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Premature Rupture of Membranes

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3. Antibiotic Therapy in Preterm Premature Rupture of the Membranes

Antibiotic Therapy in Preterm Premature Rupture of the Membranes No. 233-Antibiotic Therapy in Preterm Premature Rupture of the Membranes - Journal of Obstetrics and Gynaecology Canada Email/Username: Password: Remember me Search Terms Search within Search Volume 39, Issue 9, Pages e207–e212 No. 233-Antibiotic Therapy in Preterm Premature Rupture of the Membranes x Mark H. Yudin , MD Toronto, ON x Julie van Schalkwyk , MD Vancouver, BC x Nancy Van Eyk , MD Halifax, NS No. 233, September 2017 (...) DOI: To view the full text, please login as a subscribed user or . Click to view the full text on ScienceDirect. Abstract Objective To review the evidence and provide recommendations on the use of antibiotics in preterm premature rupture of the membranes (PPROM). Outcomes Outcomes evaluated include the effect of antibiotic treatment on maternal infection, chorioamnionitis, and neonatal morbidity and mortality. Evidence Published literature was retrieved through searches of Medline, EMBASE, CINAHL

2017 Society of Obstetricians and Gynaecologists of Canada

4. Preterm premature rupture of membranes at 22-25 weeks' gestation: perinatal and 2-year outcomes within a national population-based study (EPIPAGE-2)

Preterm premature rupture of membranes at 22-25 weeks' gestation: perinatal and 2-year outcomes within a national population-based study (EPIPAGE-2) Most clinical guidelines state that with early preterm premature rupture of membranes, obstetric and pediatric teams must share a realistic and individualized appraisal of neonatal outcomes with parents and consider their wishes for all decisions. However, we currently lack reliable and relevant data, according to gestational age at rupture (...) of membranes, to adequately counsel parents during pregnancy and to reflect on our policies of care at these extreme gestational ages.We sought to describe both perinatal and 2-year outcomes of preterm infants born after preterm premature rupture of membranes at 22-25 weeks' gestation.EPIPAGE-2 is a French national prospective population-based cohort of preterm infants born in 546 maternity units in 2011. Inclusion criteria in this analysis were women diagnosed with preterm premature rupture of membranes

2018 EvidenceUpdates

5. Prostaglandins versus oxytocin for the induction of labour in women with premature rupture of membranes at term: a systematic review and meta-analysis

Prostaglandins versus oxytocin for the induction of labour in women with premature rupture of membranes at term: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

6. The effect of prophylactic antibiotics for preterm premature rupture of membranes on perinatal outcomes: a network meta-analysis

The effect of prophylactic antibiotics for preterm premature rupture of membranes on perinatal outcomes: a network meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

7. Concurrent intraoperative uterine rupture and placenta accreta. Do preoperative chronic hypertension, preterm premature rupture of membranes, chorioamnionitis, and placental abruption provide warning to this rare occurrence? (PubMed)

Concurrent intraoperative uterine rupture and placenta accreta. Do preoperative chronic hypertension, preterm premature rupture of membranes, chorioamnionitis, and placental abruption provide warning to this rare occurrence? Uterine and placental pathology can be a major cause of morbidity and mortality in the parturient and infant. When presenting alone, placental abruption, uterine rupture, or placenta accreta can result in significant peripartum hemorrhage, requiring aggressive surgical (...) and anesthetic management; however, the presence of multiple concurrent uterine and placental pathologies can result in significant morbidity and mortality. We present the anesthetic management of a parturient who underwent an urgent cesarean delivery for non-reassuring fetal tracing in the setting of chronic hypertension, preterm premature rupture of membranes, and chorioamnionitis who was subsequently found to have placental abruption, uterine rupture, and placenta accreta.

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2018 Romanian Journal of Anaesthesia and Intensive Care

8. Maternal obesity is associated with chorioamnionitis and earlier indicated preterm delivery among expectantly managed women with preterm premature rupture of membranes. (PubMed)

Maternal obesity is associated with chorioamnionitis and earlier indicated preterm delivery among expectantly managed women with preterm premature rupture of membranes. To determine the association between maternal obesity and delivery due to chorioamnionitis prior to labor onset, among expectantly managed women with preterm premature rupture of membranes (pPROM).This was a secondary analysis of a multicenter randomized trial of magnesium sulfate versus placebo to prevent cerebral palsy

2019 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

9. A randomized trial of Foley Bulb for Labor Induction in Premature Rupture of Membranes in Nulliparas (FLIP)

A randomized trial of Foley Bulb for Labor Induction in Premature Rupture of Membranes in Nulliparas (FLIP) In premature rupture of membranes (PROM), the risk of chorioamnionitis increases with increasing duration of membrane rupture. Decreasing the time from PROM to delivery is associated with lower rates of maternal infection. The American College of Obstetricians and Gynecologists suggests that all women with PROM who do not have a contraindication to vaginal delivery have their labor

2017 EvidenceUpdates

10. Amniotic fluid volume at presentation with early preterm premature rupture of the membranes and the association with severe neonatal respiratory morbidity. (PubMed)

Amniotic fluid volume at presentation with early preterm premature rupture of the membranes and the association with severe neonatal respiratory morbidity. Amniotic fluid volume (AFV) plays an important role in early fetal lung development, and oligohydramnios in early pregnancy has been associated with pulmonary hypoplasia. We aimed to evaluate the association between AFV at the time of presentation with early preterm premature rupture of membranes (PPROM) and severe neonatal respiratory

2019 Ultrasound in Obstetrics and Gynecology

11. Intentional early delivery versus expectant management for preterm premature rupture of membranes at 28-32 weeks' gestation: A multicentre randomized controlled trial (MICADO STUDY). (PubMed)

Intentional early delivery versus expectant management for preterm premature rupture of membranes at 28-32 weeks' gestation: A multicentre randomized controlled trial (MICADO STUDY). Preterm premature rupture of fetal membranes (PPROM) exposes the fetus to preterm birth, and optimal timing for delivery is controversial. The aim of this study was to compare intentional early delivery ("active management") with expectant management in very preterm birth (28-32 weeks).We conducted a prospective (...) . Women in active management delivered 24 h after the second steroid dose. The primary outcome measure was a composite of neonatal death/severe adverse events: periventricular leukomalacia, intraventricular hemorrhage, sepsis, oxygen requirement at 36 weeks, and necrotizing enterocolitis. The secondary outcome was clinical chorioamnionitis.The trial was stopped prematurely, due to recruitment difficulties. Of 360 women assessed, 139 (40% of calculated sample size) were randomized: 70 to expectant

2019 European journal of obstetrics, gynecology, and reproductive biology

12. Azithromycin versus erythromycin for the management of preterm premature rupture of membranes. (PubMed)

Azithromycin versus erythromycin for the management of preterm premature rupture of membranes. Preterm premature rupture of membranes (PPROM) complicates 2-3% of pregnancies. Many institutions have advocated for the use of azithromycin instead of erythromycin. This is secondary to national shortages of erythromycin, ease of administration, better side effect profile and decreased cost of azithromycin as compared to erythromycin.To evaluate if there are differences in the latency from PPROM (...) to delivery in patients treated with different dosing regimens of azithromycin vs. erythromycin.This is a multicenter, retrospective cohort of women with singleton pregnancies with confirmed rupture of membranes between 230 to 336 weeks from January 2010 to June 2015. Patients were excluded if there was a contraindication to expectant management of PPROM. Patients received one of four antibiotic regimens: 1) azithromycin 1000 mg PO once (azithromycin 1 day group), 2) azithromycin 500 mg PO once, followed

2019 American Journal of Obstetrics and Gynecology

13. Expression and Clinical Significance of NOD-Like Receptor Protein 3 (NLRP3) and Caspase-1 in Fetal Membrane and Placental Tissues of Patients with Premature Rupture of Membrane (PubMed)

Expression and Clinical Significance of NOD-Like Receptor Protein 3 (NLRP3) and Caspase-1 in Fetal Membrane and Placental Tissues of Patients with Premature Rupture of Membrane BACKGROUND In this study, we aimed to investigate the expression of NOD-like receptor protein 3 (NLRP3) and caspase-1 in fetal membrane and placental tissues of patients with premature rupture of membrane (PROM), and to explore their role in PROM. MATERIAL AND METHODS Ninety women participated in this study: a control (...) group of 30 healthy pregnant women, 30 with PPROM, and 30 with TPROM. Immunohistochemistry streptavidin-peroxidase (SP) assay was used to detect the protein expression of NLRP3 and caspase-1 in the fetal membrane and placental tissues. RT-PCR was used to detect the mRNA expression of NLRP3 and caspase-1 in fetal membrane and placental tissues. RESULTS The results of SP showed that NLRP3 and caspase-1 were mainly expressed in the cytoplasm of epithelial cells, mesenchymal cells, and trophoblast cells

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2018 Medical science monitor : international medical journal of experimental and clinical research

14. Care of Women Presenting with Suspected Preterm Prelabour Rupture of Membranes from 24+0 Weeks of Gestation

search strategy PDF document, 121.8 KB Appendix S2. PPROM search strategy top up PDF document, 142.2 KB PDF document, 1.2 MB Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1 Mercer, BM . Preterm premature rupture of the membranes . Obstet Gynecol 2003 ; 101 : 178 – 93 . 2 Morris, JM , Roberts, CL (...) , Bowen, JPJ , Bond, DM , Algert, CS , Thornton, JG , Crowther, CA . Immediate delivery compared with expectant management after preterm pre‐labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial . Lancet 2016 ; 387 : 444 – 52 . 3 Peaceman, AM , Lai, Y , Rouse, DJ , Spong, CY , Mercer, BM , Varner, MW , et al. Length of latency with preterm premature rupture of membranes before 32 weeks’ gestation . Am J Perinatol 2015 ; 32 : 57 – 62 . 4 Dale, PO , Tanbo, T

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2019 Royal College of Obstetricians and Gynaecologists

15. Frequency and clinical significance of short cervix in patients with preterm premature rupture of membranes. (PubMed)

Frequency and clinical significance of short cervix in patients with preterm premature rupture of membranes. Cervical length measurement has been uggested as a useful tool for predicting intra-amniotic infection/inflammation in preterm labor, but little information is available in the setting of preterm premature rupture of membranes (pPROM). We aimed to determine whether a short cervical length is independently associated with an increased risk of intra-amniotic infection or inflammation

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2017 PLoS ONE

16. Clinical significance of histologic chorioamnionitis with a negative amniotic fluid culture in patients with preterm labor and premature membrane rupture. (PubMed)

Clinical significance of histologic chorioamnionitis with a negative amniotic fluid culture in patients with preterm labor and premature membrane rupture. To evaluate the effect of histological chorioamnionitis (HCA) with a negative amniotic fluid (AF) culture on adverse pregnancy and neonatal outcomes and inflammatory status in the AF compartment in women with preterm labor or preterm premature rupture of membranes (PPROM).This is a retrospective cohort study of 153 women diagnosed as having (...) with increased risks of preterm birth, intense intra-amniotic inflammatory response, and prematurity-associated composite neonatal morbidity, and its risks are similar to the risk posed by positive AF culture.

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2017 PLoS ONE

17. The Delta Neutrophil Index as a predictive marker of histological chorioamnionitis in patients with preterm premature rupture of membranes: A retrospective study. (PubMed)

The Delta Neutrophil Index as a predictive marker of histological chorioamnionitis in patients with preterm premature rupture of membranes: A retrospective study. Histological chorioamnionitis (HCA) is related to perinatal morbidity. However, there is no definite diagnostic method for detecting chorioamnionitis before delivery.We evaluated whether the delta neutrophil index (DNI) was an effective early marker of HCA in patients with preterm premature rupture of membranes (PPROM). We

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2017 PLoS ONE

18. Rare mutations and potentially damaging missense variants in genes encoding fibrillar collagens and proteins involved in their production are candidates for risk for preterm premature rupture of membranes. (PubMed)

Rare mutations and potentially damaging missense variants in genes encoding fibrillar collagens and proteins involved in their production are candidates for risk for preterm premature rupture of membranes. Preterm premature rupture of membranes (PPROM) is the leading identifiable cause of preterm birth with ~ 40% of preterm births being associated with PPROM and occurs in 1% - 2% of all pregnancies. We hypothesized that multiple rare variants in fetal genes involved in extracellular matrix (...) synthesis would associate with PPROM, based on the assumption that impaired elaboration of matrix proteins would reduce fetal membrane tensile strength, predisposing to unscheduled rupture. We performed whole exome sequencing (WES) on neonatal DNA derived from pregnancies complicated by PPROM (49 cases) and healthy term deliveries (20 controls) to identify candidate mutations/variants. Genotyping for selected variants from the WES study was carried out on an additional 188 PPROM cases and 175 controls

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2017 PLoS ONE

19. ShortGUIDE: Term prelabour rupture of membranes (PROM)

, Perde MP. Premature rupture of membranes at term in nulliparous women: a hazard? Obstet Gynecol 1990;76(4):671-4. 3. Conway DI, Prendiville WJ, Morris A, Speller DC, Stirrat GM. Management of spontaneous rupture of the membranes in the absence of labor in primigravid women at term. Am J Obstet Gynecol 1984;150(8):947-51. 4. Egan D, O'herlihy C. Expectant management of spontaneous rupture of membranes at term. Journal of Obstetrics and Gynaecology 1988;8(3):243-7. 5. Gunn GC, Mishell DR, Jr., Morton (...) DG. Premature rupture of the fetal membranes: a review. Am J Obstet Gynecol 1970;106(3):469-83. 6. Hannah ME, Hodnett ED, Willan A, Foster GA, Di Cecco R, Helewa M. Prelabor rupture of the membranes at term: expectant management at home or in hospital? The TermPROM Study Group. Obstet Gynecol 2000;96(4):533-8. 7. Kappy KA, Cetrulo CL, Knuppel RA, Ingardia CJ, Sbarra AJ, Scerbo JC, et al. Premature rupture of the membranes at term: a comparison of induced and spontaneous labors. J Reprod Med

2019 Queensland Health

20. ShortGUIDE: Preterm prelabour rupture of membranes (PPROM)

is unclear. 23,24 Aspect Considerations Near term · Between 34+0 and 36+6 weeks there is limited and inconsistent evidence to guide practice Less than 34+0 weeks · The risks of prematurity are generally greater than the risks of expectant management Consider expediting birth · If active labour establishes · If concern for maternal or fetal wellbeing at initial presentation or during subsequent care short GUIDE Queensland Clinical Guidelines Preterm prelabour rupture of membranes Available from (...) . No.: CD008053.) DOI:10.1002/14651858.CD008053.pub3. 3. Simhan HN, TP. C. Preterm premature rupture of membranes: diagnosis, evaluation and management strategies. British Journal of Obstetrics and Gynaecology 2005;112 (1):32-7. 4. Goldenberg RL, Culhane JF, Iams JD, R. R. Epidemiology and causes of preterm birth. Lancet 2008;371(9606):75-84. 5. Queensland Clinical Guidelines. Normal birth. Guideline No. MN17.25-V3-R22. [Internet]. Queensland Health. 2017. [cited 2018 June 26]. Available from: http

2019 Queensland Health

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