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Premature Rupture of Membranes

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2681. In vitro effect of tinidazole and furazolidone on metronidazole-resistant Trichomonas vaginalis. Full Text available with Trip Pro

In vitro effect of tinidazole and furazolidone on metronidazole-resistant Trichomonas vaginalis. Trichomonas vaginalis is a common sexually transmitted protozoan parasite. Although often considered simply a nuisance infection, T. vaginalis has been implicated in premature rupture of placental membranes and increases in the risk of acquiring human immunodeficiency virus. Metronidazole, a 5-nitroimidazole, is currently the drug of choice to treat T. vaginalis infection. Because some patients have

1996 Antimicrobial Agents and Chemotherapy

2682. Maternal and fetal indicators of oxidative stress in various obstetric complications Full Text available with Trip Pro

Maternal and fetal indicators of oxidative stress in various obstetric complications The present study demonstrates the incidence of increased lipid peroxidation and protein oxidation in both maternal and fetal erythrocytes as markers of oxygen radical activity in different complications of pregnancy. In fetuses born after premature rupture of membranes, lipid peroxidation was significantly elevated as indicated by increased malondialdehyde levels (p<0.05) as compared to controls. Proteolytic

2003 Indian Journal of Clinical Biochemistry

2683. Risk factors for early-onset group B streptococcal disease in neonates: a population-based case–control study Full Text available with Trip Pro

were no differences between the 90 cases and 489 controls in sociodemographic variables or in many reproductive and behavioural variables. Case infants were more likely than control infants to be of low birth weight (odds ratio [OR] 3.60, 95% confidence interval [CI] 1.68-7.65), to have been delivered preterm (OR 3.89, 95% CI 2.08-7.27), or to have a mother with amnionitis (OR 15.03, 95% CI 5.58-41.89), intrapartum fever (OR 4.65, 95% CI 2.48-8.69) or premature rupture of the membranes (OR 2.39, 95

2003 CMAJ: Canadian Medical Association Journal

2684. Preventing perinatal infections. Full Text available with Trip Pro

Preventing perinatal infections. 9253256 1997 09 04 2008 11 20 0959-8138 315 7102 1997 Jul 26 BMJ (Clinical research ed.) BMJ Preventing perinatal infections. 199-200 Hofmeyr G J GJ McIntyre J J eng Comment Editorial England BMJ 8900488 0959-8138 AIM IM X BMJ. 1997 Jul 26;315(7102):216-9; discussion 220 9253269 Breast Feeding adverse effects Female Fetal Membranes, Premature Rupture complications HIV Infections prevention & control transmission Humans Infant, Newborn Pregnancy Pregnancy

1997 BMJ : British Medical Journal

2685. Cervical ripening with intravaginal prostaglandin E2 gel. (Abstract)

), and lowering the rate of cesarean section (.05 less than P less than .1). One hundred fifty additional patients with varying Bishop scores and differing clinical situations were also studied. There were 35 cesarean sections (23.3%), nine failed inductions (6%), a spontaneous labor rate of 46%, and an average Bishop score change of 2.5. Twenty patients with premature rupture of the membranes and an unfavorable cervix received a modified gel containing 2.5 mg of prostaglandin E2. Average Bishop score change

1983 Obstetrics and Gynecology

2686. Neonatal metabolic effects of oral ritodrine hydrochloride administration. (Abstract)

Neonatal metabolic effects of oral ritodrine hydrochloride administration. Neonatal hypoglycemia and hyperinsulinemia have been reported following maternal ritodrine administration, but no prospective controlled study of the neonatal metabolic and cardiovascular effects of maternal ritodrine is available. We conducted a double-blind prospective study in 35 patients with preterm labor and/or ruptured membranes. Patients in premature labor received ritodrine (max dose, 350 mcg/min) or a placebo (...) intravenously for 12 hours, and then orally (20 mg every 4 hours) until labor ensued. Patients with ruptured membranes received only oral therapy. Only patients who were maintained on oral therapy for a minimum of 12 hours and who were within 6 hours of their last dose of oral therapy were included in the analysis. Glucose and insulin values in cord blood at 6 and 12 hours of age were not significantly different between the ritodrine and placebo groups. There were no hypoglycemic infants in the ritodrine

1983 Pediatric pharmacology (New York, N.Y.)

2687. Prolonged intravenous ritodrine therapy: a comparison between multiple and singleton pregnancies. (Abstract)

Prolonged intravenous ritodrine therapy: a comparison between multiple and singleton pregnancies. To compare multiple and singleton pregnancies in the treatment of threatened preterm delivery with prolonged intravenous ritodrine, 32 women with multiple pregnancy (26 twins, 6 triplets, 70 fetuses, 30.3 +/- 3.5 weeks) and 51 women with singleton pregnancy (31.3 +/- 2.6 weeks) admitted for threatened preterm delivery without rupture of the membranes were the subjects of a retrospective study

1994 European journal of obstetrics, gynecology, and reproductive biology

2688. Repeated fetal losses associated with antiphospholipid antibodies: a collaborative randomized trial comparing prednisone with low-dose heparin treatment. (Abstract)

to prednisone (p = 0.02 vs p = 0.006). Preterm delivery among prednisone-treated women was usually associated with premature rupture of the membranes or preeclampsia. These results could be generalized to the other groups of women ascertained during the course of the study.Low-dose heparin should be preferred to prednisone when treatment is indicated for high-risk pregnant women with antiphospholipid antibodies. (...) included 20 patients. Generalizability of results from randomized patients was evaluated by means of additional data from 13 women refusing and 12 women ineligible for randomization. Data from study groups were compared with Fisher's exact test, and generalizability was evaluated with a chi 2 test for trend.Live birth rates were the same (75%) with either treatment, but "serious" maternal morbidity and the frequency of preterm delivery were significantly higher among women randomly assigned

1992 American journal of obstetrics and gynecology Controlled trial quality: uncertain

2689. Management of the third stage of labour in women at low risk of postpartum haemorrhage. (Abstract)

criteria were induction or augmentation of labour, antepartum or previous postpartum haemorrhage, premature rupture of membranes, previous caesarean section, raised blood pressure, cervical lacerations and third degree tears.Active management with syntometrine and controlled cord traction; or physiological management, where the cord was not clamped and the placenta was delivered by maternal effort.Blood loss was measured subjectively at delivery and estimated objectively by comparing the haemoglobin

1993 European journal of obstetrics, gynecology, and reproductive biology Controlled trial quality: uncertain

2690. Final report of the Medical Research Council/Royal College of Obstetricians and Gynaecologists multicentre randomised trial of cervical cerclage. MRC/RCOG Working Party on Cervical Cerclage. (Abstract)

preterm delivery rate was 28%. There were fewer deliveries before 33 weeks in the cerclage group (83 (13%) compared with 110 (17%), P = 0.03) and this difference reflected deliveries characterised by features of cervical incompetence (painless cervical dilatation and prelabour rupture of the membranes). There was a corresponding difference in very low birthweight deliveries (63 (10%) compared with 86 (13%), P = 0.05). The difference in the overall rate of miscarriage, stillbirth or neonatal death (55 (...) , Iceland, Ireland, the Netherlands and Canada.One thousand two hundred and ninety-two pregnant women whose obstetricians were uncertain whether to recommend cervical cerclage, most of whom had a history of early delivery or cervical surgery.Cervical cerclage was compared with a policy of withholding the operation unless it was considered to be clearly indicated.Delivery before 33 completed weeks, preterm delivery (< 37 weeks), and vital status of the baby after completion of the pregnancy.The overall

1993 British journal of obstetrics and gynaecology Controlled trial quality: predicted high

2691. [Short-term prevention with cefoxitin in cesarean section]. (Abstract)

, a statistically significant reduction (p less than 0.05) of febrile days was found for the cefoxitin group. As compared to previous studies with a three-dose regimen of cefoxitin, the per cent reduction rate of febrile morbidity was similar. In cases with certain risk profiles, such as premature rupture of the membranes or prolonged delivery, a single-dose appears to suffice and is therefore indicated.

1984 Geburtshilfe und Frauenheilkunde Controlled trial quality: uncertain

2692. Selective intrapartum chemoprophylaxis of neonatal group B streptococcal early-onset disease. III. Interruption of mother-to-infant transmission. (Abstract)

Selective intrapartum chemoprophylaxis of neonatal group B streptococcal early-onset disease. III. Interruption of mother-to-infant transmission. The effect of intrapartum ampicillin treatment on vertical transmission of group B streptococci (GBS) was examined in 575 prenatally colonized parturient women and their 580 newborn infants. Eighty women (43 receiving ampicillin) with premature labor and/or prolonged rupture of amniotic membranes were randomized. The other 495 were stratified (...) into groups of 358 (31 receiving ampicillin) with no perinatal risk factors; 119 (28 receiving ampicillin) with premature labor and/or prolonged membrane rupture; and 23 (18 receiving ampicillin) with intrapartum fever. Ampicillin virtually eliminated vertical transmission in the treatment group with no risk factors and in both treatment groups with premature labor and/or prolonged membrane rupture. GBS colonization of neonates was detected only in women with intrapartum fever or brief (less than 1 hr

1983 The Journal of infectious diseases Controlled trial quality: uncertain

2693. Amnioinfusion: a review. (Abstract)

of operative deliveries, and improved umbilical artery and venous blood gas values. Amnioinfusion also has been suggested as means to instill antibiotics into an infected uterine cavity, or the uterine cavity of a woman with preterm premature rupture of the membranes. Transabdominal amnioinfusion may be used to improved prenatal ultrasound evaluation in pregnancies associated with oligohydramnios. Complications of amnioinfusion include umbilical cord prolapse, uterine overdistention, fetal bradycardia

1993 Obstetrical & Gynecological Survey Controlled trial quality: uncertain

2694. Zinc supplementation during pregnancy: a double blind randomised controlled trial. (Abstract)

thousand two hundred and six mothers were available for study.Volunteers were randomly selected to receive two tablets of zinc (44 mg zinc in total) or two placebo tablets containing inert substances, indistinguishable in appearance and taste from the zinc tablets.Large for gestational age (LGA), small for gestational age (SGA), premature rupture of the membrane (PROM), preterm labor (PL), preeclampsia and bleeding in the second or third trimester.There were no differences between mothers given zinc

1996 Acta Obstetricia et Gynecologica Scandinavica Controlled trial quality: predicted high

2695. A comparison of breast stimulation and intravenous oxytocin for the augmentation of labor. (Abstract)

for the study if they had inadequate labor with premature rupture of the membranes and met inclusion criteria. They were assigned to oxytocin augmentation or breast stimulation (manual or pump), and were switched to oxytocin in the event of method failure. Outcomes included time to delivery, intervention to delivery, proportion of spontaneous deliveries, and Apgar scores. One hundred participants were needed in each arm of the study to demonstrate a 2- to 3-hour difference in delivery time, with a power

1999 Birth Controlled trial quality: uncertain

2696. The efficacy of prophylactic erythromycin in preventing vertical transmission of Ureaplasma urealyticum. (Abstract)

The efficacy of prophylactic erythromycin in preventing vertical transmission of Ureaplasma urealyticum. To determine if prophylactic erythromycin alters the vertical transmission rate of Ureaplasma urealyticum. Randomized prospective study of 51 singleton pregnancies between 22 and 35 weeks' gestation with preterm premature rupture of membranes or preterm labor. Patients received oral erythromycin for 7 days in addition to routine prophylactic intravenous ampicillin or ampicillin alone. Lower

1997 American journal of perinatology Controlled trial quality: uncertain

2697. Invasive antenatal procedures and requirement for neonatal intensive care unit admission. (Abstract)

Invasive antenatal procedures and requirement for neonatal intensive care unit admission. Neonatal respiratory difficulties are increased following second trimester amniocentesis. In preterm, prolonged rupture of the membranes, respiratory outcome is particularly poor when rupture occurs in the first trimester. It therefore seems likely that first trimester/ early amniocentesis (EA) would be associated with severe respiratory problems necessitating a high neonatal intensive care unit (NICU

1997 European journal of pediatrics Controlled trial quality: uncertain

2698. Australian Collaborative Trial of Antenatal Thyrotropin-Releasing Hormone: adverse effects at 12-month follow-up. ACTOBAT Study Group. (Abstract)

rupture of the membranes, infant sex, singleton or twin status, maternal age, and maternal blood pressure (systolic and diastolic) at randomization. For the total cohort (N = 1022), treatment with TRH was associated with motor delay (odds ratio [OR], 1.51; 95% confidence interval [CI] 1.11 to 2.05); social delay (OR 1.40; 95% CI 1.01 to 1.95); sensory impairment (OR, 2.00; 95% CI 1.06 to 3.74); severe impairment (OR, 1.75; 95% CI 1.07 to 2.87); and a trend toward motor impairment (OR, 1.50; 95% CI .97 (...) scores were developed from items on the follow-up form. Treatment with TRH was associated with an increased risk of motor delay, social delay, fine motor delay, sensory impairment, and early language impairment. No differences were seen between treatment and placebo groups for motor impairment. Multivariate analyses were performed, adjusting for chronological age, duration of gestation at randomization, time from randomization to delivery, parity, history of perinatal death, history of preterm

1997 Pediatrics Controlled trial quality: predicted high

2699. High risk pregnancy monitored antenatally at home. (Abstract)

pregnancy (23%), diabetes (24%), preterm rupture of membranes (2%) and previous recurrent antenatal death (1%).Primary outcome measure was perinatal morbidity, measured by Prechtl's neonatal neurological optimality score. Secondary outcome variables were the occurrence of complications, obstetric interventions at labour, birthweight, gestational age at delivery and maternal and neonatal admission rates.In both groups there was one case of perinatal mortality. In both treatment groups the median

1997 European journal of obstetrics, gynecology, and reproductive biology Controlled trial quality: uncertain

2700. The significance of interleukin-6 concentrations in cervicovaginal fluid: its relation to umbilical cord plasma and the influence of antibiotic treatment. (Abstract)

The significance of interleukin-6 concentrations in cervicovaginal fluid: its relation to umbilical cord plasma and the influence of antibiotic treatment. This study was performed to correlate cervicovaginal fluid and umbilical cord plasma level of IL-6 and IL-8 in patients with premature rupture of the membranes (PROM) and to see the effect of antibiotics on those concentrations. As a part of a randomized controlled trial of treatment in PROM with antibiotics, cervicovaginal fluid was sampled

2000 Journal of perinatal medicine Controlled trial quality: uncertain

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