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Potassium Replacement

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141. Intracellular Potassium : A Determinant of the Sodium-Potassium Pump Rate Full Text available with Trip Pro

Intracellular Potassium : A Determinant of the Sodium-Potassium Pump Rate Normal human red cells which have had their intracellular sodium (Na(c)) reduced have a diminished Na-K pump rate, but only if intracellular potassium (K(c)) is high. If most of the K(c) is replaced by tetramethylammonium or choline, both ouabain-sensitive Na efflux and K influx are significantly increased even with Na(c) below normal. Cells with reduced Na(c) and high K(c) have an unchanged Na efflux if external (...) potassium (K(ext)) is removed. In contrast, low-Na, low-K cells have a large ouabain-sensitive Na efflux which shows a normal response to removal of K(ext). Neither low-K nor high-K cells have an altered ouabain-sensitive K efflux. Measurement at constant low Na(c) and varying K(c) shows the pump Na efflux to be an inverse function of K(c). Thus, in low-Na cells, K(c) appears to act as an inhibitor of the pump. Inhibition by high K(c) can be seen even when Na(c) is normal. The effects attributed to K(c

1974 The Journal of general physiology

142. The relation between external potassium concentration and the relaxation rate of potassium-induced contractures in frog skeletal muscle Full Text available with Trip Pro

The relation between external potassium concentration and the relaxation rate of potassium-induced contractures in frog skeletal muscle 1. Frog toe muscles and isolated fibres from frog semitendinosus muscles were allowed to develop maximum K-contractures, and after reaching peak tension were transferred to media containing intermediate [K](0) (20-40 mM-K). Under these circumstances, relaxation displayed an early rapid phase, and a subsequent slower phase whose magnitude and rate varied with [K (...) alterations in [Ca](0) or by sudden replacement of the major extracellular anion. These effects are attributed to shifts in the relation between calcium rebinding and membrane potential.

1966 The Journal of physiology

143. Potassium: potassium exchange catalysed by the sodium pump in human red cells Full Text available with Trip Pro

Potassium: potassium exchange catalysed by the sodium pump in human red cells 1. When red cells were so depleted of Na that Na:K exchange had almost ceased, the ouabain-sensitive K efflux seen in K-containing media was accompanied by an almost equal ouabain-sensitive K influx.2. This suggests that the Na pump in these cells was carrying out a one-for-one K:K exchange across the erythrocyte membrane.3. 30-40% of the (42)K efflux from resealed ghosts was sensitive to ouabain when the ghosts (...) exchange did not depend on whether the ADP concentration was roughly the same as the ATP concentration or very much less, suggesting that ADP did not affect the rate of K:K exchange.7. GTP, ITP and UTP were unable to substitute for ATP in supporting K:K exchange. CTP was a poor substitute.8. There was no evidence to support the hypothesis that K:K exchange is accompanied by a ouabain-sensitive hydrolysis of ATP.9. Internal Na was a strong inhibitor of ouabain-sensitive K efflux from ghosts containing 9

1974 The Journal of physiology

144. Potassium depletion and sodium block of potassium currents under hyperpolarization in frog sartorius muscle. Full Text available with Trip Pro

Potassium depletion and sodium block of potassium currents under hyperpolarization in frog sartorius muscle. 1. A three-electrode voltage clamp method was used to investigate the mechanism of the fall in resting potassium permeability which occurs under extreme hyperpolarization in frog sartorius muscle fibres. 2. Experiments were performed which show that this permeability change is due to a potential dependent block by Na+ ions present in the external solution. 3. Inward K-currents recorded (...) on hyperpolarization turned off exponentially with time. In the presence of Na the steady-state current-voltage relation had a region of negative slope beyond -140 mV. This negative-slope region was removed when Na was replaced by TMA, Tris or Li. Increasing [Na] to 140 mM shifted the negative-slope region to less negative membrane potentials; reducing [Na] to 14 mM shifted the region to more negative potentials. 4. The time constant for the turn-off of the currents (tau) was the same in Na and TMA-containing

1979 The Journal of physiology

145. Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions

Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02190994 Recruitment Status : Unknown Verified July 2014 by Shu Jiang, West China Hospital

2014 Clinical Trials

146. The Impact of Neut During KCL Replacement on Pain and Incidence of Phlebitis

The Impact of Neut During KCL Replacement on Pain and Incidence of Phlebitis The Impact of Neut During Potassium Chloride Replacement on Pain and Incidence of Phlebitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. The Impact of Neut During Potassium Chloride Replacement on Pain and Incidence of Phlebitis (Neut-WKBH) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02082717 Recruitment Status : Enrolling by invitation First Posted : March 10, 2014 Last Update Posted : February 5, 2018 Sponsor

2014 Clinical Trials

147. Potassium Board Review - New Wash U Nephrology Web Episode

Potassium Board Review - New Wash U Nephrology Web Episode Renal Fellow Network: Potassium Board Review - New Wash U Nephrology Web Episode | | | | | Tuesday, June 14, 2016 Potassium Board Review - New Wash U Nephrology Web Episode Hypokalemia, hypertension, and metabolic alkalosis - this clinical triad can be seen in a variety of interesting disorders that unfortunately are much more common during in-training or board certification exams than in clinical practice. That doesn't mean you should (...) cram for them the night before the exam! Understanding the way these diseases affect potassium handling in the kidney can help learners of all levels acquire a better understanding of normal renal physiology. This month's nephrology web episode from Washington University in St. Louis focuses on 4 board-style questions related to potassium disorders, and we hope you find it helpful. The full episode can be viewed below: Posted by Timothy Yau at 2 comments: said... Nice post. I have 2 comments

2016 Renal Fellow Network

148. Potassium Hydroxide Impregnated Alumina (KOH-Alumina) as a Recyclable Catalyst for the Solvent-Free Multicomponent Synthesis of Highly Functionalized Substituted Pyridazines and/or Substituted Pyridazin-3(2H)-ones under Microwave Irradiation Full Text available with Trip Pro

Potassium Hydroxide Impregnated Alumina (KOH-Alumina) as a Recyclable Catalyst for the Solvent-Free Multicomponent Synthesis of Highly Functionalized Substituted Pyridazines and/or Substituted Pyridazin-3(2H)-ones under Microwave Irradiation The work described herein employs potassium hydroxide impregnated alumina (KOH-alumina) as a mild, efficient, and recyclable catalyst for a one-pot solvent-free and environmentally safer synthesis of 3,4,6-triarylpyridazines and some substituted pyridazines

2011 ISRN organic chemistry

149. Severe Hyperkalemia in a Peritoneal Dialysis Patient After Consumption of Salt Substitute Full Text available with Trip Pro

Severe Hyperkalemia in a Peritoneal Dialysis Patient After Consumption of Salt Substitute 22383720 2012 06 19 2018 11 13 1718-4304 32 2 2012 Mar-Apr Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis Perit Dial Int Severe hyperkalemia in a peritoneal dialysis patient after consumption of salt substitute. 206-8 10.3747/pdi.2011.00198 Yip Terence T Dr. Lee Iu Cheung Memorial Renal Research Centre, Tung Wah Hospital, The University of Hong Kong, Hong (...) Kong SAR, PR China. yipterence@gmail.com Wan Winnie W Hui Pui-Chi PC Lui Sing-Leung SL Lo Wai-Kei WK eng Case Reports Journal Article Canada Perit Dial Int 8904033 0896-8608 0 Potassium, Dietary 660YQ98I10 Potassium Chloride IM Condiments adverse effects Female Humans Hyperkalemia etiology therapy Kidney Failure, Chronic therapy Middle Aged Peritoneal Dialysis, Continuous Ambulatory Potassium Chloride adverse effects Potassium, Dietary adverse effects 2012 3 3 6 0 2012 3 3 6 0 2012 6 20 6 0

2012 Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

150. BIOELECTRIC POTENTIALS IN VALONIA : THE EFFECT OF SUBSTITUTING KCl FOR NaCl IN ARTIFICIAL SEA WATER Full Text available with Trip Pro

BIOELECTRIC POTENTIALS IN VALONIA : THE EFFECT OF SUBSTITUTING KCl FOR NaCl IN ARTIFICIAL SEA WATER The P.D. across the protoplasm of Valonia macrophysa has been studied while the cells were exposed to artificial solutions resembling sea water in which the concentration of KCl was varied from 0 to 0.500 mol per liter. The P.D. across the protoplasm is decreased by lowering and increased by raising the concentration of KCl in the external solution. Changes in P.D. with time when the cell (...) .-time curve have been interpreted as indicating that potassium enters Valonia protoplasm more rapidly from alkaline than from acidified KCl-rich sea water. This conclusion is discussed in relation to certain theories which have been proposed to explain the accumulation of KCl in Valonia sap. The initial rise in P.D. when a Valonia cell is transferred from natural sea water to KCl-rich sea water has been correlated with the concentrations of KCl in the sea waters. It is assumed that the observed P.D

1932 The Journal of general physiology

151. STUDIES ON CELL METABOLISM AND CELL DIVISION : IV. COMBINED ACTION OF SUBSTITUTED PHENOLS, CYANIDE, CARBON MONOXIDE, AND OTHER RESPIRATORY INHIBITORS ON RESPIRATION AND CELL DIVISION Full Text available with Trip Pro

, by phenylurethane, by 5-isoamyl-5-ethyl barbituric acid, by malonic acid, or by iodoacetic acid. To abolish all respiratory stimulation by suboptimum concentrations of 4,6-dinitro-o-cresol, each of these inhibitors must be present in a concentration which reduces the normal respiration in the absence of substituted phenols by at least 20-40 per cent. 2. The degree of reduction of the stimulated respiration by a given concentration of carbon monoxide or potassium cyanide depends on the concentration of 4,6 (...) STUDIES ON CELL METABOLISM AND CELL DIVISION : IV. COMBINED ACTION OF SUBSTITUTED PHENOLS, CYANIDE, CARBON MONOXIDE, AND OTHER RESPIRATORY INHIBITORS ON RESPIRATION AND CELL DIVISION The effects of 4,6-dinitro-o-cresol and 2,4,5-trichlorophenol on the respiration and cell division of fertilized eggs of Arbacia punctulata have been determined in the presence of each of a number of respiratory inhibitors. The experimental results obtained appear to afford some understanding of the mechanism

1940 The Journal of general physiology

152. Substitution of Redox Chemicals for Radiation in Phytochrome-Mediated Photomorphogenesis1 Full Text available with Trip Pro

Substitution of Redox Chemicals for Radiation in Phytochrome-Mediated Photomorphogenesis1 The reducing agents, potassium ferrocyanide, beta-mercaptoethylamine, cysteine, reduced DPN, ferrous sulfate, methyl viologen and ascorbic acid caused the expansion in darkness of disks of primary leaf tissue cut from dark-grown bean plants. The reducing agents interacted synergistically with low irradiances of red radiation and additively with high irradiance of red light. Exposure of disks treated (...) with reducing agents to far red light repressed disk expansion and the decay in sensitivity to far red radiation showed the same time relations as sequential exposure to red and far red radiation.The oxidizing agents, 1,4-naphthoquinone, ferric sulfate, hydrogen peroxide, t-butyl hydroperoxide, cystine, and potassium ferricyanide repressed the expansion of leaf disks initiated by exposure to red radiation. The oxidizing agents interacted synergistically with low irradiances of far red light and additively

1966 Plant physiology

153. Ionic Conductance Changes in Lobster Axon Membrane When Lanthanum Is Substituted for Calcium Full Text available with Trip Pro

Ionic Conductance Changes in Lobster Axon Membrane When Lanthanum Is Substituted for Calcium The trivalent rare earth lanthanum was substituted for calcium in the sea water bathing the exterior of an "artificial node" of a lobster axon in a sucrose gap. It caused a progressive rise in threshold, and a decrease in the height of the action potential as well as in its rates of rise and fall. Prolonged application produced an excitation block. Voltage-clamp studies of the ionic currents showed (...) that the time courses of the ionic conductance changes for both sodium and potassium were increased. Concurrently, the potentials at which the conductance increases occurred were shifted to more positive inside values for the La+++ sea water. These effects resemble changes resulting from a high external calcium concentration. Over and above this, La+++ also causes a marked reduction in the maximum amount of conductance increase following a depolarizing potential step. Membrane action potentials similar

1966 The Journal of general physiology

154. Substitute for agar in solid media for common usages in microbiology. Full Text available with Trip Pro

Substitute for agar in solid media for common usages in microbiology. The potassium salt of carrageenan was found to be an adequate replacement for agar in solid bacteriological media. The common microbial genetic techniques, such as purifying colonies by streaking, replication tests, and titration of cultures, were carried out sucessfully with a number of mutant strains of Escherichia coli.

1976 Applied and environmental microbiology

155. Blocking of valinomycin-mediated bilayer membrane conductance by substituted benzimidazoles. Full Text available with Trip Pro

Blocking of valinomycin-mediated bilayer membrane conductance by substituted benzimidazoles. Valinomycin selectively transports alkali cations, e.g. potassium ions, across lipid bilayer membranes. The blocking of this carrier-mediated transport by four substituted benzimidazoles has been investigated. The compounds are 4,5,6,7-tetrachloro-2-trifluoromethylbenzimidazole, (TTFB); 4,5,6,7,-tetrachloro-2-methylbenzimidazole, (TMB); 2-trifluoromethylbenzimidazole, (TFB); and 2-methylbenzimidazole

1976 Biophysical journal

156. When salt substitutes are required in low-sodium diets. Full Text available with Trip Pro

When salt substitutes are required in low-sodium diets. 359821 1978 12 20 2018 11 13 0027-9684 70 4 1978 Apr Journal of the National Medical Association J Natl Med Assoc When salt substitutes are required in low-sodium diets. 255-8 Lakhanpal R K RK eng Historical Article Journal Article United States J Natl Med Assoc 7503090 0027-9684 0 Food Additives 451W47IQ8X Sodium Chloride 660YQ98I10 Potassium Chloride IM Q Diet, Sodium-Restricted adverse effects history Food Additives History, 19th (...) Century History, 20th Century History, Ancient Humans Hypertension diet therapy Potassium Chloride administration & dosage Sodium Chloride adverse effects 1978 4 1 1978 4 1 0 1 1978 4 1 0 0 ppublish 359821 PMC2609635 J Am Diet Assoc. 1954 Nov;30(11):1146-8 13211181 AMA Arch Intern Med. 1954 Oct;94(4):525-31 13196737 Pediatrics. 1953 May;11(5):554-67 13055370 Am J Cardiol. 1961 Nov;8:737-40 13894852 Am J Cardiol. 1976 Nov 23;38(6):768-85 793367 N Engl J Med. 1975 Feb 6;292(6):320 1110717 J Am Diet

1978 Journal of the National Medical Association

157. Inspired Helium for Ischemic Protection During Knee Replacement Surgery

Inspired Helium for Ischemic Protection During Knee Replacement Surgery Inspired Helium for Ischemic Protection During Knee Replacement Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Inspired (...) Helium for Ischemic Protection During Knee Replacement Surgery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02012361 Recruitment Status : Completed First Posted : December 16, 2013 Last Update Posted : August 29, 2016 Sponsor: University of Florida Information provided by (Responsible Party

2013 Clinical Trials

158. Standard versus accelerated initiation of renal replacement therapy in acute kidney injury (STARRT-AKI): study protocol for a randomized controlled trial. Full Text available with Trip Pro

of fulfilling eligibility. In the standard initiation arm, participants will be monitored over 7 days to identify indications for renal replacement therapy. For participants in the standard arm with persistent acute kidney injury, defined as a serum creatinine not declining >50% from the value at the time of eligibility, the initiation of RRT will be discouraged unless one or more of the following criteria are fulfilled: serum potassium ≥6.0 mmol/L; serum bicarbonate ≤10 mmol/L; severe respiratory failure (...) Standard versus accelerated initiation of renal replacement therapy in acute kidney injury (STARRT-AKI): study protocol for a randomized controlled trial. Acute kidney injury is a common and devastating complication of critical illness, for which renal replacement therapy is frequently needed to manage severe cases. While a recent systematic review suggested that "earlier" initiation of renal replacement therapy improves survival, completed trials are limited due to small size, single-centre

2013 Trials Controlled trial quality: predicted high

159. Characterization of Khorasan wheat (Kamut) and impact of a replacement diet on cardiovascular risk factors: cross-over dietary intervention study. Full Text available with Trip Pro

potassium and magnesium. Circulating levels of key pro-inflammatory cytokines (interleukin (IL)-6, IL-12, tumour necrosis factor-α and vascular endothelial growth factor) were significantly reduced after the consumption of Kamut products.The present results suggest that a replacement diet with Kamut products could be effective in reducing metabolic risk factors, markers of both oxidative stress and inflammatory status. (...) Characterization of Khorasan wheat (Kamut) and impact of a replacement diet on cardiovascular risk factors: cross-over dietary intervention study. Khorasan wheat (Kamut) is an ancient grain with widely acclaimed beneficial effects on human health. The objective was to characterise Kamut and to examine the effect of a replacement diet with their products on cardiovascular risk parameters.We conducted a randomized, single-blinded cross-over trial with two intervention phases on 22 healthy

2013 European journal of clinical nutrition Controlled trial quality: uncertain

160. A Novel Regulatory Locus of Phosphorylation in the C Terminus of the Potassium Chloride Cotransporter KCC2 That Interferes with N-Ethylmaleimide or Staurosporine-mediated Activation Full Text available with Trip Pro

A Novel Regulatory Locus of Phosphorylation in the C Terminus of the Potassium Chloride Cotransporter KCC2 That Interferes with N-Ethylmaleimide or Staurosporine-mediated Activation The neuron-specific cation chloride cotransporter KCC2 plays a crucial role in hyperpolarizing synaptic inhibition. Transporter dysfunction is associated with various neurological disorders, raising interest in regulatory mechanisms. Phosphorylation has been identified as a key regulatory process. Here, we retrieved (...) experimentally observed phosphorylation sites of KCC2 from public databases and report on the systematic analysis of six phosphorylated serines, Ser(25), Ser(26), Ser(937), Ser(1022), Ser(1025), and Ser(1026). Alanine or aspartate substitutions of these residues were analyzed in HEK-293 cells. All mutants were expressed in a pattern similar to wild-type KCC2 (KCC2(WT)). Tl(+) flux measurements demonstrated unchanged transport activity for Ser(25), Ser(26), Ser(1022), Ser(1025), and Ser(1026) mutants

2014 The Journal of biological chemistry

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