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Premature Rupture of Membranes

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2781. Reduction of Spontaneous Prematurity by Antibiotic Treatment (Josamycin)

of the uterine collar, a rupture of the membranes then a premature birth. Several recent publications show on the one hand that Mycoplasma hominis and Ureaplasma spp. are the bacteria most frequently found in the amniotic liquid in the second quarter of the pregnancy and that a positive PCR for these bacteria is associated with a premature birth. A probable assumption would be that Mycoplasma hominis or Ureaplasma spp. cause a premature birth by infecting the fetal membranes and the decidual, then activating (...) ] Antenatal : premature delivery [ Time Frame: at week of amenorrhea <= 34, 32, 28 ] Antenatal : hospitalisation for risk of premature delivery [ Time Frame: antenatal period ] antenatal : Number of day of hospitalisation for risk of premature delivery [ Time Frame: antenatal period ] Antenatal : premature rupture of membranes [ Time Frame: before 37 week of amenorrhea ] Antenatal : occurence of chorioamnionitis defined by 2 of the following criteria :maternal temperature > 38°C, uterine contractions

2008 Clinical Trials

2782. Prevention of Preterm Birth Using Cervical Pessary in Pregnant Women With Short Cervix

pessaries CE 0482 MED / CERT ISO 9003 /EN 46003 Outcome Measures Go to Primary Outcome Measures : Spontaneous delivery before 34 completed weeks [ Time Frame: Each 6 months ] Secondary Outcome Measures : Birth weight, Fetal or Neonatal Death, Neonatal morbidity, Maternal adverse effects , Preterm birth before 37 weeks or 28 weeks, Rupture of membranes before 34 weeks, Hospitalisation for threatened preterm labour. [ Time Frame: Each 6 months ] Eligibility Criteria Go to Information from the National (...) ´Hebron Hospital ClinicalTrials.gov Identifier: Other Study ID Numbers: PECEP-TRIAL First Posted: June 27, 2008 Last Update Posted: July 28, 2014 Last Verified: July 2014 Keywords provided by Elena Carreras, Maria Goya, Maternal-Infantil Vall d´Hebron Hospital: Short cervix preterm birth arabin pessary Additional relevant MeSH terms: Layout table for MeSH terms Premature Birth Obstetric Labor, Premature Obstetric Labor Complications Pregnancy Complications Silicon Trace Elements Micronutrients

2008 Clinical Trials

2783. PREMILOC Trial to Prevent Bronchopulmonary Dysplasia in Very Preterm Neonates

Description: Individual patients and study procedures. Entry criteria: gestational age between 24 weeks and 27 weeks + 6 days, babies born to mother with either clinical chorioamnionitis, preterm and prelabor rupture of the membranes (PPROM), or preterm labor, written informed consent obtained before inclusion and randomization. Exclusion criteria: babies born with birth weight below the 3th percentile, PPROM before 22 weeks, major fetal anomaly or congenital malformation, mother refusal or inability (...) Healthy Volunteers: No Criteria Inclusion Criteria: Gestational age between 24 weeks and 27 weeks + 6 days Babies born to mother with either clinical chorioamnionitis, preterm and prelabor rupture of the membranes (PPROM), or preterm labor Written informed consent obtained before inclusion and randomization. Exclusion Criteria: Babies born to mothers with birth weight below the 3th percentile PPROM before 22 weeks Major fetal anomaly or congenital malformation Mother refusal or inability to provide

2008 Clinical Trials

2784. The Use of Progesterone to Reduce Preterm Birth

that this technique of giving a weekly shot of progesterone does not prevent preterm birth. In addition, There are other groups of patients who are at very high risk for preterm birth which have not been studied. They include: 1.) Cervical cerclage (a stitch in the mouth of the womb); 2.) Multifetal gestation (twins, triplets, etc.); 3.) Women with preterm (<34 weeks) rupture of the membranes; 4.) Women with preterm labor during the current pregnancy with intact membranes who have been tocolyzed (have their labor (...) , you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 16 Years to 45 Years (Child, Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Pregnancy 20 - 34 weeks; cervical dilation <4 cm; risk for preterm birth; multifetal gestation; diagnosis of preterm labor during the current pregnancy effectively tocolyzed); preterm rupture

2008 Clinical Trials

2785. Vaginal PROgesterone as Maintenance Treatment After an epISode of prEterm Labor (PROMISE Study)

admitted because of preterm labor who have been successfully treated of any tocolytic drugs (β-mimetics drugs, nifedipine, atosiban) Ultrasound cervical length at discharge < 25 mm Signed patient consent form (CI) Exclusion Criteria: Known or suspected infection, premature rupture of membranes or any other pathological gravid maternal or fetal condition coexisting at hospital admission (Pre-eclampsia, RCIU) which may induce iatrogenic labor. Present or previous liver disease, present or previous (...) Threatened Premature Labor Drug: Progesterone Drug: Placebo Phase 4 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 265 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: Vaginal Progesterone as a Maintenance Treatment in Women With Previous Preterm Labor. Randomized, Double Blinded

2008 Clinical Trials

2786. Sonographic Prediction of Preterm Delivery Between 24-34 Weeks of Gestation

Years (Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: Yes Sampling Method: Non-Probability Sample Study Population women that visit a tetriary hospital for follow up Criteria Inclusion Criteria: pregnancy between 24-34 wees of gestation Exclusion Criteria: lack prenatal care fetal malformations stractural or genetical plcenta previa cerclage women who underwent conization of cervix polyhydramnious premature rupture of membranes induction of labor d/t medical condition preterm (...) Keywords provided by Soroka University Medical Center: preterm delivery shory cervix amniotic fluid sludge uterine artery doppler singeltone normal amniotic fluid index without rupter of membranes 24-34 weeks of gestation Additional relevant MeSH terms: Layout table for MeSH terms Premature Birth Obstetric Labor, Premature Obstetric Labor Complications Pregnancy Complications

2008 Clinical Trials

2787. Nifedipine Compared to Atosiban for Treating Preterm Labor

of at least 50% Multiparous women: a single cervical examination demonstrating dilatation of 1 cm to 4 cm and effacement of at least 50%. Provision of written informed consent Exclusion Criteria: Chorioamnionitis Preterm rupture of membranes Vaginal bleeding Major fetal malformations Severe hypertensive disorders Intrauterine growth restriction (< 5th percentile). Non-reassuring fetal heart rate Maternal contraindications Chronic hypertension Systolic blood pressure < 90 mmHg Cardiovascular disease (...) , 2008 Last Update Posted: March 13, 2012 Last Verified: March 2012 Keywords provided by Raed Salim, HaEmek Medical Center, Israel: Preterm labor Atosiban Nifedipine Additional relevant MeSH terms: Layout table for MeSH terms Obstetric Labor, Premature Obstetric Labor Complications Pregnancy Complications Nifedipine Atosiban Vasotocin Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Physiological Effects

2008 Clinical Trials

2788. N-Acetyl Cysteine for Prevention of Preterm Birth

weeks, having a documented history of at least one preterm labour in the previous pregnancy and having no uterine contractions at the time of the study. Patients were excluded if they refused to participate in the study, had prelabour premature rupture of membranes (PPROM), had an incompetent cervical os proved by funneling of the internal os on ultrasound examination or by a documented history with or without a cercelage done in the previous or current pregnancy. Patients with twin pregnancy (...) were subjected to confidentiality and were not made available to third party. Exclusion Criteria: Patients were excluded if they refused to participate in the study, had prelabour premature rupture of membranes (PPROM), had an incompetent cervical os proved by funneling of the internal os on ultrasound examination or by a documented history with or without a cercelage done in the previous or current pregnancy. Patients with twin pregnancy, intrauterine foetal death, malpresentations, known fetal

2007 Clinical Trials

2789. Very Early Surfactant and NCPAP for Premature Infants With RDS

), and Prenatal consent. Exclusion Criteria: Apgar score less than 2 at 5 minutes, Intubation prior to randomization, Prenatal diagnosis of major congenital anomalies, Prolonged rupture of membranes of greater than 3 weeks duration, and Infants who were likely to be transferred to another center soon after birth were not enrolled in the study. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff (...) Very Early Surfactant and NCPAP for Premature Infants With RDS Very Early Surfactant and NCPAP for Premature Infants With RDS - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Very Early Surfactant and NCPAP

2007 Clinical Trials

2790. Antibiotics and the Prolongation of Pregnancy in Preterm Labor With an Advanced Cervical Exam

by preterm labor with intact membranes.(2) Both preterm labor and preterm premature rupture of membranes have both been associated with evidence intrauterine infection. While antibiotic treatment in conservative management of preterm PROM remote from term has been shown to significantly prolong pregnancy and reduce infant morbidity, (16) data regarding the effectiveness of antibiotics for pregnancy prolongation in preterm labor are inconsistent. (3-15) Currently, narrow spectrum antibiotics (penicillin (...) admitted with the diagnosis of preterm labor between 24 0/7 and 33 6/7 weeks gestation. Preterm labor will be defined by regular contractions and/or cervical change from last documented exam. Cervical exam 4 cm or greater Intact membranes Exclusion Criteria: Multiple gestation (>2) Clinical evidence of chorioamnionitis, such as maternal fever, uterine tenderness, fetal tachycardia Lethal fetal anomaly Persistent vaginal bleeding, abruption, or placenta previa Rupture of membranes Maternal illness

2007 Clinical Trials

2791. Natural Progesterone and Preterm Birth in Twins

. Pregnancies will be managed according to each local protocol. An external statistical analysis will be performed on intention to treat basis. Main outcome measure: Preterm birth rate (<37 weeks). Secondary outcome measures: very preterm birth rate (<32 weeks); cervical length measured by vaginal ultrasound at each control visit; need for tocolytic treatments; rate of preterm premature rupture of membranes; and perinatal morbidity and mortality. Estimated period of study: 2006-2008. Study Design Go (...) Preterm birth in twin gestations Additional relevant MeSH terms: Layout table for MeSH terms Premature Birth Obstetric Labor, Premature Obstetric Labor Complications Pregnancy Complications Progesterone Progestins Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs

2007 Clinical Trials

2792. Will CPAP Reduce Length Of Respiratory Support In Premature Infants?

. A chest radiograph is not a mandatory criterion for the diagnosis of RDS if clinical signs are present Parental consent obtained. Exclusion Criteria: Infants with a major congenital anomaly Infants with pulmonary hypoplasia; 3. Infants known or suspected to have a neuromuscular disorder; Infants from mothers that had greater than 2 weeks ruptured membranes. Infants that had vigourous resuscitation including chest compressions and cardiac meds. No parental consent obtained. Contacts and Locations Go (...) Will CPAP Reduce Length Of Respiratory Support In Premature Infants? Will CPAP Reduce Length Of Respiratory Support In Premature Infants? - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Will CPAP Reduce

2007 Clinical Trials

2793. Indomethacin Versus Nifedipine for Preterm Labor Tocolysis

containing 10 mg oral nifedipine for a total of 30 mg. The patients will then receive either 25 mg of oral indomethacin every 6 hours for 48 hours, or 20 mg of oral nifedipine every 6 hours for 48 hours. Tocolysis beyond 48 hours will not be used. Condition or disease Intervention/treatment Phase Obstetric Labor, Premature Drug: Indomethacin Drug: Nifedipine Phase 1 Phase 2 Detailed Description: Patients presenting between 24-34 weeks gestation diagnosed with preterm labor who grant consent (...) contractions at least every 5 minutes, or at least 2 cm cervical dilation and 80% effacement Exclusion Criteria: Ruptured amniotic membranes Signs/symptoms of chorioamnionitis (maternal temperature greater than 100.4 F/38.0 C, fetal tachycardia, uterine tenderness) Non-reassuring fetal heart rate tracings Contra-indications to indomethacin or nifedipine Contra-indications to tocolysis Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your

2007 Clinical Trials

2794. Bacterial Vaginosis Screening and Treatment to Reduce Infective Complications, Abortion and Preterm Delivery

will reduce the risk of spontaneous preterm birth. Condition or disease Intervention/treatment Phase Vaginosis, Bacterial Abortion, Spontaneous Premature Birth Device: VS Sense Phase 3 Detailed Description: This is an open-label, comparative, and prospective study. Pregnant women, pregnancy week 26 to 36+6, between the ages 18-45, who were hospitalized in the high risk department, with history of previous preterm delivery and/or with premature contractions. Patient with premature ruptured membrane (...) years, pregnancy week 26 to 36+6, with history of previous preterm delivery or with premature contractions. Exclusion Criteria: Subject with ruptured membranes. Subject with signs and symptoms of pelvic inflammatory disease. Subject who has used vaginal douching within 12 hours prior to arrival at the hospital. Subject who has applied local antiseptic, antibiotic or vaginal treatment within the previous 3 days. Subjects who have had sexual intercourse within the last 12 hours. Subject with blood

2007 Clinical Trials

2795. Feasibility Study of Aerosolized Surfaxin in the Prevention of Respiratory Distress Syndrome (RDS) in Premature Infants

) or conditions potentially interfering with cardiopulmonary function Mother with prolonged rupture of membranes > 2 weeks Known or suspected chromosomal abnormality Need for chest compressions or administration of epinephrine, bicarbonate, or fluid boluses in the delivery room Need for mechanical ventilation within 30 minutes of birth Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using (...) Feasibility Study of Aerosolized Surfaxin in the Prevention of Respiratory Distress Syndrome (RDS) in Premature Infants Feasibility Study of Aerosolized Surfaxin in the Prevention of Respiratory Distress Syndrome (RDS) in Premature Infants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2008 Clinical Trials

2796. Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants

Healthy Volunteers: No Criteria Inclusion Criteria: <29 6/7 and >24 0/7 weeks gestational age Inborn at the participating institution enrolling the patient FIO2 >25% and Intubated with mean airway pressure > 5 cm H20 <8 hours age at randomization Signed informed consent from parent(s) Exclusion Criteria: <500 g birth weight <24 0/7 weeks gestational age (best estimate) Prolonged Premature Rupture of membranes >3 weeks (21 days) Apgar score < 3 at 5 minutes Impending death anticipated within the first (...) Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Curosurf

2007 Clinical Trials

2797. Progesterone for Prevention of Preterm Birth in Women With Short Cervix: Randomized Controlled Trial

(Utrogestan) Phase 3 Detailed Description: BACKGROUND The results of randomized studies have shown that the prophylactic use of progesterone in women who previously delivered prematurely reduces the risk of recurrence. Asymptomatic women found to have a short cervix (< 15 mm) at mid-gestation are at greatly increased risk for spontaneous early preterm delivery and it is uncertain whether in such women the risk is reduced by progesterone. METHODS Cervical length was measured by transvaginal sonography (...) for routine ultrasound examination at 20-25 weeks of gestation with a short cervical length (<15 mm). Exclusion Criteria: Women with major fetal abnormalities, Painful regular uterine contractions, or history of ruptured membranes or cervical cerclage in-situ were excluded from screening. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor

2007 Clinical Trials

2798. Does Fetal Fibronectin and Ultrasound Cervical Length Help in the Evaluation of Women With Suspected Preterm Labor?

: September 1, 2006 Last Update Posted : March 2, 2007 Sponsor: Thomas Jefferson University Information provided by: Thomas Jefferson University Study Details Study Description Go to Brief Summary: The objective of this study is to investigate the effect of the use of both sonographic cervical length (CL) and fetal fibronectin (FFN) on the length of outpatient triage and preterm labor interventions in symptomatic women with intact membranes. We performed a randomized trial of the use of transvaginal (...) Eligible for Study: Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria: gestational age between 24 and 33 weeks 6 days contractions ≥ 6/hr, uterine irritability, or symptoms such as cramping, pressure, backache with or without documented contractions which prompted evaluation for PTL cervical dilatation < 3cm and < 100% effacement intact membranes. Exclusion criteria: ruptured membranes known congenital anomaly triplets or greater; vaginal bleeding cervical dilatation ≥ 3cm or complete

2006 Clinical Trials

2799. RCT of Progesterone to Prevent Preterm Birth in Nulliparous Women With a Short Cervix

: Multifetal gestation Progesterone treatment after 14 weeks 6 days during current pregnancy Vaginal bleeding, heavier than spotting, after 15 weeks 6 days Amniotic membranes prolapsed beyond external os Preterm rupture of membranes Fetal anomaly Pregnancy without a viable fetus Current or planned cervical cerclage Congenital Mullerian abnormality of the uterus Contraindication to intra-muscular injections Hypertension requiring medication Diabetes managed with insulin or oral hypoglycemic agents DES (...) RCT of Progesterone to Prevent Preterm Birth in Nulliparous Women With a Short Cervix RCT of Progesterone to Prevent Preterm Birth in Nulliparous Women With a Short Cervix - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2007 Clinical Trials

2800. Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery

a history of late miscarriage or premature delivery or uterine malformation or DES; either a twin pregnancy. Exclusion Criteria: cervical dilatation > 3 cm, chorioamnionitis, fetal distress, placenta praevia, abruptio placenta, preterm premature rupture of membranes, polyhydramnios, Twin-twin transfusion syndrome, IUGR, preeclampsia or hypertension, other pathology justifying a preterm delivery, epilepsy drugs participation to another therapeutic trial, any patient for whom informed consent cannot (...) ; either a history of late miscarriage or premature delivery or uterine malformation or DES either a twin pregnancy. Therefore, a randomised, multicentre trial has been designed with initial stratification according to these three risk groups, opened with two parallel arms. Condition or disease Intervention/treatment Phase Preterm Delivery Drug: 17 alpha-hydroxyprogesterones caproate Phase 4 Detailed Description: Objective To demonstrate that the intramuscular administration of 17 alpha

2006 Clinical Trials

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