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Premature Rupture of Membranes

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2701. PROM (premature rupture of membranes)

PROM (premature rupture of membranes) PROM (premature rupture of membranes) - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search PROM (premature rupture of membranes) This is defined as rupture of membranes occurring after 20 and before 37 completed weeks of gestation. This event occurs in up to 8% of pregnancies. The principle complications of premature rupture of membranes are: ascending infection cord prolapse premature

2010 GP Notebook

2702. premature rupture of membranes

premature rupture of membranes premature rupture of membranes - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search premature rupture of membranes This is defined as rupture of membranes occurring after 20 and before 37 completed weeks of gestation. This event occurs in up to 8% of pregnancies. The principle complications of premature rupture of membranes are: ascending infection cord prolapse premature labour Because

2010 GP Notebook

2703. Prophylactic corticosteroids for preterm birth. (Abstract)

of crossing the placenta compared with placebo or no treatment in women expected to deliver preterm as a result of either spontaneous preterm labour, prelabour rupture of the membranes preterm, or elective preterm delivery.Eligibility and trial quality were assessed by one reviewer.Eighteen trials including data on over 3700 babies were included. Antenatal administration of 24 milligrams of betamethasone, of 24 milligrams of dexamethasone, or two grams of hydrocortisone to women expected to give birth (...) Prophylactic corticosteroids for preterm birth. Respiratory distress syndrome is a serious complication of prematurity causing significant immediate and long-term mortality and morbidity.The objective of this review was to assess the effects of corticosteroids administered to pregnant women to accelerate fetal lung maturity prior to preterm delivery.The Cochrane Pregnancy and Childbirth Group trials register was searched.Randomised and quasi-randomised trials of corticosteroid drugs capable

2000 Cochrane

2704. Elective cervical cerclage for prevention of preterm birth: a systematic review

. These differences were further explored graphically using forest plots. The authors stated that, overall, the differences in the quality of the studies did not have a large effect on the pooled summary estimate. The pooled estimates for a reduction in spontaneous pre-term birth before 34 and 37 weeks were OR 0.75 (95% confidence interval, CI: 0.59, 0.96) and OR 0.86 (95% CI: 0.71, 1.05), respectively. In the four studies that reported on adverse events, perinatal death, ruptured membranes, chorioamnionitis (...) Elective cervical cerclage for prevention of preterm birth: a systematic review Elective cervical cerclage for prevention of preterm birth: a systematic review Elective cervical cerclage for prevention of preterm birth: a systematic review Bachmann L M, Coomarasamy A, Honest H, Khan K S CRD summary This review assessed elective cervical cerclage for the prevention of pre-term birth. The authors concluded that the intervention was effective in preventing spontaneous pre-term birth before 34

2003 DARE.

2705. Nifedipine versus ritodrine for suppression of preterm labor: a meta-analysis

of 50 microg/minute to 1 mg/minute with increments every 10 to 20 minutes until a maximum dose (ranging from 300 to 350 microg/minute were reported) was reached, contractions ceased, or no limit was specified. Nifedipine doses (where stated) ranged from 10 to 30 mg sublingual, followed by varying regimes with maximum doses ranging from 80 to 160 mg. None of the studies that included women with ruptured membranes reported on the use of antibiotics. The use of corticosteroids was explicitly mentioned (...) in some studies. Other cointerventions included: intravenous morphine, intravenous magnesium sulphate, terbutaline following ritodrine infusion, and indomethacin. Participants included in the review Pregnant women in pre-term labour were eligible, with pre-term defined as labour before 37 weeks of gestation. Both single and twin pregnancies were included. Some studies were limited to women with intact membranes, whilst others also included women with ruptured membranes or provided no details

1999 DARE.

2706. Management of preterm labor. Volume 1: evidence report and appendices. Volume 2: evidence tables

. Participants included in the review Studies were selected for the review if they included pregnant women with signs and symptoms of pre-term labour. Studies were excluded if all participants experienced pre-term premature rupture of membranes, medically indicated pre-term birth, or multiple gestation. Studies of fFN and EVUSD were excluded for asymptomatic women. Outcomes assessed in the review Studies had to measure pre-term birth, and were included if they examined at least one of three main categories (...) of preterm labor: a review of the evidence. Am J Obstet Gynecol 2002;186:587-92. 3. Thorp JM, Hartmann KE. Evidence-based management of preterm labour: the role of tocolytics and antibiotics. Curr Probl Obstet Gynecol Fertil 2002;25:212-29. Indexing Status Subject indexing assigned by CRD MeSH Female; Obstetric Labor, Premature /therapy; Obstetrics; Pregnancy; Tocolytic Agents /therapeutic use AccessionNumber 12001008297 Date bibliographic record published 31/10/2003 Date abstract record published 31/10

2000 DARE.

2707. Continuous subcutaneous terbutaline administration prolongs pregnancy after recurrent preterm labour

if they had insulin-dependent diabetes, preterm premature rupture of the membranes, allergy to beta-sympathomimetic drugs, foetal anomalies, or foetal death. Setting The setting of the study was community care. The authors did not clearly state where the study was carried out, but it appears to have been conducted in Jackson (MS), USA. Dates to which data relate The effectiveness and resource use data were collected during the 12 months from January 1, 2001, to December 31, 2001. The price year (...) weight, NICU admission, need for resuscitation, morbidity or mortality, Apgar scores, arterial blood gas information, and total nursery days. The control and intervention groups were matched for cervical dilatation, gestational age at discharge from the hospital for recurrent PTL, maternal age, and the number of prior preterm births caused by PTL or preterm rupture of the membranes. However, the two groups seemed to differ in terms of the risk factors for preterm birth. Effectiveness results Women

2003 NHS Economic Evaluation Database.

2708. Consequences of nonindicated preterm delivery in singleton gestations

critical assessment on the reliability of the study and the conclusions drawn. Health technology This study considered the clinical and financial implications of delaying pre-term delivery that is classified as "elective", from 34 to 35 weeks and from 35 to 36 weeks. Elective pre-term delivery was defined as induced labour, or a scheduled Caesarean delivery, at less than 37 weeks' gestation for reasons other than pre-term labour, premature rupture of membranes, or medical induction for complicating (...) maternal or foetal circumstances (i.e. at the discretion of the patient and her primary physician). Type of intervention Treatment and management. Economic study type Cost-effectiveness analysis. Study population The study population comprised singleton births after labour was induced, or a Caesarean section, for reasons other than premature rupture of membranes or other medical indications for early delivery (e.g. maternal hypertension or foetal health). All women were considered to have a high-risk

2003 NHS Economic Evaluation Database.

2709. Hostility and anomie: Links to preterm delivery subtypes and ambulatory blood pressure at mid-pregnancy. Full Text available with Trip Pro

African American women from 52 clinics in five Michigan, USA communities. Women were interviewed at 15-27 weeks' gestation and followed to delivery. We found that relations between psychosocial factors and PTD subtypes (i.e. medically indicated, premature rupture of membranes, spontaneous labor) varied by race/ethnicity and socio-economic position (Medicaid insurance status). Among African American women not insured by Medicaid, anomie levels in mid-pregnancy were positively associated with medically (...) Hostility and anomie: Links to preterm delivery subtypes and ambulatory blood pressure at mid-pregnancy. Underlying maternal vascular disease has been implicated as one of several pathways contributing to preterm delivery (PTD) and psychosocial factors such as hostility, anomie, effortful coping, and mastery may be associated with PTD by affecting maternal vascular health. Using data from the Pregnancy Outcomes and Community Health (POUCH) study, we included 2018 non-Hispanic White and 743

2008 EvidenceUpdates

2710. Epidemiology and causes of preterm birth. (Abstract)

Epidemiology and causes of preterm birth. This paper is the first in a three-part series on preterm birth, which is the leading cause of perinatal morbidity and mortality in developed countries. Infants are born preterm at less than 37 weeks' gestational age after: (1) spontaneous labour with intact membranes, (2) preterm premature rupture of the membranes (PPROM), and (3) labour induction or caesarean delivery for maternal or fetal indications. The frequency of preterm births is about 12-13 (...) % in the USA and 5-9% in many other developed countries; however, the rate of preterm birth has increased in many locations, predominantly because of increasing indicated preterm births and preterm delivery of artificially conceived multiple pregnancies. Common reasons for indicated preterm births include pre-eclampsia or eclampsia, and intrauterine growth restriction. Births that follow spontaneous preterm labour and PPROM-together called spontaneous preterm births-are regarded as a syndrome resulting

2008 Lancet

2711. Treatment for cervical intraepithelial neoplasia and risk of preterm delivery. Full Text available with Trip Pro

subtypes.Retrospective cohort study conducted among women evaluated at a colposcopy clinic serving Auckland, New Zealand (1988-2000), comparing delivery outcomes of untreated women (n = 426) and those treated (n = 652) with laser conization, laser ablation, or LEEP. Record linkage using unique health identifiers identified women who had subsequent deliveries.Total preterm delivery and its subtypes, spontaneous labor and premature rupture of membranes before 37 weeks' gestation (pPROM).The overall rate of preterm (...) Treatment for cervical intraepithelial neoplasia and risk of preterm delivery. It is unclear whether treatments for cervical intraepithelial neoplasia (CIN) increase the subsequent risk of preterm delivery. Most studies have lacked sufficient sample size, mixed heterogeneous subtypes of preterm delivery, and failed to control for confounding factors.To determine whether cervical laser and loop electrosurgical excision procedure (LEEP) treatments increase risk of preterm delivery and its

2004 JAMA

2712. Can Ultrasound Replace Amniocentesis for Confirming Fetal Lung Maturation Among Premature Fetuses?

for Study: Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Women delivering between 27 to 37 weeks. Women undergoing amniocentesis for determining fetal lung maturity between 27 to 37 weeks. Exclusion Criteria: Major fetal malformation. Oligohydramnios or rupture of membranes diagnosed before 24 weeks of gestation. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using (...) Can Ultrasound Replace Amniocentesis for Confirming Fetal Lung Maturation Among Premature Fetuses? Can Ultrasound Replace Amniocentesis for Confirming Fetal Lung Maturation Among Premature Fetuses? - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2008 Clinical Trials

2713. Reduction of Spontaneous Prematurity by Antibiotic Treatment (Josamycin)

of the uterine collar, a rupture of the membranes then a premature birth. Several recent publications show on the one hand that Mycoplasma hominis and Ureaplasma spp. are the bacteria most frequently found in the amniotic liquid in the second quarter of the pregnancy and that a positive PCR for these bacteria is associated with a premature birth. A probable assumption would be that Mycoplasma hominis or Ureaplasma spp. cause a premature birth by infecting the fetal membranes and the decidual, then activating (...) ] Antenatal : premature delivery [ Time Frame: at week of amenorrhea <= 34, 32, 28 ] Antenatal : hospitalisation for risk of premature delivery [ Time Frame: antenatal period ] antenatal : Number of day of hospitalisation for risk of premature delivery [ Time Frame: antenatal period ] Antenatal : premature rupture of membranes [ Time Frame: before 37 week of amenorrhea ] Antenatal : occurence of chorioamnionitis defined by 2 of the following criteria :maternal temperature > 38°C, uterine contractions

2008 Clinical Trials

2714. Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants

Healthy Volunteers: No Criteria Inclusion Criteria: <29 6/7 and >24 0/7 weeks gestational age Inborn at the participating institution enrolling the patient FIO2 >25% and Intubated with mean airway pressure > 5 cm H20 <8 hours age at randomization Signed informed consent from parent(s) Exclusion Criteria: <500 g birth weight <24 0/7 weeks gestational age (best estimate) Prolonged Premature Rupture of membranes >3 weeks (21 days) Apgar score < 3 at 5 minutes Impending death anticipated within the first (...) Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Curosurf

2007 Clinical Trials

2715. Randomized Study of Pessary Versus Standard Management in Women With Increased Chance of Premature Birth

-trimester screening to have a cervix of <25 mm in length and in twin pregnancies. Condition or disease Intervention/treatment Phase Preterm Birth Device: Vaginal pessary (CE0482, MED/CERT ISO 9003 / EN 46003) Phase 3 Detailed Description: Prematurity is responsible for more than half of all neonatal deaths and whilst advances in neonatal care have dramatically improved survival of extremely premature infants, there remains a significant risk of handicap and disability in survivors and an associated (...) social and economic burden. In singleton pregnancies the rate of spontaneous premature birth before 34 weeks is about 1% and the risk of spontaneous early delivery is inversely related to cervical length. The group with cervix of 1-15 mm accounted for 28% of all spontaneous deliveries before 34 weeks and those with cervix of 16-25 mm accounted for 21%. The rate of spontaneous premature birth before 34 weeks is about 13% in twin pregnancies. Potential methods for the prevention of preterm delivery

2008 Clinical Trials

2716. Magnesium Sulfate Versus Indomethacin for Preterm Labor

of, Magnesium sulfate and/or Indomethacin Documented rupture of amniotic membranes Multiple gestations of triplets or more. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00116623 Locations Layout table for location information United States, Pennsylvania (...) : Layout table for MeSH terms Obstetric Labor, Premature Obstetric Labor Complications Pregnancy Complications Magnesium Sulfate Indomethacin Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anesthetics Central Nervous System Depressants Anti-Arrhythmia Agents Anticonvulsants Calcium Channel Blockers Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action Calcium-Regulating Hormones and Agents Tocolytic Agents Reproductive Control

2005 Clinical Trials

2717. Treatment of Preterm Labor With 17 Alpha-hydroxyprogesterone Caproate

being. Exclusion Criteria: Rupture of membranes Major known fetal anomalies Cervical dilation > 4 centimeters Uterine anomalies Cervical cerclage Treatment during this pregnancy with progesterone after 14 weeks' gestation (use up to 14 weeks' gestation is permitted) Previous admission for preterm labor Contraindications to tocolysis, including fetal distress, chorioamnionitis, preeclampsia, hemodynamic instability Coexisting maternal disease including hypertension requiring medical therapy, cancer (...) in symptomatic patients. Condition or disease Intervention/treatment Phase Premature Birth Premature Labor Drug: 17 hydroxyprogesterone caproate intramuscular injections Not Applicable Detailed Description: Preterm delivery remains one of the most important issues facing perinatal medicine today. In 1999, prematurity/low birthweight accounted for 4,304 neonatal deaths, reflecting a rate of neonatal mortality due to prematurity of 23.0 per 100,000 live births. Despite the extent of the problem, the exact

2005 Clinical Trials

2718. Two Dose Regimens of Nifedipine for the Management of Preterm Labor

for Study: Female Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: All pregnant women diagnosed with preterm labor defined as regular contractions associated with cervical change between 24 and 34 weeks of gestation Exclusion Criteria: Multiple pregnancy Preterm rupture of membranes Congenital fetal malformations IUGR (intra uterine growth restriction) Previous tocolysis in this pregnancy Chorioamnionitis Cervical dilation > 4 cms Maternal medical conditions such as renal insufficiency (...) effective and safest dose regimen of nifedipine in such patients. Condition or disease Intervention/treatment Phase Labor, Premature Drug: Nifedipine Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 102 participants Allocation: Randomized Intervention Model: Single Group Assignment Masking: Single (Outcomes Assessor) Primary Purpose: Treatment Official Title: Study of Different Doses of Nifedipine to Treat Preterm Labor Study

2005 Clinical Trials

2719. Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS)

oil). Patients are seen weekly to administer the study drug through 34 weeks 6 days gestation or delivery, whichever occurs first. Outcome Measures Go to Primary Outcome Measures : Delivery prior to 35 weeks 0 days gestation [ Time Frame: Delivery Date ] Secondary Outcome Measures : Maternal randomization to delivery interval of first fetus [ Time Frame: Delivery ] pPROM - spontaneous rupture of the membranes at least one hour prior to the start of labor, regular contractions accompanied (...) : Yes Plan Description: The data will be shared after completion and publication of the main analyses in accordance with NIH policy. The dataset can be obtained by emailing mfmudatasets@bsc.gwu.edu. Keywords provided by The George Washington University Biostatistics Center: preterm birth pregnancy multifetal Progesterone Additional relevant MeSH terms: Layout table for MeSH terms Premature Birth Obstetric Labor, Premature Obstetric Labor Complications Pregnancy Complications Progesterone 17 alpha

2004 Clinical Trials

2720. Vaginal Progesterone to Reduce the Risk of Another Preterm Birth

. The subject, in the judgment of the investigator, will be unable or unwilling to comply with study-related assessments and procedures. The subject currently has preterm rupture of membranes, vaginal bleeding, known or suspected amnionitis, or signs or symptoms of preterm labor at the time of enrollment. The subject is HIV positive with a CD4 count of _<350 cells/mm3 and is receiving more than 1 medication to prevent the transfer of AIDS to the fetus. The subject has placenta previa or a low-lying placenta (...) " is a delivery (<35 weeks), either vaginal or cesarean, that is initiated by either preterm PROM followed by contractions or preterm labor initiated with in-tact membranes. A previous preterm delivery secondary to an incompetent cervix where a cerclage is considered for this pregnancy is not considered a preterm delivery (please see Exclusion Criteria No. 10). Subjects enrolled based on a history of preterm delivery may have had a pregnancy loss (or losses) at <20 0/7 weeks gestational age between

2004 Clinical Trials

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