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Potassium Replacement

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4261. Study of Apixaban for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery

Study of Apixaban for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery Study of Apixaban for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Study of Apixaban for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00371683 Recruitment Status : Completed First Posted : September 4, 2006 Results First Posted : December

2006 Clinical Trials

4262. Study of N-Acetylcysteine (NAC) and Continuous Renal Replacement Therapy (CRRT) for the Treatment of Rhabdomyolysis

Study of N-Acetylcysteine (NAC) and Continuous Renal Replacement Therapy (CRRT) for the Treatment of Rhabdomyolysis Study of N-Acetylcysteine (NAC) and Continuous Renal Replacement Therapy (CRRT) for the Treatment of Rhabdomyolysis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Study of N-Acetylcysteine (NAC) and Continuous Renal Replacement Therapy (CRRT) for the Treatment of Rhabdomyolysis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00391911 Recruitment Status : Completed First Posted : October

2006 Clinical Trials

4263. Cardiac Hormone Replacement With Brain Natriuretic Peptide (BNP) in Heart Failure

Cardiac Hormone Replacement With Brain Natriuretic Peptide (BNP) in Heart Failure Cardiac Hormone Replacement With Brain Natriuretic Peptide (BNP) in Heart Failure - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Cardiac Hormone Replacement With Brain Natriuretic Peptide (BNP) in Heart Failure (SubqBNP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00252187 Recruitment Status : Completed First Posted : November 11, 2005 Results First Posted : December 20, 2012 Last Update Posted : December 20, 2012

2005 Clinical Trials

4264. Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery

Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery (ADVANCE-2) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00452530 Recruitment Status : Completed First

2007 Clinical Trials

4265. Complement split products and proinflammatory cytokines in intraoperatively salvaged unwashed blood during hip replacement: comparison between heparin-coated and non-heparin-coated autotransfusion systems. (Abstract)

Complement split products and proinflammatory cytokines in intraoperatively salvaged unwashed blood during hip replacement: comparison between heparin-coated and non-heparin-coated autotransfusion systems. The aim of the present study was to investigate the quality of shed blood collected in a new intraoperative autotransfusion system (Sangvia, AstraTech, Sweden) and to study whether heparin-coated surfaces in the device reduce the production of inflammatory mediators.The study was randomized (...) and polymorphonuclear elastase were found in collected blood. No significant differences in inflammatory mediators were found between the heparin-coated and the non-heparin-coated groups. The median haemoglobin concentration in the salvaged blood was 74 g/l in both groups. Plasma haemoglobin and potassium concentrations were also elevated. There were no significant differences between the groups.The present study indicates that the blood salvaged intraoperatively contains elevated levels of complement split product

2008 Vox sanguinis Controlled trial quality: uncertain

4266. Postconditioning the human heart with adenosine in heart valve replacement surgery. (Abstract)

is removed is feasible and well tolerated in patients undergoing heart valve replacement. An adenosine postconditioning adjunct to high potassium cold blood myocardial protection is related to less troponin I release, less inotropic drug use, and shorter ICU stay. (...) Postconditioning the human heart with adenosine in heart valve replacement surgery. The effect of adenosine postconditioning on myocardial protection in cardiac surgery remains uncertain. The present study evaluated the safety, feasibility, and beneficial effect of adenosine postconditioning as an adjunct to predominantly used cold-blood cardioplegic myocardial protection method in the setting of heart valve replacement operations.Sixty patients with rheumatic heart valve disease undergoing

2007 The Annals of thoracic surgery Controlled trial quality: uncertain

4267. Electrolyte mass balance during CVVH: lactate vs. bicarbonate-buffered replacement fluids. (Abstract)

bicarbonate or lactate-buffered replacement fluid delivered pre-filter.Sodium, potassium, chloride, magnesium, and phosphate, were measured in each sample. There was a mass gain of sodium, which was similar under both conditions (bicarbonate: 23.3+/-4.9 mmol/hr, lactate: 22.7+/-3.5 mmol/hr). Mass chloride gains occurred with bicarbonate-buffered replacement fluid only (12.8+/-5.3 mmol/hr), while there was an overall net loss of chloride with lactate fluids (-2.5+/-5.2 mmol/hr), resulting in a significant (...) difference in chloride mass balance (p<0.0001). Magnesium mass balance was negative with bicarbonate buffer only (-0.6+/-0.2 mmol/hr) and also differed significantly from that obtained with lactate fluids (-0.1+/-0.2 mmol/hr, p<0.0001). Phosphate losses (bicarbonate: -1.7+/-0.7 mmol/hr, lactate: -1.7+/-0.5 mmol/hr) were equivalent with both buffers. Potassium mass balance was neutral.Mass balance during isovolemic CVVH is significantly affected by the type of replacement fluid administered prefilter

2004 Renal failure Controlled trial quality: uncertain

4268. Phosphate addition to hemodiafiltration solutions during continuous renal replacement therapy. (Abstract)

unchanged 5 h after the addition of 2 ml of potassium phosphate to 5-l Hemosol solutions. Visual inspection did not reveal any precipitate. Of the 20 patients studied, 14 received more than 24 h of phosphate supplementation to dialysate and replacement solutions. Phosphate remained stable throughout CRRT despite phosphate intake from nutrition in 11 cases. No adverse event was noted on potassium, calcium, pH and bicarbonate homeostasis.The addition of phosphate to Hemosol solutions does not precipitate (...) Phosphate addition to hemodiafiltration solutions during continuous renal replacement therapy. Hypophosphatemia often occurs during continuous renal replacement therapy (CRRT). The addition of phosphate to dialysate and replacement solutions facilitates phosphate handling, but the risk of precipitation with calcium within these solutions has not been addressed.Experimental study with a retrospective observational study in a medico-surgical intensive care unit.We tested the addition of phosphate

2004 Intensive Care Medicine

4269. Body composition during GH replacement in adults - methodological variations with respect to gender. Full Text available with Trip Pro

months of GH replacement. The dose of GH was individually adjusted. Body composition was assessed by measurements of potassium-40, total body nitrogen (TBN), tritiated water dilution, dual-energy X-ray absorptiometry (DXA) and bioelectrical impedance analysis (BIA). Four- and five-compartment models for body composition were also calculated.The total daily dose of GH was similar in men and women at 6 months. Serum insulin-like growth factor-I (IGF-I) was higher in men than women at baseline and after (...) Body composition during GH replacement in adults - methodological variations with respect to gender. Men with growth hormone deficiency (GHD) may be more sensitive to GH treatment than women in terms of changes in body composition. We have studied whether age, body-mass index (BMI) and the different types of methodology used to assess body composition may explain these differences.Forty-four men and forty-four women with GHD, closely matched for age and BMI, were studied before and after 6

2006 European Journal of Endocrinology

4270. Life-threatening pulmonary hypertension and right ventricular failure complicating calcium and phosphate replacement in the intensive care unit. Full Text available with Trip Pro

Life-threatening pulmonary hypertension and right ventricular failure complicating calcium and phosphate replacement in the intensive care unit. A 43-year-old man developed septic shock and acute lung injury after surgery to drain an ischiorectal abscess. In the intensive care unit he initially improved but developed severe hypoxaemia, right ventricular failure and pulmonary hypertension 90 min after receiving intravenous calcium gluconate and potassium phosphate, best explained (...) by the formation of a calcium-phosphate precipitant that resulted in aggregate anaphylaxis. His rapid deterioration and lack of response to conventional therapies necessitated support with extracorporeal membrane oxygenation that was life saving. This adverse event has altered local practice regarding calcium and phosphate replacement and has implications for all intensive care units.

2006 Anaesthesia

4271. In primary care patients not taking eigoxin [digoxin] on diuretics who are otherwise well, at what level of serum potassium is potassium supplementation necessary?

on hypokalemia [2], this reports: "Usually, patients who have mild or moderate hypokalemia (potassium of 2.5-3.5 mEq/L), are asymptomatic, or have only minor symptoms need only oral potassium replacement therapy. If cardiac arrhythmias or significant symptoms are present, then more aggressive therapy is warranted. This treatment is similar to the treatment for severe hypokalemia. If the potassium level is less than 2.5 mEq/L, IV potassium should be given. Admission or ED observation is indicated; replacement (...) therapy takes more than a few hours." It later states: "Oral is the preferred route for potassium repletion because it is easy to administer, safe, inexpensive, and readily absorbed from the GI tract. For patients with mild hypokalemia and minimal symptoms, oral replacement is sufficient." Reference 1. Hypokalemia. GP Notebook. [Accessed 5 July 2007] 2. Answered 5 July 2007 Follow us: © 2019 Trip Database Ltd. company number 04316414. Trip is proud to be made in the UK.

2007 TRIP Answers

4272. Renal Replacement Therapy and Transplantation

Renal Replacement Therapy and Transplantation Renal Replacement Therapy and Transplantation | Patient TOPICS Try our Symptom Checker TREATMENT RESOURCES Try our Symptom Checker PROFESSIONAL Upgrade to Patient Pro / / Search Renal Replacement Therapy and Transplantation Authored by , Reviewed by | Last edited 3 May 2016 | Certified by This article is for Medical Professionals Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based (...) on research evidence, UK and European Guidelines. You may find the article more useful, or one of our other . In this article In This Article Renal Replacement Therapy and Transplantation In this article Renal replacement therapy has a vital role in the treatment of severe acute kidney injury (AKI) and end-stage kidney disease. Most patients with chronic kidney disease (CKD) stage 4-5 (estimated glomerular filtration rate (eGFR) <30 ml/minute/1.73 m 2 ) or with CKD stage 3 and rapidly deteriorating renal

2008 Mentor

4273. Linkage of aerobic glycolysis to sodium-potassium transport in rat skeletal muscle. Implications for increased muscle lactate production in sepsis. Full Text available with Trip Pro

Linkage of aerobic glycolysis to sodium-potassium transport in rat skeletal muscle. Implications for increased muscle lactate production in sepsis. Although a linkage between aerobic glycolysis and sodium-potassium transport has been demonstrated in diaphragm, vascular smooth muscle, and other cells, it is not known whether this linkage occurs in skeletal muscle generally. Metabolism of intact hind-leg muscles from young rats was studied in vitro under aerobic incubation conditions. When sodium (...) influx into rat extensor digitorum longus (EDL) and soleus muscles was facilitated by the sodium ionophore monensin, muscle weight gain and production of lactate and alanine were markedly stimulated in a dose-dependent manner. Although lactate production rose in both muscles, it was more pronounced in EDL than in soleus. Monensin-induced lactate production was inhibited by ouabain or by incubation in sodium-free medium. Preincubation in potassium-free medium followed by potassium re-addition also

1996 Journal of Clinical Investigation

4274. Reduction in blood pressure with a sodium-reduced, potassium- and magnesium-enriched mineral salt in subjects with mild essential hypertension. (Abstract)

Reduction in blood pressure with a sodium-reduced, potassium- and magnesium-enriched mineral salt in subjects with mild essential hypertension. A parallel controlled clinical trial was carried out to investigate the effect on blood pressure (BP) of replacing normal salt with mineral salt in seasonings. After a 2-wk run-in period, 21 subjects (10 men and 11 women; age, 66.0+/-7.6 yr) were given mineral salt in seasonings instead of normal salt [mineral salt (MS) group], while 20 subjects (10 men (...) concentrations decreased significantly, while the serum potassium and HDL-cholesterol concentrations increased significantly at week 5. The 24-h urinary sodium excretion decreased, and the 24-h potassium and magnesium excretions increased significantly from week 0 to week 5 in the MS group. In contrast, SBP, DBP, serum chemistry, and urinary electrolyte excretion did not change significantly in the RS group. These findings suggest that the excessive salt content and insufficient potassium and magnesium

1998 Hypertension research : official journal of the Japanese Society of Hypertension

4275. Efficacy of lignocaine in alleviating potassium chloride infusion pain. Full Text available with Trip Pro

Efficacy of lignocaine in alleviating potassium chloride infusion pain. A double-blind study was set up to investigate the effect of pretreatment with lignocaine on the incidence of potassium chloride infusion pain. Twenty-eight patients were randomly allocated into two equal groups. Patients in both groups were hypokalaemic and were scheduled for replacement consisting of potassium chloride 20 mmol diluted to 100 ml in dextrose 5% solution administered over two hours. Group A (lignocaine (...) ) patients were pretreated with a bolus dose lignocaine 3 ml 1%, Group B (control) received isotonic saline 3 ml. The incidence of potassium chloride infusion pain was significantly reduced in Group A. There was no adverse effect reported. This study demonstrates the efficacy of bolus dose of lignocaine in alleviating injection pain for the duration of a two-hour continuous infusion.

1992 Anaesthesia and intensive care Controlled trial quality: uncertain

4276. [Moderate supplementation of potassium in essential hypertension]. (Abstract)

sodium restriction. This increase in potassium intake could be achieved with a potassium-based salt substitute and a moderate increase in vegetable and fruit consumption. Moderate dietary sodium restriction with dietary potassium supplementation may obviate or reduce the need for drug treatment in some patients with mild to moderate hypertension. (...) [Moderate supplementation of potassium in essential hypertension]. 23 unselected patients with mild to moderate essential hypertension, whose average supine blood pressure after two months' observation on no treatment was 154/99 mm Hg, were entered into an eight week double blind randomised crossover study of one month's treatment with slow release potassium tablets (60 mmol/day) versus placebo without alteration of dietary sodium or potassium intake. By the fourth week mean supine blood

1984 Archives des maladies du coeur et des vaisseaux Controlled trial quality: uncertain

4277. Safety and effects of potassium- and magnesium-containing low sodium salt mixtures. (Abstract)

Safety and effects of potassium- and magnesium-containing low sodium salt mixtures. The main purpose of the present studies was to examine the safety of salt mixtures in which 35 or 55% of the NaCl in common table salt was replaced by potassium and magnesium salts. For 41 elderly hospitalized patients common salt from the hospital kitchen was replaced by Na+-K+-Mg2+ salt for 3-5 weeks; for in 85 drug-treated outpatients home use of NaCl was replaced by the use of Na+-K+-Mg2+ salt for 6 months (...) be replaced by potassium and magnesium salts without causing potassium or magnesium toxicity. The results also lend support to the concept that an increase in potassium and magnesium intake and a decrease in sodium intake may have beneficial effects in a substantial number of people.

1984 Journal of cardiovascular pharmacology Controlled trial quality: uncertain

4278. Low-sodium, high-potassium diet: feasibility and acceptability in a normotensive population. Full Text available with Trip Pro

Low-sodium, high-potassium diet: feasibility and acceptability in a normotensive population. Sixty-nine normotensive volunteers participated in an eight-week study to test the feasibility and acceptability of two low-sodium (less than 70 mEq), high-potassium (greater than 100 mEq) diets. The diet groups differed only in the use of KCl salt substitute. Both dietary groups were able to reduce sodium and increase potassium intake compared to the control group. Urine sodium excretion decreased (...) in the diet groups but no change was observed in potassium. Potassium chloride salt substitute was not used as recommended, suggesting its unacceptability.

1984 American Journal of Public Health Controlled trial quality: uncertain

4279. Effects of potassium on sodium balance, renin, noradrenaline and arterial pressure. (Abstract)

Effects of potassium on sodium balance, renin, noradrenaline and arterial pressure. To determine the effects of potassium on blood pressure and factors affecting blood pressure, we conducted a randomized, placebo controlled trial of a potassium chloride-based substitute for table salt in 23 patients with mild to moderate essential hypertension. In addition, the effects of potassium chloride on sodium balance were studied in 10 normal subjects. Potassium loading with 100 mmol/day over five days (...) to tolerate the potassium-based salt substitute in the dose given. We conclude that it is premature to recommend an increase in potassium chloride intake as treatment for raised blood pressure.

1985 Journal of hypertension Controlled trial quality: uncertain

4280. Interactions between the renin-angiotensin system and prostanoids in modulating renal function in potassium-depleted healthy women. (Abstract)

Interactions between the renin-angiotensin system and prostanoids in modulating renal function in potassium-depleted healthy women. Plasma renin activity (PRA) and urinary aldosterone excretion were determined in healthy women with normal potassium balance (N, n = 20) or experimental potassium depletion (KD). KD was induced by natriuretic treatment--associated with replacement of net NaCl and water losses--and low dietary potassium intake (< or = 10 mmol/d). By using different depletion (...) patterns, three groups were obtained with cumulative potassium deficits (mean +/- SEM) of 160 +/- 43 (KD1, n = 8), 198 +/- 22 (KD2, n = 6) and 215 +/- 54 mmol (KD3, n = 6). The renal function by the clearance (cl.) method and urinary concentrations of prostaglandin E2 (PGE2), 6-keto-PGF1 alpha (6KPGF), and thromboxane B2 (TXB2) by the RIA method were estimated during hypotonic polyuria (oral water load) and subsequent moderate antidiuresis induced by low-dose infusion of lysine-8-vasopressin (LVP). 1

1994 Prostaglandins, leukotrienes, and essential fatty acids Controlled trial quality: uncertain

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