Double-Blind, Placebo-Controlled Study of Antenatal Thyrotropin-Releasing Hormone in Pregnant Women With Threatened Premature Delivery

for Study: Female Accepts Healthy Volunteers: No Criteria PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Threatened premature delivery at 24 to 30 weeks gestation, i.e.: Premature labor Premature rupture of membranes Elective premature delivery medically indicated Fetal lung maturity immature or unknown --Prior/Concurrent Therapy-- No more than 72 hours since any initial corticosteroids --Patient Characteristics-- The following complications exclude: Fetal distress Amnionitis Severe maternal (...) Phase III Randomized, Double-Blind, Placebo-Controlled Study of Antenatal Thyrotropin-Releasing Hormone in Pregnant Women With Threatened Premature Delivery Phase III Randomized, Double-Blind, Placebo-Controlled Study of Antenatal Thyrotropin-Releasing Hormone in Pregnant Women With Threatened Premature Delivery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record

2000 Clinical Trials

2849. Bacterial vaginosis is associated with prematurity and vaginal fluid mucinase and sialidase: results of a controlled trial of topical clindamycin cream. (Abstract)

, treatment effects, and pregnancy outcomes were compared among drug- and placebo-treated women and control women without bacterial vaginosis.Presence of bacterial vaginosis at intake was associated with increased risk of preterm birth (relative risk 3.3, 95% confidence interval 1.2 to 9.1, p = 0.02), premature rupture of membranes (relative risk 3.8, 95% confidence interval 1.6 to 9.0, p = 0.002), and preterm premature rupture of membranes. Mucinase and sialidase activities were more commonly identified (...) % cream, was effective treatment for bacterial vaginosis and temporarily reduced mucinase and sialidase activities. Topical treatment of bacterial vaginosis did not reduce risks of perinatal morbidity. Women with persistent or recurrent sialidase 8 weeks after treatment were at increased risk of preterm birth (15.6% vs 7.4%) premature rupture of membranes (30% vs 15%), and low birth weight (20% vs 3%, relative risk 6.8, 95% confidence interval 1.6 to 28.1).Persistence of sialidase-producing vaginal

1994 American journal of obstetrics and gynecology Controlled trial quality: predicted high

2850. Prevention of premature birth by screening and treatment for common genital tract infections: results of a prospective controlled evaluation. (Abstract)

II). Data were analyzed according to intent to treat by means of univariate and multivariate methods.Overall, presence of bacterial vaginosis (32.5%) at enrollment was associated with pregnancy loss at < 22 weeks' gestation (relative risk 3.1, 95% confidence interval 1.4 to 6.9). Among women in the observation phase bacterial vaginosis was associated with increased risk of both preterm birth (relative risk 1.9, 95% confidence interval 1.2 to 3.0) and preterm premature rupture of membranes (...) (relative risk 3.5, 95% confidence interval 1.4 to 8.9). Within this population (phase I) 21.9% of preterm birth overall (43.8% premature rupture of membranes) is estimated as attributable to bacterial vaginosis. Among women with bacterial vaginosis phase II (treatment) was associated with reduced preterm birth (relative risk 0.5, 95% confidence interval 0.3 to 0.9); there was a similar reduction for women with preterm premature rupture of membranes (relative risk 0.5, 95% confidence interval 0.2 to 1.4

1995 American journal of obstetrics and gynecology

2851. Effect of metronidazole in patients with preterm birth in preceding pregnancy and bacterial vaginosis: a placebo-controlled, double-blind study. (Abstract)

Effect of metronidazole in patients with preterm birth in preceding pregnancy and bacterial vaginosis: a placebo-controlled, double-blind study. Our purpose was to determine whether treatment of bacterial vaginosis with metronidazole in patients with preterm delivery in the penultimate pregnancy from preterm labor or premature rupture of membranes reduces the risk of subsequent preterm birth.From January 1989 to June 1992 patients with a singleton gestation between 13 and 20 weeks and a history (...) of preterm birth in the preceding pregnancy from either idiopathic preterm labor or premature rupture of membranes were screened for bacterial vaginosis. Those with a positive screen were randomized to receive 250 mg of metronidazole three times a day for 7 days or placebo in a double-blind design. Data were analyzed with Student t and chi 2 tests, and differences considered significant at p < 0.05.Of 94 eligible patients, 80 were enrolled and completed the study, of which 44 received metronidazole. Both

1994 American journal of obstetrics and gynecology Controlled trial quality: predicted high

2852. A randomized comparison of nifedipine and ritodrine for suppression of preterm labor. (Abstract)

changes or preterm rupture of membranes. After stratification women were randomly assigned to receive either ritodrine intravenously or nifedipine orally. Fifty-five women were randomized to the nifedipine group and 47 to the ritodrine group. As expected, both groups were comparable in terms of several entry variables, including mean gestational age, ruptured membranes, treatment with tocolytic drugs, cervical examination, contraction frequency, age, and twin gestation. Delivery of women (...) A randomized comparison of nifedipine and ritodrine for suppression of preterm labor. To compare the efficacy and safety of nifedipine and ritodrine in preventing preterm labor, and to evaluate maternal side effects and neonatal outcome.Non-blind, randomized controlled trialA randomized trial of 102 pregnant women with gestational ages under 34 weeks, including 24 with twin pregnancies and 45 on betasympathicomimetic drugs, who had regular uterine contractions with either observed cervical

1998 European journal of obstetrics, gynecology, and reproductive biology Controlled trial quality: predicted high

2853. Ureaplasma urealyticum, erythromycin and respiratory morbidity in high-risk preterm neonates. (Abstract)

colonization with negative control cultures in 12/14 (86%) of treated infants. No significant differences were found between the colonized treated infants (n = 14) and those not treated (n = 14) in time with supplemental oxygen. Oxygen requirement at 36 weeks was related to lower gestational age, late appearance of PDA, late onset sepsis and signs of chorioamnionitis in the mother. We conclude that the Uu colonization is related to increasing immaturity, the presence of prolonged rupture of membranes (...) Ureaplasma urealyticum, erythromycin and respiratory morbidity in high-risk preterm neonates. We investigated colonization with Ureaplasma urealyticum (Uu) in infants <30 weeks gestation and assessed the relationship to other risk factors influencing respiratory morbidity, plus the effect of treatment with erythromycin. Ventilated preterm infants [n = 155; median GA 26 (23-29) weeks] were cultured for Uu in endotracheal aspirate and nasopharynx. Colonized infants were randomly assigned

1998 Acta paediatrica (Oslo, Norway : 1992) Controlled trial quality: uncertain

2854. Inflammatory cells in the lungs of premature infants on the first day of life: perinatal risk factors and origin of cells. Full Text available with Trip Pro

and two girls, probed for the Y chromosome with suitable control samples. Perinatal risk factors for increased airway cellularity were analysed by multiple regression. Premature rupture of membranes of more than 24 hours' duration was independently associated with increased numbers of airway leucocytes (n = 74). More than 90% of airway leucocytes from four boys with pulmonary inflammation were positive for the Y chromosome indicating that the cells were of fetal rather than maternal origin. (...) Inflammatory cells in the lungs of premature infants on the first day of life: perinatal risk factors and origin of cells. Neither the origin of leucocytes in the premature newborn airway nor their relationship to perinatal factors has been adequately determined. In order to sample airway cells, modified bronchoalveolar lavage was performed on 74 intubated infants of < 32 weeks' gestation and < 24 hours of age. Cells were counted, stained and, in a small separate group of six infants, four boys

1993 Archives of Disease in Childhood

2855. Preterm labour in association with Neisseria gonorrhoeae: case reports. Full Text available with Trip Pro

Preterm labour in association with Neisseria gonorrhoeae: case reports. We describe two cases of spontaneous rupture of the membranes, followed by premature labour at 32 and 34 weeks' gestation, in association with gonococcal infection.

1984 British Journal of Venereal Diseases

2856. Premature labour. Full Text available with Trip Pro

Premature labour. 1750772 1992 01 23 2018 11 13 1468-2044 66 10 Spec No 1991 Oct Archives of disease in childhood Arch. Dis. Child. Premature labour. 1167-70 Steer P J PJ Department of Obstetrics and Gynaecology, Charing Cross and Westminster Medical School, West London Hospital. eng Journal Article Review England Arch Dis Child 0372434 0003-9888 AIM IM Arch Dis Child. 1992 Jul;67(7 Spec No):885-6 1519998 Delivery, Obstetric methods Female Fetal Membranes, Premature Rupture therapy Fetal (...) Monitoring Humans Obstetric Labor, Premature etiology prevention & control Pregnancy Risk Factors Tocolysis 6 1991 10 1 1991 10 1 0 1 1991 10 1 0 0 ppublish 1750772 PMC1590274 Obstet Gynecol. 1989 Aug;74(2):256-8 2501721 Am J Obstet Gynecol. 1979 Dec 15;135(8):1051-6 517589 Br Med J. 1980 Nov 1;281(6249):1184-6 7427630 Am J Perinatol. 1989 Apr;6(2):226-33 2653336

1991 Archives of Disease in Childhood

2857. Cachectin/tumor necrosis factor-alpha formation in human decidua. Potential role of cytokines in infection-induced preterm labor. Full Text available with Trip Pro

-like decidua may serve a fundamental role in the pathogenesis of preterm labor, including increased prostaglandin formation and premature rupture of the membranes. (...) or at term before or after the onset of labor (n = 44); but TNF-alpha was present at concentrations between 2.8 and 22.3 ng/ml in amniotic fluids of 4 of 20 pregnancies with intact membranes complicated by preterm labor (less than 34 wk gestational age). LPS was present in 10 of the 20 amniotic fluids of preterm labor pregnancies, including all four in which TNF-alpha was present. Bacteria were identified in only one of the four LPS-positive, TNF-alpha-positive fluids. Cytokine formation in macrophage

1989 Journal of Clinical Investigation

2858. Premature labour. Full Text available with Trip Pro

Premature labour. 1519998 1992 10 07 2018 11 13 1468-2044 67 7 Spec No 1992 Jul Archives of disease in childhood Arch. Dis. Child. Premature labour. 885-6 Seidman D S DS Mashiach S S eng Comment Letter England Arch Dis Child 0372434 0003-9888 AIM IM Arch Dis Child. 1991 Oct;66(10 Spec No):1167-70 1750772 Female Fetal Membranes, Premature Rupture diagnosis Humans Obstetric Labor, Premature diagnosis Physical Examination adverse effects Pregnancy 1992 7 1 1992 7 1 0 1 1992 7 1 0 0 ppublish

1992 Archives of Disease in Childhood

2859. Antenatal onset of haemorrhagic and/or ischaemic lesions in preterm infants: prevalence and associated obstetric variables Full Text available with Trip Pro

to antenatal onset in five (7.3%). A comparison of the obstetric risk factors between the infants in group A and B, who either died or developed cerebral palsy, showed a significant difference in gestational age between the two groups (30.9 vs 28.9 weeks; p < 0.001). Prolonged rupture of membranes was significantly more common in group B (p = 0.03), while an ominous cardiotachogram was significantly more common in group A (p = 0.01), and this remained significant following logistic regression (...) Antenatal onset of haemorrhagic and/or ischaemic lesions in preterm infants: prevalence and associated obstetric variables To assess the prevalence of an antenatal onset of haemorrhagic and/or ischaemic lesions in preterm infants; to identify possibly related obstetric risk factors.A prospective cohort study was made of 1332 infants born at less than 34 completed weeks, using cranial ultrasound, for the presence of antenatal brain lesions (group A) involving the periventricular white matter

1998 Archives of Disease in Childhood. Fetal and Neonatal Edition

2860. Influence of ethnic origin on respiratory distress syndrome in very premature infants Full Text available with Trip Pro

analysis showed that ethnic origin was related to the occurrence of RDS independent of gestational age, size for dates, antenatal steroids, hypertension during pregnancy, premature rupture of membranes, maternal smoking, mode of delivery and infant gender.The enhanced lung maturation found in certain ethnic groups, even when born prematurely, has implications for clinical management. (...) Influence of ethnic origin on respiratory distress syndrome in very premature infants To determine whether the incidence of respiratory distress syndrome (RDS) is related to ethnic origin in very premature infants (< or = 32 weeks of gestational age and birthweight < or = 2.0 kg).A retrospective cohort study was performed to determine the incidence of respiratory disorders in African, Caribbean, and caucasian infants. An African infant was matched with two infants (one of Caribbean and one

1998 Archives of Disease in Childhood. Fetal and Neonatal Edition

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>