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3,157 results for

Premature Rupture of Membranes

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2741. Sonographic Prediction of Preterm Delivery Between 24-34 Weeks of Gestation

Years (Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: Yes Sampling Method: Non-Probability Sample Study Population women that visit a tetriary hospital for follow up Criteria Inclusion Criteria: pregnancy between 24-34 wees of gestation Exclusion Criteria: lack prenatal care fetal malformations stractural or genetical plcenta previa cerclage women who underwent conization of cervix polyhydramnious premature rupture of membranes induction of labor d/t medical condition preterm (...) Keywords provided by Soroka University Medical Center: preterm delivery shory cervix amniotic fluid sludge uterine artery doppler singeltone normal amniotic fluid index without rupter of membranes 24-34 weeks of gestation Additional relevant MeSH terms: Layout table for MeSH terms Premature Birth Obstetric Labor, Premature Obstetric Labor Complications Pregnancy Complications

2008 Clinical Trials

2742. Does Progesterone Prevent Very Preterm Delivery in Twin Pregnancies?

gestations account for 2% of all pregnancies, but cause more than 10% of the cases of preterm delivery. Due to increasing maternal age and use of assisted reproduction the number of multiple gestations is larger than ever. If markers of preterm delivery can be identified and means of preventing preterm delivery are found, it will be possible to reduce the number of children admitted to hospital because of prematurity. Recently, two larger randomised studies investigated the effect of progesterone (...) : Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Twin pregnancy Informed consent 18-23 weeks' gestation Participants must be fluent in the language spoken in the respective centres Exclusion Criteria: Age < 18 years Known allergy to progesterone or peanuts Active thromboembolic disorders or a history of hormone-associated thromboembolic disorders Rupture of membranes at the time of inclusion Monoamniotic twins Pregnancies treated for or with signs of twin-to-twin transfusion

2006 Clinical Trials

2743. Randomized Trial Comparing Misoprostol and Foley Bulb for Labor Induction in the Preterm Gestation

: University of Florida Information provided by (Responsible Party): University of Florida Study Details Study Description Go to Brief Summary: The purpose of this study is to compare the time to delivery of two different cervical ripening methods on the preterm gestation. Condition or disease Intervention/treatment Phase Premature Birth Cervical Ripening Drug: Misoprostol Device: Foley bulb Phase 2 Detailed Description: Labor induction for the preterm gestation is indicated for various maternal and fetal (...) Eligible for Study: 18 Years to 45 Years (Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: singleton gestation, gestational age 23-35 weeks, indication for induction Exclusion Criteria: multiple gestation, non-cephalic presentation, previous uterine surgery, rupture of membranes, intrauterine fetal death Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact

2006 Clinical Trials

2744. Dynamic Cervical Change: Prediction of Preterm Labor in Symptomatic Patients

. Regular uterine contractions, uterine cramping, or pelvic pressure). Exclusion Criteria: Cervical cerclage Ruptured membranes noted on initial speculum examination Cervical os dilation >4 cm noted on initial digital examination Known HIV-positive or active HSV(to minimize the risk of perinatal exposure) Presence of multiple genital warts Patients under extreme duress from their uterine contractions Contacts and Locations Go to Information from the National Library of Medicine To learn more about (...) Dynamic Cervical Change: Prediction of Preterm Labor in Symptomatic Patients Dynamic Cervical Change: Prediction of Preterm Labor in Symptomatic Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2006 Clinical Trials

2745. Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth

, increased CRP or another acute phase protein, uterine tenderness) lethal disease of the fetus informed consent obtained premature rupture of membranes is not contraindication for the trial entry *Gestational age will be calculated from the mother’s last menstrual period and confirmed by ultrasound before 20 weeks’ gestation. In case the discrepancy in the estimates exceeds two weeks, ultrasound date is accepted. **Very high risk of premature delivery is described as follows: elective delivery within (...) within 4-48 hours, as indicated by the obstetrician on the basis of the clinical status of the mother and/or the fetus very high risk of spontaneous delivery within 4-48 hours, i.e. cervix is open > 3 cm contractions of the uterus at 5-10 min intervals rupture of the membranes after the first course of ANC fetal and/or maternal indication for elective premature delivery or cesarean section Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study

2006 Clinical Trials

2746. Does Fetal Fibronectin and Ultrasound Cervical Length Help in the Evaluation of Women With Suspected Preterm Labor?

: September 1, 2006 Last Update Posted : March 2, 2007 Sponsor: Thomas Jefferson University Information provided by: Thomas Jefferson University Study Details Study Description Go to Brief Summary: The objective of this study is to investigate the effect of the use of both sonographic cervical length (CL) and fetal fibronectin (FFN) on the length of outpatient triage and preterm labor interventions in symptomatic women with intact membranes. We performed a randomized trial of the use of transvaginal (...) Eligible for Study: Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria: gestational age between 24 and 33 weeks 6 days contractions ≥ 6/hr, uterine irritability, or symptoms such as cramping, pressure, backache with or without documented contractions which prompted evaluation for PTL cervical dilatation < 3cm and < 100% effacement intact membranes. Exclusion criteria: ruptured membranes known congenital anomaly triplets or greater; vaginal bleeding cervical dilatation ≥ 3cm or complete

2006 Clinical Trials

2747. Microarray Expression Profiling to Identify Stereotypic mRNA Profiles for Preterm Delivery in Order to Unravel the Biological Mechanisms

of Child Health and Human Development (NICHD) ClinicalTrials.gov Identifier: Other Study ID Numbers: 999999056 OH99-CH-N056 First Posted: June 21, 2006 Last Update Posted: January 3, 2019 Last Verified: April 19, 2018 Keywords provided by National Institutes of Health Clinical Center (CC) ( Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) ): Premature Rupture of Membranes Genetic Risk Factors Tissue Specific Expression Quantitative Real Time PCR Preterm Birth (...) ) Sexes Eligible for Study: Female Accepts Healthy Volunteers: Yes Criteria INCLUSION CRITERIA: Consecutive patients admitted with the following diagnoses from four different ethnic groups (Hispanic, African American, Asian, and Caucasian): Preterm labor with intact membranes and with acute inflammation; chronic villitis; vascular pathology; no identifiable lesions. Preterm delivery without labor because of the following reasons: pre-eclampsia; abruptio placentae; fetal anomalies; Other complications

2006 Clinical Trials

2748. Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery

a history of late miscarriage or premature delivery or uterine malformation or DES; either a twin pregnancy. Exclusion Criteria: cervical dilatation > 3 cm, chorioamnionitis, fetal distress, placenta praevia, abruptio placenta, preterm premature rupture of membranes, polyhydramnios, Twin-twin transfusion syndrome, IUGR, preeclampsia or hypertension, other pathology justifying a preterm delivery, epilepsy drugs participation to another therapeutic trial, any patient for whom informed consent cannot (...) ; either a history of late miscarriage or premature delivery or uterine malformation or DES either a twin pregnancy. Therefore, a randomised, multicentre trial has been designed with initial stratification according to these three risk groups, opened with two parallel arms. Condition or disease Intervention/treatment Phase Preterm Delivery Drug: 17 alpha-hydroxyprogesterones caproate Phase 4 Detailed Description: Objective To demonstrate that the intramuscular administration of 17 alpha

2006 Clinical Trials

2749. Trial of Magnesium Sulfate Tocolysis Versus Nifedipine Tocolysis in Women With Preterm Labor

previa or abruptio placenta Preterm premature rupture of membranes Prolapsed membranes Human immunodeficiency virus positive Multiple gestation Patients on procardia within 24 hours of po intake Magnesium sulfate tocolysis prior to randomization Patient refusal Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer (...) Posted : November 9, 2009 Sponsor: University of Cincinnati Collaborator: University Hospital Information provided by: University of Cincinnati Study Details Study Description Go to Brief Summary: Primary Hypothesis: Acute tocolysis (48 hours) using oral nifedipine is more effective than intravenous magnesium sulfate in prolonging pregnancy in women with preterm labor with intact membranes between 24 and 32 6/7 weeks' gestation. Condition or disease Intervention/treatment Phase Premature Birth

2006 Clinical Trials

2750. RCT of Progesterone to Prevent Preterm Birth in Nulliparous Women With a Short Cervix

: Multifetal gestation Progesterone treatment after 14 weeks 6 days during current pregnancy Vaginal bleeding, heavier than spotting, after 15 weeks 6 days Amniotic membranes prolapsed beyond external os Preterm rupture of membranes Fetal anomaly Pregnancy without a viable fetus Current or planned cervical cerclage Congenital Mullerian abnormality of the uterus Contraindication to intra-muscular injections Hypertension requiring medication Diabetes managed with insulin or oral hypoglycemic agents DES (...) RCT of Progesterone to Prevent Preterm Birth in Nulliparous Women With a Short Cervix RCT of Progesterone to Prevent Preterm Birth in Nulliparous Women With a Short Cervix - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2007 Clinical Trials

2751. Progesterone for Prevention of Preterm Birth in Women With Short Cervix: Randomized Controlled Trial

(Utrogestan) Phase 3 Detailed Description: BACKGROUND The results of randomized studies have shown that the prophylactic use of progesterone in women who previously delivered prematurely reduces the risk of recurrence. Asymptomatic women found to have a short cervix (< 15 mm) at mid-gestation are at greatly increased risk for spontaneous early preterm delivery and it is uncertain whether in such women the risk is reduced by progesterone. METHODS Cervical length was measured by transvaginal sonography (...) for routine ultrasound examination at 20-25 weeks of gestation with a short cervical length (<15 mm). Exclusion Criteria: Women with major fetal abnormalities, Painful regular uterine contractions, or history of ruptured membranes or cervical cerclage in-situ were excluded from screening. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor

2007 Clinical Trials

2752. A Proof of Concept Study Assessing the Effect of Four Different Single Bolus Intravenous Doses of FE200440 and Placebo on Stopping Preterm Labor

or disease Intervention/treatment Phase Labor, Premature Premature Birth Drug: FE200440 Phase 2 Detailed Description: To determine the effects of four different single bolus doses of FE200440 administered intravenously on stopping preterm labour compared to placebo in pregnant women with advanced gestational age To establish the effects of four different single bolus doses of FE200440 administered intravenously on uterine contractions compared to placebo To evaluate the effects of four different single (...) placenta known or suspected infection (e.g. urinary tract infection, chorioamnionitis) Controlled or uncontrolled diabetes mellitus (pre-gestational or gestational) Eclampsia or severe preeclampsia in the current pregnancy Previous major uterine surgery (e.g. myomectomy for leiomyomas), congenital uterine abnormalities, large leiomyomas, or retained intrauterine device Rupture of membrane in the current pregnancy Placenta praevia in the current pregnancy a) Oligohydramnios or polyhydramnios

2005 Clinical Trials

2753. Aerosolized iloprost in the treatment of pulmonary hypertension in extremely preterm infants: a pilot study. (Abstract)

Aerosolized iloprost in the treatment of pulmonary hypertension in extremely preterm infants: a pilot study. In premature infants with preterm prolonged rupture of membranes, death after birth is often due to persistent pulmonary hyper-tension.Aerosolized iloprost was used to treat pulmonary hypertension due to prolonged preterm rupture of fetal membranes (7-56 days) in four extremely low-birthweight neonates (23-25 weeks' gestation, weight 448-645 g) under spontaneous breathing supported

2008 Klinische Pädiatrie

2754. Nifedipine vs Placebo for Maintenance Tocolysis of Preterm Labor.

, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years to 55 Years (Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria: - arrested preterm labor Exclusion Criteria: - ruptured membranes, fetal distress, placenta previa, placental abruption, maternal medical contraindication to tocolysis Contacts and Locations Go (...) by: Stanford University Study Details Study Description Go to Brief Summary: Comparing nifedipine to placebo for the maintenance tocolysis of preterm labor Condition or disease Intervention/treatment Phase Obstetric Labor, Premature Venous Thrombosis Drug: Nifedipine Not Applicable Detailed Description: To estimate whether maintenance nifedipine tocolysis after arrested preterm labor prolongs pregnancy and improves neonatal outcomes. Study Design Go to Layout table for study information Study Type

2005 Clinical Trials

2755. Magnesium Sulfate Versus Nifedipine for the Acute Tocolysis of Preterm Labor: A Prospective, Randomized Trial

Inclusion Criteria::- Uterine contractions and cervical change or ruptured membranes in a preterm gestation Exclusion Criteria:- placental abruption, fetal distress, placenta previa, maternal medical contraindication to tocolysis Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov (...) First Posted : October 2, 2018 Last Update Posted : November 19, 2018 Sponsor: Stanford University Information provided by (Responsible Party): Yasser Yehia El-Sayed, Stanford University Study Details Study Description Go to Brief Summary: To compare intravenous magnesium sulfate to oral nifedipine for acute tocolysis of preterm labor Condition or disease Intervention/treatment Phase Obstetric Labor, Premature Drug: Magnesium Sulfate Drug: Nifedipine Not Applicable Study Design Go to Layout table

2005 Clinical Trials

2756. Impaired collagen chaperone results in preterm PROM Full Text available with Trip Pro

eng Comment Journal Article 2006 08 28 United States Proc Natl Acad Sci U S A 7505876 0027-8424 0 HSP47 Heat-Shock Proteins 0 Molecular Chaperones 0 SERPINH1 protein, human 9007-34-5 Collagen IM Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13463-7 16938879 African Americans African Continental Ancestry Group genetics Collagen biosynthesis European Continental Ancestry Group genetics Female Fetal Membranes, Premature Rupture epidemiology ethnology genetics HSP47 Heat-Shock Proteins genetics (...) Impaired collagen chaperone results in preterm PROM 16938862 2006 10 19 2018 11 13 0027-8424 103 36 2006 Sep 05 Proceedings of the National Academy of Sciences of the United States of America Proc. Natl. Acad. Sci. U.S.A. Impaired collagen chaperone results in preterm PROM. 13267-8 Taylor Kristen H KH Department of Pathology and Anatomical Sciences and Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA. taylorjerr@missouri.edu Schnabel Robert D RD Taylor Jeremy F JF

2006 Proceedings of the National Academy of Sciences of the United States of America

2757. Investigation of Midtrimester Amniotic Fluid Factors as Potential Predictors of Term and Preterm Deliveries Full Text available with Trip Pro

inflammation/infection and preterm labor.Concentrations of all substances were not statistically different among mothers, delivering preterm or at term. SLPI concentrations significantly increased in women, going into labor without ruptured membranes, irrespective of pre- or term delivery (P < .007, P < .001, resp) and correlated with elastase (r = 0.508, P < .002).Midtrimester amniotic fluid SLPI concentrations significantly decrease when membrane rupture precedes pre- or full-term labor. However, none (...) Investigation of Midtrimester Amniotic Fluid Factors as Potential Predictors of Term and Preterm Deliveries Our aim is to investigate, in 13 cases (delivering preterm) and 21 matched (for age, parity, and gestational age) controls (delivering at term), whether midtrimester amniotic fluid concentrations of elastase, secretory leukocyte proteinase inhibitor (SLPI), soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule predict asymptomatic intra-amniotic

2006 Mediators of inflammation

2758. Epidemiology of preterm birth Full Text available with Trip Pro

Epidemiology of preterm birth 15374920 2004 09 28 2018 11 13 1756-1833 329 7467 2004 Sep 18 BMJ (Clinical research ed.) BMJ Epidemiology of preterm birth. 675-8 Tucker Janet J Dugald Baird Centre, Department of Obstetrics and Gynaecology, University of Aberdeen. McGuire William W eng Journal Article Review England BMJ 8900488 0959-8138 AIM IM BMJ. 2004 Nov 27;329(7477):1287; author reply 1287 15564268 Birth Weight Female Fetal Membranes, Premature Rupture Gestational Age Humans Obstetric Labor (...) , Premature epidemiology etiology Pregnancy Pregnancy Outcome Pregnancy, Multiple 0 2004 9 18 5 0 2004 9 29 5 0 2004 9 18 5 0 ppublish 15374920 10.1136/bmj.329.7467.675 329/7467/675 PMC517653 BMJ. 1999 Oct 23;319(7217):1093-7 10531097 Cochrane Database Syst Rev. 2000;(2):CD001055 10796228 N Engl J Med. 2000 Aug 10;343(6):378-84 10933736 Paediatr Perinat Epidemiol. 2000 Jul;14(3):194-210 10949211 Arch Dis Child Fetal Neonatal Ed. 2002 May;86(3):F142-6 11978741 Lancet. 2002 Nov 9;360(9344):1489-97 12433531

2004 BMJ : British Medical Journal

2759. Singleton Preterm Births in Korle Bu Teaching Hospital, Accra, Ghana - Origins and Outcomes Full Text available with Trip Pro

-five (42%, [95% Confidence Interval (CI) 37.4%, 46.8%]) preterm births followed spontaneous onset of preterm labour (group A), 82 (18.6%, [95% CI 15.2%, 22.7%]) followed preterm premature rupture of membranes, PPROM (group B) and 173 (39.3%, [95% CI 34.8%, 44.1%]) were medically indicated (group C). The commonest indication for delivery in group C was severe pre-eclampsia/eclampsia. Although there was no significant difference in the mean gestational ages at delivery between the groups, babies (...) Singleton Preterm Births in Korle Bu Teaching Hospital, Accra, Ghana - Origins and Outcomes To determine the singleton preterm birth rate, the relative proportions of the clinical categories of preterm births and to compare the outcomes in these categories.Department of Obstetrics & Gynaecology, Korle Bu Teaching Hospital.Preterm births from 1(st) July to 31(st) December 2003.Out of a total of 4731 singleton births 440 were preterm, giving a preterm birth rate of 9.3%. One hundred and eighty

2006 Ghana Medical Journal

2760. TOCOX--a randomised, double-blind, placebo-controlled trial of rofecoxib (a COX-2-specific prostaglandin inhibitor) for the prevention of preterm delivery in women at high risk. (Abstract)

weeks in those on rofecoxib (40%vs 67%, M-H-adjusted risk 1.59, 95% CI 1.09-2.32). Rates of preterm prelabour rupture of membranes (PPROM) were higher in those on rofecoxib (RR 2.5, 95% CI 1.3-4.7).Rofecoxib has a significant but reversible effect on fetal renal function and the ductus arteriosus. It does not reduce the incidence of early preterm delivery <30 weeks and is associated with an increased risk of delivery before 37 weeks in women at high risk. (...) TOCOX--a randomised, double-blind, placebo-controlled trial of rofecoxib (a COX-2-specific prostaglandin inhibitor) for the prevention of preterm delivery in women at high risk. To assess the safety and efficacy of the long term prophylactic use of rofecoxib (a COX-2-specific inhibitor) in women at high risk of preterm delivery.A randomised, double-blind, placebo-controlled trial.Queen Charlotte's and Chelsea Hospital, London and Guys and St Thomas' Hospitals, London.Ninety-eight singleton

2005 BJOG Controlled trial quality: predicted high

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