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Premature Rupture of Membranes

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2. Care of Women Presenting with Suspected Preterm Prelabour Rupture of Membranes from 24+0 Weeks of Gestation Full Text available with Trip Pro

search strategy PDF document, 121.8 KB Appendix S2. PPROM search strategy top up PDF document, 142.2 KB PDF document, 1.2 MB Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1 Mercer, BM . Preterm premature rupture of the membranes . Obstet Gynecol 2003 ; 101 : 178 – 93 . 2 Morris, JM , Roberts, CL (...) , Bowen, JPJ , Bond, DM , Algert, CS , Thornton, JG , Crowther, CA . Immediate delivery compared with expectant management after preterm pre‐labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial . Lancet 2016 ; 387 : 444 – 52 . 3 Peaceman, AM , Lai, Y , Rouse, DJ , Spong, CY , Mercer, BM , Varner, MW , et al. Length of latency with preterm premature rupture of membranes before 32 weeks’ gestation . Am J Perinatol 2015 ; 32 : 57 – 62 . 4 Dale, PO , Tanbo, T

2019 Royal College of Obstetricians and Gynaecologists

3. Antibiotic Therapy in Preterm Premature Rupture of the Membranes

Antibiotic Therapy in Preterm Premature Rupture of the Membranes No. 233-Antibiotic Therapy in Preterm Premature Rupture of the Membranes - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 39, Issue 9, Pages e207–e212 No. 233-Antibiotic Therapy in Preterm Premature Rupture of the Membranes x Mark H. Yudin , MD Toronto, ON x Julie van Schalkwyk , MD Vancouver, BC x Nancy Van Eyk , MD Halifax, NS No. 233, September 2017 (...) DOI: To view the full text, please login as a subscribed user or . Click to view the full text on ScienceDirect. Abstract Objective To review the evidence and provide recommendations on the use of antibiotics in preterm premature rupture of the membranes (PPROM). Outcomes Outcomes evaluated include the effect of antibiotic treatment on maternal infection, chorioamnionitis, and neonatal morbidity and mortality. Evidence Published literature was retrieved through searches of Medline, EMBASE, CINAHL

2017 Society of Obstetricians and Gynaecologists of Canada

5. ShortGUIDE: Preterm prelabour rupture of membranes (PPROM)

is unclear. 23,24 Aspect Considerations Near term · Between 34+0 and 36+6 weeks there is limited and inconsistent evidence to guide practice Less than 34+0 weeks · The risks of prematurity are generally greater than the risks of expectant management Consider expediting birth · If active labour establishes · If concern for maternal or fetal wellbeing at initial presentation or during subsequent care short GUIDE Queensland Clinical Guidelines Preterm prelabour rupture of membranes Available from (...) . No.: CD008053.) DOI:10.1002/14651858.CD008053.pub3. 3. Simhan HN, TP. C. Preterm premature rupture of membranes: diagnosis, evaluation and management strategies. British Journal of Obstetrics and Gynaecology 2005;112 (1):32-7. 4. Goldenberg RL, Culhane JF, Iams JD, R. R. Epidemiology and causes of preterm birth. Lancet 2008;371(9606):75-84. 5. Queensland Clinical Guidelines. Normal birth. Guideline No. MN17.25-V3-R22. [Internet]. Queensland Health. 2017. [cited 2018 June 26]. Available from: http

2019 Queensland Health

6. Deliver or wait with late preterm membrane rupture?

recommends delivery for all women with ruptured membranes after 34 weeks' gestation, a new study finds expectant management may be the way to go. Practice changer: In the absence of clinical indications for delivery, consider expectant management in women with premature rupture of membranes in late preterm stages (34 weeks to 36 weeks, 6 days). Stength of recommendation: B: Based on one well-designed randomized controlled trial: Morris JM, Roberts CL, Bowen JR, et al; PPROMT Collaboration. Immediate (...) Deliver or wait with late preterm membrane rupture? Deliver or wait with late preterm membrane rupture? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics Deliver or wait with late preterm membrane rupture? View/ Open Date 2016-11 Format Metadata Abstract Deliver or wait with late preterm membrane rupture? While ACOG

2017 PURLS

7. Vitamin D-binding protein in cervicovaginal fluid as a non-invasive predictor of intra-amniotic infection and impending preterm delivery in women with preterm labor or preterm premature rupture of membranes. Full Text available with Trip Pro

Vitamin D-binding protein in cervicovaginal fluid as a non-invasive predictor of intra-amniotic infection and impending preterm delivery in women with preterm labor or preterm premature rupture of membranes. To determine whether vitamin D-binding protein (VDBP) in cervicovaginal fluid (CVF) is independently predictive of intra-amniotic infection and imminent spontaneous preterm delivery (SPTD, delivery within 48 hours) in women with preterm labor with intact membranes (PTL) or preterm premature (...) rupture of membranes (PPROM).This was a single-center retrospective cohort study. CVF samples for VDBP assays were obtained along with serum C-reactive protein (CRP) levels immediately after amniocentesis in consecutive women with PTL (n = 148) or PPROM (n = 103) between 23.0 and 34.0 weeks of gestation. VDBP levels in CVF were determined by enzyme-linked immunosorbent assay kits. The primary outcome measures were intra-amniotic infection [defined as positive amniotic fluid (AF) culture] and SPTD

2018 PLoS ONE

8. Preterm premature rupture of membranes at 22-25 weeks' gestation: perinatal and 2-year outcomes within a national population-based study (EPIPAGE-2) Full Text available with Trip Pro

Preterm premature rupture of membranes at 22-25 weeks' gestation: perinatal and 2-year outcomes within a national population-based study (EPIPAGE-2) Most clinical guidelines state that with early preterm premature rupture of membranes, obstetric and pediatric teams must share a realistic and individualized appraisal of neonatal outcomes with parents and consider their wishes for all decisions. However, we currently lack reliable and relevant data, according to gestational age at rupture (...) of membranes, to adequately counsel parents during pregnancy and to reflect on our policies of care at these extreme gestational ages.We sought to describe both perinatal and 2-year outcomes of preterm infants born after preterm premature rupture of membranes at 22-25 weeks' gestation.EPIPAGE-2 is a French national prospective population-based cohort of preterm infants born in 546 maternity units in 2011. Inclusion criteria in this analysis were women diagnosed with preterm premature rupture of membranes

2018 EvidenceUpdates

9. Dilation and evacuation after preterm premature rupture of membranes with abdominal cerclage in situ. (Abstract)

Dilation and evacuation after preterm premature rupture of membranes with abdominal cerclage in situ. For women with a history of cervical insufficiency, treatment with transvaginal (TV) or abdominal (TA) cerclage is often recommended; however management of pregnancy complications necessitating uterine evacuation in the second trimester are challenging. We present a patient at 17 weeks 3 day gestation with preterm premature rupture of membranes, and chorioamnionitis with an abdominal cerclage

2020 Contraception

10. Maternal human telomerase reverse transcriptase variants are associated with preterm labor and preterm premature rupture of membranes. Full Text available with Trip Pro

Maternal human telomerase reverse transcriptase variants are associated with preterm labor and preterm premature rupture of membranes. Premature aging and short telomere lengths of fetal tissues are associated with spontaneous preterm labor (PTL) and preterm premature rupture of membranes (pPROM). Maintenance of telomere length is performed by the enzyme telomerase. Human telomerase reverse transcriptase (hTERT) is a subunit of telomerase, and its dysfunction affects telomere shortening

2018 PLoS ONE

11. Sealing procedures for preterm prelabour rupture of membranes. Full Text available with Trip Pro

Sealing procedures for preterm prelabour rupture of membranes. Preterm prelabour rupture of the membranes (PPROM) complicates approximately 2% of pregnancies and can be either spontaneous or iatrogenic in nature. Complications of PPROM include prematurity, chorioamnionitis, neonatal sepsis, limb position defects, respiratory distress syndrome, pulmonary hypoplasia chronic lung disease, periventricular leukomalacia and intraventricular haemorrhage.A number of different sealing techniques have (...) Register (30 May 2016) and reference lists of retrieved studies.Randomised and quasi-randomised controlled trials comparing different techniques for sealing preterm prelabour ruptured membranes. Cluster-randomised trials and trials using a cross-over design were not eligible for inclusion in this review. We planned to include abstracts when sufficient information was provided.Two review authors independently assessed trials for inclusion and assessed trial quality. Two review authors independently

2016 Cochrane

12. Phenotypic overlap in neonatal respiratory morbidity following preterm premature rupture of membranes versus spontaneous preterm labor. (Abstract)

Phenotypic overlap in neonatal respiratory morbidity following preterm premature rupture of membranes versus spontaneous preterm labor. Background: Bronchopulmonary dysplasia (BPD), a major source of morbidity in premature neonates, has been associated with intrauterine infection and preterm birth. Both preterm premature rupture of membranes (PPROM) and spontaneous preterm labor (sPTL) are linked with intrauterine inflammation. Whether PPROM and sPTL, as two phenotypic categories of preterm (...) a differentially greater risk for neonatal BPD than sPTL. A secondary objective was to determine if PPROM was associated with a greater risk of adverse neonatal respiratory outcomes other than BPD and whether gestational latency following PPROM or sPTL diagnosis constitutes a risk factor for fetal lung injury. Study design: We conducted a retrospective secondary analysis of a large cohort of women at risk for spontaneous preterm birth, who were originally enrolled in a randomized controlled trial of magnesium

2019 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Controlled trial quality: predicted high

13. Maternal obesity is associated with chorioamnionitis and earlier indicated preterm delivery among expectantly managed women with preterm premature rupture of membranes. (Abstract)

Maternal obesity is associated with chorioamnionitis and earlier indicated preterm delivery among expectantly managed women with preterm premature rupture of membranes. To determine the association between maternal obesity and delivery due to chorioamnionitis prior to labor onset, among expectantly managed women with preterm premature rupture of membranes (pPROM).This was a secondary analysis of a multicenter randomized trial of magnesium sulfate versus placebo to prevent cerebral palsy

2019 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Controlled trial quality: predicted high

14. Inflammatory proteins in maternal plasma, cervicovaginal and amniotic fluids as predictors of intra-amniotic infection in preterm premature rupture of membranes. Full Text available with Trip Pro

Inflammatory proteins in maternal plasma, cervicovaginal and amniotic fluids as predictors of intra-amniotic infection in preterm premature rupture of membranes. We aimed to assess the correlations among multiple cytokine concentrations in the maternal plasma, cervicovaginal fluid (CVF), and amniotic fluid (AF) compartments in women with preterm premature rupture of membranes (pPROM), and to develop a prediction model based on non-invasive measures, having better sensitivity and specificity

2018 PLoS ONE

15. Concurrent intraoperative uterine rupture and placenta accreta. Do preoperative chronic hypertension, preterm premature rupture of membranes, chorioamnionitis, and placental abruption provide warning to this rare occurrence? Full Text available with Trip Pro

Concurrent intraoperative uterine rupture and placenta accreta. Do preoperative chronic hypertension, preterm premature rupture of membranes, chorioamnionitis, and placental abruption provide warning to this rare occurrence? Uterine and placental pathology can be a major cause of morbidity and mortality in the parturient and infant. When presenting alone, placental abruption, uterine rupture, or placenta accreta can result in significant peripartum hemorrhage, requiring aggressive surgical (...) and anesthetic management; however, the presence of multiple concurrent uterine and placental pathologies can result in significant morbidity and mortality. We present the anesthetic management of a parturient who underwent an urgent cesarean delivery for non-reassuring fetal tracing in the setting of chronic hypertension, preterm premature rupture of membranes, and chorioamnionitis who was subsequently found to have placental abruption, uterine rupture, and placenta accreta.

2018 Romanian Journal of Anaesthesia and Intensive Care

16. The value of amniopatch in pregnancies associated with spontaneous preterm premature rupture of fetal membranes: a randomized controlled trial. (Abstract)

The value of amniopatch in pregnancies associated with spontaneous preterm premature rupture of fetal membranes: a randomized controlled trial. To evaluate the efficacy and safety of amniopatch in pregnancies associated with spontaneous preterm premature rupture of fetal membranes (PPROM).A randomized controlled trial that involved 100 women diagnosed with PPROM between 24 and 34 weeks of gestational age. Participants were randomized equally into two groups. Group I in which amniopatch was done (...) in addition to the routine management. Group II was treated with routine management including antibiotics and corticosteroids.Amniopatch was successful in complete sealing of the membrane defect in 6/50 (12%) of women while none the control group have undergone similar sealing (p = .0144, RR = 0.88). Women in the amniopatch group showed a significant increase of AFI compared to controls (12 versus 0, p = .0001, RR = 0.56).The amniopatch procedure is a successful technique that safely enhances sealing

2019 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Controlled trial quality: uncertain

17. Intentional early delivery versus expectant management for preterm premature rupture of membranes at 28-32 weeks' gestation: A multicentre randomized controlled trial (MICADO STUDY). (Abstract)

Intentional early delivery versus expectant management for preterm premature rupture of membranes at 28-32 weeks' gestation: A multicentre randomized controlled trial (MICADO STUDY). Preterm premature rupture of fetal membranes (PPROM) exposes the fetus to preterm birth, and optimal timing for delivery is controversial. The aim of this study was to compare intentional early delivery ("active management") with expectant management in very preterm birth (28-32 weeks).We conducted a prospective (...) . Women in active management delivered 24 h after the second steroid dose. The primary outcome measure was a composite of neonatal death/severe adverse events: periventricular leukomalacia, intraventricular hemorrhage, sepsis, oxygen requirement at 36 weeks, and necrotizing enterocolitis. The secondary outcome was clinical chorioamnionitis.The trial was stopped prematurely, due to recruitment difficulties. Of 360 women assessed, 139 (40% of calculated sample size) were randomized: 70 to expectant

2019 European journal of obstetrics, gynecology, and reproductive biology Controlled trial quality: predicted high

18. The Effect of Non-penicillin Antibiotic Regimens on Neonatal Outcomes in Preterm Premature Rupture of Membranes. Full Text available with Trip Pro

The Effect of Non-penicillin Antibiotic Regimens on Neonatal Outcomes in Preterm Premature Rupture of Membranes. Objective  A 7-day course of a penicillin (PCN) and macrolide is standard of care (SAR) in preterm premature rupture of membranes (PPROM). Data regarding alternative antibiotic regimens are limited. We sought to assess the impact of non-PCN regimens on neonatal outcomes. Study Design  Secondary analysis of randomized controlled trial of antenatal magnesium sulfate. Singleton

2019 AJP Reports Controlled trial quality: predicted high

19. A pilot randomized controlled trial of complete bed rest versus activity restriction after preterm premature rupture of the membranes. (Abstract)

A pilot randomized controlled trial of complete bed rest versus activity restriction after preterm premature rupture of the membranes. To assess the impact of bed rest on maternal and neonatal outcomes in pregnancies complicated by preterm premature rupture of the membranes (PPROM), enabling proper sample size calculation for a powered randomized controlled trial (RCT).We conducted a pilot unblinded randomized controlled trial with a 1:1 allocation ratio (complete bed rest vs activity

2019 European journal of obstetrics, gynecology, and reproductive biology Controlled trial quality: predicted high

20. Azithromycin versus erythromycin for the management of preterm premature rupture of membranes. Full Text available with Trip Pro

Azithromycin versus erythromycin for the management of preterm premature rupture of membranes. Preterm premature rupture of membranes (PPROM) complicates 2-3% of pregnancies. Many institutions have advocated for the use of azithromycin instead of erythromycin. This is secondary to national shortages of erythromycin, ease of administration, better side effect profile and decreased cost of azithromycin as compared to erythromycin.To evaluate if there are differences in the latency from PPROM (...) to delivery in patients treated with different dosing regimens of azithromycin vs. erythromycin.This is a multicenter, retrospective cohort of women with singleton pregnancies with confirmed rupture of membranes between 230 to 336 weeks from January 2010 to June 2015. Patients were excluded if there was a contraindication to expectant management of PPROM. Patients received one of four antibiotic regimens: 1) azithromycin 1000 mg PO once (azithromycin 1 day group), 2) azithromycin 500 mg PO once, followed

2019 American Journal of Obstetrics and Gynecology

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