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Potassium Replacement

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41. Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles Full Text available with Trip Pro

Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles Replacing the naphthalene C-unit of the anti-tuberculosis drug bedaquiline with a range of bicyclic heterocycles of widely differing lipophilicity gave analogs with a 4.5-fold range in clogP values. The biological results for these compounds indicate on average a lower clogP limit of about 5.0 in this series for retention of potent inhibitory activity (...) (MIC90s) against M.tb in culture. Some of the compounds also showed a significant reduction in inhibition of hERG channel potassium current compared with bedaquiline, but there was no common structural feature that distinguished these.Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

2018 Bioorganic & medicinal chemistry

42. FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU

FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU (FURTHER) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov

2018 Clinical Trials

43. Targeting Pulsatile Load to Increase Exercise Capacity and Quality of Life After Aortic Valve Replacement for Severe Aortic Stenosis (PULSE AS)

inorganic nitrate enhances oxygen uptake and exercise capacity in this population. Condition or disease Intervention/treatment Phase Aortic Valve Stenosis Drug: Potassium Nitrate Drug: Potassium Chloride Phase 2 Detailed Description: This is a randomized double-blind crossover clinical trial, in which 22 subjects who underwent transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS) three or more months prior to enrollment will receive the following 2 interventions, in randomized (...) Targeting Pulsatile Load to Increase Exercise Capacity and Quality of Life After Aortic Valve Replacement for Severe Aortic Stenosis (PULSE AS) Targeting Pulsatile Load to Increase Exercise Capacity and Quality of Life After Aortic Valve Replacement for Severe Aortic Stenosis (PULSE AS) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save

2018 Clinical Trials

44. Timing of Renal Replacement Therapy

Cohort Study Estimated Study Start Date : October 1, 2019 Estimated Primary Completion Date : December 31, 2019 Estimated Study Completion Date : December 31, 2019 Groups and Cohorts Go to Group/Cohort Intervention/treatment early RRT A patient where initiation of RRT is started without the absolute indications Device: CRRT Continuous Renal Replacement Therapy late RRT CRRT based on absolute indications. Absolute indications: hyperkalemia (serum potassium≥6 mEq/L), severe acidosis (pH≤7.15), plasma (...) Timing of Renal Replacement Therapy Timing of Renal Replacement Therapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Timing of Renal Replacement Therapy (TORRT) The safety and scientific validity

2018 Clinical Trials

45. Efficacy and safety of a phosphate replacement strategy for severe hypophosphatemia in the ICU. (Abstract)

hypophosphatemia (p = 0.01). Mild hyperphosphatemia was observed in one patient only (1.53 mmol/l), hyperkalemia was observed in three patients (all three had severe hypophosphatemia, average potassium after supplementation was 5.2 ±; 0.2 mmol/l) and serum calcium levels remained unchanged in both groups.Individualized phosphate replacement was effective and safe for both moderate and severe hypophosphatemia, but was more accurate in moderate hypophosphatemia. (...) Efficacy and safety of a phosphate replacement strategy for severe hypophosphatemia in the ICU. Experience with individualized phosphate replacement is limited in patients with severe hypophosphatemia. This study compares the efficacy and safety of an individualized regimen of serum phosphate < 0.4 mmol/l treatment in ICU patients to patients with moderate hypophosphatemia (0.4-0.6 mmol/l).This retrospective cohort study included 36 patients with severe and 35 patients with moderate

2018 Netherlands Journal of Medicine

46. Substitutes for Potassium in Metabolism of the Lowest Fungi Full Text available with Trip Pro

Substitutes for Potassium in Metabolism of the Lowest Fungi 16559960 2006 05 25 2018 11 13 0021-9193 32 4 1936 Oct Journal of bacteriology J. Bacteriol. Substitutes for Potassium in Metabolism of the Lowest Fungi. 393-9 Rahn O O Bacteriological Laboratory, New York State College of Agriculture, Cornell University, Ithaca, New York. eng Journal Article United States J Bacteriol 2985120R 0021-9193 1936 10 1 0 0 1936 10 1 0 1 1936 10 1 0 0 ppublish 16559960 PMC543805 J Bacteriol. 1916 Nov;1(6):627

1936 Journal of bacteriology

47. Structure and antiviral activity of substituted potassium benzylaminothiomethane-sulphonates and allied compounds. Full Text available with Trip Pro

Structure and antiviral activity of substituted potassium benzylaminothiomethane-sulphonates and allied compounds. 6055246 1967 12 26 2018 11 13 0366-0826 31 1 1967 Sep British journal of pharmacology and chemotherapy Br J Pharmacol Chemother Structure and antiviral activity of substituted potassium benzylaminothiomethane-sulphonates and allied compounds. 11-8 Rao K V KV Rao P L PL Praphulla H B HB Puttaswamy T L TL Ramanathan S S eng Journal Article England Br J Pharmacol Chemother 0154627

1967 British journal of pharmacology and chemotherapy

48. Reduction of potassium permeability by chloride substitution in cardiac cells. Full Text available with Trip Pro

Reduction of potassium permeability by chloride substitution in cardiac cells. 1. The efflux of radioactive K and Cl ions was measured in cow Purkinje fibres and ventricular preparations of cow, cat and frog. The effect of K and Cl was studied by changing the extracellular K concentration between zero and 54 mM, and by substituting Cl ions by acetylglycinate, isethionate, benzenesulphonate, propionate and nitrate. 2. In the absence of Cl the rate coefficient for 42K efflux showed a pronounced

1977 The Journal of physiology

49. The effects of external sodium substitution on cell sodium and potassium in vascular smooth muscle Full Text available with Trip Pro

The effects of external sodium substitution on cell sodium and potassium in vascular smooth muscle 1. The entry of Li into the vascular smooth muscle cells of the rat tail artery follows first-order kinetics with a rate constant of approximately 1.3 hr(-1) at 10 mM-[Li](o). The rate constant decreases gradually to ca. 0.5 hr(-1) when the [Li](o)/[Na](o) ratio is increased.2. Replacement of Na with Li over the range of [Li](o) from 1 to 115 mM, accomplished at constant ionic strength (...) and osmolarity of the bathing solution, produces changes in cell Na and K without apparent change in cell water. At equilibrium, cell Li increases in linear proportion to [Li](o), at a ratio of 2:1 throughout the range. The increase in cell Li is associated with inverse falls in both cell K and Na such that the ratio of cell K to cell Na remains constant at ca. 10:1 throughout.3. The changes in the ionic contents, induced by equilibration of the tissue with a Na-free, Li-substituted solution, are reversible

1977 The Journal of physiology

50. Serum Potassium Levels and Risk of Sudden Cardiac Death Among Patients With Chronic Kidney Disease and Significant Coronary Artery Disease Full Text available with Trip Pro

catheterization at our institution between 1999 and 2011, 6181 patients had an estimated glomerular filtration rate of ≤60 ml/min per 1.73 m2 and were not receiving renal replacement therapy. The risk of SCA/SCD and all-cause mortality associated with potassium concentration was evaluated at the time of cardiac catheterization (baseline) and most proximate to SCA/SCD events. Covariate-adjusted Cox models were used to examine relationships between baseline potassium measurements and outcomes. A propensity (...) Serum Potassium Levels and Risk of Sudden Cardiac Death Among Patients With Chronic Kidney Disease and Significant Coronary Artery Disease Chronic kidney disease (CKD) patients have increased risks of sudden cardiac arrest and sudden cardiac death (SCA/SCD) that are not explained by traditional risk factors. We examined associations between serum potassium and SCA/SCD in a large cohort of patients with coronary artery disease (CAD) and moderate CKD.Among 22,009 patients who underwent cardiac

2017 Kidney international reports

51. Ocular Injury due to Potassium Permanganate Granules Full Text available with Trip Pro

Ocular Injury due to Potassium Permanganate Granules We report a rare case of ocular injury due to potassium permanganate (KMnO4) granules in a child.This is a retrospective case report.A 2-year-old boy was transferred to our emergency room with severe pain in his right eye, inflamed eyelids, and brownish stains on his fingers. Chemical injury was suspected. Copious eye irrigation was immediately performed. Diffuse brownish splotches were then observed at the inferior bulbar conjunctiva (...) management for mild to moderate degree of ocular burn. Pseudomembrane developed early and transformed into symblepharon within a few days after the injury. Membrane adhesion was lysed, and more aggressive medications were then substituted. Commercial amniotic membrane (PROKERA®) was also applied to promote wound healing and to prevent recurrence of symblepharon. The ocular surface was eventually restored, and corneal transparency was preserved.Ocular injury with the granular form of KMnO4 is rare. Its

2018 Case reports in ophthalmology

52. Synthetic analogs of the snail toxin 6-bromo-2-mercaptotryptamine dimer (BrMT) reveal that lipid bilayer perturbation does not underlie its modulation of voltage-gated potassium channels Full Text available with Trip Pro

Synthetic analogs of the snail toxin 6-bromo-2-mercaptotryptamine dimer (BrMT) reveal that lipid bilayer perturbation does not underlie its modulation of voltage-gated potassium channels Drugs do not act solely by canonical ligand-receptor binding interactions. Amphiphilic drugs partition into membranes, thereby perturbing bulk lipid bilayer properties and possibly altering the function of membrane proteins. Distinguishing membrane perturbation from more direct protein-ligand interactions (...) for its inhibition of Kv1.4 activation. Further, we found that alkyl or ether linkages can replace the chemically labile disulfide bond in the BrMT pharmacophore, and we identified additional regions of the scaffold that are amenable to chemical modification. Our work demonstrates a strategy for determining if drugs act by specific interactions or bilayer-dependent mechanisms, and chemically stable modulators of Kv1 channels are reported.

2018 Biochemistry

53. Mechanisms of oxidative stress-induced in vivo mutagenicity by potassium bromate and nitrofurantoin Full Text available with Trip Pro

Mechanisms of oxidative stress-induced in vivo mutagenicity by potassium bromate and nitrofurantoin Oxidative stress is well known as a key factor of chemical carcinogenesis. However, the actual role of oxidative stress in carcinogenesis, such as oxidative stress-related in vivo mutagenicity, remains unclear. It has been reported that 8-hydroxydeoxyguanosine (8-OHdG), an oxidized DNA lesion, might contribute to chemical carcinogenesis. Potassium bromate (KBrO3) and nitrofurantoin (NFT (...) oxidative stress and subsequent genotoxicity. Administration of 1,500 ppm of KBrO3 in drinking water resulted in an increase in deletion mutations accompanied by an increase in 8-OHdG level, and administration of 2,500 ppm of NFT in diet induced an increase in guanine base substitution mutations without elevation of the 8-OHdG level in Nrf2-deficient mice. These results demonstrated that the formation of 8-OHdG, which resulted from the oxidizing potential of KBrO3, was directly involved in the increase

2018 Journal of toxicologic pathology

54. Myocardial Protection by Glucose-Insulin-Potassium in Moderate- to High-Risk Patients Undergoing Elective On-Pump Cardiac Surgery: A Randomized Controlled Trial. (Abstract)

) scheduled for elective aortic valve replacement and/or coronary artery bypass surgery. Patients were randomized to GIK (20 IU of insulin, 10 mEq of potassium chloride in 50 mL of glucose 40%) or saline infusion given over 60 minutes on anesthetic induction. The primary end point was postcardiotomy ventricular dysfunction (PCVD), defined as new/worsening left ventricular dysfunction requiring inotropic support (≥120 minutes). Secondary end points were the intraoperative changes in left ventricular (...) Myocardial Protection by Glucose-Insulin-Potassium in Moderate- to High-Risk Patients Undergoing Elective On-Pump Cardiac Surgery: A Randomized Controlled Trial. Low cardiac output syndrome is a main cause of death after cardiac surgery. We sought to assess the impact of glucose-insulin-potassium (GIK) to enhance myocardial protection in moderate- to high-risk patients undergoing on-pump heart surgery.A randomized controlled trial was performed in adult patients (Bernstein-Parsonnet score >7

2018 Anesthesia and Analgesia Controlled trial quality: predicted high

55. Bedtime Potassium Losartan on CKD With Nocturnal Hypertension Patients With Nondipping Blood Pressure Pattern

doses of potassium losartan Other Name: Kesiya Experimental: bedtime dosing ARB for the prognosis bedtime administration of potassium losartan has benefit for the prognosis of CKD patients Drug: potassium losartan treated with bedtime or awakening doses of potassium losartan Other Name: Kesiya Outcome Measures Go to Primary Outcome Measures : renal events and Cardiovascular events [ Time Frame: 5 years ] doubled creatine or renal replacement, myocardial infarction, heart failure, stroke, vascular (...) Bedtime Potassium Losartan on CKD With Nocturnal Hypertension Patients With Nondipping Blood Pressure Pattern Bedtime Potassium Losartan on CKD With Nocturnal Hypertension Patients With Nondipping Blood Pressure Pattern - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2018 Clinical Trials

56. Clinical Efficacy of Potassium Canrenoate in Sinus Rhythm Restoration Among Patients With Atrial Fibrillation.

relevant MeSH terms: Layout table for MeSH terms Atrial Fibrillation Arrhythmias, Cardiac Heart Diseases Cardiovascular Diseases Pathologic Processes Canrenone Canrenoic Acid Mineralocorticoid Receptor Antagonists Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs Diuretics, Potassium Sparing Diuretics Natriuretic Agents (...) Clinical Efficacy of Potassium Canrenoate in Sinus Rhythm Restoration Among Patients With Atrial Fibrillation. Clinical Efficacy of Potassium Canrenoate in Sinus Rhythm Restoration Among Patients With Atrial Fibrillation. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2018 Clinical Trials

57. Potassium Reduction Initiative to Optimize RAAS Inhibition Therapy With Sodium Zirconium Cyclosilicate in Heart Failure

Potassium Reduction Initiative to Optimize RAAS Inhibition Therapy With Sodium Zirconium Cyclosilicate in Heart Failure Potassium Reduction Initiative to Optimize RAAS Inhibition Therapy With Sodium Zirconium Cyclosilicate in Heart Failure - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Potassium Reduction Initiative to Optimize RAAS Inhibition Therapy With Sodium Zirconium Cyclosilicate in Heart Failure (PRIORITIZE HF) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our

2018 Clinical Trials

58. Study in HFpEF Patients to Compare the Effect of AZD9977 and Spironolactone on Serum Potassium

Study in HFpEF Patients to Compare the Effect of AZD9977 and Spironolactone on Serum Potassium Study in HFpEF Patients to Compare the Effect of AZD9977 and Spironolactone on Serum Potassium - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Study in HFpEF Patients to Compare the Effect of AZD9977 and Spironolactone on Serum Potassium The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03682497 Recruitment Status : Recruiting

2018 Clinical Trials

59. THE ACCUMULATION OF ELECTROLYTES : IX. REPLACEMENT OF AMMONIA BY SODIUM AND POTASSIUM Full Text available with Trip Pro

THE ACCUMULATION OF ELECTROLYTES : IX. REPLACEMENT OF AMMONIA BY SODIUM AND POTASSIUM Experiments on Valonia were carried out as follows: Stage I.-Cells in dim light accumulated 0.08 M ammonia (NH(3) + NH(4)OH + NH(4) (+)) from sea water containing 0.0025 M ammonia (but the concentration of undissociated ammonia appeared to remain less inside than outside). Potassium came out. Stage II.-Cells in dim light in nearly ammonia-free normal sea water lost ammonia which was replaced by sodium entering (...) from the sea water. Potassium in the sap remained practically constant. Stage III.-The cells were placed in stronger light where the loss of ammonia continued and potassium entered. Sodium entered more rapidly than in Stage II. Stage IV.-Cells transferred to sea water containing 0.0025 M ammonia again accumulated ammonia up to 0.1345 M. The results in general harmonize with the view that the direction of movement of a base M through the protoplasm depends on the difference of the activity products

1938 The Journal of general physiology

60. Contracture Coupling of Slow Striated Muscle in Non-Ionic Solutions and Replacement of Calcium, Sodium, and Potassium Full Text available with Trip Pro

Contracture Coupling of Slow Striated Muscle in Non-Ionic Solutions and Replacement of Calcium, Sodium, and Potassium The development of contracture related to changes of ionic environment (ionic contracture coupling) has been studied in the slowly responding fibers of frog skeletal muscle. When deprived of external ions for 30 minutes by use of solutions of sucrose, mannitol, or glucose, the slow skeletal muscle fibers, but not the fast, develop pronounced and easily reversible contractures (...) . Partial replacement of the non-ionic substance with calcium or sodium reduces the development of the contractures but replacement by potassium does not. The concentration of calcium necessary to prevent contracture induced by a non-ionic solution is greater than that needed to maintain relaxation in ionic solutions. To suppress the non-ionic-induced contractures to the same extent as does calcium requires several fold higher concentrations of sodium. Two types of ionic contracture coupling occur

1964 The Journal of general physiology

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