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62081. What is the actual evidence relating to an increased risk of bleeding when NSAIDs are taken with SSRIs? How relevant is this to clinical practice?

is this to clinical practice? The NLH Q&A Service have previously answered this question [1]. Since then CKS (formerly PRODIGY) have updated their guidance on NSAIDs [2] and this specifically mentions SSRIs: “Selective serotonin reuptake inhibitors (SSRIs) or venlafaxine — there is an increased risk of bleeding with NSAID use. Note: this has recently been upgraded to a potentially hazardous interaction [BNF 48, 2004]. A study linking hospital-episode data with prescribing data has showed that upper-GI bleeding (...) What is the actual evidence relating to an increased risk of bleeding when NSAIDs are taken with SSRIs? How relevant is this to clinical practice? What is the actual evidence relating to an increased risk of bleeding when NSAIDs are taken with SSRIs? How relevant is this to clinical practice? - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only

2007 TRIP Answers

62082. Antiretroviral Treatment Simplified Follow-up Management Assessment (ANRS 12110 STRATALL)

Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Expanded Access to Antiretroviral Therapy in Africa: Assessment of the Patients' Management in District Hospitals With a Simplified Follow-up Approach (ANRS 12110 STRATALL) Study Start Date : May 2006 Actual Primary Completion Date : April 2010 Actual Study Completion Date : October 2010 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm (...) Antiretroviral Treatment Simplified Follow-up Management Assessment (ANRS 12110 STRATALL) Antiretroviral Treatment Simplified Follow-up Management Assessment (ANRS 12110 STRATALL) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2006 Clinical Trials

62083. Sequential Whole Bladder Photodynamic Therapy (WBPDT) in the Management of Superficial Bladder Cancer

-Randomized Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Sequential Whole Bladder Photodynamic Therapy (WBPDT) in the Management of Superficial Bladder Cancer Study Start Date : February 2005 Actual Primary Completion Date : April 2010 Actual Study Completion Date : March 2011 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment (...) Sequential Whole Bladder Photodynamic Therapy (WBPDT) in the Management of Superficial Bladder Cancer Sequential Whole Bladder Photodynamic Therapy (WBPDT) in the Management of Superficial Bladder Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2006 Clinical Trials

62084. A Patient-Spouse Intervention for Self-Managing High Cholesterol

A Patient-Spouse Intervention for Self-Managing High Cholesterol A Patient-Spouse Intervention for Self-Managing High Cholesterol - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Patient-Spouse (...) Intervention for Self-Managing High Cholesterol (CouPLES) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00321789 Recruitment Status : Completed First Posted : May 4, 2006 Results First Posted : September 26, 2014 Last Update Posted : April 24, 2015 Sponsor: US Department of Veterans Affairs Information

2006 Clinical Trials

62085. Addition of Zinc to the Current Case Management Package of Diarrhea in a Primary Health Care Setting

in 7.8% and 9.8% episodes. Care seeking for diarrhea, prescription of drugs of unknown identity and antibiotics for diarrhea reduced in intervention communities. The study demonstrated that an intervention to improve diarrhea management with ORS and zinc is feasible and highly acceptable in rural Indian communities. The resulting health benefits were substantial and accomplished with a reduction in the cost to families for diarrhea treatment from current practices. Study Design Go to Layout table (...) Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: 1 Zinc and ORS were promoted for treatment of diarrhea in underfive children Drug: Zinc and ORS Government and private providers and village health workers were trained to prescribe zinc and ORS for use in diarrheal episodes in 1 month to 5 years old children in intervention communities 2 Promoted routine management of diarrhea in underfive

2006 Clinical Trials

62086. Use of Rapid Diagnostic Tests for Malaria Case Management in Kenya

Division of Malaria Control KEMRI-Wellcome Trust Collaborative Research Program Information provided by: Centers for Disease Control and Prevention Study Details Study Description Go to Brief Summary: The purpose of this study is to investigate the impact of rapid diagnostic tests (RDTs) in the context of a newly implemented malaria case management guidelines using artemisinin-based combination therapy on the malaria prescribing practices of health care workers in Kenya. Condition or disease (...) Randomized Trial to Evaluate Adherence and Acceptance by Health Care Workers, Impact on Antimalarial Prescription Practices, and Patient Perceptions Study Start Date : July 2006 Actual Primary Completion Date : September 2006 Actual Study Completion Date : September 2006 Resource links provided by the National Library of Medicine related topics: resources: Arms and Interventions Go to Outcome Measures Go to Primary Outcome Measures : Sensitivity and specificity of malaria diagnosis 6 weeks after

2006 Clinical Trials

62087. Clinical Use and Safety of the Fentanyl Transdermal Therapeutic System (TTS) in the Management of Pain in Patients With Cancer

) Enrollment : 32 participants Allocation: Non-Randomized Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: The Clinical Use and Safety of TTS (Fentanyl) in the Management of Pain in Patients With Cancer Study Start Date : October 1987 Study Completion Date : April 1988 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Outcome Measures Go to Primary Outcome Measures : Assessment of pain (...) Clinical Use and Safety of the Fentanyl Transdermal Therapeutic System (TTS) in the Management of Pain in Patients With Cancer Clinical Use and Safety of the Fentanyl Transdermal Therapeutic System (TTS) in the Management of Pain in Patients With Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2005 Clinical Trials

62088. Evaluation of Case Management to Improve the Outpatient Care of Alcohol-related Disorders

or disease Intervention/treatment Phase Alcohol-related Disorders Procedure: Online Comprehensive Quality Management System (CQM) of alcohol-related disorders in primary care Procedure: Physician training Procedure: Practice team training Not Applicable Detailed Description: In the first funding phase the project AQAH ("Ambulantes Qualitätsmanagement alkoholbezogener Störungen in der hausärztlichen Praxis"-"comprehensive quality management for alcohol-related disorders in primary care") systematically (...) investigated three issues: (1) the outpatient care system and evidence-base for screening, diagnosis and treatment was examined; it developed (2) a comprehensive quality management system (CQM) consisting of documentation material, a pathway of care and evidence-based practice guidelines; (3) the effects of the CQM on the detection and treatment of alcohol-related disorders were investigated in a randomized controlled pre-post design and the results show positive effects of the CQM. In the second funding

2006 Clinical Trials

62089. Maximizing the Efficacy of Cognitive Behavior Therapy and Contingency Management

information Study Type : Interventional (Clinical Trial) Actual Enrollment : 205 participants Allocation: Randomized Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Maximizing the Efficacy of Cognitive Behavior Therapy and Contingency Management Study Start Date : December 2004 Actual Primary Completion Date : September 2010 Actual Study Completion Date : September 2010 Resource links provided by the National Library of Medicine related (...) Maximizing the Efficacy of Cognitive Behavior Therapy and Contingency Management Maximizing the Efficacy of Cognitive Behavior Therapy and Contingency Management - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2006 Clinical Trials

62090. Conservative Management With Isolated Sentinel Lymph Node Biopsy in Vulvar Cancer Patients.

by a Gynecologic Oncologist practicing out of Women & Infants Hospital Condition or disease Intervention/treatment Phase Vulvar Cancer Procedure: Sentinel Node Biopsy Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 74 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Conservative Management With Isolated Sentinel Lymph Node Biopsy in Vulvar Cancer (...) Conservative Management With Isolated Sentinel Lymph Node Biopsy in Vulvar Cancer Patients. Conservative Management With Isolated Sentinel Lymph Node Biopsy in Vulvar Cancer Patients. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2006 Clinical Trials

62091. A Survey Study of the Treatment and Outcome Management in Patients Diagnosed With Alzheimer's Disease

(an inactive substance), this study will include a wider variety of patients and treatment options to more closely represent the management of Alzheimer's disease in current clinical practice. Information will be collected from patients in Europe and other countries who are being treated by a doctor for mild to moderate Alzheimer's disease. Patients receiving treatment with one of the following medications approved for treatment of Alzheimer's disease (galantamine, donepezil, rivastigmine or tacrine (...) A Survey Study of the Treatment and Outcome Management in Patients Diagnosed With Alzheimer's Disease A Survey Study of the Treatment and Outcome Management in Patients Diagnosed With Alzheimer's Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2006 Clinical Trials

62092. Family Management of Type 1 Diabetes in Children

that influence the effectiveness of family management of diabetes during this developmental period. Condition or disease Intervention/treatment Phase Diabetes Mellitus, Type 1 Behavioral: family diabetes management intervention Phase 2 Detailed Description: The purpose of this study is to test the effectiveness of a practical, low-cost, low-intensity behavioral intervention that can be integrated directly into diabetes clinic routines. The goal of the intervention is to prevent the deterioration in glycemic (...) control, treatment adherence, and quality of life that often occur during the transition to adolescence in families of youth with type 1 diabetes. Four-hundred and eighty families (120 from each of the four sites) will be randomly assigned by the coordinating center to intervention or standard care conditions. Standard care will be the multidisciplinary management of type 1 diabetes as currently practiced at the clinical sites. Randomization will be stratified by main versus recent-onset subgroup, age

2006 Clinical Trials

62093. A Primary Care Intervention for Weight Management

Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 50 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Primary Care Intervention for Weight Management Study Start Date : September 2005 Actual Primary Completion Date : June 2008 Actual Study Completion Date : June 2008 Resource links provided by the National Library of Medicine related topics (...) A Primary Care Intervention for Weight Management A Primary Care Intervention for Weight Management - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Primary Care Intervention for Weight Management

2005 Clinical Trials

62094. Family Management of Childhood Diabetes Study

(CC) Study Details Study Description Go to Brief Summary: This study will test the effectiveness of a practical, low-cost, problem-solving method called WE CAN that can be taught to families at diabetes clinics. The goal is to see if this teaching and support can help with controlling the level of blood sugar in children with type 1 diabetes as they approach adolescence. Attention would go to young people's completion of tasks necessary to manage diabetes, quality of life, and psychological (...) of diabetes during this developmental period. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 1298 participants Primary Purpose: Treatment Official Title: Family Management of Childhood Diabetes Study Study Start Date : November 8, 2004 Actual Primary Completion Date : March 1, 2009 Actual Study Completion Date : August 20, 2009 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go

2006 Clinical Trials

62095. Effects of Disease Management on Development of End Stage Renal Disease in Type 2 Diabetic Patients With Nephropathy

to translate these scientific evidence collected in closely monitored clinical trial situations into daily clinical practice. Results from this multi-centre, randomized study will provide important information to health care policy makers regarding the cost effectiveness of disease management using a multidisciplinary team to deliver a structured care model in light of the growing diabetes epidemic and the constraints of finite resources and the need for equity. Study Design Go to Layout table for study (...) Effects of Disease Management on Development of End Stage Renal Disease in Type 2 Diabetic Patients With Nephropathy Effects of Disease Management on Development of End Stage Renal Disease in Type 2 Diabetic Patients With Nephropathy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2006 Clinical Trials

62096. The Efficacy of the HIV/AIDS Symptom Management Manual

Label) Official Title: The Efficacy of the HIV/AIDS Symptom Management Manual Study Start Date : October 2005 Actual Primary Completion Date : December 2006 Actual Study Completion Date : December 2006 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Intervention Details: Behavioral: Symptom Management Manual Participants receive the Symptom Management Manual, and are shown an example. They are given the Manual to take home with them and use (...) The Efficacy of the HIV/AIDS Symptom Management Manual The Efficacy of the HIV/AIDS Symptom Management Manual - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Efficacy of the HIV/AIDS Symptom Management

2005 Clinical Trials

62097. Patient Controlled Oral Analgesia for Postoperative Pain Management After Total Knee Replacement

of practice for post-operative pain management in most acute care hospitals today is intravenous patient controlled analgesia (IV PCA). However, despite the fact that patients prefer IV PCA because it affords them greater control and provides them with better pain relief (Ballantyne, Carr, deFerranti, Suarez, Lau, Chalmers, Angelillo, Mosteller, 1998 ; Rawal, 2001), hospitals routinely take control of pain medications away from patients once they are switched to pain tablets. Patients must then wait (...) Patient Controlled Oral Analgesia for Postoperative Pain Management After Total Knee Replacement Patient Controlled Oral Analgesia for Postoperative Pain Management After Total Knee Replacement - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2005 Clinical Trials

62098. The Potential of Technology to Improve Chronic Disease Management and Quality of Care

patients with chronic diseases to achieve improved outcomes in a cost effective fashion. At the Cleveland Clinic Foundation (CCF) an ambulatory EMR has been implemented to foster patient safety and institutional best practice guidelines, to facilitate research, and to achieve efficiencies in practice management. Our EMR is the foundation of the CCF patient portal. One of the functions of the portal is to allow patients to enter specific data elements that become part of their permanent medical record (...) : Crossover Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: The Potential of Technology to Improve Chronic Disease Management and Quality of Care Study Start Date : September 2004 Actual Study Completion Date : September 2007 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Outcome Measures Go to Primary Outcome Measures : Clinical Outcome Measures: HbA1c, LDL,and the presence or absence of clinically significant

2005 Clinical Trials

62099. ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study

ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. ASTHMA (AntibioticS To Help Manage Asthma) Pilot (...) infection. The secondary hypothesis is that randomized, controlled treatment trials can be carried out successfully in a geographically dispersed practice-based research network. Condition or disease Intervention/treatment Phase Asthma Drug: azithromycin Phase 3 Detailed Description: Asthma is a chronic inflammatory bronchial condition of unknown etiology. Decades ago many clinicians believed that infection played a major role in asthma etiology, but current expert opinion favors the view that asthma

2005 Clinical Trials

62100. Primary Care Management/Action Plans for Advanced Chronic Diseases

Care Nurse Specialist (PCNS) compared to usual care (control group). The primary outcomes will be degree of adherence to clinical practice guidelines. Secondary outcomes will be patient satisfaction, quality of life, use of community-based services, number of emergency room visits, and number of hospitalizations. Condition or disease Intervention/treatment Phase Heart Failure Chronic Obstructive Lung Disease Behavioral: Application of a management action plan Phase 2 Phase 3 Detailed Description (...) : The available evidence suggests that there are opportunities to optimize the primary care of patients with ACD. We are proposing to build upon the current evidence and guidelines for disease management programs, our existing specialized resources, our existing primary care practices, and develop and test a model of care that is primary care based, sensitive to the unique demands and characteristics of different primary practices. Our goal is to design linkage and care strategies of relevance and importance

2005 Clinical Trials

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