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Potassium Replacement

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4241. A Pilot Study of Potassium Supplementation for Adult Patients With Rheumatoid Arthritis

of the investigator, may place the participant at unacceptable risk during the study Pregnancy Vegetarian Use of estrogen replacement therapy Current use of diuretics, beta-blockers, anabolic drugs (steroids or other), angiotensin converting enzyme (ACE) inhibitors, or angiotensin receptor blockers (ARBs), etc, or any drug (s) other than drugs indicated for the purpose of RA therapy which is (are) known to effect serum potassium levels Hyperparathyroidism Untreated thyroid disease Significant immune disorder (...) A Pilot Study of Potassium Supplementation for Adult Patients With Rheumatoid Arthritis A Pilot Study of Potassium Supplementation for Adult Patients With Rheumatoid Arthritis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2007 Clinical Trials

4242. Effect of Potassium Bicarbonate Supplementation on Bone and Muscle in Older Adults

Effect of Potassium Bicarbonate Supplementation on Bone and Muscle in Older Adults Effect of Potassium Bicarbonate Supplementation on Bone and Muscle in Older Adults - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Effect of Potassium Bicarbonate Supplementation on Bone and Muscle in Older Adults The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00357214 Recruitment Status : Completed First Posted : July 27, 2006 Last Update Posted : August 9, 2011 Sponsor: Tufts University Collaborator: National

2006 Clinical Trials

4243. Spironolactone to Decrease Potassium Wasting in Hypercalciurics on Thiazides Diuretics

Diseases Endocrine System Diseases Diuretics Spironolactone Sodium Chloride Symporter Inhibitors Natriuretic Agents Physiological Effects of Drugs Mineralocorticoid Receptor Antagonists Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Diuretics, Potassium Sparing Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action (...) Spironolactone to Decrease Potassium Wasting in Hypercalciurics on Thiazides Diuretics Spironolactone to Decrease Potassium Wasting in Hypercalciurics on Thiazides Diuretics - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2006 Clinical Trials

4244. Effects of Potassium Citrate in Urine of Children With Elevated Calcium in Urine and Kidney Stones

, lower the urinary saturation of calcium oxalate and phosphate, and restore normal intestinal calcium absorption. However thiazides induce hypokalemia and hypocitraturia, and the latter attenuates the beneficial effects of the drug on stone formation. Currently, the drug of choice replacing thiazides in treating idiopathic hypercalciuria is potassium citrate. Potassium citrate is readily absorbed from the gastrointestinal tract, and after being excreted in the urine, it inhibits the crystallization (...) Effects of Potassium Citrate in Urine of Children With Elevated Calcium in Urine and Kidney Stones Effects of Potassium Citrate in Urine of Children With Elevated Calcium in Urine and Kidney Stones - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2005 Clinical Trials

4245. The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1: contributions of the pore domains Full Text available with Trip Pro

The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1: contributions of the pore domains We have investigated the contribution to ionic selectivity of residues in the selectivity filter and pore helices of the P1 and P2 domains in the acid sensitive potassium channel TASK-1. We used site directed mutagenesis and electrophysiological studies, assisted by structural models built through computational methods. We have measured selectivity in channels (...) expressed in Xenopus oocytes, using voltage clamp to measure shifts in reversal potential and current amplitudes when Rb+ or Na+ replaced extracellular K+. Both P1 and P2 contribute to selectivity, and most mutations, including mutation of residues in the triplets GYG and GFG in P1 and P2, made channels non-selective. We interpret the effects of these--and of other mutations--in terms of the way the pore is likely to be stabilised structurally. We show also that residues in the outer pore mouth

2007 Pflugers Archiv : European journal of physiology

4246. Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension Full Text available with Trip Pro

Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension Hypertension is the most prevalent risk factor for cardiovascular diseases, present in almost 30% of adults. A key element in the control of vascular tone is the large-conductance, Ca(2+)-dependent K(+) (BK) channel. The BK channel in vascular smooth muscle is formed by an ion-conducting alpha subunit and a regulatory beta(1) subunit, which couples local increases (...) in intracellular Ca(2+) to augmented channel activity and vascular relaxation. Our large population-based genetic epidemiological study has identified a new single-nucleotide substitution (G352A) in the beta(1) gene (KCNMB1), corresponding to an E65K mutation in the protein. This mutation results in a gain of function of the channel and is associated with low prevalence of moderate and severe diastolic hypertension. BK-beta(1E65K) channels showed increased Ca(2+) sensitivity, compared with wild-type channels

2004 Journal of Clinical Investigation

4247. Differences Between the Negatively Activating Potassium Conductances of Mammalian Cochlear and Vestibular Hair Cells Full Text available with Trip Pro

Differences Between the Negatively Activating Potassium Conductances of Mammalian Cochlear and Vestibular Hair Cells Cochlear and type I vestibular hair cells of mammals express negatively activating potassium (K(+)) conductances, called g(K,n) and g(K,L) respectively, which are important in setting the hair cells' resting potentials and input conductances. It has been suggested that the channels underlying both conductances include KCNQ4 subunits from the KCNQ family of K(+) channels. In whole (...) with a double-exponential decay. g(K,L), but not g(K,n), had appreciable permeability to Cs(+). Unlike g(K,L), g(K,n)'s properties did not change ("wash out") during the replacement of cytoplasmic solution with pipette solution during ruptured-patch recordings. These differences in the functional expression of g(K,n) and g(K,L) channels suggest that there are substantial differences in their molecular structure as well.

2004 JARO: Journal of the Association for Research in Otolaryngology

4248. The potassium sensitivity test: a predictor of treatment response in interstitial cystitis. Full Text available with Trip Pro

The potassium sensitivity test: a predictor of treatment response in interstitial cystitis. To determine whether the potassium sensitivity test (PST) can be used to predict the response to treatment with intravesical sodium hyaluronate in patients with interstitial cystitis.Thirty-eight patients diagnosed with interstitial cystitis were recruited; each had a PST, carried out in a double-blind fashion, followed by six weekly doses of intravesical sodium hyaluronate. The patients were assessed (...) PST developed a urinary tract infection.Although the role of the PST in the diagnosis of interstitial cystitis requires further clarification, the test helps to predict the response to treatment with glycosaminoglycan-substitution therapy.

2005 BJU international Controlled trial quality: uncertain

4249. "Initial, continuous and intermittent bolus" administration of minimally-diluted blood cardioplegia supplemented with potassium and magnesium for hypertrophied hearts. (Abstract)

into the myocardium. We previously introduced "initial, continuous and intermittent bolus" administration of minimally-diluted blood cardioplegia (mini-BCP) supplemented with potassium and magnesium, and this study was designed to elucidate its efficacy in patients with hypertrophied hearts.Thirty patients (M:F=17:13, 69.2+/-7.8 years) with left ventricular mass index greater than 150 g/m(2) who underwent aortic valve replacement between 1996 and 2002 were enrolled, and were allocated to one of the two groups (...) "Initial, continuous and intermittent bolus" administration of minimally-diluted blood cardioplegia supplemented with potassium and magnesium for hypertrophied hearts. Hypertrophied hearts are subject to the deleterious effects of intraoperative ischemia-reperfusion, and stable maintenance of myocardial cardioplegic arrest is essential. Continuous cardioplegia infusion appears an ideal modification to overcome this issue, except for a large amount of crystalloid solution infused

2006 Heart, lung & circulation Controlled trial quality: uncertain

4250. Novel P-Type ATPases Mediate High-Affinity Potassium or Sodium Uptake in Fungi Full Text available with Trip Pro

Novel P-Type ATPases Mediate High-Affinity Potassium or Sodium Uptake in Fungi Fungi have an absolute requirement for K+, but K+ may be partially replaced by Na+. Na+ uptake in Ustilago maydis and Pichia sorbitophila was found to exhibit a fast rate, low Km, and apparent independence of the membrane potential. Searches of sequences with similarity to P-type ATPases in databases allowed us to identify three genes in these species, Umacu1, Umacu2, and PsACU1, that could encode P-type ATPases

2004 Eukaryotic cell

4251. TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones Full Text available with Trip Pro

TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones TRESK (TWIK-related spinal cord K(+) channel) is the most recently identified member of the two-pore-domain potassium channel (K(2P)) family, the molecular source of background potassium currents. Human TRESK channels are not affected by external acidification. However, the mouse orthologue displays moderate pH dependence isolated to a single histidine (...) residue adjacent to the GYG selectivity filter. In the human protein, sequence substitution of tyrosine by histidine at this critical position generated a mutant that displays almost identical proton sensitivity compared with mouse TRESK. In contrast to human TRESK, which is specifically located in spinal cord, we detected mouse TRESK (mTRESK) mRNA in several epithelial and neuronal tissues including lung, liver, kidney, brain and spinal cord. As revealed by endpoint and quantitative RT-PCR, mTRESK

2007 The Journal of physiology

4252. Catalytic mechanism and substrate specificity of the β-subunit of the voltage-gated potassium (Kv) channel Full Text available with Trip Pro

Catalytic mechanism and substrate specificity of the β-subunit of the voltage-gated potassium (Kv) channel The beta-subunits of voltage-gated potassium (Kv) channels are members of the aldo-keto reductase (AKR) superfamily. These proteins regulate inactivation and membrane localization of Kv1 and Kv4 channels. The Kvbeta proteins bind to pyridine nucleotides with high affinity; however, their catalytic properties remain unclear. Here we report that recombinant rat Kvbeta2 catalyzes (...) the reduction of a wide range of aldehydes and ketones. The rate of catalysis was slower (0.06-0.2 min(-1)) than those of most other AKRs but displayed the expected hyperbolic dependence on substrate concentration, with no evidence of allosteric cooperativity. Catalysis was prevented by site-directed substitution of Tyr-90 with phenylalanine, indicating that the acid-base catalytic residue, identified in other AKRs, has a conserved function in Kvbeta2. The protein catalyzed the reduction of a broad range

2008 Biochemistry

4253. The cellular contribution to effluent potassium and its relation to free water transport during peritoneal dialysis. Full Text available with Trip Pro

The cellular contribution to effluent potassium and its relation to free water transport during peritoneal dialysis. Aquaporin-1 (AQP-1) dysfunction is one of the valid theories for decreased free water transport (FWT) in long-term peritoneal dialysis (PD) ultrafiltration failure (UFF). We questioned whether apoptosis of peritoneal cells could be reflected in an increased release of cellular (CR) K(+) and explain AQP-1 dysfunction. If so, negative relationships between CR-K(+) and FWT would (...) < 0.01). CR-K(+) had a positive correlation with FWT in groups I and II, but not in group III. These correlations were also present using much simpler methodologies: replacement of CR-K(+) by mass transfer area coefficient (MTAC)-K(+)/MTAC-creatinine ratio or dialysate over plasma (D/P)-K(+)/D/P-creatinine ratio and replacement of FWT by Na(+)-sieving. No relationship with CA125 was present.This study shows that other than diffusive and convectional, K(+) transport is not excluded in patients treated

2007 Transplantation

4254. Genotype-phenotype correlations in children with congenital hyperinsulinism due to recessive mutations of the adenosine triphosphate-sensitive potassium channel genes. Full Text available with Trip Pro

Genotype-phenotype correlations in children with congenital hyperinsulinism due to recessive mutations of the adenosine triphosphate-sensitive potassium channel genes. Congenital hyperinsulinism (HI) is most commonly caused by recessive mutations of the pancreatic beta-cell ATP-sensitive potassium channel (K(ATP)), encoded by two genes on chromosome 11p, SUR1 and Kir6.2. The two mutations that have been best studied, SUR1 g3992-9a and SUR1 delF1388, are null mutations yielding nonfunctional (...) positive AIR to both tolbutamide and leucine in diffuse HI cases or positive AIR to leucine in focal HI cases. One patient with partial K(ATP) function also responded to treatment with the channel agonist, diazoxide. Six of the seven patients with partial defects had amino acid substitutions or insertions; whereas, the other patient was compound heterozygous for two premature stop codons. These results indicate that some K(ATP) mutations can yield partially functioning channels, including cases

2005 Journal of Clinical Endocrinology and Metabolism

4255. New mutations of SCN4A cause a potassium-sensitive normokalemic periodic paralysis. (Abstract)

New mutations of SCN4A cause a potassium-sensitive normokalemic periodic paralysis. Periodic paralysis is classified into hypokalemic (hypoPP) and hyperkalemic (hyperPP) periodic paralysis according to variations of blood potassium levels during attacks.To describe new mutations in the muscle sodium channel gene SCN4A that cause periodic paralysis.A thorough clinical, electrophysiologic, and molecular study was performed of four unrelated families who presented with periodic paralysis.The nine (...) affected members had episodes of muscle weakness reminiscent of both hyperPP and hypoPP. A provocative test with potassium chloride was positive in two patients. However, repeated and carefully performed tests of blood potassium levels during attacks resulted in normal potassium levels. Remarkably, two patients experienced hypokalemic episodes of paralysis related to peculiar provocative factors (corticosteroids and thyrotoxicosis). Similarly to hyperPP, electromyography in nine patients revealed

2004 Neurology

4256. Potassium channels Kv1.3 and Kv1.5 are expressed on blood-derived dendritic cells in the central nervous system. (Abstract)

Potassium channels Kv1.3 and Kv1.5 are expressed on blood-derived dendritic cells in the central nervous system. Potassium (K(+)) channels on immune cells have gained attention recently as promising targets of therapy for immune-mediated neurological diseases such as multiple sclerosis (MS). We examined K(+) channels on dendritic cells (DCs), which infiltrate the brain in MS and may impact disease course.We identified K(+) channels on blood-derived DCs by whole-cell patch-clamp analysis (...) , confirmed by immunofluorescent staining. We also stained K(+) channels in brain sections from MS patients and control subjects. To test functionality, we blocked K(v)1.3 and K(v)1.5 in stimulated DCs with pharmacological blockers or with an inducible dominant-negative K(v)1.x adenovirus construct and analyzed changes in costimulatory molecule upregulation.Electrophysiological analysis of DCs showed an inward-rectifying K(+) current early after stimulation, replaced by a mix of voltage-gated K(v)1.3

2006 Annals of Neurology

4257. Stable 5,6-epoxyeicosatrienoic acid analog relaxes coronary arteries through potassium channel activation. Full Text available with Trip Pro

Stable 5,6-epoxyeicosatrienoic acid analog relaxes coronary arteries through potassium channel activation. 5,6-epoxyeicosatrienoic acid (5,6-EET) is a cytochrome P450 epoxygenase metabolite of arachidonic acid that causes vasorelaxation. However, investigations of its role in biological systems have been limited by its chemical instability. We developed a stable agonist of 5,6-EET, 5-(pentadeca-3(Z),6(Z),9(Z)-trienyloxy)pentanoic acid (PTPA), in which the 5,6-epoxide was replaced with a 5-ether

2005 Hypertension

4258. Moderate potassium supplementation in essential hypertension. (Abstract)

restriction. This increase in potassium intake could be achieved with a potassium-based salt substitute and a moderate increase in vegetable and fruit consumption. Moderate dietary sodium restriction with dietary potassium supplementation may obviate or reduce the need for drug treatment in some patients with mild to moderate hypertension. (...) Moderate potassium supplementation in essential hypertension. 23 unselected patients with mild to moderate essential hypertension, whose average supine blood pressure after two months' observation on no treatment was 154/99 mm Hg, were entered into an eight week double blind randomised crossover study of one month's treatment with slow release potassium tablets (60 mmol/day) versus placebo without alteration of dietary sodium or potassium intake. By the fourth week mean supine blood pressure

1982 Lancet Controlled trial quality: uncertain

4259. Raltegravir and Atazanavir Replacing Current Suppressive Treatment Because of Side Effects in Current Treatment

Raltegravir and Atazanavir Replacing Current Suppressive Treatment Because of Side Effects in Current Treatment Raltegravir and Atazanavir Replacing Current Suppressive Treatment Because of Side Effects in Current Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Raltegravir and Atazanavir Replacing Current Suppressive Treatment Because of Side Effects in Current Treatment The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00751153 Recruitment Status : Unknown Verified September 2008 by Peter J

2008 Clinical Trials

4260. Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Hip Replacement Surgery (ADVANCE-3)

Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Hip Replacement Surgery (ADVANCE-3) Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Hip Replacement Surgery (ADVANCE-3) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Study of an Investigational Drug for the Prevention of Thrombosis-related Events Following Hip Replacement Surgery (ADVANCE-3) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00423319 Recruitment Status

2007 Clinical Trials

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