How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

4,480 results for

Potassium Replacement

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

121. Computer-guided normal-low versus normal-high potassium control after cardiac surgery: No impact on atrial fibrillation or atrial flutter. (Abstract)

after cardiac surgery (coronary artery bypass grafting and/or valvular surgery). Patients were assigned to either the normal-low potassium target (nLP group, 4.0 mmol/L) or the normal-high potassium target (nHP group, 4.5 mmol/L) in alternating blocks of 50 patients. Potassium levels were regulated using a validated computer-assisted potassium replacement protocol (GRIP-II). The primary end point was the incidence of AF/AFL on a 12-lead electrocardiogram during the first postoperative week.Of (...) Computer-guided normal-low versus normal-high potassium control after cardiac surgery: No impact on atrial fibrillation or atrial flutter. This study was designed to determine the effect of 2 different potassium regulation strategies with different targets (within the reference range) on atrial fibrillation (AF) or atrial flutter (AFL) in a cohort of intensive care unit patients after cardiac surgery.The GRIP-COMPASS study was a prospective double-blinded interventional study in 910 patients

2016 American Heart Journal Controlled trial quality: uncertain

122. A Study on the Efficacy and Safety of Continuous Renal Replacement Therapy (CVVHDF) Using a Commercial Citrate-containing Replacement Fluid (Prismocitrate 18/0)

] filter lifespan will be recorded as the time duration from commencement of renal replacement therapy till filter clotted or therapy ended Secondary Outcome Measures : metabolic and electrolyte control [ Time Frame: up to 4days ] Serum electrolytes (calcium, sodium, potassium, magnesium, acid-base)will be monitored at baseline, then every 6 hours onwards during the CRRT bleeding/transfusion requirement [ Time Frame: up to 4 days ] blood counts including the hemoglobin level and patient clinical status (...) A Study on the Efficacy and Safety of Continuous Renal Replacement Therapy (CVVHDF) Using a Commercial Citrate-containing Replacement Fluid (Prismocitrate 18/0) A Study on the Efficacy and Safety of Continuous Renal Replacement Therapy (CVVHDF) Using a Commercial Citrate-containing Replacement Fluid (Prismocitrate 18/0) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study

2013 Clinical Trials

123. China Salt Substitute and Stroke Study

-fatal strokes a home visit will be made. A series of process indicators including urinary sodium, urinary potassium, blood pressure, knowledge about sodium and use of salt substitute will also be measured on a random sample of at least 20 individuals drawn from a random selection of 60 villages at baseline and every year thereafter. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 21000 participants Allocation: Randomized (...) to Arm Intervention/treatment No Intervention: Control Dietary advice at baseline only Experimental: Dietary sodium reduction Dietary advice and reduced-sodium added-potassium salt substitute Behavioral: Dietary sodium reduction Ongoing dietary advice and a supply of a reduced-sodium added-potassium salt substitute Other Name: Reduced-sodium added-potassium salt substitute Outcome Measures Go to Primary Outcome Measures : Stroke [ Time Frame: 5 years ] The primary outcome will be stroke defined

2014 Clinical Trials

124. Launching a salt substitute to reduce blood pressure at the population level: a cluster randomized stepped wedge trial in Peru. Full Text available with Trip Pro

of a population-level intervention based on sodium reduction and potassium increase - in practice, introducing a low-sodium, high-potassium salt substitute - on adult blood pressure levels.The proposed implementation research study includes two components: Phase 1, an exploratory component, and Phase 2, an intervention component. The exploratory component involves a triangle taste test and a formative research study designed to gain an understanding of the best implementation methods. Phase 2 involves (...) Launching a salt substitute to reduce blood pressure at the population level: a cluster randomized stepped wedge trial in Peru. Controlling hypertension rates and maintaining normal blood pressure, particularly in resource-constrained settings, represent ongoing challenges of effective and affordable implementation in health care. One of the strategies being largely advocated to improve high blood pressure calls for salt reduction strategies. This study aims to estimate the impact

2014 Trials Controlled trial quality: uncertain

125. The relation between external potassium concentration and the relaxation rate of potassium-induced contractures in frog skeletal muscle Full Text available with Trip Pro

The relation between external potassium concentration and the relaxation rate of potassium-induced contractures in frog skeletal muscle 1. Frog toe muscles and isolated fibres from frog semitendinosus muscles were allowed to develop maximum K-contractures, and after reaching peak tension were transferred to media containing intermediate [K](0) (20-40 mM-K). Under these circumstances, relaxation displayed an early rapid phase, and a subsequent slower phase whose magnitude and rate varied with [K (...) alterations in [Ca](0) or by sudden replacement of the major extracellular anion. These effects are attributed to shifts in the relation between calcium rebinding and membrane potential.

1966 The Journal of physiology

126. Intracellular Potassium : A Determinant of the Sodium-Potassium Pump Rate Full Text available with Trip Pro

Intracellular Potassium : A Determinant of the Sodium-Potassium Pump Rate Normal human red cells which have had their intracellular sodium (Na(c)) reduced have a diminished Na-K pump rate, but only if intracellular potassium (K(c)) is high. If most of the K(c) is replaced by tetramethylammonium or choline, both ouabain-sensitive Na efflux and K influx are significantly increased even with Na(c) below normal. Cells with reduced Na(c) and high K(c) have an unchanged Na efflux if external (...) potassium (K(ext)) is removed. In contrast, low-Na, low-K cells have a large ouabain-sensitive Na efflux which shows a normal response to removal of K(ext). Neither low-K nor high-K cells have an altered ouabain-sensitive K efflux. Measurement at constant low Na(c) and varying K(c) shows the pump Na efflux to be an inverse function of K(c). Thus, in low-Na cells, K(c) appears to act as an inhibitor of the pump. Inhibition by high K(c) can be seen even when Na(c) is normal. The effects attributed to K(c

1974 The Journal of general physiology

127. Potassium: potassium exchange catalysed by the sodium pump in human red cells Full Text available with Trip Pro

Potassium: potassium exchange catalysed by the sodium pump in human red cells 1. When red cells were so depleted of Na that Na:K exchange had almost ceased, the ouabain-sensitive K efflux seen in K-containing media was accompanied by an almost equal ouabain-sensitive K influx.2. This suggests that the Na pump in these cells was carrying out a one-for-one K:K exchange across the erythrocyte membrane.3. 30-40% of the (42)K efflux from resealed ghosts was sensitive to ouabain when the ghosts (...) exchange did not depend on whether the ADP concentration was roughly the same as the ATP concentration or very much less, suggesting that ADP did not affect the rate of K:K exchange.7. GTP, ITP and UTP were unable to substitute for ATP in supporting K:K exchange. CTP was a poor substitute.8. There was no evidence to support the hypothesis that K:K exchange is accompanied by a ouabain-sensitive hydrolysis of ATP.9. Internal Na was a strong inhibitor of ouabain-sensitive K efflux from ghosts containing 9

1974 The Journal of physiology

128. THE SELECTIVE ABSORPTION OF POTASSIUM BY ANIMAL CELLS : II. THE CAUSE OF POTASSIUM SELECTION AS INDICATED BY THE ABSORPTION OF RUBIDIUM AND CESIUM. Full Text available with Trip Pro

THE SELECTIVE ABSORPTION OF POTASSIUM BY ANIMAL CELLS : II. THE CAUSE OF POTASSIUM SELECTION AS INDICATED BY THE ABSORPTION OF RUBIDIUM AND CESIUM. 1. Frog muscles perfused with Ringer solution in which potassium chloride has been replaced by an equivalent amount of rubidium or cesium chloride take up rubidium or cesium and incorporate them into the tissue substance in such form as to be retained during a subsequent perfusion with potassium-free Ringer solution, provided the muscles contract (...) during the first perfusion. Retention of rubidium or cesium by a resting muscle does not occur. 2. Rats on synthetic diets, adequate in all respects except that potassium was replaced by an equivalent amount of rubidium or cesium, died after a period varying from 10 to 17 days with characteristic symptoms including tetanic spasms. Muscle, heart, liver, kidney, spleen, and lung tissues were then found to contain significant amounts of rubidium or cesium. The concentration of these metals in the muscle

1921 The Journal of general physiology

129. Potassium depletion and sodium block of potassium currents under hyperpolarization in frog sartorius muscle. Full Text available with Trip Pro

Potassium depletion and sodium block of potassium currents under hyperpolarization in frog sartorius muscle. 1. A three-electrode voltage clamp method was used to investigate the mechanism of the fall in resting potassium permeability which occurs under extreme hyperpolarization in frog sartorius muscle fibres. 2. Experiments were performed which show that this permeability change is due to a potential dependent block by Na+ ions present in the external solution. 3. Inward K-currents recorded (...) on hyperpolarization turned off exponentially with time. In the presence of Na the steady-state current-voltage relation had a region of negative slope beyond -140 mV. This negative-slope region was removed when Na was replaced by TMA, Tris or Li. Increasing [Na] to 140 mM shifted the negative-slope region to less negative membrane potentials; reducing [Na] to 14 mM shifted the region to more negative potentials. 4. The time constant for the turn-off of the currents (tau) was the same in Na and TMA-containing

1979 The Journal of physiology

130. Alkali replacement raises urinary citrate excretion in patients with topiramate‐induced hypocitraturia Full Text available with Trip Pro

Alkali replacement raises urinary citrate excretion in patients with topiramate‐induced hypocitraturia The aims of this study were to assess (1) the magnitude and temporality of decreased urinary citrate excretion in patients just starting topiramate and (2) the effect of alkali replacement on topiramate-induced hypocitraturia.Study 1 was a prospective, non-intervention study in which patients starting topiramate for headache remediation provided pre- and post-topiramate 24 h urine (...) hypocitraturia (citrate <320 mg day(-1) ). At 60 days, urine citrate was even lower than at baseline (P = 0.0032) and 86% of patients had developed hypocitraturia. After starting alkali, urine citrate increased in stone-forming patients on topiramate (198 ± 120 to 408 ± 274 mg day(-1) ; P = 0.042 for difference). 85% of patients were hypocitraturic on topiramate alone vs. 40% after adding alkali. The increase in urinary citrate was greater in patients provided ≥ 90 mEq potassium citrate.Our study

2015 British journal of clinical pharmacology

131. The Safety and Efficacy of Tolvaptan for Patients With Tricuspid Regurgitation and Right Heart Failure After Left Heart Valves Replacement

: tolvaptan safety and efficacy left heart valves replacement Additional relevant MeSH terms: Layout table for MeSH terms Heart Failure Tricuspid Valve Insufficiency Heart Diseases Cardiovascular Diseases Heart Valve Diseases Tolvaptan Torsemide Antidiuretic Hormone Receptor Antagonists Molecular Mechanisms of Pharmacological Action Natriuretic Agents Physiological Effects of Drugs Antihypertensive Agents Diuretics Sodium Potassium Chloride Symporter Inhibitors Membrane Transport Modulators (...) The Safety and Efficacy of Tolvaptan for Patients With Tricuspid Regurgitation and Right Heart Failure After Left Heart Valves Replacement The Safety and Efficacy of Tolvaptan for Patients With Tricuspid Regurgitation and Right Heart Failure After Left Heart Valves Replacement - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study

2015 Clinical Trials

132. Hormone Replacement Therapy on the Postmenopausal Endometrium

receptors Additional relevant MeSH terms: Layout table for MeSH terms Hormones Tibolone Drospirenone Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs Mineralocorticoid Receptor Antagonists Hormone Antagonists Diuretics, Potassium Sparing Diuretics Natriuretic Agents Androgen Antagonists Antihypertensive Agents Antineoplastic Agents, Hormonal Antineoplastic Agents Estrogen Receptor Modulators Anabolic Agents (...) Hormone Replacement Therapy on the Postmenopausal Endometrium Hormone Replacement Therapy on the Postmenopausal Endometrium - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Hormone Replacement Therapy

2015 Clinical Trials

133. Comparison of two strategies for initiating renal replacement therapy in the intensive care unit: study protocol for a randomized controlled trial (AKIKI). Full Text available with Trip Pro

Comparison of two strategies for initiating renal replacement therapy in the intensive care unit: study protocol for a randomized controlled trial (AKIKI). There is currently no validated strategy for the timing of renal replacement therapy (RRT) for acute kidney injury (AKI) in the intensive care unit (ICU) when short-term life-threatening metabolic abnormalities are absent. No adequately powered prospective randomized study has addressed this issue to date. As a result, significant practice (...) ' strategy, clinical and metabolic conditions are closely monitored and RRT is initiated only when one or more events (severity criteria) occur, including: oliguria or anuria for more than 72 hours after randomization, serum urea concentration >40 mmol/l, serum potassium concentration >6 mmol/l, serum potassium concentration >5.5 mmol/l persisting despite medical treatment, arterial blood pH <7.15 in a context of pure metabolic acidosis (PaCO2 < 35 mmHg) or in a context of mixed acidosis with a PaCO2

2015 Trials Controlled trial quality: predicted high

134. Ability of a novel system for neonatal extracorporeal renal replacement therapy with an ultra-small volume circuit to remove solutes in vitro. (Abstract)

Ability of a novel system for neonatal extracorporeal renal replacement therapy with an ultra-small volume circuit to remove solutes in vitro. We automated our manual, syringe-driven extracorporeal renal replacement therapy (eRRT) system with an ultra-small volume circuit (3.2 ml) that is suitable for neonates without blood priming. Our objective was to determine the solute clearance and water balance of the automated and manual systems in vitro.Stored whole blood samples containing exogenous (...) urea, creatinine (Cr), potassium (K), and ammonia (NH3) to imitate acute kidney injury (AKI) and hyperammonemia were dialyzed for 3 h (blood flow, 4.0 ml/min; dialysate flow, 600 ml/h) with a continuous infusion of heparin. Solute clearance and sample weight were then compared with values before dialysis.The median clearance of blood urea nitrogen, Cr, K, and NH3 ranged from 1.7 to 2.3 and from 2.4 to 2.6 ml/min, and the median weight of the samples was decreased by 3.8 g and increased by 8.3 g

2015 Pediatric Nephrology

135. Glucose-Insulin-Potassium Reduces the Incidence of Low Cardiac Output Episodes After Aortic Valve Replacement for Aortic Stenosis in Patients With Left Ventricular Hypertrophy: Results From the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) Trial Full Text available with Trip Pro

Glucose-Insulin-Potassium Reduces the Incidence of Low Cardiac Output Episodes After Aortic Valve Replacement for Aortic Stenosis in Patients With Left Ventricular Hypertrophy: Results From the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) Trial Patients undergoing aortic valve replacement for critical aortic stenosis often have significant left ventricular hypertrophy. Left ventricular hypertrophy has been identified as an independent predictor of poor outcome after aortic valve (...) replacement as a result of a combination of maladaptive myocardial changes and inadequate myocardial protection at the time of surgery. Glucose-insulin-potassium (GIK) is a potentially useful adjunct to myocardial protection. This study was designed to evaluate the effects of GIK infusion in patients undergoing aortic valve replacement surgery.Patients undergoing aortic valve replacement for aortic stenosis with evidence of left ventricular hypertrophy were randomly assigned to GIK or placebo. The trial

2011 EvidenceUpdates Controlled trial quality: predicted high

136. Launching a Salt Substitute to Reduce Blood Pressure at the Population Level in Peru

Collaborator: Johns Hopkins University Information provided by (Responsible Party): Jaime Miranda, Universidad Peruana Cayetano Heredia Study Details Study Description Go to Brief Summary: This protocol aims to implement, using a stepped wedge trial design, a population-level intervention to replace high-sodium salt for a salt substitute (low-sodium, high-potassium salt) to reduce blood pressure levels among adults aged 18 years and over of the semi-urban area of Tumbes. We hypothesize that participants (...) aged 18 years and over from villages receiving a salt substitute will have lower blood pressure compared to control villages. Condition or disease Intervention/treatment Phase Blood Pressure Hypertension Other: Salt substitute Not Applicable Detailed Description: Several randomized clinical trials and meta-analysis have reported that reduction of sodium intake decreases blood pressure. Also, the increase of potassium ingestion in minimal doses has been found in systematic reviews to produce a small

2013 Clinical Trials

137. Long-term effects of salt substitution on blood pressure in a rural north Chinese population. Full Text available with Trip Pro

Long-term effects of salt substitution on blood pressure in a rural north Chinese population. Dietary sodium and potassium intake can influence blood pressure. The effects of salt substitution on patients with hypertension and normotensive family member controls, however, have not been evaluated in a rural Chinese population. The objective of this study, accordingly, was to assess the long-term effects of salt substitution on blood pressure. We conducted a double-blind, randomized controlled (...) trial among 200 families in rural China to establish the 2-year effects of a reduced-sodium, high-potassium salt substitute (65% sodium chloride, 25% potassium chloride, 10% magnesium sulfate) compared with normal salt (100% sodium chloride) on blood pressure. Of the 462 individuals in the trial, 372 completed the study (81%). For normotensive subjects, the mean overall difference in systolic and diastolic blood pressure between the two groups at the 24-month follow-up was 2 mm Hg (95% confidence

2013 Journal of human hypertension Controlled trial quality: predicted high

138. Potassium Board Review - New Wash U Nephrology Web Episode

Potassium Board Review - New Wash U Nephrology Web Episode Renal Fellow Network: Potassium Board Review - New Wash U Nephrology Web Episode | | | | | Tuesday, June 14, 2016 Potassium Board Review - New Wash U Nephrology Web Episode Hypokalemia, hypertension, and metabolic alkalosis - this clinical triad can be seen in a variety of interesting disorders that unfortunately are much more common during in-training or board certification exams than in clinical practice. That doesn't mean you should (...) cram for them the night before the exam! Understanding the way these diseases affect potassium handling in the kidney can help learners of all levels acquire a better understanding of normal renal physiology. This month's nephrology web episode from Washington University in St. Louis focuses on 4 board-style questions related to potassium disorders, and we hope you find it helpful. The full episode can be viewed below: Posted by Timothy Yau at 2 comments: said... Nice post. I have 2 comments

2016 Renal Fellow Network

139. STUDIES ON CELL METABOLISM AND CELL DIVISION : IV. COMBINED ACTION OF SUBSTITUTED PHENOLS, CYANIDE, CARBON MONOXIDE, AND OTHER RESPIRATORY INHIBITORS ON RESPIRATION AND CELL DIVISION Full Text available with Trip Pro

, by phenylurethane, by 5-isoamyl-5-ethyl barbituric acid, by malonic acid, or by iodoacetic acid. To abolish all respiratory stimulation by suboptimum concentrations of 4,6-dinitro-o-cresol, each of these inhibitors must be present in a concentration which reduces the normal respiration in the absence of substituted phenols by at least 20-40 per cent. 2. The degree of reduction of the stimulated respiration by a given concentration of carbon monoxide or potassium cyanide depends on the concentration of 4,6 (...) STUDIES ON CELL METABOLISM AND CELL DIVISION : IV. COMBINED ACTION OF SUBSTITUTED PHENOLS, CYANIDE, CARBON MONOXIDE, AND OTHER RESPIRATORY INHIBITORS ON RESPIRATION AND CELL DIVISION The effects of 4,6-dinitro-o-cresol and 2,4,5-trichlorophenol on the respiration and cell division of fertilized eggs of Arbacia punctulata have been determined in the presence of each of a number of respiratory inhibitors. The experimental results obtained appear to afford some understanding of the mechanism

1940 The Journal of general physiology

140. Ionic Conductance Changes in Lobster Axon Membrane When Lanthanum Is Substituted for Calcium Full Text available with Trip Pro

Ionic Conductance Changes in Lobster Axon Membrane When Lanthanum Is Substituted for Calcium The trivalent rare earth lanthanum was substituted for calcium in the sea water bathing the exterior of an "artificial node" of a lobster axon in a sucrose gap. It caused a progressive rise in threshold, and a decrease in the height of the action potential as well as in its rates of rise and fall. Prolonged application produced an excitation block. Voltage-clamp studies of the ionic currents showed (...) that the time courses of the ionic conductance changes for both sodium and potassium were increased. Concurrently, the potentials at which the conductance increases occurred were shifted to more positive inside values for the La+++ sea water. These effects resemble changes resulting from a high external calcium concentration. Over and above this, La+++ also causes a marked reduction in the maximum amount of conductance increase following a depolarizing potential step. Membrane action potentials similar

1966 The Journal of general physiology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>