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Potassium Replacement

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81. Adaptation of Bacillus subtilis to Life at Extreme Potassium Limitation Full Text available with Trip Pro

were strongly increased, suggesting that these amino acids can partially substitute for potassium. This was confirmed by the observation that the supplementation with positively charged amino acids allows growth of B. subtilis even at the extreme potassium limitation that the bacteria experience if no potassium is added to the medium. In addition, a second class of suppressor mutations allowed growth at extreme potassium limitation. These mutations result in increased expression of KtrAB (...) Adaptation of Bacillus subtilis to Life at Extreme Potassium Limitation Potassium is the most abundant metal ion in every living cell. This ion is essential due to its requirement for the activity of the ribosome and many enzymes but also because of its role in buffering the negative charge of nucleic acids. As the external concentrations of potassium are usually low, efficient uptake and intracellular enrichment of the ion is necessary. The Gram-positive bacterium Bacillus subtilis possesses

2017 mBio

82. Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids Full Text available with Trip Pro

Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids We are reporting a rare case of acute liver injury that developed after an internal hemorrhoid treatment with the aluminum potassium sulfate and tannic acid (ALTA) regimen. A 41-year-old man developed a fever and liver injury after undergoing internal hemorrhoid treatment with a submucosal injection of ALTA with lidocaine. The acute liver injury was classified clinically as hepatocellular and pathologically (...) as cholestastic. We could not classify the mechanism of injury. High eosinophil and immunoglobulin E levels characterized the injury, and a drug lymphocyte stimulation test was negative on postoperative day 25. Fluid replacement for two weeks after hospitalization improved the liver injury. ALTA therapy involves injecting chemicals into the submucosa, from the rectum to the anus, and this is the first description of a case that developed a severe liver disorder after this treatment; hence, an analysis

2017 World Journal of Gastroenterology

83. An Open-Label Trial of Losartan Potassium in Participants With Eosinophilic Esophagitis (EoE)

hydrochlorothiazide, digoxin, warfarin, cimetidine, phenobarbital, rifampin, or fluconazole. taking or planning to take potassium supplements or salt substitutes containing potassium. A female participant who is pregnant or nursing or, if of childbearing potential, is not using a medically accepted, effective method of birth control (e.g., condom, oral/injectable/subcutaneous contraceptive, intrauterine device, or sexual abstinence). Participated/participating in any investigative drug or device study within 30 (...) An Open-Label Trial of Losartan Potassium in Participants With Eosinophilic Esophagitis (EoE) An Open-Label Trial of Losartan Potassium in Participants With Eosinophilic Esophagitis (EoE) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2017 Clinical Trials

84. Potassium Supplementation in CKD

Criteria: Hyperkalemia (serum potassium > 5.5 mmol/l) at study visit V0 Medical reasons to continue dual RAAS-blockade, mineralocorticoid receptor blockers, potassium-sparing diuretics, or oral potassium binders. Patients with previous history of ventricular cardiac arrhythmia Patients with a life expectancy < 6 months Expected initiation of renal replacement therapy < 2 years Incapacitated subjects Women who are pregnant, breastfeeding or consider pregnancy in the coming 2 years. Contacts (...) Potassium Supplementation in CKD Potassium Supplementation in CKD - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Potassium Supplementation in CKD (K+ in CKD) The safety and scientific validity

2017 Clinical Trials

85. The mechano-sensitivity of cardiac ATP-sensitive potassium channels is mediated by intrinsic MgATPase activity. (Abstract)

The mechano-sensitivity of cardiac ATP-sensitive potassium channels is mediated by intrinsic MgATPase activity. Cardiac ATP-sensitive K+ (KATP) channel activity plays an important cardio-protective role in regulating excitability in response to metabolic stress. Evidence suggests that these channels are also mechano-sensitive and therefore may couple KATP channel activity to increased cardiac workloads. However, the molecular mechanism that couples membrane stretch to channel activity (...) ATP analog AMP-PNP or the ATPase inhibitor BeFx significantly reduced the stimulatory effect of stretch. We employed a point mutagenic approach to determine that a single residue (K1337) in the hairpin loop proximal to the major MgATPase catalytic site in the SUR2A subunit is responsible for the difference in mechano-sensitivity between SUR2A and SUR1 containing KATP channels. Moreover, using a double cysteine mutant substitution in the hairpin loop region revealed the importance of a key residue

2017 Journal of Molecular and Cellular Cardiology

86. The replacement of potassium by uranium in perfusion of the heart Full Text available with Trip Pro

The replacement of potassium by uranium in perfusion of the heart 16993497 2007 02 05 2008 11 20 0022-3751 55 1-2 1921 May 24 The Journal of physiology J. Physiol. (Lond.) The replacement of potassium by uranium in perfusion of the heart. 33-7 Zwaardemaker H H eng Journal Article England J Physiol 0266262 0022-3751 1921 5 24 0 0 1921 5 24 0 1 1921 5 24 0 0 ppublish 16993497 PMC1405362

1921 The Journal of physiology

87. THE ACCUMULATION OF ELECTROLYTES : IX. REPLACEMENT OF AMMONIA BY SODIUM AND POTASSIUM Full Text available with Trip Pro

THE ACCUMULATION OF ELECTROLYTES : IX. REPLACEMENT OF AMMONIA BY SODIUM AND POTASSIUM Experiments on Valonia were carried out as follows: Stage I.-Cells in dim light accumulated 0.08 M ammonia (NH(3) + NH(4)OH + NH(4) (+)) from sea water containing 0.0025 M ammonia (but the concentration of undissociated ammonia appeared to remain less inside than outside). Potassium came out. Stage II.-Cells in dim light in nearly ammonia-free normal sea water lost ammonia which was replaced by sodium entering (...) from the sea water. Potassium in the sap remained practically constant. Stage III.-The cells were placed in stronger light where the loss of ammonia continued and potassium entered. Sodium entered more rapidly than in Stage II. Stage IV.-Cells transferred to sea water containing 0.0025 M ammonia again accumulated ammonia up to 0.1345 M. The results in general harmonize with the view that the direction of movement of a base M through the protoplasm depends on the difference of the activity products

1938 The Journal of general physiology

88. The reversible replacement of internal potassium by caesium in isolated turtle heart. Full Text available with Trip Pro

The reversible replacement of internal potassium by caesium in isolated turtle heart. 1. By perfusing the isolated turtle heart with Cs solution, most of the intracellular K can be replaced by Cs. After 3--4 hr, Cs approaches a steady-state distribution with a concentration slightly below initial K concentration. 2. During the initial stages of perfusion, the heart accumulated Cs and lost K, the exchange ratio of K for Cs was estimated to be about 0.6. Subsequently perfusion yielded an equi (...) -ionic substitution of K by Cs. 3. In presence of DNP (2 x 10(-4) M), K efflux and Cs accumulation increased but the low initial K--Cs exchange was abolished. Then, the replacement of K by Cs took place at a ratio of K:Cs of about 0.8. Ouabain (10(-5) M) suppressed uptake of Cs whereas K loss was the same as with DNP. 4. These results confirm that permeability of the cardiac sarcolemma to Cs is low, and suggest that the movement of Cs must be mainly attributed to its active transport into cells

1979 The Journal of physiology

89. Contracture Coupling of Slow Striated Muscle in Non-Ionic Solutions and Replacement of Calcium, Sodium, and Potassium Full Text available with Trip Pro

Contracture Coupling of Slow Striated Muscle in Non-Ionic Solutions and Replacement of Calcium, Sodium, and Potassium The development of contracture related to changes of ionic environment (ionic contracture coupling) has been studied in the slowly responding fibers of frog skeletal muscle. When deprived of external ions for 30 minutes by use of solutions of sucrose, mannitol, or glucose, the slow skeletal muscle fibers, but not the fast, develop pronounced and easily reversible contractures (...) . Partial replacement of the non-ionic substance with calcium or sodium reduces the development of the contractures but replacement by potassium does not. The concentration of calcium necessary to prevent contracture induced by a non-ionic solution is greater than that needed to maintain relaxation in ionic solutions. To suppress the non-ionic-induced contractures to the same extent as does calcium requires several fold higher concentrations of sodium. Two types of ionic contracture coupling occur

1964 The Journal of general physiology

90. Potassium replacement therapy Full Text available with Trip Pro

Potassium replacement therapy Potassium replacement is often an important therapeutic measure, and the advantages of effervescing potassium-containing granules are put forward in this article.

1961 Gut

91. Potassium toxicity at low serum potassium levels with refeeding syndrome. (Abstract)

Potassium toxicity at low serum potassium levels with refeeding syndrome. Refeeding syndrome is a life-threatening condition occurring in severely malnourished patients after initiating feeding. Severe hypophosphatemia with reduced adenosine triphosphate production has been implicated, but little data are available regarding electrolyte abnormalities. In this case, we report electrocardiographic changes consistent with hyperkalemia during potassium replacement after a serum level increase from (...) 1.9 to 2.9 mEq/L. This was reversed by lowering serum potassium back to 2.0 mEq/L. In conclusion, the patient with prolonged malnutrition became adapted to low potassium levels and developed potassium toxicity with replacement. Copyright © 2015 Elsevier Inc. All rights reserved.

2015 American Journal of Cardiology

92. Impact of a Potassium-enriched, Chloride-depleted 5% Glucose Solution on Gastrointestinal Function after Major Abdominopelvic Surgery: Results of a Randomized Controlled Trial Full Text available with Trip Pro

different between groups (G5K group, 93 h [19 to 168 h] and control group, 120 h [43 to 241 h]); estimator of the group difference, -16 (95% CI, -38 to 6); P = 0.173. Return of normal GI function occurred faster in the G5K group than in the control group (median, 138 h [range, 54 to 262 h] vs. 169 h [108 to 318 h]); estimator of the group difference, -38 (95% CI, -74 to -12); P = 0.004. Potassium and magnesium were less frequently substituted in the G5K group (13.6 vs. 54.5% [P = 0.010] and 18.2 vs (...) . 77.3% [P < 0.001]), respectively. The incidence of renal dysfunction (Risk, Injury, Failure, Loss and End-stage kidney disease stage "risk") at discharge was 9.1% in the G5K group and 4.5% in the control group; P = 1.000.Perioperative administration of a G5K did not enhance first defecation, but may accelerate recovery of normal GI function, and reduces potassium and magnesium substitution after radical cystectomy and urinary diversion.

2016 EvidenceUpdates Controlled trial quality: predicted high

93. Glucose-Insulin-Potassium Reduces the Incidence of Low Cardiac Output Episodes After Aortic Valve Replacement for Aortic Stenosis in Patients With Left Ventricular Hypertrophy: Results From the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) Trial Full Text available with Trip Pro

Glucose-Insulin-Potassium Reduces the Incidence of Low Cardiac Output Episodes After Aortic Valve Replacement for Aortic Stenosis in Patients With Left Ventricular Hypertrophy: Results From the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) Trial Patients undergoing aortic valve replacement for critical aortic stenosis often have significant left ventricular hypertrophy. Left ventricular hypertrophy has been identified as an independent predictor of poor outcome after aortic valve (...) replacement as a result of a combination of maladaptive myocardial changes and inadequate myocardial protection at the time of surgery. Glucose-insulin-potassium (GIK) is a potentially useful adjunct to myocardial protection. This study was designed to evaluate the effects of GIK infusion in patients undergoing aortic valve replacement surgery.Patients undergoing aortic valve replacement for aortic stenosis with evidence of left ventricular hypertrophy were randomly assigned to GIK or placebo. The trial

2011 EvidenceUpdates Controlled trial quality: predicted high

94. Dietary Potassium

Potassium , Foods with High Potassium Content , Potassium Content in Food II. Precautions Potassium Content in Food is not an exact replacement Renal disease patients or those with other risk factors should avoid high foods III. Background: Potassium Elemental (K+): 39 mg/meq Chloride (KCl): 75 mg/meq IV. Preparations: Salt Substitute contains extremely high Potassium Most salt substitutes (e.g. no-salt) are composed of chloride (75 mg/meq) Chloride Salt-Substitute Products Nu-Salt (mg): 530 mg per 1 g (...) tsp (as calculated above) Mrs. Dash only contains 0.4 meq per 1/4 tsp Highly concentrated, chloride salt substitute can easily be over-dosed ( caution) At 67 to 82 meq per teaspoon, NoSalt, Nu-Salt or Morton's Salt Substitute can easily exceed safe limits VI. Preparations: Potassium content (from USDA, with meq based on 39 mg/meq for elemental Potassium) Acorn Squash (cooked) : 448 mg or 11.5 meq per 1/2 cub acorn squash cubes Almonds 200 mg or 5 meq per 1 ounce of almonds cot (dried) : 41 mg

2018 FP Notebook

95. A Single Amino-Acid Substitution in the Sodium Transporter HKT1 Associated with Plant Salt Tolerance Full Text available with Trip Pro

A Single Amino-Acid Substitution in the Sodium Transporter HKT1 Associated with Plant Salt Tolerance A crucial prerequisite for plant growth and survival is the maintenance of potassium uptake, especially when high sodium surrounds the root zone. The Arabidopsis HIGH-AFFINITY K(+) TRANSPORTER1 (HKT1), and its homologs in other salt-sensitive dicots, contributes to salinity tolerance by removing Na(+) from the transpiration stream. However, TsHKT1;2, one of three HKT1 copies in Thellungiella (...) cells. Mutant hkt1-1 plants complemented with both AtHKT1(N) (-) (D) and TsHKT1;2 showed higher tolerance to salt stress than lines complemented by the wild-type AtHKT1 Electrophysiological analysis in Xenopus laevis oocytes confirmed the functional properties of these transporters and the differential selectivity for Na(+) and K(+) based on the n/d variance in the pore region. This change also dictated inward-rectification for Na(+) transport. Thus, the introduction of Asp, replacing Asn, in HKT1

2016 Plant physiology

96. Lipid Extracted Microalgal Biomass Residue as a Fertilizer Substitute for Zea mays L. Full Text available with Trip Pro

Lipid Extracted Microalgal Biomass Residue as a Fertilizer Substitute for Zea mays L. High volumes of lipid extracted microalgal biomass residues (LMBRs) are expected to be produced upon commencement of biodiesel production on a large scale, thus necessitating its value addition for sustainable development. LMBRs of Chlorella variabilis and Lyngbya majuscula were employed to substitute the nitrogen content of recommended rate of fertilizer (RRF) for Zea mays L. The pot experiment comprised (...) of 10 treatments, i.e., T1 (No fertilizer); T2 (RRF-120 N: 60 P2O5: 40 K2O kg ha(-1)); T3 to T6-100, 75, 50, and 25% N through LMBR of the Chlorella sp., respectively; T7 to T10-100, 75, 50, and 25% N through LMBR of Lyngbya sp., respectively. It was found that all LMBR substitution treatments were at par to RRF with respect to grain yield production. T10 gave the highest grain yield (65.16 g plant(-1)), which was closely followed by that (63.48 g plant(-1)) under T5. T10 also recorded the highest

2016 Frontiers in plant science

97. Effect of Positional Isomerism and Vanadium Substitution on 51V Magic Angle Spinning NMR Spectra of Wells-Dawson Polyoxotungstates Full Text available with Trip Pro

Effect of Positional Isomerism and Vanadium Substitution on 51V Magic Angle Spinning NMR Spectra of Wells-Dawson Polyoxotungstates We examined the positional isomerism and vanadium substitution on the 51V magic angle spinning NMR spectra of potassium salts of vanadium-substituted polyoxotungstates of the Wells-Dawson series. NMR parameters of this class of catalytically active polyoxotungstates effect of are reported. Multiple species, indicative of differences in the local environment (...) at the substitution sites, are observed in solid-state NMR spectra of the di- and tri- substituted complexes in contrast to solution NMR spectra, where single average chemical shift was observed. The quadrupolar and chemical shift anisotropy parameters depend strongly on the position and the degree of the vanadium substitution into the oxoanion core establishing 51V SATRAS NMR spectroscopy as a sensitive probe of the local electronic environment in these catalytically active solids.Copyright © 2016 Elsevier Inc

2016 Solid state nuclear magnetic resonance

98. Preparation of resorbable carbonate-substituted hollow hydroxyapatite microspheres and their evaluation in osseous defects in vivo Full Text available with Trip Pro

substitution (0-12 wt.%) were created using a novel glass conversion route and evaluated in vitro and in vivo. Hollow HA microspheres with ~12 wt.% of carbonate (designated CHA12) showed a higher surface area (236 m(2) g(-1)) than conventional hollow HA microspheres (179 m(2)g(-1)) and a faster degradation rate in a potassium acetate buffer solution. When implanted for 12 weeks in rat calvarial defects, the CHA12 and HA microspheres showed a limited capacity to regenerate bone but the CHA12 microspheres (...) Preparation of resorbable carbonate-substituted hollow hydroxyapatite microspheres and their evaluation in osseous defects in vivo Hollow hydroxyapatite (HA) microspheres, with a high-surface-area mesoporous shell, can provide a unique bioactive and osteoconductive carrier for proteins to stimulate bone regeneration. However, synthetic HA has a slow resorption rate and a limited ability to remodel into bone. In the present study, hollow HA microspheres with controllable amounts of carbonate

2015 Materials science & engineering. C, Materials for biological applications

99. Impact of Light Salt Substitution for Regular Salt on Blood Pressure of Hypertensive Patients Full Text available with Trip Pro

Impact of Light Salt Substitution for Regular Salt on Blood Pressure of Hypertensive Patients Studies have shown sodium restriction to have a beneficial effect on blood pressure (BP) of hypertensive patients.To evaluate the impact of light salt substitution for regular salt on BP of hypertensive patients.Uncontrolled hypertensive patients of both sexes, 20 to 65 years-old, on stable doses of antihypertensive drugs were randomized into Intervention Group (IG - receiving light salt) and Control (...) Group (CG - receiving regular salt). Systolic BP (SBP) and diastolic BP (DBP) were analyzed by using casual BP measurements and Home Blood Pressure Monitoring (HBPM), and sodium and potassium excretion was assessed on 24-hour urine samples. The patients received 3 g of salt for daily consumption for 4 weeks.The study evaluated 35 patients (65.7% women), 19 allocated to the IG and 16 to the CG. The mean age was 55.5 ± 7.4 years. Most participants had completed the Brazilian middle school (up

2015 Arquivos brasileiros de cardiologia Controlled trial quality: uncertain

100. Renin-angiotensin II-aldosterone system blockers and time to renal replacement therapy in children with CKD. Full Text available with Trip Pro

Renin-angiotensin II-aldosterone system blockers and time to renal replacement therapy in children with CKD. Clinical care decisions to treat chronic kidney disease (CKD) in a growing child must often be made without the benefit of evidence from clinical trials. We used observational data from the Chronic Kidney Disease in Children cohort to estimate the effectiveness of renin-angiotensin II-aldosterone system blockade (RAAS) to delay renal replacement therapy (RRT) in children with CKD.A total (...) proteinuria, anemia, elevated blood pressure, acidosis, elevated phosphate and elevated potassium.There were 217 RRT events over a 4.1-year median follow-up. At baseline, 472 children (55 %) were prevalent RAAS users, who were more likely to be older, have a glomerular etiology, have higher urine protein, be anemic, have elevated serum phosphate and potassium, take more medications, but less likely to have elevated blood pressure, compared with non-users. RAAS use was found to reduce the risk of RRT by 21

2016 Pediatric Nephrology

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