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Premature Rupture of Membranes

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2801. Does Progesterone Prevent Very Preterm Delivery in Twin Pregnancies?

gestations account for 2% of all pregnancies, but cause more than 10% of the cases of preterm delivery. Due to increasing maternal age and use of assisted reproduction the number of multiple gestations is larger than ever. If markers of preterm delivery can be identified and means of preventing preterm delivery are found, it will be possible to reduce the number of children admitted to hospital because of prematurity. Recently, two larger randomised studies investigated the effect of progesterone (...) : Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Twin pregnancy Informed consent 18-23 weeks' gestation Participants must be fluent in the language spoken in the respective centres Exclusion Criteria: Age < 18 years Known allergy to progesterone or peanuts Active thromboembolic disorders or a history of hormone-associated thromboembolic disorders Rupture of membranes at the time of inclusion Monoamniotic twins Pregnancies treated for or with signs of twin-to-twin transfusion

2006 Clinical Trials

2802. Microarray Expression Profiling to Identify Stereotypic mRNA Profiles for Preterm Delivery in Order to Unravel the Biological Mechanisms

of Child Health and Human Development (NICHD) ClinicalTrials.gov Identifier: Other Study ID Numbers: 999999056 OH99-CH-N056 First Posted: June 21, 2006 Last Update Posted: January 3, 2019 Last Verified: April 19, 2018 Keywords provided by National Institutes of Health Clinical Center (CC) ( Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) ): Premature Rupture of Membranes Genetic Risk Factors Tissue Specific Expression Quantitative Real Time PCR Preterm Birth (...) ) Sexes Eligible for Study: Female Accepts Healthy Volunteers: Yes Criteria INCLUSION CRITERIA: Consecutive patients admitted with the following diagnoses from four different ethnic groups (Hispanic, African American, Asian, and Caucasian): Preterm labor with intact membranes and with acute inflammation; chronic villitis; vascular pathology; no identifiable lesions. Preterm delivery without labor because of the following reasons: pre-eclampsia; abruptio placentae; fetal anomalies; Other complications

2006 Clinical Trials

2803. Trial of Magnesium Sulfate Tocolysis Versus Nifedipine Tocolysis in Women With Preterm Labor

previa or abruptio placenta Preterm premature rupture of membranes Prolapsed membranes Human immunodeficiency virus positive Multiple gestation Patients on procardia within 24 hours of po intake Magnesium sulfate tocolysis prior to randomization Patient refusal Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer (...) Posted : November 9, 2009 Sponsor: University of Cincinnati Collaborator: University Hospital Information provided by: University of Cincinnati Study Details Study Description Go to Brief Summary: Primary Hypothesis: Acute tocolysis (48 hours) using oral nifedipine is more effective than intravenous magnesium sulfate in prolonging pregnancy in women with preterm labor with intact membranes between 24 and 32 6/7 weeks' gestation. Condition or disease Intervention/treatment Phase Premature Birth

2006 Clinical Trials

2804. Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth

, increased CRP or another acute phase protein, uterine tenderness) lethal disease of the fetus informed consent obtained premature rupture of membranes is not contraindication for the trial entry *Gestational age will be calculated from the mother’s last menstrual period and confirmed by ultrasound before 20 weeks’ gestation. In case the discrepancy in the estimates exceeds two weeks, ultrasound date is accepted. **Very high risk of premature delivery is described as follows: elective delivery within (...) within 4-48 hours, as indicated by the obstetrician on the basis of the clinical status of the mother and/or the fetus very high risk of spontaneous delivery within 4-48 hours, i.e. cervix is open > 3 cm contractions of the uterus at 5-10 min intervals rupture of the membranes after the first course of ANC fetal and/or maternal indication for elective premature delivery or cesarean section Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study

2006 Clinical Trials

2805. Dynamic Cervical Change: Prediction of Preterm Labor in Symptomatic Patients

. Regular uterine contractions, uterine cramping, or pelvic pressure). Exclusion Criteria: Cervical cerclage Ruptured membranes noted on initial speculum examination Cervical os dilation >4 cm noted on initial digital examination Known HIV-positive or active HSV(to minimize the risk of perinatal exposure) Presence of multiple genital warts Patients under extreme duress from their uterine contractions Contacts and Locations Go to Information from the National Library of Medicine To learn more about (...) Dynamic Cervical Change: Prediction of Preterm Labor in Symptomatic Patients Dynamic Cervical Change: Prediction of Preterm Labor in Symptomatic Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2006 Clinical Trials

2806. A Proof of Concept Study Assessing the Effect of Four Different Single Bolus Intravenous Doses of FE200440 and Placebo on Stopping Preterm Labor

or disease Intervention/treatment Phase Labor, Premature Premature Birth Drug: FE200440 Phase 2 Detailed Description: To determine the effects of four different single bolus doses of FE200440 administered intravenously on stopping preterm labour compared to placebo in pregnant women with advanced gestational age To establish the effects of four different single bolus doses of FE200440 administered intravenously on uterine contractions compared to placebo To evaluate the effects of four different single (...) placenta known or suspected infection (e.g. urinary tract infection, chorioamnionitis) Controlled or uncontrolled diabetes mellitus (pre-gestational or gestational) Eclampsia or severe preeclampsia in the current pregnancy Previous major uterine surgery (e.g. myomectomy for leiomyomas), congenital uterine abnormalities, large leiomyomas, or retained intrauterine device Rupture of membrane in the current pregnancy Placenta praevia in the current pregnancy a) Oligohydramnios or polyhydramnios

2005 Clinical Trials

2807. Randomized Trial Comparing Misoprostol and Foley Bulb for Labor Induction in the Preterm Gestation

: University of Florida Information provided by (Responsible Party): University of Florida Study Details Study Description Go to Brief Summary: The purpose of this study is to compare the time to delivery of two different cervical ripening methods on the preterm gestation. Condition or disease Intervention/treatment Phase Premature Birth Cervical Ripening Drug: Misoprostol Device: Foley bulb Phase 2 Detailed Description: Labor induction for the preterm gestation is indicated for various maternal and fetal (...) Eligible for Study: 18 Years to 45 Years (Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: singleton gestation, gestational age 23-35 weeks, indication for induction Exclusion Criteria: multiple gestation, non-cephalic presentation, previous uterine surgery, rupture of membranes, intrauterine fetal death Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact

2006 Clinical Trials

2808. Two Dose Regimens of Nifedipine for the Management of Preterm Labor

for Study: Female Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: All pregnant women diagnosed with preterm labor defined as regular contractions associated with cervical change between 24 and 34 weeks of gestation Exclusion Criteria: Multiple pregnancy Preterm rupture of membranes Congenital fetal malformations IUGR (intra uterine growth restriction) Previous tocolysis in this pregnancy Chorioamnionitis Cervical dilation > 4 cms Maternal medical conditions such as renal insufficiency (...) effective and safest dose regimen of nifedipine in such patients. Condition or disease Intervention/treatment Phase Labor, Premature Drug: Nifedipine Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 102 participants Allocation: Randomized Intervention Model: Single Group Assignment Masking: Single (Outcomes Assessor) Primary Purpose: Treatment Official Title: Study of Different Doses of Nifedipine to Treat Preterm Labor Study

2005 Clinical Trials

2809. Treatment of Preterm Labor With 17 Alpha-hydroxyprogesterone Caproate

being. Exclusion Criteria: Rupture of membranes Major known fetal anomalies Cervical dilation > 4 centimeters Uterine anomalies Cervical cerclage Treatment during this pregnancy with progesterone after 14 weeks' gestation (use up to 14 weeks' gestation is permitted) Previous admission for preterm labor Contraindications to tocolysis, including fetal distress, chorioamnionitis, preeclampsia, hemodynamic instability Coexisting maternal disease including hypertension requiring medical therapy, cancer (...) in symptomatic patients. Condition or disease Intervention/treatment Phase Premature Birth Premature Labor Drug: 17 hydroxyprogesterone caproate intramuscular injections Not Applicable Detailed Description: Preterm delivery remains one of the most important issues facing perinatal medicine today. In 1999, prematurity/low birthweight accounted for 4,304 neonatal deaths, reflecting a rate of neonatal mortality due to prematurity of 23.0 per 100,000 live births. Despite the extent of the problem, the exact

2005 Clinical Trials

2810. Vaginal Progesterone to Reduce the Risk of Another Preterm Birth

. The subject, in the judgment of the investigator, will be unable or unwilling to comply with study-related assessments and procedures. The subject currently has preterm rupture of membranes, vaginal bleeding, known or suspected amnionitis, or signs or symptoms of preterm labor at the time of enrollment. The subject is HIV positive with a CD4 count of _<350 cells/mm3 and is receiving more than 1 medication to prevent the transfer of AIDS to the fetus. The subject has placenta previa or a low-lying placenta (...) " is a delivery (<35 weeks), either vaginal or cesarean, that is initiated by either preterm PROM followed by contractions or preterm labor initiated with in-tact membranes. A previous preterm delivery secondary to an incompetent cervix where a cerclage is considered for this pregnancy is not considered a preterm delivery (please see Exclusion Criteria No. 10). Subjects enrolled based on a history of preterm delivery may have had a pregnancy loss (or losses) at <20 0/7 weeks gestational age between

2004 Clinical Trials

2811. Singleton Preterm Births in Korle Bu Teaching Hospital, Accra, Ghana - Origins and Outcomes Full Text available with Trip Pro

-five (42%, [95% Confidence Interval (CI) 37.4%, 46.8%]) preterm births followed spontaneous onset of preterm labour (group A), 82 (18.6%, [95% CI 15.2%, 22.7%]) followed preterm premature rupture of membranes, PPROM (group B) and 173 (39.3%, [95% CI 34.8%, 44.1%]) were medically indicated (group C). The commonest indication for delivery in group C was severe pre-eclampsia/eclampsia. Although there was no significant difference in the mean gestational ages at delivery between the groups, babies (...) Singleton Preterm Births in Korle Bu Teaching Hospital, Accra, Ghana - Origins and Outcomes To determine the singleton preterm birth rate, the relative proportions of the clinical categories of preterm births and to compare the outcomes in these categories.Department of Obstetrics & Gynaecology, Korle Bu Teaching Hospital.Preterm births from 1(st) July to 31(st) December 2003.Out of a total of 4731 singleton births 440 were preterm, giving a preterm birth rate of 9.3%. One hundred and eighty

2006 Ghana Medical Journal

2812. Epidemiology of preterm birth Full Text available with Trip Pro

Epidemiology of preterm birth 15374920 2004 09 28 2018 11 13 1756-1833 329 7467 2004 Sep 18 BMJ (Clinical research ed.) BMJ Epidemiology of preterm birth. 675-8 Tucker Janet J Dugald Baird Centre, Department of Obstetrics and Gynaecology, University of Aberdeen. McGuire William W eng Journal Article Review England BMJ 8900488 0959-8138 AIM IM BMJ. 2004 Nov 27;329(7477):1287; author reply 1287 15564268 Birth Weight Female Fetal Membranes, Premature Rupture Gestational Age Humans Obstetric Labor (...) , Premature epidemiology etiology Pregnancy Pregnancy Outcome Pregnancy, Multiple 0 2004 9 18 5 0 2004 9 29 5 0 2004 9 18 5 0 ppublish 15374920 10.1136/bmj.329.7467.675 329/7467/675 PMC517653 BMJ. 1999 Oct 23;319(7217):1093-7 10531097 Cochrane Database Syst Rev. 2000;(2):CD001055 10796228 N Engl J Med. 2000 Aug 10;343(6):378-84 10933736 Paediatr Perinat Epidemiol. 2000 Jul;14(3):194-210 10949211 Arch Dis Child Fetal Neonatal Ed. 2002 May;86(3):F142-6 11978741 Lancet. 2002 Nov 9;360(9344):1489-97 12433531

2004 BMJ : British Medical Journal

2813. Aerosolized iloprost in the treatment of pulmonary hypertension in extremely preterm infants: a pilot study. (Abstract)

Aerosolized iloprost in the treatment of pulmonary hypertension in extremely preterm infants: a pilot study. In premature infants with preterm prolonged rupture of membranes, death after birth is often due to persistent pulmonary hyper-tension.Aerosolized iloprost was used to treat pulmonary hypertension due to prolonged preterm rupture of fetal membranes (7-56 days) in four extremely low-birthweight neonates (23-25 weeks' gestation, weight 448-645 g) under spontaneous breathing supported

2008 Klinische Pädiatrie

2814. TOCOX--a randomised, double-blind, placebo-controlled trial of rofecoxib (a COX-2-specific prostaglandin inhibitor) for the prevention of preterm delivery in women at high risk. Full Text available with Trip Pro

weeks in those on rofecoxib (40%vs 67%, M-H-adjusted risk 1.59, 95% CI 1.09-2.32). Rates of preterm prelabour rupture of membranes (PPROM) were higher in those on rofecoxib (RR 2.5, 95% CI 1.3-4.7).Rofecoxib has a significant but reversible effect on fetal renal function and the ductus arteriosus. It does not reduce the incidence of early preterm delivery <30 weeks and is associated with an increased risk of delivery before 37 weeks in women at high risk. (...) TOCOX--a randomised, double-blind, placebo-controlled trial of rofecoxib (a COX-2-specific prostaglandin inhibitor) for the prevention of preterm delivery in women at high risk. To assess the safety and efficacy of the long term prophylactic use of rofecoxib (a COX-2-specific inhibitor) in women at high risk of preterm delivery.A randomised, double-blind, placebo-controlled trial.Queen Charlotte's and Chelsea Hospital, London and Guys and St Thomas' Hospitals, London.Ninety-eight singleton

2005 BJOG Controlled trial quality: predicted high

2815. Vaginal progesterone is associated with a decrease in risk for early preterm birth and improved neonatal outcome in women with a short cervix: a secondary analysis from a randomized, double-blind, placebo-controlled trial. Full Text available with Trip Pro

-controlled trial, in which women were randomized between 18 + 0 and 22 + 6 weeks of gestation to receive daily treatment with 90 mg of vaginal progesterone gel or placebo. Cervical length was measured with transvaginal ultrasound at enrollment and at 28 weeks of gestation. Treatment continued until either delivery, 37 weeks of gestation or development of preterm rupture of membranes. Maternal and neonatal outcomes were evaluated for the subset of all randomized women with cervical length < 28 mm (...) Vaginal progesterone is associated with a decrease in risk for early preterm birth and improved neonatal outcome in women with a short cervix: a secondary analysis from a randomized, double-blind, placebo-controlled trial. To investigate the efficacy of vaginal progesterone to prevent early preterm birth in women with sonographic evidence of a short cervical length in the midtrimester.This was a planned, but modified, secondary analysis of our multinational, multicenter, randomized, placebo

2007 Ultrasound in Obstetrics and Gynecology Controlled trial quality: predicted high

2816. Progesterone vaginal gel for the reduction of recurrent preterm birth: primary results from a randomized, double-blind, placebo-controlled trial. (Abstract)

of preterm rupture of membranes. The primary outcome was preterm birth at preterm birth at preterm birth: primary results from a randomized, double-blind, placebo-controlled trial. Preterm birth is the leading cause of perinatal morbidity and mortality worldwide. Treatment of preterm labor with tocolysis has not been successful in improving infant outcome. The administration of progesterone and related compounds has been proposed as a strategy to prevent preterm birth. The objective of this trial was to determine whether

2007 Ultrasound in Obstetrics and Gynecology Controlled trial quality: predicted high

2817. Heterogeneity of perinatal outcomes in the preterm delivery syndrome. (Abstract)

of labor, either with or without maternal obstetric and medical complications; preterm deliveries after prelabor spontaneous rupture of amniotic membranes (PROM), either with or without obstetric and medical complications; and medically indicated preterm deliveries with maternal obstetric and medical complications. Severe neonatal morbidity and neonatal mortality were the primary outcomes.Fifty-six percent of all preterm deliveries were spontaneous, without maternal complications. Small for gestational (...) Heterogeneity of perinatal outcomes in the preterm delivery syndrome. Our aim was to document the differential neonatal morbidity and intrapartum and neonatal mortality of subgroups of preterm delivery.This analysis included 38,319 singleton pregnancies, of which 3,304 (8.6%) were preterm deliveries (less than 37 completed weeks) enrolled in the World Health Organization randomized trial of a new antenatal care model. We classified them as preterm deliveries after spontaneous initiation

2004 Obstetrics and Gynecology Controlled trial quality: uncertain

2818. The Randomized Nitric Oxide Tocolysis Trial (RNOTT) for the treatment of preterm labor. (Abstract)

The Randomized Nitric Oxide Tocolysis Trial (RNOTT) for the treatment of preterm labor. This study was undertaken to assess the effectiveness of glyceryl trinitrate (GTN) patches in comparison with beta2 sympathomimetics (beta2) for the treatment of preterm labor.A multicenter, multinational, randomized controlled trial was conducted in tertiary referral teaching hospitals. Women in threatened preterm labor with positive fetal fibronectin or ruptured membranes between 24 and 35 weeks' gestation

2004 American journal of obstetrics and gynecology Controlled trial quality: predicted high

2819. Magnesium Sulfate Versus Indomethacin for Preterm Labor

of, Magnesium sulfate and/or Indomethacin Documented rupture of amniotic membranes Multiple gestations of triplets or more. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00116623 Locations Layout table for location information United States, Pennsylvania (...) : Layout table for MeSH terms Obstetric Labor, Premature Obstetric Labor Complications Pregnancy Complications Magnesium Sulfate Indomethacin Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anesthetics Central Nervous System Depressants Anti-Arrhythmia Agents Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Tocolytic Agents Reproductive Control

2005 Clinical Trials

2820. Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS)

oil). Patients are seen weekly to administer the study drug through 34 weeks 6 days gestation or delivery, whichever occurs first. Outcome Measures Go to Primary Outcome Measures : Delivery prior to 35 weeks 0 days gestation [ Time Frame: Delivery Date ] Secondary Outcome Measures : Maternal randomization to delivery interval of first fetus [ Time Frame: Delivery ] pPROM - spontaneous rupture of the membranes at least one hour prior to the start of labor, regular contractions accompanied (...) : Yes Plan Description: The data will be shared after completion and publication of the main analyses in accordance with NIH policy. The dataset can be obtained by emailing mfmudatasets@bsc.gwu.edu. Keywords provided by The George Washington University Biostatistics Center: preterm birth pregnancy multifetal Progesterone Additional relevant MeSH terms: Layout table for MeSH terms Premature Birth Obstetric Labor, Premature Obstetric Labor Complications Pregnancy Complications Progesterone 17 alpha

2004 Clinical Trials

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