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Postpartum Endometritis

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141. Effect of Vaginal Douching With Betadine Before CS for Prevention of Post Operative Infections

: Betadine douches subjects received a vaginal preparation with povidone-iodine solution immediately prior to caesarean delivery Behavioral: Betadine douches subjects received a vaginal preparation with povidone-iodine solution immediately prior to caesarean delivery No Intervention: Non betadine douches subjects didnot received a vaginal preparation prior to caesarean delivery Outcome Measures Go to Primary Outcome Measures : Postpartum endometritis [ Time Frame: 6 weeks after Cesarean section

2018 Clinical Trials

142. Foley Bulb Insertion Method: Blind vs. Direct

: Within 30 minutes of placement procedure ] In the time period immediately following placement Artificial rupture of membranes [ Time Frame: At time of placement of Foley bulb transcervical dilator ] Rupture of amniotic sac Chorioamnionitis or "triple I" [ Time Frame: From beginning of labor process until time of delivery ] Presumptive or confirmed diagnosis Endometritis [ Time Frame: From time of delivery to 30 days postpartum ] Postpartum intrauterine infection Eligibility Criteria Go to Information (...) bulb transcervical dilator. Outcome Measures Go to Primary Outcome Measures : Infection [ Time Frame: Labor to 30 days postpartum ] Pooled maternal infection Secondary Outcome Measures : Maternal fever [ Time Frame: From beginning of labor process to time of discharge, up to seven days ] Greater than or equal to 38 degrees Celsius Request for pain relief [ Time Frame: Within 30 minutes of placement procedure ] Request for IV pain medications or epidural placement Vaginal bleeding [ Time Frame

2018 Clinical Trials

143. Antibiotic Prophylaxis in Ragged Placental Membranes

Hospital Study Details Study Description Go to Brief Summary: In some centres, women are routinely given a course of antibiotics postnatally if ragged placental membranes were present at delivery. The investigators examined the necessity such an intervention. Condition or disease Intervention/treatment Phase Endometritis Postpartum Endometritis Membranes; Retained Drug: Prophylactic antibiotics Other: No prophylaxis (Amox-clav withheld) Not Applicable Detailed Description: Postpartum endometritis (...) resulting in sepsis remain one of the leading cause of maternal mortality in developing countries. Ragged placental membrane is a risk factor for endometritis and is not infrequently encountered. Several hospitals in Malaysia, largely those geographically-removed currently practice administering prophylactic antibiotics for women with ragged placental membranes. The aim is to reduce the risk of postpartum endometritis in a subgroup of women who may present in dire straits. The investigators sought

2018 Clinical Trials

144. Low Implanted Second Trimester Placenta and Placenta Previa

to. Although various studies have tried to address risk factors associated with Placenta Previa development, the etiology of placenta previa still remains obscure. Several risk actors have been identified as strong contributors to placenta previa development. It is also a significant contributor to severe postpartum hemorrhage.Risk factors include; history of previous cesarean section, advanced maternal age, history of previous abortions, high parity and substance abuse during pregnancy (cigarette smoking (...) ), placental size (multiple pregnancy), endometrial damage (previous dilatation and curettage), uterine scars and pathology (previous myomectomy or endometritis), placental pathology (marginal cord insertions and succenturiate lobes), previous placental Previa, and curiously. Condition or disease Intervention/treatment Placenta Previa Radiation: ultrasound Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 52 participants Observational Model: Cohort Time

2018 Clinical Trials

145. Prevalence and Clinical Significance of Streptococcus dysgalactiae subspecies equisimilis (Groups C or G Streptococci) Colonization in Pregnant Women: A Retrospective Cohort Study (PubMed)

taken at 35-37 weeks of pregnancy were analyzed at Tampere University Hospital, Finland, between 2012 and 2014. From this laboratory data, all Streptococcus G or C-positive cultures were included to study maternal and neonatal infectious morbidity after delivery. This study population was compared to women with a positive Streptococcus B culture and to women with a negative culture.The prevalence of Streptococcus G or C colonization was 2.9%. Significantly more postpartum endometritis was found (...) in this study group. No association was found between colonization and neonatal bacteremia.Streptococcus G or C colonization is associated with postpartum endometritis. More research is needed to clarify if antibiotic prophylaxis is reasonable for this group during delivery.

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2018 Infectious diseases in obstetrics and gynecology

146. Effects of ACS in Twin With LPB: Study Protocol for a RCT

death Secondary Outcome Measures : Maternal complication [ Time Frame: 72 hours after birth ] Chorioamnionitis and Postpartum endometritis Respiratory distress syndrome [ Time Frame: 72 hours after birth ] Presence of clinical signs of respiratory distress (tachypnea, retractions, flaring, grunting, or cyanosis), with a requirement for supplemental oxygen with a fraction of inspired oxygen of more than 0.21 and a chest radiograph showing hypoaeration and reticulogranular infiltrates Transient

2018 Clinical Trials

147. Outpatient Foley For Starting Induction of Labor at Term in Nulliparous Women

: From baseline to delivery ] Rates of chorioamnionitis [ Time Frame: From baseline to delivery ] Rates of endometritis [ Time Frame: From delivery until 30 days post-discharge ] Mode of delivery [ Time Frame: From baseline to delivery ] Rates of vaginal delivery, cesarean delivery, and operative vaginal delivery (vacuum or forceps) Postpartum hemorrhage [ Time Frame: At delivery ] Rates of hospital readmission within 30 days [ Time Frame: From hospital discharge until 30 days post-discharge ] Rates

2018 Clinical Trials

148. Addition of Azithromycin to Cefazolin Will Reduce Post CS Infections More Than Cefazolin Only.

(at a dose of 1g) 2 hours preoperative. Study Group: This group will include 200women undergoing elective cs. In this group, patients will receive only standard prophylaxis antibiotic(CEFAZOLIN) Inclusion criteria: Gestational age of 37 0/7 weeks and greater Elective cesarean section Medicaly free pregnant women Exclusion criteria: a known allergy to azithromycin obstetric complications azithromycin use within 7 days before randomization chorioamnionitis or other infection requiring postpartum antibiotic (...) Group This group will include 200women undergoing elective cs. In this group, patients will receive only standard prophylaxis antibiotic(CEFAZOLIN) Outcome Measures Go to Primary Outcome Measures : endometritis [ Time Frame: 6 weeks after surgery ] Endometritis was defined as the presence of at least two of the following signs with no other recognized cause: fever (temperature of at least 38°C [100.4°F]), abdominal pain, uterine tenderness, or purulent drainage from the uterus Eligibility Criteria

2018 Clinical Trials

149. Antibiotics During Intrauterine Balloon Tamponade Placement

Center Information provided by (Responsible Party): Kimberly Gregory, Cedars-Sinai Medical Center Study Details Study Description Go to Brief Summary: The goal of this study is to identify whether antibiotics given at the time of placement of an intrauterine balloon tamponade (IBT) will result in reduction of the risk of endometritis. The investigators hypothesize that antibiotics given at the time of intrauterine balloon tamponade will reduce the likelihood of postpartum endometritis. Condition (...) or disease Intervention/treatment Phase Obstetric Complication Postpartum Hemorrhage Postpartum Endometritis Drug: CeFAZolin 1000 MG Drug: Clindamycin 900 MG in 6 ML Injection Phase 4 Detailed Description: The investigators will perform a randomized, controlled trial of women who have had a postpartum hemorrhage and received an intrauterine balloon tamponade. Patients who are candidates for study enrollment will be identified on Labor & Delivery or in the Maternal-Fetal Care Unit. Patients who give

2018 Clinical Trials

150. Routine Cervical Dilatation at the Non-labour Caesarean Section and Its Influence on Postoperative Pain

defined to reduce the risk of peri/post-operative morbidity. The digital dilatation of cervix during elective caesarean section has still been a concern when evaluating this issue. This procedure is supposed to help the drainage of blood and lochia postpartum, thus reducing infection or the risk of postpartum haemorrhage (PPH). However, on the contrary, this mechanical manipulation may also result in contamination by a vaginal micro-organism and increase the risk of infections or cervical trauma (...) in obstetrics. With the recent increase in the rate of this procedure, it is wise to understand and implement the optimal surgical technique. Therefore, different operational methods have been defined to reduce the risk of peri/post-operative morbidity. The digital dilatation of cervix during elective caesarean section has still been a concern when evaluating this issue. This procedure is supposed to help the drainage of blood and lochia postpartum, thus reducing infection or the risk of postpartum

2018 Clinical Trials

151. Mechanical Dilation of the Cervix in a Scarred Uterus

, cord blood pH of ≤7.0, admission to NICU, neonatal hypoxic-ischaemic encephalopathy, neonatal death. Infectious complications [ Time Frame: Within 24-48hours of intervention ] intrauterine infection, maternal sepsis (e.g. endometritis, UTI), neonatal sepsis, maternal pyrexia, onset of antibiotics Labour complications [ Time Frame: Within 24-48hours of intervention ] uterine hyperstimulation (i.e. >5 contractions / 10mins with abnormal CTG), placental abruption, cord prolapse, postpartum haemorrhage

2018 Clinical Trials

152. Preterm Induction of Labor Timing of Amniotomy: A Randomized Controlled Trial

of the induction. ] Time (hours) from the start of induction (initiation of first cervical ripening agent) to vaginal delivery only Composite maternal morbidity [ Time Frame: Measured from start of induction of labor up to 42 days following delivery ] Composed of six outcomes: chorioamnionitis: defined as a clinical diagnosis before delivery endometritis: defined as a clinical diagnosis surgical site infection: infection within 30 days at the surgical site including wound reopened for infection or cellulitis (...) requiring antibiotics pneumonia: radiologic diagnosis of pneumonia accompanied by clinical signs/symptoms urinary tract infection: >100,000 colonies of a single species in urine culture accompanied by clinical signs/symptoms postpartum hemorrhage: estimated blood loss >1000 mL Composite neonatal morbidity [ Time Frame: Measured up to 28 days of life for the newborn ] Composed of five outcomes: perinatal death: death of a live fetus during labor or <28 days of life neonatal sepsis: critically ill infant

2018 Clinical Trials

153. Digital Cervical and Cesarean Section

University Study Details Study Description Go to Brief Summary: Cesarean delivery is one of the most commonly performed surgical operations worldwide Cesarean delivery even as an elective procedure has been associated with considerable maternal risks compared with vaginal delivery. Some of the complications include postpartum hemorrhage, uterine infection, urinary tract infection, wound infection, septicemia and maternal death. Over the years, many variations in the surgical technique of Cesarean (...) Caesarean section Procedure: Caesarean section Caesarean section will be done to deliver the baby Other: cervical dilatation Cervical dilatation will be done by double gloves digital dilatation postpartum Group A: non cervical dilatation patients who will have not cervical dilatation during Caesarean section Procedure: Caesarean section Caesarean section will be done to deliver the baby Other: No cervical dilatation after delivery of the baby cervix will be remain closed Outcome Measures Go to Primary

2018 Clinical Trials

154. Impact of Uterine Closure Techniques on the Cesarean Scar Thickness After Repeated Cesarean Section

and postoperatively 48 hours Blood product transfusion [ Time Frame: One week after cesarean ] unite number of transfused packed erythrocyte Maternal infectious morbidity [ Time Frame: six weeks after cesarean ] prevalence of postpartum endometritis, skin wound dehiscence and post operative fever. Length of hospitalization [ Time Frame: One month after cesarean ] Duration in days Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important

2018 Clinical Trials

155. Comparison of Misoprostol Ripening Efficacy With Dilapan

or Misoprostol for cervical ripening Percentage of women who developed endometritis within 14 days of intervention [ Time Frame: From delivery until two weeks after discharge (approximately up to 3 weeks) ] This is to measure the safety of either Dilapan or Misoprostol for cervical ripening Percentage of women who developed postpartum hemorrhage [ Time Frame: From delivery until two weeks after discharge (approximately up to 3 weeks) ] This is to measure the safety of either Dilapan or Misoprostol (...) for cervical ripening, postpartum hemorrhage is defined as estimated blood loss (EBL) > 1000cc and/or drop in Hematocrit (HCT) by 10 points. Percentage of newborns with Apgar score <7 at 5 min [ Time Frame: From birth until two weeks after birth ] This is to measure the safety of either Dilapan or Misoprostol for cervical ripening by studying the effect on newborns Percentage of newborns with cord arterial blood potential hydrogen (pH) < 7 [ Time Frame: From birth until two weeks after birth

2018 Clinical Trials

156. Comparison of Insulin Alone to Insulin With Metformin to Treat Gestational Diabetes Mellitus

disorder of pregnancy [ Time Frame: from enrollment through study completion (30 days after delivery) ] gestational HTN, superimposed pre-eclampsia, pre-eclampsia-eclampsia Incidence of composite of adverse maternal outcomes [ Time Frame: from enrollment through study completion (30 days after delivery) ] death, ICU admission, postpartum hemorrhage, blood transfusion, organ failure, chorioamnionitis/endometritis Breast feeding status [ Time Frame: Will be recorded at the time of hospital discharge (...) was collected as part of routine care prior to enrollment, this value will be compared to the hemoglobin A1c collected at delivery Incidence of maternal side effects [ Time Frame: Will be assessed weekly until delivery ] maternal reported medication side effects (i.e. nausea, vomiting, diarrhea) Treatment acceptability [ Time Frame: Will be collected postpartum after delivery ] determined using Diabetes Treatment Satisfaction Questionnaire. Survey includes 8 questions that are answered on a scale of 0-6; 0

2018 Clinical Trials

157. Mechanical Dilatation of the Cervix at Elective Caesarean Section to Reduce Post-Operative Blood Loss

for national guideline development. Some obstetricians believe that the cervix of women at non-labor cesarean section is undilated and might cause obstruction of blood or lochia drainage, leading to postpartum hemorrhage and endometritis from the collection of lochia or debris. Dilatation of the cervix helps with the drainage of blood during postpartum, reducing intrauterine infection or the risk of postpartum hemorrhage. To avoid this problem, some obstetricians routinely dilate the cervix from above

2018 Clinical Trials

158. Routine Early vs Delayed Amniotomy for Preterm Pregnancies: A Randomized Open Label Trial

cm or they have been on an oxytocin drip for greater than 10 hours with no cervical change. It is possible that a woman in the late amniotomy group will not undergo AROM at all. The primary outcome under consideration is time in labor. Secondary outcomes include rates of chorioamnionitis, postpartum endometritis, mode of delivery, and neonatal outcomes. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 104 participants (...) for cesarean delivery Maternal/Labor Outcomes:Operative vaginal delivery [ Time Frame: at delivery ] Use of either a vacuum device or obstetrical forceps Maternal intrapartum fever or chorioamnionitis [ Time Frame: during labor to delivery ] Defined as persistent intrapartum fever and/or suspected or confirmed intraamniotic infection (20) Post-partum endometritis: [ Time Frame: up to 10 days ] defined as postpartum febrile morbidity in the absence of another causative factor (i.e. wound infection, deep

2018 Clinical Trials

159. Azithromycin-based Extended-Spectrum Antibiotic Prophylaxis for Cesarean: Role of Placental Colonization with Genital Ureaplasmas and Mycoplasmas. (PubMed)

prophylaxis at cesarean. Chorioamnion/placenta specimens were tested for genital mycoplasmataceae colonization by polymerase chain reaction. Primary outcome was a composite of endometritis, wound infection, or other infections up to 6 weeks postpartum. Analysis was intent-to-treat; logistic regression was used to evaluate interactions between treatment assignment (AZI/placebo) and the presence/absence of mycoplasmataceae and to quantify effects of AZI in analyses stratified by the presence/absence (...) (OR: 0.49; 95% CI: 0.24-1) of mycoplasmataceae. Results were similar with endometritis/wound infections and with ureaplasmas/mycoplasmas considered separately. The reduction in postcesarean infection with AZI does not vary based on the presence or absence of genital mycoplasmataceae placental colonization.Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

2018 American journal of perinatology

160. The effect of mechanical cervical dilatation during scheduled cesarean section on the blood loss: a randomized controlled trial. (PubMed)

and haematocrit levels in group II (p = 0.014 and 0.033 respectively). The mean duration of CS was significantly shorter in the cervical dilatation group (p = 0.002). No difference between both groups regarding the rate of postpartum hemorrhage (PPH) (p = 0.21), the duration of hospital stay (p = 0.17), the rate of wound infection (p = 0.32), the rate of endometritis (p = 0.82).Mechanical cervical dilatation during scheduled CS could be associated with lower postoperative blood loss, higher postoperative (...) spinal anesthesia if they met our inclusion criteria. Eligible participants were randomized to one of two groups. Group (I): Women with intraoperative cervical dilatation and Group (II): women with no intraoperative cervical dilatation. The primary outcome of this study was the mean volume of total blood loss during CS. The secondary outcomes included the mean reduction in the hemoglobin and hematocrit, the rate of primary postpartum hemorrhage, the duration of surgery, the duration of hospital stay

2018 The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

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