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Premature Rupture of Membranes

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181. Neonatal and Infant Outcomes in Twin Gestations With Preterm Premature Rupture of Membranes at 24-31 Weeks of Gestation. (PubMed)

Neonatal and Infant Outcomes in Twin Gestations With Preterm Premature Rupture of Membranes at 24-31 Weeks of Gestation. To describe the perinatal and infant and early childhood morbidity associated with preterm premature rupture of membranes (PROM) in a cohort of twin pregnancies evaluated prospectively with neonatal follow-up to 2 years of age.This was a secondary analysis of a randomized controlled trial of magnesium sulfate for prevention of cerebral palsy. Inclusion criteria were twin (...) gestation with preterm PROM diagnosed between 24 0/7 and 31 6/7 weeks of gestation and planned expectant management. Latency (time from membrane rupture to delivery) and perinatal outcomes were evaluated by gestational age at membrane rupture. Long-term neonatal outcomes were also analyzed.Among 151 women who met inclusion criteria, the median gestational age at preterm PROM was 28.1 weeks (range 24.1-31.6 weeks). Approximately one-third of women achieved a latency of at least 1 week. Gestational age

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2014 Obstetrics and Gynecology Controlled trial quality: predicted high

182. Using vaginal Group B Streptococcus colonisation in women with preterm premature rupture of membranes to guide the decision for immediate delivery: a secondary analysis of the PPROMEXIL trials. (PubMed)

Using vaginal Group B Streptococcus colonisation in women with preterm premature rupture of membranes to guide the decision for immediate delivery: a secondary analysis of the PPROMEXIL trials. To investigate whether vaginal Group B Streptococcus (GBS) colonisation or other baseline characteristics of women with preterm premature rupture of membranes (PPROM) can help in identifying subgroups of women who would benefit from immediate delivery.Secondary analysis of the PPROMEXIL trials.Sixty

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2014 BJOG Controlled trial quality: uncertain

183. Comparative study of placental α-microglobulin-1, insulin-like growth factor binding protein-1 and nitrazine test to diagnose premature rupture of membranes: A randomized controlled trial. (PubMed)

Comparative study of placental α-microglobulin-1, insulin-like growth factor binding protein-1 and nitrazine test to diagnose premature rupture of membranes: A randomized controlled trial. The aim of this study was to compare the accuracy of placental α-microglobulin-1 (PAMG-1), insulin-like growth factor binding protein-1 (IGFBP-1) and nitrazine test to diagnose premature rupture of membranes.A total of 120 pregnant women between 11 and 42 weeks with signs/symptoms of membrane rupture were (...) coincidence rate was 94.17%, and kappa value was 0.85. In a comparison of the PAMG-1 test and the IGFBP-1 test, the positive coincidence rate, negative coincidence rate and total coincidence rate were 96.55%, 97.80%, and 97.50%, and kappa value was 0.93.PAMG-1 assay was the most accurate method to diagnose premature rupture of membranes with the highest sensitivity, specificity, positive predictive value and negative predictive value.© 2014 The Authors. Journal of Obstetrics and Gynaecology Research ©

2014 The journal of obstetrics and gynaecology research Controlled trial quality: uncertain

184. Neonatal and early childhood outcomes following early vs. later preterm premature rupture of membranes. (PubMed)

Neonatal and early childhood outcomes following early vs. later preterm premature rupture of membranes. Data regarding long-term outcomes of neonates reaching viability following early preterm premature rupture of membranes (PPROM; <25.0 weeks at rupture) are limited. We hypothesized that babies delivered after early PPROM would have increased rates of major childhood morbidity compared with those with later PPROM (≥25.0 weeks at rupture).This was a secondary analysis of a multicenter (...) ) and composite severe childhood morbidity at age 2 years (moderate or severe cerebral palsy and/or Bayley II Infant and Toddler Development scores greater than 2 SD below the mean) were compared.A total of 1531 women (275 early PPROM cases) were included. Demographics were similar between the groups. Cases delivered earlier (26.6 vs 30.1 weeks, P < .001) and had a longer rupture-to-delivery interval (20.0 vs 10.4 days, P < .001). Case neonates had high rates of severe composite neonatal morbidity (75.6% vs

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2014 American journal of obstetrics and gynecology Controlled trial quality: predicted high

185. Removal versus retention of cerclage in preterm premature rupture of membranes: A randomized controlled trial. (PubMed)

Removal versus retention of cerclage in preterm premature rupture of membranes: A randomized controlled trial. The decision of whether to retain or remove a previously placed cervical cerclage in women who subsequently rupture fetal membranes in a premature gestation is controversial and all studies to date are retrospective. We performed a multicenter randomized controlled trial of removal vs retention of cerclage in these patients to determine whether leaving the cerclage in place prolonged (...) that there may be no advantage to retaining a cerclage after preterm premature rupture of membranes and a possibility of increased infection with cerclage retention.Copyright © 2014 Elsevier Inc. All rights reserved.

2014 American journal of obstetrics and gynecology Controlled trial quality: predicted high

186. Can neonatal sepsis be predicted in late preterm premature rupture of membranes? Development of a prediction model. (PubMed)

Can neonatal sepsis be predicted in late preterm premature rupture of membranes? Development of a prediction model. Women with late preterm premature rupture of membranes (PROM) have an increased risk that their child will develop neonatal sepsis. We evaluated whether neonatal sepsis can be predicted from antepartum parameters in these women.We used multivariable logistic regression to develop a prediction model. Data were obtained from two recent randomized controlled trials on induction

2014 European journal of obstetrics, gynecology, and reproductive biology Controlled trial quality: uncertain

187. Amnioinfusion in very early preterm premature rupture of membranes - pregnancy, neonatal and maternal outcomes in the AMIPROM randomised controlled pilot study. (PubMed)

Amnioinfusion in very early preterm premature rupture of membranes - pregnancy, neonatal and maternal outcomes in the AMIPROM randomised controlled pilot study. To assess short- and long-term outcomes of pregnant women with very early rupture of membranes randomized to serial amnioinfusion or expectant management, and to collect data to inform a larger, more definitive clinical trial.This was a prospective non-blinded randomized controlled trial with randomization stratified for pregnancies (...) in which the membranes ruptured between 16 + 0 and 19 + 6 weeks' gestation and 20 + 0 and 23 + 6 weeks' gestation to minimize the risk of random imbalance in gestational age distribution between randomized groups. Intention-to-treat analysis was used. The study was conducted in four UK hospital-based fetal medicine units (Liverpool Women's NHS Trust, St Mary's Hospital Manchester, Birmingham Women's NHS Foundation Trust and Wirral University Hospitals Trust). The participants were women with confirmed

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2014 Ultrasound in Obstetrics and Gynecology Controlled trial quality: predicted high

188. Does Vitamin C and Vitamin E Supplementation Prolong the Latency Period before Delivery following the Preterm Premature Rupture of Membranes? A Randomized Controlled Study. (PubMed)

Does Vitamin C and Vitamin E Supplementation Prolong the Latency Period before Delivery following the Preterm Premature Rupture of Membranes? A Randomized Controlled Study. To determine whether maternal vitamin C and vitamin E supplementation after the premature rupture of membranes is associated with an increase in the latency period before delivery.In the present prospective open randomized trial, 229 pregnant women with preterm premature rupture of membranes (PPROM) at ≥ 24.0 and < 34.0

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2014 American journal of perinatology Controlled trial quality: predicted high

189. Premature labour

progress to actual labour and delivery. Risk factors include previous premature labour, cervical surgery, urinary tract infections, and multiple (multi-fetal) pregnancies. Bleeding and premature rupture of membranes at any gestation is associated with higher rates of preterm delivery. Early spontaneous birth can be predicted using serial digital examination or transvaginal ultrasound of the cervix. Fetal fibronectin detected in cervico-vaginal secretions can also be used after 22 weeks' gestation (...) as threatened premature labour (TPTL) progress to actual labour and delivery. The remainder of preterm birth is due to iatrogenic delivery, most commonly because of pre-eclampsia and intrauterine growth restriction. Preterm premature rupture of membranes (PPROM) is defined as the rupture of membranes at <37 weeks' gestation and prior to the onset of labour. This topic will focus on the management of spontaneous premature labour that may follow TPTL or PPROM. History and exam presence of risk factors uterine

2018 BMJ Best Practice

190. Premature newborn care

preterm premature rupture of membranes (PPROM) pre-eclampsia/pregnancy-induced hypertension abruption/antepartum haemorrhage abnormal amniotic fluid volume severe bacterial vaginosis multiple gestation previous preterm birth fetal abnormality cervical incompetence/uterine abnormality gestational diabetes maternal surgery during pregnancy chronic maternal illness short inter-pregnancy time interval drug use (tobacco, cocaine, heroin) maternal pregnancy body mass index <19 or >35 stress/depression non (...) Premature newborn care Premature newborn care - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Premature newborn care Last reviewed: February 2019 Last updated: February 2019 Summary A premature infant is an infant born before 37 weeks' gestation. In addition to immediate post-birth resuscitation, efforts to reduce excessive oxygen exposure, hyperventilation, hypothermia, and hypoglycaemia must be made. Consultation

2018 BMJ Best Practice

191. Expectant management of preterm premature rupture of membranes: is it all about gestational age? (PubMed)

Expectant management of preterm premature rupture of membranes: is it all about gestational age? We sought to compare neonatal outcome in cases of uncomplicated preterm premature rupture of membranes (PPROM) (ie, no evidence of clinical chorioamnionitis, placental abruption, or fetal distress) with that of spontaneous preterm deliveries (PTDs) and to determine the effect of the latency period.The study group included women with PPROM at gestational age 28⁰(/)⁷-33⁶(/)⁷ weeks (n = 488). Neonatal (...) , and nulliparity.Consultation regarding prematurity-related morbidity in infants exposed to uncomplicated PPROM cannot be extrapolated from PTDs and should be stratified by the duration of the latency period and the other risk factors identified in the current study.Copyright © 2011 Mosby, Inc. All rights reserved.

2011 EvidenceUpdates

192. The effect of preterm premature rupture of membranes on neonatal mortality rates (PubMed)

The effect of preterm premature rupture of membranes on neonatal mortality rates To estimate the effect of preterm premature rupture of membranes (PROM) on neonatal mortality.A cross-sectional study using a state perinatal database (California Perinatal Quality Care Collaborative) was performed. Prenatal data, including ruptured membranes, corticosteroid administration, maternal age, maternal race, maternal hypertension, mode of delivery, and prenatal care, were recorded. Mortality rates were (...) those born with and without membrane rupture before delivery. The presence of prolonged preterm PROM was associated with decreased mortality at 24 to 26 weeks of gestation (18% compared with 31% for recent preterm PROM; odds ratio [OR] 1.79; confidence interval [CI] 1.25-2.56) but increased mortality at 28 to 30 weeks of gestation (4% compared with 3% for recent preterm PROM; OR 0.44; CI 0.22, 0.88) when adjusted for possible confounding factors. Sepsis rates did not differ between those with recent

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2011 EvidenceUpdates

193. Premature Rupture of Membranes (Overview)

Premature Rupture of Membranes (Overview) Premature Rupture of Membranes: Overview, Premature Rupture of Membranes (at Term), Premature Preterm Rupture of Membranes Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjYxMTM3LW92ZXJ2aWV3 processing > Premature Rupture of Membranes Updated: Oct 05, 2018 Author: Allahyar Jazayeri, MD, PhD, FACOG, DACOG, FSMFM; Chief Editor: Carl V Smith, MD Share Email Print Feedback Close Sections Sections Premature Rupture of Membranes Overview Overview Premature rupture of membranes (PROM) refers to a patient who is beyond 37 weeks' gestation and has presented with rupture of membranes (ROM) prior to the onset of labor. Preterm premature rupture of membranes (PPROM) is ROM prior to 37 weeks

2014 eMedicine.com

194. Premature Rupture of Membranes (Follow-up)

Premature Rupture of Membranes (Follow-up) Premature Rupture of Membranes: Overview, Premature Rupture of Membranes (at Term), Premature Preterm Rupture of Membranes Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjYxMTM3LW92ZXJ2aWV3 processing > Premature Rupture of Membranes Updated: Oct 05, 2018 Author: Allahyar Jazayeri, MD, PhD, FACOG, DACOG, FSMFM; Chief Editor: Carl V Smith, MD Share Email Print Feedback Close Sections Sections Premature Rupture of Membranes Overview Overview Premature rupture of membranes (PROM) refers to a patient who is beyond 37 weeks' gestation and has presented with rupture of membranes (ROM) prior to the onset of labor. Preterm premature rupture of membranes (PPROM) is ROM prior to 37 weeks

2014 eMedicine.com

195. Premature Rupture of Membranes (Diagnosis)

Premature Rupture of Membranes (Diagnosis) Premature Rupture of Membranes: Overview, Premature Rupture of Membranes (at Term), Premature Preterm Rupture of Membranes Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjYxMTM3LW92ZXJ2aWV3 processing > Premature Rupture of Membranes Updated: Oct 05, 2018 Author: Allahyar Jazayeri, MD, PhD, FACOG, DACOG, FSMFM; Chief Editor: Carl V Smith, MD Share Email Print Feedback Close Sections Sections Premature Rupture of Membranes Overview Overview Premature rupture of membranes (PROM) refers to a patient who is beyond 37 weeks' gestation and has presented with rupture of membranes (ROM) prior to the onset of labor. Preterm premature rupture of membranes (PPROM) is ROM prior to 37 weeks

2014 eMedicine.com

196. Premature Rupture of Membranes (Treatment)

Premature Rupture of Membranes (Treatment) Premature Rupture of Membranes: Overview, Premature Rupture of Membranes (at Term), Premature Preterm Rupture of Membranes Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjYxMTM3LW92ZXJ2aWV3 processing > Premature Rupture of Membranes Updated: Oct 05, 2018 Author: Allahyar Jazayeri, MD, PhD, FACOG, DACOG, FSMFM; Chief Editor: Carl V Smith, MD Share Email Print Feedback Close Sections Sections Premature Rupture of Membranes Overview Overview Premature rupture of membranes (PROM) refers to a patient who is beyond 37 weeks' gestation and has presented with rupture of membranes (ROM) prior to the onset of labor. Preterm premature rupture of membranes (PPROM) is ROM prior to 37 weeks

2014 eMedicine.com

197. Progesterone administration after preterm premature rupture of membranes

Progesterone administration after preterm premature rupture of membranes Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect

2017 PROSPERO

198. A Pilot RCT on the Management of Term Prelabour Rupture of Membranes

) First Posted: August 19, 2016 Last Update Posted: November 16, 2016 Last Verified: November 2016 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Keywords provided by Lucia Ramirez-Montesinos, University of Central Lancashire: Prelabour rupture of membranes term pregnancy management vaginal examination induction of labour expectant management Additional relevant MeSH terms: Layout table for MeSH terms Rupture Fetal Membranes, Premature Rupture Wounds and Injuries Obstetric (...) A Pilot RCT on the Management of Term Prelabour Rupture of Membranes A Pilot RCT on the Management of Term Prelabour Rupture of Membranes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Pilot RCT

2016 Clinical Trials

199. Pregnancy Outcomes in Women With a History of Previable, Preterm Prelabor Rupture of Membranes. (PubMed)

Pregnancy Outcomes in Women With a History of Previable, Preterm Prelabor Rupture of Membranes. To characterize subsequent pregnancy outcomes among women with a history of previable, preterm prelabor rupture of membranes (PROM) and assess factors associated with recurrent preterm birth.This was a retrospective cohort study of women cared for with a history of one or more singleton pregnancy complicated by preterm PROM at less than 24 weeks of gestation between 2002 and 2013 who were cared (...) . The primary outcome was recurrent preterm birth at less than 37 weeks of gestation. Data were analyzed by χ, Fisher exact, t test, Wilcoxon rank-sum, and logistic regression.Two hundred ninety-four women had one or more pregnancies complicated by previable, preterm PROM. One hundred eight of 294 (37%) had one or more subsequent pregnancies in our health care systems and 50 of 108 (46%) had two or more. In the pregnancy immediately after the index delivery, the risk of prematurity was high: 50 (46

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2016 Obstetrics and Gynecology

200. Ureaplasma Infection Mediated Release of Matrix Metalloproteinase-9 and PGP - a Novel Mechanism of Preterm Rupture of Membranes and Chorioamnionitis. (PubMed)

Ureaplasma Infection Mediated Release of Matrix Metalloproteinase-9 and PGP - a Novel Mechanism of Preterm Rupture of Membranes and Chorioamnionitis. Premature rupture of membranes and preterm delivery are associated with Ureaplasma infection. We hypothesized that Ureaplasma induced extracellular collagen fragmentation results in production of the tripeptide PGP (proline-glycine-proline), a neutrophil chemoattractant. PGP release from collagen requires matrix metalloproteases (MMP-8/MMP-9 (...) , suggesting Ureaplasma spp. induced collagen fragmentation contributes to preterm rupture of membranes and neutrophil influx causing chorioamnionitis.

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2016 Pediatric Research

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