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Premature Rupture of Membranes

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2821. Nifedipine vs Placebo for Maintenance Tocolysis of Preterm Labor.

, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years to 55 Years (Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria: - arrested preterm labor Exclusion Criteria: - ruptured membranes, fetal distress, placenta previa, placental abruption, maternal medical contraindication to tocolysis Contacts and Locations Go (...) by: Stanford University Study Details Study Description Go to Brief Summary: Comparing nifedipine to placebo for the maintenance tocolysis of preterm labor Condition or disease Intervention/treatment Phase Obstetric Labor, Premature Venous Thrombosis Drug: Nifedipine Not Applicable Detailed Description: To estimate whether maintenance nifedipine tocolysis after arrested preterm labor prolongs pregnancy and improves neonatal outcomes. Study Design Go to Layout table for study information Study Type

2005 Clinical Trials

2822. Magnesium Sulfate Versus Nifedipine for the Acute Tocolysis of Preterm Labor: A Prospective, Randomized Trial

Inclusion Criteria::- Uterine contractions and cervical change or ruptured membranes in a preterm gestation Exclusion Criteria:- placental abruption, fetal distress, placenta previa, maternal medical contraindication to tocolysis Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov (...) First Posted : October 2, 2018 Last Update Posted : November 19, 2018 Sponsor: Stanford University Information provided by (Responsible Party): Yasser Yehia El-Sayed, Stanford University Study Details Study Description Go to Brief Summary: To compare intravenous magnesium sulfate to oral nifedipine for acute tocolysis of preterm labor Condition or disease Intervention/treatment Phase Obstetric Labor, Premature Drug: Magnesium Sulfate Drug: Nifedipine Not Applicable Study Design Go to Layout table

2005 Clinical Trials

2823. Risk of preterm delivery in relation to maternal low birth weight. (Abstract)

Risk of preterm delivery in relation to maternal low birth weight. We examined the relationship between maternal low birth weight and preterm delivery risk.Information concerning maternal birth weight was collected during in-person interviews. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI). Preterm delivery cases were studied in aggregate, in subgroups (spontaneous preterm labor, preterm premature rupture of membranes, medically induced preterm (...) delivery, moderate preterm delivery [gestational age at delivery 34-36 weeks], and early preterm delivery [gestational age at delivery<34 weeks]).After adjusting for confounders, women weighing<2,500 g at birth had a 1.54-fold increased risk of preterm delivery versus women weighing=2,500 g (95% CI 0.97-2.44). Maternal low birth weight was associated with a 2-fold increased risk of spontaneous preterm delivery (95% CI 1.03-3.89), but weakly associated with preterm premature rupture of membranes

2007 Acta Obstetricia et Gynecologica Scandinavica

2824. Infant mortality of very preterm infants by mode of delivery, institutional policies and maternal diagnosis. (Abstract)

assessed the association between mode of delivery, gestational age (GA), calendar year, maternal condition, and institutional policies on infant mortality outcome.At 23-25 weeks, 38% of infants (range: 34-69%) were delivered by cesarean section (CS), while at 26-27 weeks, 66% (59-80%) were delivered by CS. The CS rate for fetal or maternal indications was 98% in cases of pre-eclampsia/eclampsia, 42% for premature rupture of membranes (PROM), 68% for hemorrhage, 76% for PROM+hemorrhage, 56% for breech (...) Infant mortality of very preterm infants by mode of delivery, institutional policies and maternal diagnosis. The aim of this study was to analyse infant mortality among infants born extremely preterm in relation to mode of delivery, maternal diagnosis, and different institutional policies.We conducted a national tertiary health care center study using Swedish Medical Birth Register (MBR) data from 1990 to 2002, to examine the 2,094 live births of infants at 23+0 to 27+6 weeks gestation. We

2007 Acta Obstetricia et Gynecologica Scandinavica

2825. Impaired collagen chaperone results in preterm PROM Full Text available with Trip Pro

eng Comment Journal Article 2006 08 28 United States Proc Natl Acad Sci U S A 7505876 0027-8424 0 HSP47 Heat-Shock Proteins 0 Molecular Chaperones 0 SERPINH1 protein, human 9007-34-5 Collagen IM Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13463-7 16938879 African Americans African Continental Ancestry Group genetics Collagen biosynthesis European Continental Ancestry Group genetics Female Fetal Membranes, Premature Rupture epidemiology ethnology genetics HSP47 Heat-Shock Proteins genetics (...) Impaired collagen chaperone results in preterm PROM 16938862 2006 10 19 2018 11 13 0027-8424 103 36 2006 Sep 05 Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. Impaired collagen chaperone results in preterm PROM. 13267-8 Taylor Kristen H KH Department of Pathology and Anatomical Sciences and Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA. taylorjerr@missouri.edu Schnabel Robert D RD Taylor Jeremy F JF

2006 Proceedings of the National Academy of Sciences of the United States of America

2826. Investigation of Midtrimester Amniotic Fluid Factors as Potential Predictors of Term and Preterm Deliveries Full Text available with Trip Pro

inflammation/infection and preterm labor.Concentrations of all substances were not statistically different among mothers, delivering preterm or at term. SLPI concentrations significantly increased in women, going into labor without ruptured membranes, irrespective of pre- or term delivery (P < .007, P < .001, resp) and correlated with elastase (r = 0.508, P < .002).Midtrimester amniotic fluid SLPI concentrations significantly decrease when membrane rupture precedes pre- or full-term labor. However, none (...) Investigation of Midtrimester Amniotic Fluid Factors as Potential Predictors of Term and Preterm Deliveries Our aim is to investigate, in 13 cases (delivering preterm) and 21 matched (for age, parity, and gestational age) controls (delivering at term), whether midtrimester amniotic fluid concentrations of elastase, secretory leukocyte proteinase inhibitor (SLPI), soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule predict asymptomatic intra-amniotic

2006 Mediators of inflammation

2827. Maternal-fetal conditions necessitating a medical intervention resulting in preterm birth. (Abstract)

-for-gestational-age birth, fetal distress, placental abruption, placenta previa, unexplained vaginal bleeding, pregestational and gestational diabetes, renal disease, Rh sensitization, and congenital malformations. We examined the association between each of the aforementioned conditions and risk of medically indicated preterm birth at less than 35 weeks. Medically indicated preterm birth was defined as a labor induction or a prelabor cesarean in the absence of premature rupture of membranes at preterm (...) Maternal-fetal conditions necessitating a medical intervention resulting in preterm birth. The objective of the study was to evaluate the extent to which maternal and fetal conditions necessitate medically indicated preterm birth.A population-based, retrospective, cohort study of women who delivered a singleton live birth at 20 weeks or longer in Missouri, 1989 to 1997 was performed (n = 684,711). Maternal-fetal conditions that necessitated iatrogenic preterm birth included preeclampsia, small

2006 American Journal of Obstetrics and Gynecology

2828. Association of maternal IL-1 receptor antagonist intron 2 gene polymorphism and preterm birth. (Abstract)

Association of maternal IL-1 receptor antagonist intron 2 gene polymorphism and preterm birth. This study was undertaken to determine whether the interleukin-1 receptor antagonist (IL-1RN) variable number tandem repeat polymorphism is associated with preterm birth.A case-control study was performed. Cases (n = 95) delivered before 37 weeks after preterm labor (PTL) or preterm premature rupture of membranes (PPROM) and controls (n = 105) delivered after 37 weeks. Maternal DNA was genotyped (...) copy of the IL-1RN allele 2 appears to be associated with increased risk of preterm birth.

2006 American Journal of Obstetrics and Gynecology

2829. Bacterial vaginosis in a cohort of Danish pregnant women: prevalence and relationship with preterm delivery, low birthweight and perinatal infections. Full Text available with Trip Pro

delivery, previous conisation, smoking, gestational diabetes, fetal death and preterm premature rupture of membranes, showed that BV was significantly associated with low birthweight (OR 1.95, 95% CI 1.3-2.9), preterm delivery of a low-birthweight infant (OR 2.5, 95% CI 1.6-3.9), indicated preterm delivery (OR 2.4, 95% CI 1.4-4.1) and clinical chorioamnionitis (OR 2.7, 95% CI 1.4-5.1).The prevalence of BV determined using the Schmidt criteria in the early second trimester of pregnancy was similar (...) Bacterial vaginosis in a cohort of Danish pregnant women: prevalence and relationship with preterm delivery, low birthweight and perinatal infections. To determine the prevalence of bacterial vaginosis (BV) in the second trimester of pregnancy in a Danish population using the Schmidt criteria and to examine whether BV was associated with subsequent preterm delivery, low birthweight or perinatal infections.Prospective cohort study.Department of Obstetrics and Gynaecology at a University Hospital

2006 BJOG

2830. Adenomyosis and risk of preterm delivery. Full Text available with Trip Pro

term delivery and who matched with age, body mass index, smoking, and status of previous preterm delivery were recruited concurrently and served as control group. Preterm delivery cases were further divided into spontaneous preterm delivery and preterm premature rupture of membranes (PPROM) cases.Risk analysis of preterm delivery between gravid women with and without adenomyosis.One-hundred and four preterm delivery case subjects and 208 control subjects were assessed. Overall, gravid women (...) Adenomyosis and risk of preterm delivery. To evaluate the risk of preterm delivery in patients with adenomyosis.A 1:2 nested case-control study.Tertiary-care institution.A base cohort population of 2138 pregnant women who attended routine prenatal check-up between July 1999 and June 2005.From this base cohort population, gravid women with singleton pregnancy who delivered prior to the completion of 37 weeks of gestation were identified and formed the study group. Singleton gravid women who had

2007 BJOG

2831. The use of high-dimensional biology (genomics, transcriptomics, proteomics, and metabolomics) to understand the preterm parturition syndrome. Full Text available with Trip Pro

in reproductive tissues associated with preterm labour and preterm prelabour rupture of membranes; 3) proteomics to identify differentially expressed proteins in amniotic fluid of women with preterm labour; and 4) metabolomics to identify the metabolic footprints of women with preterm labour likely to deliver preterm and those who will deliver at term. The complementary nature of discovery science and HDB is emphasised. (...) The use of high-dimensional biology (genomics, transcriptomics, proteomics, and metabolomics) to understand the preterm parturition syndrome. High-dimensional biology (HDB) refers to the simultaneous study of the genetic variants (DNA variation), transcription (messenger RNA [mRNA]), peptides and proteins, and metabolites of an organ, tissue, or an organism in health and disease. The fundamental premise is that the evolutionary complexity of biological systems renders them difficult

2006 BJOG

2832. Pentraxin 3 in plasma and vaginal fluid in women with preterm delivery. Full Text available with Trip Pro

Pentraxin 3 in plasma and vaginal fluid in women with preterm delivery. OBJECTIVE To investigate the role of pentraxin 3 (PTX3), an acute-phase protein produced by cells of innate immunity in response to inflammatory signals, in spontaneous preterm delivery (PTD). DESIGN Cohort study. SETTING Department of Obstetrics and Gynecology of the University of Milano-Bicocca. POPULATION Forty-six pregnant women with preterm rupture of membranes (n=33) or preterm labour with intact membranes (n=13

2007 BJOG

2833. Fetal vasculitis in preterm newborns: interrelationships, modifiers, and antecedents. (Abstract)

Fetal vasculitis in preterm newborns: interrelationships, modifiers, and antecedents. Histologic expressions of the fetal inflammatory response predict preterm delivery and neonatal disorders. We examined 1146 placentas in the Developmental Epidemiology Network data set for histologic evidence of membrane inflammation (subchorionitis, chorionitis, and chorioamnionitis) and fetal vasculitis (acute umbilical vasculitis or chorionic vasculitis). Our main findings are that (1) in the presence (...) of membrane inflammation, fetal vasculitis is common, (2) duration of membrane rupture and gestational age appear to modify the risk of fetal vasculitis, (3) this risk modification differs for the different components of fetal vasculitis, i.e. umbilical and chorionic vasculitis, and (4) antecedents can be identified that appear to increase or decrease the risk of fetal vasculitis among births with membrane inflammation. We conclude that fetal vasculitis, the morphologic component of the fetal inflammatory

2004 Placenta

2834. Changes in matrix metalloproteinase (MMP)-2 and MMP-9 in the fetal amnion and chorion during gestation and at term and preterm labor. (Abstract)

Changes in matrix metalloproteinase (MMP)-2 and MMP-9 in the fetal amnion and chorion during gestation and at term and preterm labor. Increased matrix metalloproteinase (MMP)-9 proteolytic activity is associated with term birth, preterm birth and premature rupture of membranes. However, most studies show no changes with MMP-2, which binds tightly to cell and matrix proteins. We hypothesized better protein extraction would reveal new MMP patterns. Human amnion and chorion were collected from 25 (...) regulator of membrane rupture and other labor-associated mechanisms at term parturition, and its role(s) should be examined further.

2006 Placenta

2835. Readily treatable reproductive tract infections and preterm birth among black women. (Abstract)

, and preterm premature rupture of membranes were the primary outcomes that were examined.Bacterial vaginosis, infection with Chlamydia trachomatis, Trichomonas vaginalis, Mycoplasma hominis, Neisseria gonorrhoeae, and group B streptococcal colonization were more common among black women (P < .01) than among comparators. Preterm birth occurred more often among black women with infections that were being studied (20.4%), compared with uninfected black women (9.5%; relative risk, 2.2; 95% CI, 1.1-4.1). Up (...) to 42% of preterm births among black women were attributable to the presence of bacterial vaginosis, T vaginalis, or C trachomatis alone or in combinations. The risk for preterm birth among infected black women who received Centers for Disease Control and Prevention recommended treatment was reduced significantly (relative risk, 0.16; 95% CI, 0.04-0.66).Black women have increased risks of prematurity that are associated with prevalent reproductive tract infections during pregnancy. Preterm birth

2006 American Journal of Obstetrics and Gynecology

2836. Teenage antenatal clinics may reduce the rate of preterm birth: a prospective study. Full Text available with Trip Pro

% CI 0.29-0.68), preterm, prelabour, prolonged rupture of membranes (OR 0.34; 95% CI 0.18-0.63) or deliver preterm (OR 0.40; 95% CI 0.25-0.62) compared with those from general clinics. However, there was no independent effect of clinic care upon newborn biometry outcomes. Clinic care did not significantly alter rates of initiation of breastfeeding in hospital. However, significantly more of the teenage antenatal clinic mothers were discharged on contraception (OR 1.58; 95% CI 1.07-2.25).Teenage (...) Teenage antenatal clinics may reduce the rate of preterm birth: a prospective study. To examine whether teenage antenatal clinics reduce the incidence of preterm birth.A multicentre prospective study was performed.Three Australian hospitals with maternity services.Consecutive teenage patients (N= 731) were approached at their first or second antenatal visit.Cases were women attending multidisciplinary teenage antenatal clinics and controls attended general hospital-based antenatal clinics

2004 BJOG

2837. Role of cytokines in preterm labour and brain injury. Full Text available with Trip Pro

characterised. The rate of preterm birth in Sweden is lower, and the rate of chorioamnionitis, bacterial vaginosis (BV), neonatal sepsis, and urinary tract infections during pregnancy is lower compared with the USA. In a Swedish population of women with preterm labour or preterm premature rupture of the membranes (PPROM) <34 weeks of gestation, microorganisms were detected in the amniotic fluid in 25% of women with PPROM and in 16% of those in preterm labour. Nearly half of these women had intra-amniotic (...) Role of cytokines in preterm labour and brain injury. Intrauterine infection induces an intra-amniotic inflammatory response involving the activation of a number of cytokines and chemokines which, in turn, may trigger preterm contractions, cervical ripening and rupture of the membranes. Infection and cytokine-mediated inflammation appear to play a prominent role in preterm birth at early gestations (<30 weeks). The role of infection/inflammation in preterm birth in Europe has been incompletely

2005 BJOG

2838. Role of matrix metalloproteinases in preterm labour. Full Text available with Trip Pro

Role of matrix metalloproteinases in preterm labour. Extracellular matrix homeostasis is a key process in the maintenance of the tensile strength of the amniochorion. This tensile strength guarantees the role of the membranes as a physical and functional boundary for the fetus during human pregnancy. Pathological rupture of these structures before 37 completed weeks of gestation is known as preterm prelabour rupture of the membranes (PPROM) and it is a major cause of spontaneous preterm labour (...) and preterm birth. A mechanism involving the activation of matrix metalloproteinases (MMP)-9, a 92-kDa type IV collagenase, as an essential mediator of tissue damage is under investigation. The proposed mechanism involves the abnormal expression and activity of MMP-9 with subsequent connective tissue degradation taking place at a time that does not synchronise with other events of labour. The local physiological signal by amniochorion cells to induce MMP-9 expression is not known, but bacterial products

2005 BJOG

2839. Previous induced abortions and the risk of very preterm delivery: results of the EPIPAGE study. Full Text available with Trip Pro

preterm live-born singletons (33-34 weeks) and 618 unmatched full-term controls (39-40 weeks).Data from the EPIPAGE study were analysed using polytomous logistic regression models to control for social and demographic characteristics, lifestyle habits during pregnancy and obstetric history. The main mechanisms of preterm delivery were classified as gestational hypertension, antepartum haemorrhage, fetal growth restriction, premature rupture of membranes, idiopathic preterm labor and other causes.Odds (...) to very preterm delivery. A history of induced abortion was associated with an increased risk of premature rupture of the membranes, antepartum haemorrhage (not in association with hypertension) and idiopathic spontaneous preterm labour that occur at very small gestational ages (< 28 weeks). Conversely, no association was found between induced abortion and very preterm delivery due to hypertension.Previous induced abortion was associated with an increased risk of very preterm delivery. The strength

2005 BJOG

2840. The complex relationship between smoking in pregnancy and very preterm delivery. Results of the Epipage study. (Abstract)

controls.Data from the French Epipage study were analysed using a polytomous logistic regression model to control for social and demographic characteristics, pre-pregnancy body mass index and obstetric history. The main mechanisms of preterm delivery were classified as gestational hypertension, antepartum haemorrhage, premature rupture of membranes, spontaneous preterm labour and other miscellaneous mechanisms.Odds ratios for very preterm birth for low to moderate (1-9 cigarettes/day) and heavy (>/=10 (...) The complex relationship between smoking in pregnancy and very preterm delivery. Results of the Epipage study. To assess the relationship between cigarette smoking during pregnancy and very preterm births, according to the main mechanisms of preterm birth.Case-control study (the French Epipage study).Regionally defined population of births in France.Eight hundred and sixty-four very preterm live-born singletons (between 27 and 32 completed weeks of gestation) and 567 unmatched full-term

2004 BJOG

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