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Potassium Replacement

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61. Replacing American Breakfast Foods with Ready-To-Eat (RTE) Cereals Increases Consumption of Key Food Groups and Nutrients among US Children and Adults: Results of an NHANES Modeling Study Full Text available with Trip Pro

Replacing American Breakfast Foods with Ready-To-Eat (RTE) Cereals Increases Consumption of Key Food Groups and Nutrients among US Children and Adults: Results of an NHANES Modeling Study Replacing the typical American breakfast with ready-to-eat cereals (RTECs) may improve diet quality. Our goal was to assess the impact of RTECs on diet quality measures for different age groups, using substitution modeling. Dietary intakes came from the 2007-2010 National Health and Examination Surveys (NHANES (...) (+104.6%), as compared to observed diets. Model 2 diets were additionally higher in dairy (+15.8%), calcium (+11.3%) and potassium (+3.95%). In Model 1, added sugar increased (+5.0%), but solid fats declined (-10.9%). Energy from solid fats and added sugars declined (-3.2%) in both models. Model 2 offered higher diet quality (57.1 vs. 54.6, p-value < 0.01) at a lower cost ($6.70 vs. $6.92; p < 0.01), compared to observed diets. Substitution modeling of NHANES data can assess the nutritional

2017 Nutrients

62. Partial substitution of sodium with potassium in white bread: feasibility and bioavailability. (Abstract)

Partial substitution of sodium with potassium in white bread: feasibility and bioavailability. A high sodium intake, to which bread makes a major contribution, and a low potassium intake are believed to be important factors in the promotion of cardiovascular disease. Our aims was to determine to what extent salts of potassium could substitute sodium chloride and potassium-rich soya flour could replace wheat flour without detrimental effect on acceptability, and to measure the bioavailability (...) of a potassium salt added to bread. A single-blind organoleptic evaluation was carried out on eight different potassium-enriched breads by 41 panellists. Thereafter, six volunteers consumed standard or potassium-chloride-fortified bread in an 11-day single-blind cross-over feeding trial to determine the bioavailability of the supplemental potassium. Two breads in which 30% of the sodium was replaced by potassium salts, and bread in which 10% of wheat flour was replaced with soy flour, had acceptability

2012 International journal of food sciences and nutrition Controlled trial quality: uncertain

63. Structure and antiviral activity of substituted potassium benzylaminothiomethane-sulphonates and allied compounds. Full Text available with Trip Pro

Structure and antiviral activity of substituted potassium benzylaminothiomethane-sulphonates and allied compounds. 6055246 1967 12 26 2018 11 13 0366-0826 31 1 1967 Sep British journal of pharmacology and chemotherapy Br J Pharmacol Chemother Structure and antiviral activity of substituted potassium benzylaminothiomethane-sulphonates and allied compounds. 11-8 Rao K V KV Rao P L PL Praphulla H B HB Puttaswamy T L TL Ramanathan S S eng Journal Article England Br J Pharmacol Chemother 0154627

1967 British journal of pharmacology and chemotherapy

64. Substitutes for Potassium in Metabolism of the Lowest Fungi Full Text available with Trip Pro

Substitutes for Potassium in Metabolism of the Lowest Fungi 16559960 2006 05 25 2018 11 13 0021-9193 32 4 1936 Oct Journal of bacteriology J. Bacteriol. Substitutes for Potassium in Metabolism of the Lowest Fungi. 393-9 Rahn O O Bacteriological Laboratory, New York State College of Agriculture, Cornell University, Ithaca, New York. eng Journal Article United States J Bacteriol 2985120R 0021-9193 1936 10 1 0 0 1936 10 1 0 1 1936 10 1 0 0 ppublish 16559960 PMC543805 J Bacteriol. 1916 Nov;1(6):627

1936 Journal of bacteriology

65. Reduction of potassium permeability by chloride substitution in cardiac cells. Full Text available with Trip Pro

Reduction of potassium permeability by chloride substitution in cardiac cells. 1. The efflux of radioactive K and Cl ions was measured in cow Purkinje fibres and ventricular preparations of cow, cat and frog. The effect of K and Cl was studied by changing the extracellular K concentration between zero and 54 mM, and by substituting Cl ions by acetylglycinate, isethionate, benzenesulphonate, propionate and nitrate. 2. In the absence of Cl the rate coefficient for 42K efflux showed a pronounced

1977 The Journal of physiology

66. The effects of external sodium substitution on cell sodium and potassium in vascular smooth muscle Full Text available with Trip Pro

The effects of external sodium substitution on cell sodium and potassium in vascular smooth muscle 1. The entry of Li into the vascular smooth muscle cells of the rat tail artery follows first-order kinetics with a rate constant of approximately 1.3 hr(-1) at 10 mM-[Li](o). The rate constant decreases gradually to ca. 0.5 hr(-1) when the [Li](o)/[Na](o) ratio is increased.2. Replacement of Na with Li over the range of [Li](o) from 1 to 115 mM, accomplished at constant ionic strength (...) and osmolarity of the bathing solution, produces changes in cell Na and K without apparent change in cell water. At equilibrium, cell Li increases in linear proportion to [Li](o), at a ratio of 2:1 throughout the range. The increase in cell Li is associated with inverse falls in both cell K and Na such that the ratio of cell K to cell Na remains constant at ca. 10:1 throughout.3. The changes in the ionic contents, induced by equilibration of the tissue with a Na-free, Li-substituted solution, are reversible

1977 The Journal of physiology

67. Potassium Replacement

Potassium Replacement Potassium Replacement Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Potassium Replacement Potassium (...) Replacement Aka: Potassium Replacement , Potassium Supplementation II. Indications III. Precautions is typically needed in conjunction with Adjust protocol for renal disease : < 30 ml/hour : > 3.0 mg/dl IV. Preparations Extended release tablets (preferred) Order generic chloride ER ($15 per month) KDUR brand-name is not available in U.S. as of 2016 Immediate-release powder Expensive ($290 per month) Diluted in liquid and are less than palatable Better tolerated in divided dosing (20 mEq at a time

2015 FP Notebook

68. The Role of the Gut for Potassium Homeostasis in CKD

The Role of the Gut for Potassium Homeostasis in CKD Renal Fellow Network: The Role of the Gut for Potassium Homeostasis in CKD | | | | | Sunday, May 27, 2018 The Role of the Gut for Potassium Homeostasis in CKD Recently the FDA approved one of the newer exchange resins (Lokelma, ZS-9) for the treatment of hyperkalemia. (Veltassa, Patiromer), a calcium based cation exchange resin, was recently developed and approved since 2015 for the treatment of hyperkalemia. These two new drugs, which each (...) have large randomized placebo controlled trials confirming their effectiveness, now seem bound to replace the ancient but much experienced Kayexalate (Sodium Polystyrene Sulfonate; SPS) for the management of hyperkalemia. However, they are not approved in Canada and their cost makes them less enticing options in a publicly funded health care system. Also, what about safety concerns? SPS has been used since the 1950s, however it took decades for case reports to come out possibly linking fatal colon

2018 Renal Fellow Network

69. Fatality after Cardiac Arrest in Thyrotoxic Periodic Paralysis due to Profound Hypokalemia Resulting from Intravenous Glucose Administration and Inadequate Potassium Replacement. (Abstract)

Fatality after Cardiac Arrest in Thyrotoxic Periodic Paralysis due to Profound Hypokalemia Resulting from Intravenous Glucose Administration and Inadequate Potassium Replacement.

2012 Thyroid

70. Potassium Supplementation in CKD

Criteria: Hyperkalemia (serum potassium > 5.5 mmol/l) at study visit V0 Medical reasons to continue dual RAAS-blockade, mineralocorticoid receptor blockers, potassium-sparing diuretics, or oral potassium binders. Patients with previous history of ventricular cardiac arrhythmia Patients with a life expectancy < 6 months Expected initiation of renal replacement therapy < 2 years Incapacitated subjects Women who are pregnant, breastfeeding or consider pregnancy in the coming 2 years. Contacts (...) Potassium Supplementation in CKD Potassium Supplementation in CKD - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Potassium Supplementation in CKD (K+ in CKD) The safety and scientific validity

2017 Clinical Trials

71. A Study to Test Whether ZS (Sodium Zirconium Cyclosilicate) Can Reduce the Incidence of Increased Blood Potassium Levels Among Dialized Patients.

A Study to Test Whether ZS (Sodium Zirconium Cyclosilicate) Can Reduce the Incidence of Increased Blood Potassium Levels Among Dialized Patients. A Study to Test Whether ZS (Sodium Zirconium Cyclosilicate) Can Reduce the Incidence of Increased Blood Potassium Levels Among Dialized Patients. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study to Test Whether ZS (Sodium Zirconium Cyclosilicate) Can Reduce the Incidence of Increased Blood Potassium Levels Among Dialized Patients. (DIALIZE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details

2017 Clinical Trials

72. An Open-Label Trial of Losartan Potassium in Participants With Eosinophilic Esophagitis (EoE)

hydrochlorothiazide, digoxin, warfarin, cimetidine, phenobarbital, rifampin, or fluconazole. taking or planning to take potassium supplements or salt substitutes containing potassium. A female participant who is pregnant or nursing or, if of childbearing potential, is not using a medically accepted, effective method of birth control (e.g., condom, oral/injectable/subcutaneous contraceptive, intrauterine device, or sexual abstinence). Participated/participating in any investigative drug or device study within 30 (...) An Open-Label Trial of Losartan Potassium in Participants With Eosinophilic Esophagitis (EoE) An Open-Label Trial of Losartan Potassium in Participants With Eosinophilic Esophagitis (EoE) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2017 Clinical Trials

73. The mechano-sensitivity of cardiac ATP-sensitive potassium channels is mediated by intrinsic MgATPase activity. (Abstract)

The mechano-sensitivity of cardiac ATP-sensitive potassium channels is mediated by intrinsic MgATPase activity. Cardiac ATP-sensitive K+ (KATP) channel activity plays an important cardio-protective role in regulating excitability in response to metabolic stress. Evidence suggests that these channels are also mechano-sensitive and therefore may couple KATP channel activity to increased cardiac workloads. However, the molecular mechanism that couples membrane stretch to channel activity (...) ATP analog AMP-PNP or the ATPase inhibitor BeFx significantly reduced the stimulatory effect of stretch. We employed a point mutagenic approach to determine that a single residue (K1337) in the hairpin loop proximal to the major MgATPase catalytic site in the SUR2A subunit is responsible for the difference in mechano-sensitivity between SUR2A and SUR1 containing KATP channels. Moreover, using a double cysteine mutant substitution in the hairpin loop region revealed the importance of a key residue

2017 Journal of Molecular and Cellular Cardiology

74. Comparison of enteral versus intravenous potassium supplementation in hypokalaemia in paediatric patients in intensive care post cardiac surgery: open-label randomised equivalence trial (EIPS). Full Text available with Trip Pro

Comparison of enteral versus intravenous potassium supplementation in hypokalaemia in paediatric patients in intensive care post cardiac surgery: open-label randomised equivalence trial (EIPS). The primary objective was to compare the efficacy of enteral potassium replacement (EPR) and intravenous potassium replacement (IVPR) as first-line therapy. Secondary objectives included comparison of adverse effects and number of doses required to resolve the episode of hypokalaemia.The EIPS trial (...) is designed as a randomised, equivalence trial between two treatment arms.The study was conducted at the paediatric cardiac intensive care unit (PCICU) at Aga Khan University Hospital, Karachi.41 patients (aged 1 month to 15 years) who were admitted to PCICU post cardiac surgery were recruited (23 IVPR arm and 18 EPR arm).Intervention arms were block randomised on alternate weeks for IVPR and EPR.Change in serum potassium levels in (mmol/L) and percentage change after each event of potassium replacement

2017 BMJ open

75. Adaptation of Bacillus subtilis to Life at Extreme Potassium Limitation Full Text available with Trip Pro

were strongly increased, suggesting that these amino acids can partially substitute for potassium. This was confirmed by the observation that the supplementation with positively charged amino acids allows growth of B. subtilis even at the extreme potassium limitation that the bacteria experience if no potassium is added to the medium. In addition, a second class of suppressor mutations allowed growth at extreme potassium limitation. These mutations result in increased expression of KtrAB (...) Adaptation of Bacillus subtilis to Life at Extreme Potassium Limitation Potassium is the most abundant metal ion in every living cell. This ion is essential due to its requirement for the activity of the ribosome and many enzymes but also because of its role in buffering the negative charge of nucleic acids. As the external concentrations of potassium are usually low, efficient uptake and intracellular enrichment of the ion is necessary. The Gram-positive bacterium Bacillus subtilis possesses

2017 mBio

76. Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids Full Text available with Trip Pro

Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids We are reporting a rare case of acute liver injury that developed after an internal hemorrhoid treatment with the aluminum potassium sulfate and tannic acid (ALTA) regimen. A 41-year-old man developed a fever and liver injury after undergoing internal hemorrhoid treatment with a submucosal injection of ALTA with lidocaine. The acute liver injury was classified clinically as hepatocellular and pathologically (...) as cholestastic. We could not classify the mechanism of injury. High eosinophil and immunoglobulin E levels characterized the injury, and a drug lymphocyte stimulation test was negative on postoperative day 25. Fluid replacement for two weeks after hospitalization improved the liver injury. ALTA therapy involves injecting chemicals into the submucosa, from the rectum to the anus, and this is the first description of a case that developed a severe liver disorder after this treatment; hence, an analysis

2017 World Journal of Gastroenterology

77. Dynamic role of the tether helix in PIP2-dependent gating of a G protein–gated potassium channel Full Text available with Trip Pro

Dynamic role of the tether helix in PIP2-dependent gating of a G protein–gated potassium channel G protein-gated inwardly rectifying potassium (GIRK) channels control neuronal excitability in the brain and are implicated in several different neurological diseases. The anionic phospholipid phosphatidylinositol 4,5 bisphosphate (PIP2) is an essential cofactor for GIRK channel gating, but the precise mechanism by which PIP2 opens GIRK channels remains poorly understood. Previous structural (...) and dynamic interaction with PIP2 When Lys200 is mutated to an uncharged amino acid, it activates the channel by enhancing the interaction with PIP2 Atomistic molecular dynamic simulations of neuronal GIRK2 with the same 6' substitution reveal an open GIRK2 channel with PIP2 molecules adopting novel positions. This dynamic interaction with PIP2 may explain the intrinsic low open probability of GIRK channels and the mechanism underlying activation by G protein Gβγ subunits and ethanol.© 2017 Lacin et al.

2017 The Journal of general physiology

78. Consequences of Different Corticosteroids on Serum Potassium and Prostate-Specific Antigen in Patients Receiving Abiraterone for Castration-Resistant Prostate Cancer: A Retrospective Observational Study Full Text available with Trip Pro

Consequences of Different Corticosteroids on Serum Potassium and Prostate-Specific Antigen in Patients Receiving Abiraterone for Castration-Resistant Prostate Cancer: A Retrospective Observational Study Abiraterone acetate is an androgen synthesis inhibitor approved for the treatment of castration-resistant prostate cancer (CRPC). Although co-administration of either prednisone or prednisolone at 10 mg/d has been recommended to reduce the risk of abiraterone-induced hyperaldosteronism (notably (...) hypokalemia) and to give adjunctive pain relief effects, whether these glucocorticoids can be substituted by dexamethasone remains unknown.We performed a retrospective review of medical records of patients who were given abiraterone for the treatment of CRPC with either prednisolone (ABI/PSL) 10 mg/d or dexamethasone (ABI/DEX) 0.5 or 1 mg/d between 2014 and 2017 in Juntendo University Nerima Hospital. Demographic and biochemical data including prostate-specific antigen (PSA) level were retrieved from

2017 Clinical Medicine Insights. Oncology

79. TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes Full Text available with Trip Pro

channel named TbIRK. The protein is localized to acidocalcisomes in procyclic and in bloodstream form parasites. Functional properties of this channel were established after expression in Xenopus oocytes. Currents recorded in potassium medium show inward rectification and little time dependence. Surprisingly, this channel retains selectivity for potassium ions over sodium ions >7, in spite of the lack of the classical selectivity filter. The sequence GGYVG was predicted in silico to replace (...) TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes Potassium channels from prokaryotes and eukaryotes are usually recognized by a typical amino acid sequence TXTGY(F)G representing the ionic selectivity filter. Using a screening approach with ion channel family profiles but without the above motif, we identified a gene in Trypanosoma brucei that exhibits homology to inward rectifying potassium channels. We report here cloning of this ion

2017 Scientific reports

80. Rhythmic potassium transport regulates the circadian clock in human red blood cells Full Text available with Trip Pro

Rhythmic potassium transport regulates the circadian clock in human red blood cells Circadian rhythms organize many aspects of cell biology and physiology to a daily temporal program that depends on clock gene expression cycles in most mammalian cell types. However, circadian rhythms are also observed in isolated mammalian red blood cells (RBCs), which lack nuclei, suggesting the existence of post-translational cellular clock mechanisms in these cells. Here we show using electrophysiological (...) and pharmacological approaches that human RBCs display circadian regulation of membrane conductance and cytoplasmic conductivity that depends on the cycling of cytoplasmic K+ levels. Using pharmacological intervention and ion replacement, we show that inhibition of K+ transport abolishes RBC electrophysiological rhythms. Our results suggest that in the absence of conventional transcription cycles, RBCs maintain a circadian rhythm in membrane electrophysiology through dynamic regulation of K+ transport.

2017 Nature communications

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